A Comparison of Clinical Features and Mechanisms of Trigeminal Postherpetic Neuralgia and Trigeminal Neuralgia

  • Barry J. SessleEmail author
  • C. Peter N. Watson


This chapter compares and contrasts trigeminal postherpetic neuralgia (TPHN) and trigeminal neuralgia (TN) with regard to clinical features, pathology, putative pathophysiology, and treatment. These two forms of neuropathic facial pain are completely different and easy to distinguish clinically. A failure to appreciate these clinical differences will result in therapeutic failure medically and surgically.



Alpha-amino-3-hydroxy-5-isoxazde-proprionic acid


Calcitonin gene-related peptide


Gamma amino butyric acid




Central nervous system


Dorsal root ganglion


Herpes zoster


Microvascular decompression


Nociceptive specific


Postherpetic neuralgia


Serotonin reuptake inhibitors


Tricyclic antidepressants


Trigeminal neuralgia


Trigeminal postherpetic neuralgia


Trigeminal brainstem sensory nuclear complex


Wide dynamic range


Varicella zoster virus


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© Springer International Publishing Switzerland 2017

Authors and Affiliations

  1. 1.Faculty of Dentistry, Department of Physiology, Faculty of Medicine, and Centre for the Study of PainUniversity of TorontoTorontoCanada
  2. 2.Department of MedicineUniversity of TorontoTorontoCanada

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