Nanoparticles for Ultrasound-Guided Imaging of Cell Implantation



Regenerative medicine uses stem cells to repair damaged tissue. Imaging plays a key role in this process because imaging can reveal the location of cells and how they are interacting with the surrounding tissue. Ultrasound imaging is particularly powerful because it offers excellent temporal and spatial resolution and is ubiquitously present at low cost. Here, we explain different types of ultrasound imaging in tandem with stem cell therapy. The two main classes are direct imaging that labels a stem cell with an exogenous contrast agent and indirect imaging in which a reporter gene expresses a protein that can then be targeted with a contrast agent as substrate. We also describe photoacoustic imaging as one of the latest techniques for increasing acoustic contrast in imaging. Finally, we close with some perspectives on growth and needs in the field.


Stem cell Regenerative medicine Ultrasound Nanoparticle Molecular imaging Image-guided delivery Theranostics 


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Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  1. 1.Department of NanoEngineeringUniversity of CaliforniaSan Diego, La JollaUSA

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