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Microglia in Cancer: For Good or for Bad?

  • Anna Carolina Carvalho da Fonseca
  • Rackele Amaral
  • Celina Garcia
  • Luiz Henrique Geraldo
  • Diana Matias
  • Flavia Regina Souza Lima
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 949)

Abstract

Glioblastoma is a malignant tumor of astrocytic origin that is highly invasive, proliferative and angiogenic. Despite current advances in multimodal therapies, such as surgery, radio- and chemotherapy, the outcome for patients with glioblastoma is nearly always fatal. The glioblastoma microenvironment has a tremendous influence over the tumor growth and spread. Microglia and macrophages are abundant cells in the tumor mass. Increasing evidence indicates that glioblastoma recruits these cell populations and signals in a way that microglia and macrophages are subverted to promote tumor progression. In this chapter, we discuss some aspects of the interaction between microglia and glioblastoma, consequences of this interaction for tumor progression and the possibility of microglial cells being used as therapeutic vectors, which opens up new alternatives for the development of GBM therapies targeting microglia.

Keywords

Microglia Glioblastoma Central nervous system Therapy 

Abbreviations and Acronyms

CNS

Central nervous system

IL

Interleukin

TNF

Tumor necrosis factor

GBM

Glioblastoma

MMP

Matrix metalloproteinase

VEGF

Vascular endothelial growth factor

DLL4

Delta-like ligand 4

NO

Nitric oxide

MCP-1 (CCL2)

Macrophage chemoattractant protein 1

CCR2

CCL2 receptor

TNFR1

TNF receptor 1

IkBa

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

NF-kB

Nuclear factor of kappa light polypeptide gene enhancer in B-cells

uPA

Urokinase-type plasminogen activator

STI1

Stress-inducible protein 1

Hsp

Heat shock protein

MG CM

Microglial conditioned medium

MYD88/TLR8

Myeloid Differentiation Primary Response 88/Toll-like receptor 8

TLR

Toll-like receptor

MT1-MMP

Membrane-type-1 MMP

GDNF

Glial cell-line-derived neurotrophic factor

GFRa

GDNF receptor

EGFR

Epidermal growth factor receptor

EGF

Epidermal growth factor

poly [I:C]

Polyinosinic-polycytidylic acid

TRAIL

TNF-related apoptosis inducing ligand

mTOR

Mammalian target of rapamycin

iNOS

Inducible nitric oxide synthase

MIF

Macrophage migration inhibitory factor

STAT

Signal transducer and activator of transcription

RAGE

Receptor for Advanced Glycation End products

S100B

S100 calcium binding protein B

CpG-ODN

Oligodeoxynucleotides containing CpG motifs

TROY/TNFRSF19

Tumor necrosis factor receptor of mouse embryo

GSC

Glioma stem cell

MRI

Magnetic resonance imaging

GCV

Gancyclovir

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Anna Carolina Carvalho da Fonseca
    • 1
  • Rackele Amaral
    • 1
  • Celina Garcia
    • 1
  • Luiz Henrique Geraldo
    • 1
  • Diana Matias
    • 1
  • Flavia Regina Souza Lima
    • 1
  1. 1.Instituto de Ciências Biomédicas, Centro de Ciências da SaúdeUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil

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