System Calibration for Quantitative Contrast-Enhanced Digital Breast Tomosynthesis (CEDBT)

  • Melissa L. Hill
  • James G. Mainprize
  • Martin J. Yaffe
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 9699)


In contrast-enhanced (CE) breast imaging, lesion contrast agent content may be diagnostic, relating to vascularization and tumour angiogenesis. However, factors in CE digital breast tomosynthesis (DBT) such as incomplete angular sampling, beam hardening and scatter can confound quantitative measurement. We propose system calibration to improve CEDBT quantitative potential. Fifteen projection images of an iodine calibration phantom, with various breast-equivalent compositions, thicknesses and lesion locations, were acquired over 40°, and reconstructed using SART. A separate breast-equivalent phantom with iodinated spherical lesions was imaged to test quantification accuracy. Excellent linearity between voxel signal and iodine concentration was achieved in the calibration data. In test phantom cases, lesion signal faithfully represented the true iodine concentration, but with wide confidence intervals for small lesions. While promising, it remains to be determined whether the iodine quantification accuracy is sufficient for lesion differentiation, and whether lesion shape, position, and non-uniform breast tissue would impair this estimation.


Contrast-enhanced Tomosynthesis Mammography Iodine Quantitative imaging 



This work was conducted with the support of the Ontario Institute for Cancer Research through funding provided by the Government of Ontario. The authors thank Michael Kempston for his contributions.


  1. 1.
    Fallenberg, E.M., Dromain, C., Diekmann, F., Engelken, F., Krohn, M., Singh, J.M., Ingold-Heppner, B., Winzer, K.J., Bick, U., Renz, D.M.: Contrast-enhanced spectral mammography versus MRI: Initial results in the detection of breast cancer and assessment of tumour size. Eur. Radiol. 24, 256–264 (2014)CrossRefGoogle Scholar
  2. 2.
    Chou, C.-P., Lewin, J.M., Chiang, C.-L., Hung, B.-H., Yang, T.-L., Huang, J.-S., Liao, J.-B., Pan, H.-B.: Clinical evaluation of contrast-enhanced digital mammography and contrast enhanced tomosynthesis-comparison to contrast-enhanced breast MRI. Eur. J. Radiol. 84, 2501–2508 (2015)CrossRefGoogle Scholar
  3. 3.
    Lewin, J.M., Isaacs, P.K., Vance, V., Larke, F.J.: Dual-energy contrast-enhanced digital subtraction mammography: feasibility. Radiology 229, 261–268 (2003)CrossRefGoogle Scholar
  4. 4.
    Jong, R.A., Yaffe, M.J., Skarpathiotakis, M., Shumak, R.S., Danjoux, N.M., Gunesekara, A.: Contrast-enhanced digital mammography: initial clinical experience. Radiology 228, 842–850 (2003)CrossRefGoogle Scholar
  5. 5.
    Dromain, C., Balleyguier, C., Muller, S., Mathieu, M.-C., Rochard, F., Opolon, P., Sigal, R.: Evaluation of tumor angiogenesis of breast carcinoma using contrast-enhanced digital mammography. Am. J. Roentgenol. 187, W528–W537 (2006)CrossRefGoogle Scholar
  6. 6.
    Hill, M.L., Liu, K., Mainprize, J.G., Levitin, R.B., Shojaii, R., Yaffe, M.J.: Pre-clinical evaluation of tumour angiogenesis with contrast-enhanced breast tomosynthesis. In: Maidment, A.D., Bakic, P.R., Gavenonis, S. (eds.) IWDM 2012. LNCS, vol. 7361, pp. 1–8. Springer, Heidelberg (2012)CrossRefGoogle Scholar
  7. 7.
    Prionas, N.D., Lindfors, K.K., Ray, S., Beckett, L.A., Monsky, W.L., Boone, J.M.: Contrast-enhanced dedicated breast CT: initial clinical experience. Radiology 256, 714–723 (2010)CrossRefGoogle Scholar
  8. 8.
    He, N., Wu, Y.-P., Kong, Y., Lv, N., Huang, Z.-M., Li, S., Wang, Y., Geng, Z., Wu, P.-H., Wei, W.-D.: The utility of breast cone-beam computed tomography, ultrasound, and digital mammography for detecting malignant breast tumors: a prospective study with 212 patients. Eur. J. Radiol. 85, 392–403 (2016)CrossRefGoogle Scholar
  9. 9.
    Shafer, C.M., Samei, E., Lo, J.Y.: The quantitative potential for breast tomosynthesis imaging. Med. Phys. 37, 1004–1016 (2010)CrossRefGoogle Scholar
  10. 10.
    Lu, Y., Peng, B., Lau, B.A., Hu, Y.-H., Scaduto, D.A., Zhao, W., Gindi, G.: A scatter correction method for contrast-enhanced dual-energy digital breast tomosynthesis. Phys. Med. Biol. 60, 6323–6354 (2015)CrossRefGoogle Scholar
  11. 11.
    Andersen, A.H., Kak, A.C.: Simultaneous algebraic reconstruction technique (SART): a superior implementation of the ART algorithm. Ultrason. Imaging 6, 81–94 (1984)CrossRefGoogle Scholar
  12. 12.
    Hill, M.L., Mainprize, J.G., Mawdsley, G.E., Yaffe, M.J.: A solid iodinated phantom material for use in tomographic x-ray imaging. Med. Phys. 36, 4409–4420 (2009)CrossRefGoogle Scholar
  13. 13.
    Hill, M.L., Mainprize, J.G., Yaffe, M.J.: Sensitivity of contrast-enhanced digital breast tomosynthesis to changes in iodine concentration during acquisition. In: Krupinski, E.A. (ed.) IWDM 2008. LNCS, vol. 5116, pp. 643–650. Springer, Heidelberg (2008)CrossRefGoogle Scholar
  14. 14.
    Boone, J.M., Lindfors, K.K., Cooper, V.N., Seibert, J.A.: Scatter/primary in mammography: comprehensive results. Med. Phys. 27, 2408–2416 (2000)CrossRefGoogle Scholar
  15. 15.
    Johns, P.C., Yaffe, M.J.: X-ray characterisation of normal and neoplastic breast tissues. Phys. Med. Biol. 32, 675–695 (1987)CrossRefGoogle Scholar
  16. 16.
    Hill, M.L., Mainprize, J.G., Carton, A.-K., Muller, S., Ebrahimi, M., Jong, R.A., Dromain, C., Yaffe, M.J.: Anatomical noise in contrast-enhanced digital mammography. Part I. Single-energy imaging. Med. Phys. 40, 051910 (2013)CrossRefGoogle Scholar
  17. 17.
    Hu, Y.-H., Zhao, B., Zhao, W.: Image artifacts in digital breast tomosynthesis: investigation of the effects of system geometry and reconstruction parameters using a linear system approach. Med. Phys. 35, 5242–5252 (2008)CrossRefGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Melissa L. Hill
    • 1
  • James G. Mainprize
    • 1
  • Martin J. Yaffe
    • 1
    • 2
  1. 1.Physical SciencesSunnybrook Research InstituteTorontoCanada
  2. 2.Department of Medical BiophysicsUniversity of TorontoTorontoCanada

Personalised recommendations