Role of Topical Therapy: Imiquimod

  • Elise Ng
  • Vicki LevineEmail author


The gold standard for treatment of lentigo maligna is complete surgical excision. Second-line non-surgical modalities include radiotherapy, laser therapy, and topical therapies. Evidence for the use of various topical agents, including tretinoin, azelaic acid, and 5-fluorouracil, is limited. The greatest evidence exists for imiquimod 5 % cream, which has been investigated in multiple case series and studies. Topical imiquimod appears to be effective in a subset of cases, but clinical response is unpredictable and guidelines for monitoring and follow-up remain to be established. As such, its role in the treatment of lentigo maligna remains controversial and additional studies with higher quality evidence are needed.


Imiquimod Lentigo maligna Melanoma in-situ Melanoma Topical immunomodulator Immune response modifier 


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Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  1. 1.The Ronald O. Perelman Department of DermatologyNew York University School of MedicineNew YorkUSA
  2. 2.Department of DermatologyNYU/LangoneNew YorkUSA

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