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DHA-Rich Algae Oil Is a Safe and Effective Vegetarian Source of Omega-3

  • Scott DoughmanEmail author
  • Sreerama Krupanidhi
  • C. B. Sanjeevi
Chapter

Abstract

Algal source of omega-3s is good for supplementation of DHA and DPA that mediate to sustain our vascular health. The ratio of DHA and DPA between breast milk and micro algae is comparable and found safe. Hence, supplementation as a component of food is now being accepted at all levels. That option has proven safe for vegetarians, type 2 diabetics, the elderly, and those with fish allergies. DHA is also recommended for pregnant and nursing mothers as a supplement, especially during the 3rd trimester and when nursing. Imperatively, the omega-3 bond can be a powerful co-therapy.

Keywords

Algae Schizochytrium DHA DPA Pregnant Vascular 

References

  1. 1.
    Bowles RD, Hunt AE, Bremer GB, Duchars MG, Eaton RA. Long chain n-polyunsaturated fatty acid production by members of the marine protistan group the thraustochytrids: screening of isolates and optimisation of docosahexaenoic acid production. J Biotech. 1999;70:193–202.CrossRefGoogle Scholar
  2. 2.
    Yokochi T, Honda D, Higashihara T, Nakahara T. Optimization of docohexaenoic acid production by Schizochytrium limacinum SR21. Appl Microbiol Biotech. 1998;49:72–6.CrossRefGoogle Scholar
  3. 3.
    Tsui CK, Marshall W, Yokoyama R, Honda D, Lippmeier JC, Craven KD, Peterson PD, Berbee ML. Labyrinthulomycetes phylogeny and its implications for the evolutionary loss of chloroplasts and gain of ectoplasmic gliding. Mol Phylogenet Evol. 2009;50(1):129–40.CrossRefPubMedGoogle Scholar
  4. 4.
    Doughman SD, Ryan AS, Krupanidhi S, Sanjeevi CB, Mohan V. High DHA dosage from algae oil improves postprandial hypertriglyceridemia and is safe for type-2 diabetics. Int J Diab Dev Count. 2013;33(2):75–82.CrossRefGoogle Scholar
  5. 5.
    Doughman SD, Krupanidhi S, Sanjeevi CB. Omega-3 fatty acids for nutrition and medicine: considering algae oil as a vegetarian source of EPA and DHA. Curr Diab Rev. 2007;3:198–203.CrossRefGoogle Scholar
  6. 6.
    Bernstein AM, Ding EL, Willett WC, Rimm EB. A meta-analysis shows that docosahexaenoic acid from algal oil reduces serum triglycerides and increases HDL-cholesterol and LDL-cholesterol in persons without coronary heart disease. J Nutr. 2012;142:99–104.CrossRefPubMedGoogle Scholar
  7. 7.
    Sanders TA, Gleason K, Griffin B, Miller GJ. Influence of an algal triacylglycerol containing docosahexaenoic acid (22: 6n–3) and docosapentaenoic acid (22: 5n–6) on cardiovascular risk factors in healthy men and women. Br J Nutr. 2006;95:525–31.CrossRefPubMedGoogle Scholar
  8. 8.
    Koletzko B, Thiel I, Abiodun PO. The fatty acid composition of human milk in Europe and Africa. J Pediatr. 1992;120:S62–70.CrossRefPubMedGoogle Scholar
  9. 9.
    Mozaffarian D, Wu JH. (n-3) fatty acids and cardiovascular health: are effects of EPA and DHA shared or complementary? J Nutr. 2012;142(3):614S–25S. Review.Google Scholar
  10. 10.
    Manav M, Su J, Hughes K, Lee HP, Ong CN. Omega-3 fatty acids and selenium as coronary heart disease risk modifying factors in Asian Indian and Chinese males. Nutrition. 2004;20:967–73.CrossRefPubMedGoogle Scholar
  11. 11.
    Bhoraskar A. Nutrition in prediabetes. J Indian Med Assoc. 2005;103(596):598–9.Google Scholar
  12. 12.
    Friedberg CE, Janssen MJ, Heine RJ, Grobbee DE. Fish oil and glycemic control in diabetes. A meta-analysis. Diab Care. 1998;21:494–500.CrossRefGoogle Scholar
  13. 13.
    Woodman RJ, Mori TA, Burke V, Puddey IB, Watts GF, Beilin LJ. Effects of purified eicosapentaenoic and docosahexaenoic acids on glycemic control, blood pressure, and serum lipids in type 2 diabetic patients with treated hypertension. Am J Clin Nutr. 2002;76:1007–15.PubMedGoogle Scholar
  14. 14.
    von Schacky C. Omega-3 index and cardiovascular health. Nutrients. 2014;6(2):799–814. Review.Google Scholar
  15. 15.
    Koletzko B, Boey CC, Campoy C, Carlson SE, Chang N, Guillermo-Tuazon MA, Joshi S, Prell C, Quak SH, Sjarif DR, Su Y, Supapannachart S, Yamashiro Y, Osendarp SJ. Current information and Asian perspectives on long-chain polyunsaturated fatty acids in pregnancy, lactation, and infancy: systematic review and practice recommendations from an early nutrition academy workshop. Ann Nutr Metab. 2014;65(1):49–80.CrossRefPubMedGoogle Scholar
  16. 16.
    Carlson SE, Colombo J, Gajewski BJ, Gustafson KM, Mundy D, Yeast J, Georgieff MK, Markley LA, Kerling EH, Shaddy DJ. DHA supplementation and pregnancy outcomes. Am J Clin Nutr. 2013;97:808–15.CrossRefPubMedPubMedCentralGoogle Scholar
  17. 17.
    Larqué E, Pagán A, Prieto MT, Blanco JE, Gil-Sánchez A, Zornoza-Moreno M, Ruiz-Palacios M, Gázquez A, Demmelmair H, Parrilla JJ, Koletzko B. Placental fatty acid transfer: a key factor in fetal growth. Ann Nutr Metab. 2014;64(3–4):247–53.CrossRefPubMedGoogle Scholar
  18. 18.
    Olsen SF, Hansen HS, Sorensen TI, Jensen B, Secher NJ, Sommer S, Knudsen LB. Intake of marine fat, rich in (n-3)-polyunsaturated fatty acids, may increase birthweight by prolonging gestation. Lancet. 1986;2:367–9.CrossRefPubMedGoogle Scholar
  19. 19.
    Hendler I, Goldenberg RL, Mercer BM, Iams JD, Meis PJ, Moawad AH, MacPherson CA, Caritis SN, Miodovnik M, Menard KM, Thurnau GR, Sorokin Y. The preterm prediction study: association between maternal body mass index and spontaneous and indicated preterm birth. Am J Obstet Gynecol. 2005;192:882–6.CrossRefPubMedGoogle Scholar
  20. 20.
    Kelley DS, Siegel D, Vemuri M, Mackey BE. Docosahexaenoic acid supplementation improves fasting and postprandial lipid profiles in hypertriglyceridemic men. Am J Clin Nutr. 2007;86:324–33.PubMedGoogle Scholar
  21. 21.
    Grimsgaard S, Bonaa KH, Hansen JB, Nordøy A. Highly purified eicosapentaenoic acid and docosahexaenoic acid in humans have similar triacylglycerol-lowering effects but divergent effects on serum fatty acids. Am J Clin Nutr. 1997;66:649–59.PubMedGoogle Scholar
  22. 22.
    Valdivielso P, Rioja J, García-Arias C, Sánchez-Chaparro MA, González-Santos P. Omega 3 fatty acids induce a marked reduction of apolipoprotein B48 when added to fluvastatin in patients with Type-2 diabetes and mixed hyperlipidemia: a preliminary report. Cardiovasc Diabetol. 2009;8:1.CrossRefPubMedPubMedCentralGoogle Scholar
  23. 23.
    Engler MM, Engler MB, Malloy MJ, Paul SM, Kulkarni KR, Mietus-Snyder ML. Effect of docosahexaenoic acid on lipoprotein subclasses in hyperlipidemic children (the EARLY study). Am J Cardiol. 2005;95:869–71.CrossRefPubMedGoogle Scholar
  24. 24.
    Health RB, Karpe F, Milne RW, Burdge GC, Wootton SA, Frayn KN. Selective portioning of dietary fatty acids into the VLDL TG pool in the early postprandial period. J Lipid Res. 2003;44:2065–72.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Scott Doughman
    • 1
    Email author
  • Sreerama Krupanidhi
    • 2
  • C. B. Sanjeevi
    • 3
  1. 1.Source-Omega, LLCChapel HillUSA
  2. 2.Department of BiotechnologyVignan UniversityGunturIndia
  3. 3.Department of Molecular Medicine and SurgeryKarolinska InstituteStockholmSweden

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