In this chapter we define pigmented lesions and their differences between melanocytic lesions. Physicians are continuously consulted regarding tumors or tumor-like lesions of the skin, because of their high frequency and the public concern regarding skin cancer. Furthermore, their importance lies predominantly in the cosmetic defect they may create or in their occasional association with systemic disease. Considering these facts, it is important establish their types, origins, features, differences, and instruments for diagnosis and treatment.
KeywordsPigmented lesions Melanocytic nevi Skin tumors Congenital melanocytic nevi Halo nevus Nevus spilus Becker’s nevus Freckles Lentigines Mongolian spots Blue nevi Spitz nevus Reed tumor Recurrent nevus Atypical nevus
A technique that uses an extremely cold liquid or instrument to freeze and destroy abnormal skin cells that require removal.
Electrochemical process whereby current is passed between two electrodes through an ionized solution (electrolyte) to deposit positive ions (anions) on the negative electrode (cathode) and negative ions (cations) on the positive electrode (anode). It is used for removing unwanted hair by destroying the hair root.
An aromatic organic compound that is a type of phenol, having the chemical formula C6H4(OH)2. It is prescribed to reduce pigmentation of the skin in certain conditions whereby an excess of melanin causes hyperpigmentation.
A monoclonal antibody that reacts against an antigen present in melanocytic tumors such as melanomas. The use of immunohistochemistry with melanocytic markers such as HMB-45 and Melan A, increases the detection rate of micrometastases.
The Ki-67 protein (also known as MKI67) is a cellular marker for proliferation. It is strictly associated with cell proliferation.
The excessive deposit of melanin by increasing the number of melanocytes, usually seen as a signal in the convexities of subarachnoid spaces, or brain parenchyma such as cerebellum, temporal lobes, pons, and medulla on noncontrast images.
A type of lesion that contains nevus cells (a type of melanocyte).
Peeling skin, called desquamation in medical terms, can be caused by different conditions. Very often, skin peels following chemical, thermal, or sunburn, with the latter being the most common cause.
Cytoplasmic structures found in some eukaryotes. Pseudopods are one of the three locomotion modes of unicellular organisms (together with flagella and cilia). Pseudopods can also capture prey by phagocytosis.
An oxidase that is the rate-limiting enzyme for controlling the production of melanin.
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