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Adhesion GPCRs Govern Polarity of Epithelia and Cell Migration

  • David StruttEmail author
  • Ralf SchnabelEmail author
  • Franziska Fiedler
  • Simone PrömelEmail author
Chapter
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 234)

Graphical Abstract

Abstract

In multicellular organisms cells spatially arrange in a highly coordinated manner to form tissues and organs, which is essential for the function of an organism. The component cells and resulting structures are often polarised in one or more axes, and how such polarity is established and maintained correctly has been one of the major biological questions for many decades. Research progress has shown that many adhesion GPCRs (aGPCRs) are involved in several types of polarity. Members of the two evolutionarily oldest groups, Flamingo/Celsr and Latrophilins, are key molecules in planar cell polarity of epithelia or the propagation of cellular polarity in the early embryo, respectively. Other adhesion GPCRs play essential roles in cell migration, indicating that this receptor class includes essential molecules for the control of various levels of cellular organisation.

Keywords

Planar Polarity Planar Cell Polarity Spindle Orientation Collective Cell Migration Junctional Localisation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

Work in the Strutt laboratory is funded by a Wellcome Trust Senior Fellowship in Basic Biomedical Science. Work in the Prömel laboratory is funded by grants from the Deutsche Forschungsgemeinschaft (PR1534 1-1; FOR2149 Project 2 [PR 1534/2-1]) and the Medical Faculty of the University of Leipzig (Formel 1 junior research grant).

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Copyright information

© Springer International Publishing AG 2016

Authors and Affiliations

  1. 1.Bateson Centre and Department of Biomedical ScienceUniversity of SheffieldSheffieldUK
  2. 2.Institute of Genetics, TU BraunschweigBraunschweigGermany
  3. 3.Medical FacultyInstitute of Biochemistry, Leipzig UniversityLeipzigGermany

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