Neurosurgical Overview



Stroke refers to any new neurological symptoms with sudden onset. This commonly used term can refer to any cerebrovascular disease of the nervous system that interrupts neural tissue function abruptly. When patients present to the emergency room with an abrupt onset of new focal neurologic deficits, the etiology of 95 % will be vascular (i.e., stroke), and 5 % will be other disease processes such as seizures, tumor, or psychogenic. Stroke is most commonly used to describe an ischemic event involving an acute occlusion of an artery supplying neural tissue. However, stroke can also result from loss of neural tissue function secondary to sudden hemorrhage into the neural tissue. Approximately 85 % of all strokes are ischemic in nature, while the remaining 15 % of strokes are hemorrhagic in nature [1].


Traumatic Brain Injury Ischemic Stroke Arteriovenous Malformation Hemorrhagic Stroke Stereotactic Radiosurgery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ, Dai S, Ford ES, Fox CS, Franco S, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Huffman MD, Judd SE, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Mackey RH, Magid DJ, Marcus GM, Marelli A, Matchar DB, McGuire DK, Mohler 3rd ER, Moy CS, Mussolino ME, Neumar RW, Nichol G, Pandey DK, Paynter NP, Reeves MJ, Sorlie PD, Stein J, Towfighi A, Turan TN, Virani SS, Wong ND, Woo D, Turner MB, American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Executive summary: heart disease and stroke statistics – 2014 update: a report from the American Heart Association. Circulation. 2014;129(3):399–410 12p.PubMedCrossRefGoogle Scholar
  2. 2.
    Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ, Dai S, Ford ES, Fox CS, Franco S, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Huffman MD, Judd SE, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Mackey RH, Magid DJ, Marcus GM, Marelli A, Matchar DB, McGuire DK, Mohler ER, Moy CS, Mussolino ME, Neumar RW, Nichol G, Pandey DK, Paynter NP, Reeves MJ, Sorlie PD, Stein J, Towfighi A, Turan TN, Virani SS, Wong ND, Woo D, Turner MB, American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics—2014 update: a report from the American Heart Association. Circulation. 2014;129:e28–292.PubMedCrossRefGoogle Scholar
  3. 3.
    Chung YA, Hyun OJ, Kim JY, Kim KJ, Ahn KJ. Hypoperfusion and ischemia in cerebral amyloid angiopathy documented by 99mTc-ECD brain perfusion SPECT. J Nucl Med. 2009;50(12):1969–74.PubMedCrossRefGoogle Scholar
  4. 4.
    Weller RO, Preston SD, Subash M, Carare RO. Cerebral amyloid angiopathy in the aetiology and immunotherapy of Alzheimer disease. Alzheimers Res Ther. 2009;1(2):6.PubMedPubMedCentralCrossRefGoogle Scholar
  5. 5.
    Mehdi A, Hajj-Ali RA. Reversible cerebral vasoconstriction syndrome: a comprehensive update. Curr Pain Headache Rep. 2014;18(9):1–10.CrossRefGoogle Scholar
  6. 6.
    Adams Jr HP, del Zoppo G, Alberts MJ, Bhatt DL, Brass L, Furlan A, Grubb RL, Higashida RT, Jauch EC, Kidwell C, Lyden PD, Morgenstern LB, Qureshi AI, Rosenwasser RH, Scott PA, Wijdicks EF, American Heart Association; American Stroke Association Stroke Council; Clinical Cardiology Council; Cardiovascular Radiology and Intervention Council; Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups. Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: the American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Stroke (00392499). 2007;38(5):1655–711 57p.CrossRefGoogle Scholar
  7. 7.
    Albers GW, Amarenco P, Easton JD, Sacco RL, Teal P. Antithrombotic and thrombolytic therapy for ischemic stroke: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th edition). Chest. 2008;133(6 Suppl):630S–69S.PubMedCrossRefGoogle Scholar
  8. 8.
    Hemphill 3rd JC, Greenberg SM, Anderson CS, Becker K, Bendok BR, Cushman M, Fung GL, Goldstein JN, Macdonald RL, Mitchell PH, Scott PA, Selim MH, Woo D, American Heart Association Stroke Council; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology. Guidelines for the management of spontaneous intracerebral hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke J Cereb Circulation. 2015;46(7):2032–60.CrossRefGoogle Scholar
  9. 9.
    Smith W, Tsao J, Billings M, Johnston S, Hemphill J, Bonovich D, Dillon W. Prognostic significance of angiographically confirmed large vessel intracranial occlusion in patients presenting with acute brain ischemia. Neurocrit Care. 2006;4(1):14–7.PubMedCrossRefGoogle Scholar
  10. 10.
    Sarraj A, Gupta R. Endovascular treatment for ischemic strokes with large vessel occlusion: proven therapy and bright future. Stroke J Cereb Circulation. 2015;46(5):1431–2.CrossRefGoogle Scholar
  11. 11.
    Feigin VL, Rinkel GJ, Lawes CM, et al. Risk factors for subarachnoid hemorrhage: an updated systematic review of epidemiological studies. Stroke. 2005;36(12):2773–80.PubMedCrossRefGoogle Scholar
  12. 12.
    Adams Jr HP, Butler MJ, Biller J, Toffol GJ. Nonhemorrhagic cerebral infarction in young adults. Arch Neurol. 1986;43:793–6.PubMedCrossRefGoogle Scholar
  13. 13.
    Ferguson GG, Eliasziw M, Barr HW, Clagett GP, Barnes RW, Wallace MC, Taylor DW, Haynes RB, Finan JW, Hachinski VC, Barnett HJ. The North American symptomatic carotid endarterectomy trial – surgical results in 1415 patients. Stroke. 1999;30(9):1751–8.PubMedCrossRefGoogle Scholar
  14. 14.
    Morgenstern LB, Frankowski RF, Shedden P, Pasteur W, Grotta JC. Surgical treatment for intracerebral hemorrhage (STICH): a single-center, randomized clinical trial. Neurology. 1998;51:1359–63.PubMedCrossRefGoogle Scholar
  15. 15.
    Rubin MN, Barrett KM. What to do with wake-up stroke. Neurohospitalist. 2015;5(3):161–72.PubMedPubMedCentralCrossRefGoogle Scholar
  16. 16.
    Yamane F, Takeshita M, Izawa M, Kagawa M, Sato K, Takakura K. Natural history of arteriovenous malformations: analysis of non-radically treated patients. J Clin Neurosci. 1998;5(suppl):26–9.PubMedCrossRefGoogle Scholar
  17. 17.
    Berger MS, Rostomily RC. Low grade gliomas: functional mapping resection strategies, extent of resection, and outcome. J Neurooncol. 1997;34(1):85–101.PubMedCrossRefGoogle Scholar
  18. 18.
    Eyüpoglu I, Hore N, Savaskan N, Grummich P, Roessler K, Buchfelder M, Ganslandt O. Improving the extent of malignant glioma resection by dual intraoperative visualization approach. Plos ONE. 2012;7(9):e44885.PubMedPubMedCentralCrossRefGoogle Scholar
  19. 19.
    Patchell RA, Tibbs PA, Walsh JW, et al. A randomized trial of surgery in the treatment of single metastases to the brain. New Eng J Med. 1990;322(8):494–500.PubMedCrossRefGoogle Scholar
  20. 20.
    Patchell RA, Tibbs PA, Regine WF, et al. Postoperative radiotherapy in the treatment of single metastases to the brain: a randomized trial. J Am Med Assoc. 1998;280:1485–9.CrossRefGoogle Scholar
  21. 21.
    Kondziolka D, Patel A, Lunsford LD, Kassam A, Flickinger JC. Clinical investigations: stereotactic radiosurgery plus whole brain radiotherapy versus radiotherapy alone for patients with multiple brain metastases. Int J Radiat Oncol Biol Phys. 1999;45:427–34.PubMedCrossRefGoogle Scholar
  22. 22.
    Glantz MJ, Cole BF, Forsyth PA, Recht LD, Wen PY, Chamberlain MC, Grossman SA, Cairncross JG. Practice parameter: anticonvulsant prophylaxis in patients with newly diagnosed brain tumors: report of the quality standards subcommittee of the American Academy of Neurology. Neurology. 2000;54(10):1886–93.PubMedCrossRefGoogle Scholar
  23. 23.
    Ireland S, Carlino K, Gould L, Frazier F, Haycock P, Ilton S, Deptuck R, Bousfield B, Verge D, Antoni K, MacRae L, Renshaw H, Bialachowski A, Chagnon C, Reddy K. Shampoo after craniotomy: a pilot study. Can J Neurosci Nurs. 2007;29(1):14–9 6p.PubMedGoogle Scholar
  24. 24.
    Greenberg MS. Chiari malformation handbook of neurosurgery. 5th ed. New York: Thieme; 2001. p. 143–6.Google Scholar
  25. 25.
    Carmel PF. Management of the Chiari malformations in childhood. Clini Neurosurg. 1983;30:385–406.Google Scholar
  26. 26.
    Paul K, Lye R, Strang F, Dutton J. Arnold-Chiari malformation. Review of 71 cases. J Neurosurgery. 1983;58(2):183–7.CrossRefGoogle Scholar
  27. 27.
    Levy W, Mason L, Hahn J. Chiari malformation presenting in adults: a surgical experience in 127 cases. Neurosurgery. 1983;12(4):377–90.PubMedCrossRefGoogle Scholar
  28. 28.
    Alden TD, Ojemann JG, Park TS. Surgical treatment of Chiari I malformation: indications and approaches. Neurosurg Focus. 2001;11(1):E2.PubMedCrossRefGoogle Scholar
  29. 29.
    Duddy JC, Allcutt D, Crimmins D, O’Brien D, O’Brien DF, Rawluk D, Sattar MT, Young S, Caird J. Foramen magnum decompression for Chiari I malformation: a procedure not to be underestimated. Br J Neurosurgery. 2014;28(3):330–4.CrossRefGoogle Scholar
  30. 30.
    Vakharia V, Guilfoyle M, Laing R. Prospective study of outcome of foramen magnum decompressions in patients with syrinx and non-syrinx associated Chiari malformations. Br J Neurosurgery. 2012;26(1):7–11.CrossRefGoogle Scholar
  31. 31.
    Greenberg MS. Handbook of neurosurgery. New York: Thieme; 2010.Google Scholar
  32. 32.
    Bergsneider M, Black P, Klinge P, Marmarou A, Relkin N. Surgical management of idiopathic normal-pressure hydrocephalus. Neurosurgery. 2005;57(3):29–39.Google Scholar
  33. 33.
    Malm J, Kristensen B, Stegmayr B, Fagerlund M, Koskinen LO. Three-year survival and functional outcome of patients with idiopathic adult hydrocephalus syndrome. Neurology. 2000;55:576–8.PubMedCrossRefGoogle Scholar
  34. 34.
    Mamelak AN, Mampalam TJ, Obana WG, Rosenblum ML. Improved management of multiple brain abscesses: a combined surgical and medical approach. Neurosurgery. 1995;36:76–86.PubMedCrossRefGoogle Scholar
  35. 35.
    Calfee DP, Wispelwey B. Brain abscess. Semin Neurol. 2000;20(3):353–60.PubMedCrossRefGoogle Scholar
  36. 36.
    Dill S, Cobbs C, McDonald C. Subdural empyema: analysis of 32 cases and review. Clin Infect Dis. 1995;20(2):372–86.PubMedCrossRefGoogle Scholar
  37. 37.
    Carpio A. Neurocysticercosis: an update. Lancet Infect Dis. 2002;20(12):751–62.CrossRefGoogle Scholar
  38. 38.
    Tyler KL. Update on herpes simplex encephalitis. Rev Neurol Dis. 2004;1(4):169–78.PubMedGoogle Scholar
  39. 39.
    Minari A, et al. The incidence of invasive aspergillosis among solid organ transplant recipients and implications for prophylaxis in lung transplants. Transpl Infect Dis. 2002;4(4):195–200.PubMedCrossRefGoogle Scholar
  40. 40.
    Darouiche RO. Spinal epidural abscess. N Engl J Med. 2006;355:2012–202.PubMedCrossRefGoogle Scholar
  41. 41.
    Kanev PM, et al. Reflections on shunt infection. Pediatr Neurosurg. 2003;39(6):285–90.PubMedCrossRefGoogle Scholar
  42. 42.
    Forgacs P, et al. Characterization of chemical meningitis after neurological surgery. Clin Infect Dis. 2001;32(2):179–85.PubMedCrossRefGoogle Scholar
  43. 43.
    Bruce J, Bruce S. Preservation of bone flaps in patients with postcraniotomy infections. J Neurosurgery. 2003;98(6):1203–7.CrossRefGoogle Scholar
  44. 44.
    Cold G. Cerebral blood flow in acute head injury. The regulation of cerebral blood flow and metabolism during the acute phase of head injury, and its significance for therapy. Acta Neurochir Suppl. 1990;49:1–64.PubMedGoogle Scholar
  45. 45.
    Parkinson D. Evaluating cerebral concussion. Surg Neurol. 1996;45(5):459–62.PubMedCrossRefGoogle Scholar
  46. 46.
    Alves WM, Jane JA. Post-traumatic syndrome. In: Youmans JR, editor. Neurological surgery, vol. 3. 3rd ed. Philadelphia: WB Saunders; 1990. p. 2230–42.Google Scholar
  47. 47.
    Reilly P, Graham D, Hume Adams J, Jennett B. Patients with head injury who talk and die. Lancet. 1975;306(7931):375–7.CrossRefGoogle Scholar
  48. 48.
    Duus B, Lind B, Christensen H, Nielsen O. The role of neuroimaging in the initial management of patients with minor head injury. Anna Emerg Med. 1994;23(6):1279–83.CrossRefGoogle Scholar
  49. 49.
    Stein SC, Ross SE. Mild head injury: a plea for routine early ct scanning. J Trauma Injury Inf Critical Care. 1992;33(1):11–3.CrossRefGoogle Scholar
  50. 50.
    Jordan BD, Kanik AB, Horwich MS, Sweeney D, Relkin NR, Petito CK, Gandy S. Apolipoprotein E epsilon 4 and fatal cerebral amyloid angiopathy associated with dementia pugilistica. Annals Neurol. 1995;38(4):698–9.CrossRefGoogle Scholar
  51. 51.
    Wilberger JE, Deeb Z, Deeb W. Magnetic resonance imaging after closed head injury. Neurosurgery. 1987;20:571–6.PubMedCrossRefGoogle Scholar
  52. 52.
    Cohen TI, Gudeman SK. Delayed traumatic intracranial hematoma. In: Narayan RK, Wilberger JE, Povlishock JT, editors. Neurotrauma. New York: McGraw-Hil; 1996. p. 689–701.Google Scholar
  53. 53.
    Cooper P, Maravilla K, Moody S, Kemp Clark W. Serial computerized tomographic scanning and the prognosis of severe head injury. Neurosurgery. 1979;5(5):566–9.PubMedCrossRefGoogle Scholar
  54. 54.
    Taneda M, Kataoka K, Akai F, Asai T, Sakata I. Traumatic subarachnoid hemorrhage as a predictable indicator of delayed ischemic symptoms. J Neurosurgery. 1996;84(5):762–8.CrossRefGoogle Scholar
  55. 55.
    Jaeger M, Schuhmann M, Soehle M, Nagel C, Meixensberger J. Continuous monitoring of cerebrovascular autoregulation after subarachnoid hemorrhage by brain tissue oxygen pressure reactivity and its relation to delayed cerebral infarction. Stroke (00392499). 2007;38(3):981–6 6p.CrossRefGoogle Scholar
  56. 56.
    Link TE, Murakami K, Beem-Miller M, Tranmer BI, Wellman GC. Oxyhemoglobin-induced expression of R-Type Ca2+ channels in cerebral arteries. Stroke. 2008;39(7):2122–8.PubMedPubMedCentralCrossRefGoogle Scholar
  57. 57.
    Findlay J, Macdonald R, Weir B (n.d) Current concepts of pathophysiology and management of cerebral vasospasm following aneurysmal subarachnoid hemorrhage. Cerebrovascular Brain Metab Rev. . 1991 Winter;3(4):336–61.Google Scholar
  58. 58.
    Tian H, Xu T, Hu J, Cui Y, Chen H, Zhou L. Risk factors related to hydrocephalus after traumatic subarachnoid hemorrhage. Surg Neurol. 2008;69(3):241–6.PubMedCrossRefGoogle Scholar
  59. 59.
    Rivas J, Lobato R, Sarabia R, Cordobes F, Cabrera A, Gomez P. Extradural hematoma: analysis of factors influencing the courses of 161 patients. Neurosurgery. 1988;23(1):44–51.PubMedCrossRefGoogle Scholar
  60. 60.
    Mckissock W, Taylor J, Bloom W, Till K. Extradural hæmatoma. Observations on 125 cases. Lancet. 1960;276(7143):167–72.CrossRefGoogle Scholar
  61. 61.
    Bullock R, Chesnut RM, Clifton G, Ghajar J, Marion DW, Narayan RK, Newell DW, Pitts LH, Rosner MJ, Wilberger JW. Guidelines for the management of severe head injury. Brain Trauma Foundation. Eur J Emerg Med Off J Euro Soc Emerg Med. 1996;3(2):109–27.CrossRefGoogle Scholar
  62. 62.
    Bullock MR, Chesnut R, Ghajar J, Gordon D, Hartl R, Newell DW, Servadei F, Walters BC, Wilberger J, Surgical Management of Traumatic Brain Injury. Surgical management of traumatic parenchymal lesions. Neurosurgery. 2006;58(3 Suppl):S25.PubMedGoogle Scholar
  63. 63.
    Bullock MR, Chesnut R, Ghajar J, Gordon D, Hartl R, Newell DW, Servadei F, Walters BC, Wilberger JE, Surgical Management of Traumatic Brain Injury. Surgical management of acute subdural hematomas. Neurosurgery. 2006;58(3 Suppl):S16.PubMedGoogle Scholar
  64. 64.
    Robinson R. Chronic subdural hematoma: surgical management in 133 patients. J Neurosurgery. 1984;61(2):263–8.CrossRefGoogle Scholar
  65. 65.
    Abouzari M, Armin R, Rezaii J, Esfandiari K, Asadollahi M, Aleali H, Abdollahzadeh M. The role of postoperative patient posture in the recurrence of traumatic chronic subdural hematoma after burr-hole surgery. Neurosurgery. 2007;61(4):794–7.PubMedCrossRefGoogle Scholar
  66. 66.
    Sambasivan M. An overview of chronic subdural hematoma: experience with 2300 cases. Surg Neurol. 1997;47(5):418–22.PubMedCrossRefGoogle Scholar
  67. 67.
    Sahuquillo-Barris J, Lamarca-Ciuro J, Vilalta-Castan J, Rubio-Garcia E, Rodriquez-Pazos M. Acute subdural hematoma and diffuse axonal injury after severe head trauma. J Neurosurgery. 1988;68(6):894–900.CrossRefGoogle Scholar
  68. 68.
    Bouma G, Muizelaar J, Choi S, Newlon P, Young H. Cerebral circulation and metabolism after severe traumatic brain injury: the elusive role of ischemia. J Neurosurg. 1991;75(5):685–93.PubMedCrossRefGoogle Scholar
  69. 69.
    Alberico A, Ward J, Choi S, Marmarou A, Young H. Outcome after severe head injury. Relationship to mass lesions, diffuse injury, and ICP course in pediatric and adult patients. J Neurosurgery. 1987;67(5):648–56.CrossRefGoogle Scholar
  70. 70.
    Polin R, Shaffrey M, Bogaev C, Tisdale N, Germanson T, Bocchicchio B, Jane J. Decompressive bifrontal craniectomy in the treatment of severe refractory posttraumatic cerebral edema. Neurosurgery. 1997;41(1):84–94.PubMedCrossRefGoogle Scholar
  71. 71.
    Aarabi B, Hesdorffer D, Ahn E, Aresco C, Scalea T, Eisenberg H. Outcome following decompressive craniectomy for malignant swelling due to severe head injury. J Neurosurgery. 2006;104(4):469–79.CrossRefGoogle Scholar
  72. 72.
    Dacey Jr R, Alves W, Rimel R, Winn H, Jane J. Neurosurgical complications after apparently minor head injury: assessment of risk in a series of 610 patients. J Neurosurgery. 1986;65(2):203–10.CrossRefGoogle Scholar
  73. 73.
    Chang B, Lowenstein D. Practice parameter: antiepileptic drug prophylaxis in severe traumatic brain injury: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2003;60(1):10–6.PubMedCrossRefGoogle Scholar
  74. 74.
    Bratton SL, Chestnut RM, Ghajar J, Hammond FFM, Harris OA, Hartl R, et al. Brain Trauma Foundation: anti-seizure prophylaxis. J Neurotrauma. 2007;24:S83–6.Google Scholar
  75. 75.
    Lewin W. Cerebrospinal fluid rhinorrhœa in closed head injuries. Br J Surg. 1954;42(171):1.PubMedCrossRefGoogle Scholar
  76. 76.
    Esslen E. Electrodiagnosis of facial palsy. In: Miehlke A, editor. Surgery of the facial nerve. 2nd ed. Philadelphia: W B Saunders; 1973. p. 45–51.Google Scholar
  77. 77.
    Gudeman S, Kishore P, Miller J, Girevendulis A, Lipper M, Becker D. The genesis and significance of delayed traumatic intracerebral hematoma. Neurosurgery. 1979;5(3):309–13.PubMedGoogle Scholar
  78. 78.
    Chan KH, Lai EC, Tuen H, Ngan JH, Mok F, Fan YW, Fung CF, Yu WC. Prospective double-blind placebo-controlled randomized trial on the use of ranitidine in preventing postoperative gastroduodenal complications in high- risk neurosurgical patients. J Neurosurgery. 1995;82(3):413–7.CrossRefGoogle Scholar
  79. 79.
    Kaufman HH, Satterwhite T, McConnell BJ, Costin B, Borit A, Gould L, Pruessner J, Bernstein D, Gildenberg PL. Deep vein thrombosis and pulmonary embolism in head injured patients. Angiology. 1983;34(10):627.PubMedCrossRefGoogle Scholar
  80. 80.
    Bratton SL, Chestnut RM, Ghajar J, Hammond FFM, Harris OA, Hartl R, et al. Brain Trauma Foundation: deep vein thrombosis prophylaxis. J Neurotrauma. 2007;24:S32–6.Google Scholar
  81. 81.
    Poca M, Sahuquillo J, Arikan F, Mataró M, Benejam B, Báguena M. Ventricular enlargement after moderate or severe head injury: a frequent and neglected problem. J Neurotrauma. 2005;22(11):1303–10.PubMedCrossRefGoogle Scholar
  82. 82.
    Marmarou A, Foda MA, Bandoh K, Yoshihara M, Yamamoto T, Tsuji O, et al. Posttraumatic ventriculomegaly: hydrocephalus or atrophy? A new approach for diagnosis using CSF dynamics. J Neurosurgery. 1996;85(6):1026–35.CrossRefGoogle Scholar
  83. 83.
    Clark J, Raggatt P, Edwards O. Hypothalamic hypogonadism following major head injury. Clini Endocrinol (Oxf). 1988;29(2):153–65.CrossRefGoogle Scholar
  84. 84.
    Edwards O, Clark J. Post-traumatic hypopituitarism: six cases and a review of the literature. Med (US). 1986;65(5):281–90.Google Scholar
  85. 85.
    Mayeux R, Ottman R, Tang M, Marder K, Stern Y, Gurland B, Noboa-Bauza L. Genetic susceptibility and head injury as risk factors for Alzheimer’s disease among community-dwelling elderly persons and their first-degree relatives. Anna Neurol. 1993;33(5):494–501.CrossRefGoogle Scholar
  86. 86.
    Roberts G, Gentleman S, Lynch A, Murray L, Graham D, Landon M. β3 Amyloid protein deposition in the brain after severe head injury: Implications for the pathogenesis of Alzheimer’s disease. J Neurol Neurosurgery Psychiatry. 1994;57(4):419–25.CrossRefGoogle Scholar
  87. 87.
    Bratton SL, Chestnut RM, Ghajar J, Hammond FFM, Harris OA, Hartl R, et al. Brain Trauma Foundation: steroids. J Neurotrauma. 2007;24:S 91–5.Google Scholar
  88. 88.
    Deutschman C, Konstantinides F, Raup S, Thienprasit P, Cerra F. Physiological and metabolic response to isolated closed-head injury. Part 1: Basal metabolic state: correlations of metabolic and physiological parameters with fasting and stressed controls. J Neurosurgery. 1986;64(1):89–98.CrossRefGoogle Scholar
  89. 89.
    Rapp R, Young D, Twyman D, Bivins B, Haack D, Tibbs P, Bean J. The favorable effect of early parenteral feeding on survival in head-injured patients. J Neurosurgery. 1983;58(6):906–12.CrossRefGoogle Scholar
  90. 90.
    Hadley M, Grahm T, Harrington T, Schiller W, McDermott M, Posillico D. Nutritional support and neurotrauma: a critical review of early nutrition in forty-five acute head injury patients. Neurosurgery. 1986;19(3):367–73.PubMedCrossRefGoogle Scholar
  91. 91.
    Vespa PM, McArthur D, O’Phelan K, Glenn T, Etchepare M, Kelly D, Bergsneider M, Martin NA, Hovda DA. Persistently low extracellular glucose correlates with poor outcome 6 months after human traumatic brain injury despite a lack of increased lactate: a microdialysis study. J Cereb Blood Flow Met. 2003;23(7):865–77.CrossRefGoogle Scholar
  92. 92.
    Kaufman H, Bretaudiere J, Rowlands B, Stein D, Bernstein D, Wagner K, Gildenberg P. General metabolism in head injury. Neurosurgery. 1987;20(2):254–65.PubMedCrossRefGoogle Scholar
  93. 93.
    Senelick R, Dougherty K. Living with Brain Injury. 2nd ed. Birmingham: HealthSouth Press; 2001.Google Scholar

Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  1. 1.Neurosurgeons of New JerseyWest Long BranchUSA
  2. 2.Monmouth Medical CenterLong BranchUSA
  3. 3.Columbia University Medical CenterNew YorkUSA

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