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Engineering and Clinical Considerations in Pulsatile Blood Pump

  • Oliver VoigtEmail author
  • Friedrich Kaufmann
Chapter

Abstract

The development of mechanical circulatory support systems (“MCSS”) has been in parallel to donor heart transplantation. In 1966, Michael E. DeBakey did the first successful implant of a partial artificial heart at Methodist Hospital in Houston, USA, by using a paracorporeal blood pump to assist the failing left ventricle of a female patient until her heart has recovered after 10 days [1]. A blood pump connected to the patient’s circulatory system to support the pumping function is called ventricular assist device or “VAD.” Three years later, in 1969 Denton Cooley implanted the first total artificial heart (“TAH” – a full replacement of the patient’s native heart) which was developed by Domingo Liotta into the chest of a 47-year-old patient for 64 h to bridge him for heart transplantation [2]. The first implantations with the aim of permanent life support (so-called destination therapy, “DT”) took place 13 years later in 1982 by William DeVries and his team at Utah Medical Center, USA, using the Jarvik-7 TAH developed by Willem Kolff and his team [3]. The first MCSS mimic the layout (anatomy) and function of the natural heart using pulsatile pumping mode of displacement pumps. Nowadays nonpulsatile rotary blood pumps are the first choice for long-term LVAD support. Only for pediatric use and for short- to medium-term support the pulsatile displacement pumps are being used in the clinical arena. The first implantation of an axial flow rotary blood pump was in 1998 at the German Heart Institute Berlin, Germany, performed by Roland Hetzer [4]. In 2012, Martin Strueber reported the first use of two continuous flow centrifugal blood pumps as TAH in a patient after cardioectomy at Hannover Medical School, Germany [5]. Nevertheless, the current TAH systems and those in clinical or preclinical evaluation are all pulsatile pump systems. The pulsatile TAH offers advantages like high physiologic flows in case of biventricular failure.

References

  1. 1.
    Liotta D (2002) Early clinical application of assisted circulation. Tex Heart Inst J 29(3):229–230PubMedPubMedCentralGoogle Scholar
  2. 2.
    Cooley DA (2001) The total artificial heart as a bridge to cardiac transplantation: personal recollections. Tex Heart Inst J 28(3):200–202PubMedPubMedCentralGoogle Scholar
  3. 3.
    DeVries WC, Anderson JL, Joyce LD, Anderson FL, Hammond EH, Jarvik RK, Kolff WJ (1984) Clinical use of the total artificial heart. N Engl J Med 310(5):273–278CrossRefPubMedGoogle Scholar
  4. 4.
    Noon GP, Morley DL, Irwin S, Abdelsayed SV, Benkowski RJ, Lynch BE (2001) Clinical experience with the MicroMed DeBakey ventricular assist device. Ann Thorac Surg 71(3 Suppl):S133–8; discussion S144–6Google Scholar
  5. 5.
    Strueber M, Schmitto J, Kutschka I, Haverich A (2012) Placement of 2 implantable centrifugal pumps to serve as a total artificial heart after cardiectomy. J Thorac Cardiovasc Surg 143(2):507–509CrossRefPubMedGoogle Scholar
  6. 6.
    Werkkala K, Jokinen JJ, Soininen L, Dellgren G et al (2016) Clinical durability of the CARMEDA® BioActive Surface in EXCOR® VAD pumps. ASAIO J 62:139–142PubMedGoogle Scholar
  7. 7.
    Völz S, Holmberg M, Redfors B, Dellgren G (2014) Acute tamponade of the left paracorporeal pump house due to membrane defect in a patient with a Berlin Heart EXCOR biventricular assist device. Eur J Cardiothorac Surg 46:743–744CrossRefPubMedGoogle Scholar
  8. 8.
    Jaroszewski DE, Anderson EM, Pierce CN, Arabia FA (2011) The SynCardia freedom driver: a portable driver for discharge home with the total artificial heart. J Heart Lung Transplant 30:844–845CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  1. 1.SynCardia Systems Europe GmbHBad OeynhausenGermany
  2. 2.Department of Cardiothoracic and Vascular SurgeryDeutsches Herzzentrum BerlinBerlinGermany

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