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A Comparison of Clinical Features and Mechanisms of Trigeminal Postherpetic Neuralgia and Trigeminal Neuralgia

  • Barry J. Sessle
  • C. Peter N. Watson
Chapter

Abstract

This chapter compares and contrasts trigeminal postherpetic neuralgia (TPHN) and trigeminal neuralgia (TN) with regard to clinical features, pathology, putative pathophysiology, and treatment. These two forms of neuropathic facial pain are completely different and easy to distinguish clinically. A failure to appreciate these clinical differences will result in therapeutic failure medically and surgically.

Acronyms

AMPA

Alpha-amino-3-hydroxy-5-isoxazde-proprionic acid

CGRB

Calcitonin gene-related peptide

GABA

Gamma amino butyric acid

NMDA

N-methyl-D-aspartate

CNS

Central nervous system

DRG

Dorsal root ganglion

HZ

Herpes zoster

MVD

Microvascular decompression

NS

Nociceptive specific

PHN

Postherpetic neuralgia

SNRIs

Serotonin reuptake inhibitors

TCAs

Tricyclic antidepressants

TN

Trigeminal neuralgia

TPHN

Trigeminal postherpetic neuralgia

VBSNC

Trigeminal brainstem sensory nuclear complex

WDR

Wide dynamic range

VZV

Varicella zoster virus

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Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  1. 1.Faculty of Dentistry, Department of Physiology, Faculty of Medicine, and Centre for the Study of PainUniversity of TorontoTorontoCanada
  2. 2.Department of MedicineUniversity of TorontoTorontoCanada

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