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The Relevance of Genomic Signatures at Adhesion GPCR Loci in Humans

  • Peter KovacsEmail author
  • Torsten SchönebergEmail author
Chapter
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 234)

Graphical Abstract

Abstract

Adhesion G protein-coupled receptors (aGPCRs) have a long evolutionary history dating back to very basal unicellular eukaryotes. Almost every vertebrate is equipped with a set of different aGPCRs. Genomic sequence data of several hundred extinct and extant species allows for reconstruction of aGPCR phylogeny in vertebrates and non-vertebrates in general but also provides a detailed view into the recent evolutionary history of human aGPCRs. Mining these sequence sources with bioinformatic tools can unveil many facets of formerly unappreciated aGPCR functions. In this review, we extracted such information from the literature and open public sources and provide insights into the history of aGPCR in humans. This includes comprehensive analyses of signatures of selection, variability of human aGPCR genes, and quantitative traits at human aGPCR loci. As indicated by a large number of genome-wide genotype-phenotype association studies, variations in aGPCR contribute to specific human phenotypes. Our survey demonstrates that aGPCRs are significantly involved in adaptation processes, phenotype variations, and diseases in humans.

Keywords

Adhesion G protein-coupled receptors Population genetics Natural selection Genome-wide association studies Mutation Disease 

Notes

Acknowledgments

P.K. is supported by the Federal Ministry of Education and Research (BMBF), Germany, FKZ, 01EO1501 (AD2-060E), and by the German Research Foundation (CRC 1052; B03). T.S. is supported by the German Research Foundation (FOR 2149, P4, P5).

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Copyright information

© Springer International Publishing AG 2016

Authors and Affiliations

  1. 1.Integrated Research and Treatment Center (IFB) AdiposityDiseasesMedical Faculty, University of LeipzigLeipzigGermany
  2. 2.Institute of BiochemistryMedical Faculty, University of LeipzigLeipzigGermany

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