Humidified High-Flow Nasal Cannula Therapy

  • Andrea LamplandEmail author
  • Mark C. Mammel


Humidified high-flow nasal cannula (HFNC) is a means to deliver noninvasive, positive pressure respiratory support


Neonatal Humidified High-flow Nasal Cannula 

Suggested Reading

  1. Abdel-Hady H, Shouman B, Aly H. Early weaning from CPAP to high flow nasal cannula in preterm infants in associated with prolonged oxygen requirement: a randomized controlled trial. Early Hum Dev. 2011;87:205–8.CrossRefPubMedGoogle Scholar
  2. Campbell DM, Shah PS, Shah V, Kelly EN. Nasal continuous positive airway pressure from high flow cannula versus Infant Flow for preterm infants. J Perinatol. 2006;26:546–9.CrossRefPubMedGoogle Scholar
  3. Collins CL, Holberton JR, Barfield C, Davis PG. A randomized controlled trial to compare heated humidified high-flow nasal cannulae with nasal continuous positive airway pressure postextubation in premature infants. J Pediatr. 2013;162:949–54.CrossRefPubMedGoogle Scholar
  4. Dani C, Pratesi S, Migliori C, Bertini G. High flow nasal cannula therapy as respiratory support in the preterm infant. Pediatr Pulmonol. 2009;44:629–34.CrossRefPubMedGoogle Scholar
  5. Dysart K, Miller TL, Wolfson MR, Shaffer TH. Research in high flow therapy: mechanisms of action. Respir Med. 2009;103:1400–5.CrossRefPubMedGoogle Scholar
  6. Fernandez-Alvarez JR, Gandhi RS, Amess P, Mahoney L, Watkins R, Rabe H. Heated humidified high-flow nasal cannula versus low-flow nasal cannula as weaning mode from nasal CPAP in infants ≤28 weeks of gestation. Eur J Pediatr. 2014;173:93–8.CrossRefPubMedGoogle Scholar
  7. Frizzola M, Miller TL, Rodriguez ME, Zhu Y, Rojas J, Hesek A, Stump A, Shaffer TH, Dysart K. High-flow nasal cannula: impact on oxygenation and ventilation in an acute lung injury model. Pediatr Pulmonol. 2011;46:67–74.CrossRefPubMedGoogle Scholar
  8. Haq I, Gopalakaje S, Fenton A, McKean M, O’Brien C, Brodlie M. The evidence for high flow nasal cannula devices in infants. Paediatr Respir Rev. 2014;15:124–34.PubMedGoogle Scholar
  9. Holleman-Duray D, Kaupie D, Weiss MG. Heated humidified high-flow nasal cannula: use and a neonatal early extubation protocol. J Perinatol. 2007;27:776–81.CrossRefPubMedGoogle Scholar
  10. Jasin LR, Kern S, Thompson S, Walter C, Rone JM, Yohannan MD. Subcutaneous scalp emphysema, pneumo-orbitis, and pneumocephalus in a neonate on high humidity high flow nasal cannula. J Perinatol. 2008;28:779–81.CrossRefPubMedGoogle Scholar
  11. Kubicka ZJ, Limauro J, Darnall RA. Heated, humidified high-flow nasal cannula therapy: yet another way to deliver continuous positive airway pressure? Pediatrics. 2008;121:82–8.CrossRefPubMedGoogle Scholar
  12. Lampland AL, Plumm B, Meyers PA, Worwa CT, Mammel MC. Observational study of humidified high-flow nasal cannula compared with nasal continuous positive airway pressure. J Pediatr. 2009;154:177–82.CrossRefPubMedGoogle Scholar
  13. Manley BJ, Owen LS, Doyle LW, Andersen CC, Cartwright DW, Pritchard MA, Donath SM, Davis PG. High-flow nasal cannulae in very preterm infants after extubation. N Engl J Med. 2013;369:1425–33.CrossRefPubMedGoogle Scholar
  14. Miller SM, Dowd SA. High-flow nasal cannula and extubation success in the premature infants: a comparison of two modalities. J Perinatol. 2010;30:805–8.CrossRefPubMedGoogle Scholar
  15. Saslow JG, Aghai ZH, Nakhla TA, Hart JJ, Lawrysh R, Stahl GE, Pyon KH. Work of breathing using high-flow nasal cannula in preterm infants. J Perinatol. 2006;26:476–80.CrossRefPubMedGoogle Scholar
  16. Shetty S, Greenough A. Review finds insufficient evidence to support the routine use of heated and humidified high-flow nasal cannula use in neonates. Acta Paediatr. 2014;103:898–903.CrossRefPubMedGoogle Scholar
  17. Shoemaker MT, Pierce MR, Yoder BA, DiGeronimo RJ. High flow nasal cannula versus nasal CPAP for neonatal respiratory disease: a retrospective study. J Perinatol. 2007;27:85–91.CrossRefPubMedGoogle Scholar
  18. Sreenan C, Lemke RP, Hudson-Mason A, Osiovich H. High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure. Pediatrics. 2011;107:1081–3.CrossRefGoogle Scholar
  19. Wilkinson D, Andersen C, O’Donnell CPF, De Paoli AG. High flow nasal cannula for respiratory support in preterm infants. Cochrane Database Syst Rev. 2011;(5):CD006405.Google Scholar
  20. Woodhead DD, Lambert DK, Clark JM, Christensen RD. Comparing two methods of delivering high-flow gas therapy by nasal cannula following endotracheal intubation: a prospective, randomized, masked cross-over trial. J Perinatol. 2006;26:481–5.CrossRefPubMedGoogle Scholar
  21. Yoder BA, Stoddard RA, Li M, King J, Dirnberger DR, Abbasi S. Heated, humidified high-flow nasal cannula versus nasal CPAP for respiratory support in neonates. Pediatrics. 2013;131:e1482–90.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  1. 1.Department of Newborn MedicineChildren’s Hospitals and Clinics of MinnesotaSt. PaulUSA
  2. 2.Department of PediatricsUniversity of MinnesotaMinneapolisUSA

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