Difficult Cases and Complications from Catheterization Laboratory: Successful Percutaneous Mitral Valve Repair with Three MitraClip Devices in a Complex Case of Severe Functional Mitral Regurgitation

  • G. GrassiEmail author
  • F. Ronco


A 62-year-old man with nonischemic dilated cardiomyopathy (DCM) was referred to our center for evaluation of percutaneous mitral valve repair (PMVR) as he had developed significantly reduced left ventricular ejection fraction (LVEF) and severe functional mitral valve regurgitation (MR).


Mitral Valve Leave Ventricular Ejection Fraction Mitral Regurgitation Cardiac Resynchronization Therapy Mitral Regurgitation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We are grateful to Marlies Osterman MD for editing the manuscript.

Supplementary material

Video 14.1

(MOV 5162 kb)

Video 14.2

(MOV 8232 kb)

Video 14.3

(MOV 2697 kb)

Video 14.4

(MOV 1864 kb)

Video 14.5

(MOV 1249 kb)

Video 14.6

(MOV 641 kb)

Video 14.7

(MOV 660 kb)

Video 14.8

(MOV 2757 kb)

Video 14.9

(MOV 3951 kb)


  1. 1.
    Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC), European Association for Cardio-Thoracic Surgery (EACTS), Vahanian A, Alfieri O, Andreotti F, Antunes MJ, Barón-Esquivias G, Baumgartner H, Borger MA, Carrel TP, De Bonis M, Evangelista A, Falk V, Iung B, Lancellotti P, Pierard L, Price S, Schäfers HJ, Schuler G, Stepinska J, Swedberg K, Takkenberg J, Von Oppell UO, Windecker S, Zamorano JL, Zembala M. Guidelines on the management of valvular heart disease. Eur Heart J. 2012;33:2451–96.CrossRefGoogle Scholar
  2. 2.
    Whitlow PL, Feldman T, Pedersen WR, Lim DS, Kipperman R, Smalling R, Bajwa T, Herrmann HC, Lasala J, Maddux JT, Tuzcu M, Kapadia S, Trento A, Siegel RJ, Foster E, Glower D, Mauri L, Kar S, on behalf of the EVEREST II Investigators. Acute and 12-month results with catheter-based mitral valve leaflet repair the EVEREST II (Endovascular Valve Edge-to-Edge Repair) high risk study. J Am Coll Cardiol. 2012;59:130–9.CrossRefPubMedGoogle Scholar
  3. 3.
    Lim S, Reynolds MR, Feldman T, Kar S, Herrmann HC, Wang A, Whitlow PL, Gray WA, Grayburn P, Mack MJ, Glower DD. Improved functional status and quality of life in prohibitive surgical risk patients with degenerative mitral regurgitation after transcatheter mitral valve repair. J Am Coll Cardiol. 2014;64:182–92.CrossRefPubMedGoogle Scholar
  4. 4.
    Maisano F, Franzen O, Baldus S, Schäfer U, Hausleiter J, Butter C, Ussia GP, Sievert H, Richardt G, Widder JD, Moccetti T, Schillinger W. Percutaneous mitral valve interventions in the real world early and 1-year results from the ACCESS-EU, a prospective, multicenter, nonrandomized post-approval. J Am Coll Cardiol. 2013;62:1052–61.CrossRefPubMedGoogle Scholar
  5. 5.
    Paranskaya L, Turan I, Kische S, Nienaber C, Ince H. Rapid pacing facilitates grasping and MitraClip implantation in severe mitral leaflet prolapse. Clin Res Cardiol. 2012;101:69–71.CrossRefPubMedGoogle Scholar
  6. 6.
    Ussia GP, Cammalleri V, Sergi D, De Vico P, Romeo F. Annulus remodeling and double orifice repair using a multiple clip approach in complex mitral valve anatomy. JACC Cardiovasc Interv. 2014;7:53–4.CrossRefGoogle Scholar
  7. 7.
    Kische S, Nienaber C, Ince H. Use of four MitraClip devices in a patient with ischemic cardiomyopathy and mitral regurgitation: “zipping by clipping”. Catheter Cardiovasc Interv. 2012;80:1007–13.Google Scholar

Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  1. 1.Emodinamica e Cardiologia Interventistica, Dipartimento Cardiovascolare, ULSS 12 VenezianaVeniceItaly

Personalised recommendations