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Dermatoscopy in the Public Health Environment

  • Alejandra Larre Borges
  • Sofía Nicoletti
  • Lídice Dufrechou
  • Andrea Nicola Centanni
Chapter

Abstract

Dermoscopy is a diagnostic technique that can diminish the refraction and reflection at the skin. It facilitates the visualization of colors and structures in subsurface skin structures located within the epidermis, dermoepidermal junction, and papillary dermis, which are otherwise not visible to the naked eye. It improves diagnostic accuracy, sensitivity, and specificity for skin cancer diagnosis. The two-step analytic algorithm attempts in the first step to differentiate melanocytic lesions from the nonmelanocytic lesions: dermatofibroma, basal cell carcinoma, seborrheic keratosis, and hemangioma. The second step is proposed to differentiate nevi from melanoma using scoring systems. Dermoscopy is also useful for the assessment of other skin cancers such as squamous cell carcinoma, as well as for inflammatory and infectious diseases. This chapter provides a review of the dermoscopic features that are seen in various pigmented and nonpigmented tumoral and nontumoral skin lesions as well as the dermoscopic criteria used for monitoring patients who are prone to skin cancer.

Keywords

Dermoscopy Dermatoscopy Skin cancer Pigmented Nonpigmented Inflammatory Infectious 

References

  1. 1.
    Pehamberger H, Binder M, Steiner A, et al. In vivo epiluminiscence microscopy: improvement of early diagnosis of melanoma. J Invest Dermatol. 1993;100:356S–62S.PubMedCrossRefGoogle Scholar
  2. 2.
    Marghoob AA, Usatine RP, Jaimes N. Dermoscopy for the family physician. Am Fam Physician. 2013;88(7):441–50.PubMedGoogle Scholar
  3. 3.
    Ochaita P, Avilés JA. Dermatoscopia digital. Análisis de los diferentes sistemas. Piel. 2004;19(7):395–401.CrossRefGoogle Scholar
  4. 4.
    Marghoob AA, Swindle LD, Moricz CZ, et al. Instruments and new technologies for the in vivo diagnosis of melanoma. J Am Acad Dermatol. 2003;49:777–97.PubMedCrossRefGoogle Scholar
  5. 5.
    Zalaudek I, Argenziano G, Di Stefani A, Ferrara G, Marghoob AA, Hofmann-Wellenhof R, et al. Dermatology. 2006;212:7–18.PubMedCrossRefGoogle Scholar
  6. 6.
    Chevolet I, Hoorens I, Janssens A, Speeckaert R, Van Geel N, Van Maele G, et al. Short dermoscopy training increases diagnostic performance in both inexperienced and experienced dermatologists. Australas J Dermatol. 2015;56(1):52–5.PubMedCrossRefGoogle Scholar
  7. 7.
    Vestergaard ME, Macaskill P, Holt PE, Menzies SW. Dermoscopy compared with naked eye examination for the diagnosis of primary melanoma: a meta-analysis of studies performed in a clinical setting. Br J Dermatol. 2008;159(3):669–76.PubMedGoogle Scholar
  8. 8.
    Tschandl P, Kittler H, Schmid K, Zalaudek I, Argenziano G. Teaching dermatoscopy of pigmented skin tumours to novices: comparison of analytic vs. heuristic approach. J Eur Acad Dermatol Venereol. 2015;29(6):1198–204.PubMedCrossRefGoogle Scholar
  9. 9.
    Blum A, Giacomel J. “Tape dermoscopy” consists in six steps: “Tape dermatoscopy”: constructing a low-cost dermatoscope using a mobile phone, immersion fluid and transparent adhesive tape. Dermatol Pract Concept. 2015;5(2):17.Google Scholar
  10. 10.
    Longo I, Chaeta P. Novedades en dispositivos y software en dermatoscopia digital. Piel. 2007;22(3):107–8.CrossRefGoogle Scholar
  11. 11.
    Malvhey J, Puig S. Parámetros dermatoscópicos: definición e histopatología. En Principles of dermoscopy. 2009 Ed 2011. www.cege.es. 37–38.
  12. 12.
    Zalaudek I, Kreusch J, Giacomel J, Ferrara G, Catricalà C, Argenziano G. How to diagnose nonpigmented skin tumors: a review of vascular structures seen with dermoscopy: part I. Melanocytic skin tumors. J Am Acad Dermatol. 2010;63(3):361–74.CrossRefPubMedGoogle Scholar
  13. 13.
    Zalaudek I, Kreusch J, Giacomel J, Ferrara G, Catricalà C, Argenziano G. How to diagnose nonpigmented skin tumors: a review of vascular structures seen with dermoscopy: part II. Nonmelanocytic skin tumors. J Am Acad Dermatol. 2010;63(3):377–86.CrossRefPubMedGoogle Scholar
  14. 14.
    Bajaj S, Marchetti MA, Navarrete-Dechent C, Dusza SW, Kose K, Marghoob AA. The role of color and morphologic characteristics in dermoscopic diagnosis. JAMA Dermatol. 2016;152(6):676–82.PubMedCentralPubMedCrossRefGoogle Scholar
  15. 15.
    Argenziano G, Soyer HP, Chimenti S, Talamini R, Corona R, Sera F, et al. Dermoscopy of pigmented skin lesions: results of a consensus meeting via the internet. J Am Acad Dermatol. 2003;48(5):679–93.CrossRefPubMedGoogle Scholar
  16. 16.
    Chen LL, Dusza SW, Jaimes N, Marghoob AA. Performance of the first step of the 2-step dermoscopy algorithm. JAMA Dermatol. 2015;151(7):715–21.CrossRefPubMedGoogle Scholar
  17. 17.
    Marghoob AA, Braun R. Proposal for a revised 2-step algorithm for the classification of lesions of the skin using dermoscopy. Arch Dermatol. 2010;146(4):426–8.CrossRefPubMedGoogle Scholar
  18. 18.
    Carrera C, Marchetti MA, Dusza SW, Argenziano G, Braun RP, Halpern AC, et al. Validity and reliability of dermoscopic criteria used to differentiate nevi from melanoma: a web-based International Dermoscopy Society study. JAMA Dermatol. 2016;152(7):798–806.PubMedCentralPubMedCrossRefGoogle Scholar
  19. 19.
    Soyer HP, Argenziano G, Zalaudek I, Corona R, Sera F, Talamini R, et al. Three-point checklist of dermoscopy. A new screening method for early detection of melanoma. Dermatology. 2004;208(1):27–31.CrossRefPubMedGoogle Scholar
  20. 20.
    Nachbar F, Stolz W, Merkle T, Congetta AB, Vogt T, Landthaler M, et al. The ABCD rule of dermatoscopy: high prospective value in the diagnosis of doubtful melanocytic skin lesions. J Am Acad Dermatol. 1994;30(4):551–9.CrossRefPubMedGoogle Scholar
  21. 21.
    Larre Borges A, Zalaudek I, Longo C, Dufrechou L, Argenziano G, Lallas A, et al. Melanocytic nevi with special features: clinical-dermoscopic and reflectance confocal microscopic-findings. J Eur Acad Dermatol Venereol. 2014;28(7):833–45.CrossRefPubMedGoogle Scholar
  22. 22.
    Kittler H, Tschandl P. Dysplastic nevus: why this term should be abandoned in dermatoscopy. Dermatol Clin. 2013;31(4):579–88.PubMedCrossRefGoogle Scholar
  23. 23.
    Hofman-Wellenhof R, Carrera C. Dermoscopic classification of Clark Nevi. In Malvhey J, Puig S. Principles of dermoscopy. 2009 Ed. www.cege.es www.dermoscop.com. Chap 8.3 377–84.
  24. 24.
    Argenziano G, Albertini G, Castagnetti F, De Pace B, Di Lernia V, Longo C, et al. Early diagnosis of melanoma: what is the impact of dermoscopy? Dermatol Ther. 2012;25(5):403–9.CrossRefPubMedGoogle Scholar
  25. 25.
    Geller AC, Mayer JE, Sober AJ, Miller DR, Argenziano G, Johnson TM, et al. Total nevi, atypical nevi, and melanoma thickness: an analysis of 566 patients at 2 US centers. JAMA Dermatol. 2016;152(4):413–8.CrossRefPubMedGoogle Scholar
  26. 26.
    Cengiz FP, Cengiz AB, Emiroglu N, Comert E, Wellenhof RH. Dermoscopic and clinical features of head and neck melanoma. An Bras Dermatol. 2015;90(4):488–93.PubMedCentralPubMedCrossRefGoogle Scholar
  27. 27.
    Saida T, Oguchi S, Miayazaki A. Dermoscopy for acral pigmented skin lesions. Clin Dermatol. 2002;20:279–85.CrossRefPubMedGoogle Scholar
  28. 28.
    Zaballos P, Llambrich A, Puig S, Malvehy J. Criterios Dermatoscópicos de las lesiones melanocíticas palmplantares. Piel. 2006;21:31–6.CrossRefGoogle Scholar
  29. 29.
    Saida T, Koga H. Dermoscopic patterns of acral melanocytic nevi. Their variations, changes and significance. Arch Dermatol. 2007;143:1423–6.PubMedGoogle Scholar
  30. 30.
    Miyazaki A, Saida T, Koga H, Oguchi S, Suzuki T, Tsuchida T. Anatomical and histopathologic correlates of the dermoscopic patterns seen in melanocytic nevi on the sole: a retrospective study. J Am Acad Dermatol. 2005;53:230–6.PubMedCrossRefGoogle Scholar
  31. 31.
    Malvehy J, Puig S. Dermoscopic patterns of benign volar melanocytic lesions in patients with atypical mole syndrome. Arch Dermatol. 2004;140:538–44.PubMedCrossRefGoogle Scholar
  32. 32.
    Altamura D, Altobelli E, Micantonio T, Piccolo D, Fargnoli MC, Peris K. Dermoscopic patterns of acral melanocytic nevi and melanomas in a white population in central Italy. Arch Dermatol. 2006;142:1123–8.PubMedCrossRefGoogle Scholar
  33. 33.
    Barquet V, Dufrechou L, Nicoletti S, Acosta MA, Magliano J, Martínez M, et al. Dermoscopic patterns of 158 acral melanocytic nevi in a Latin American population. Actas Dermosifiliogr. 2013;104(7):586–92.PubMedCrossRefGoogle Scholar
  34. 34.
    Bowling J. Fibrillar pattern of an acquired plantar acral melanocytic naevus: correspondence between epiluminiscence light microscopy and transverse section histology. Clin Exp Dermatol. 2006;31:449–51.CrossRefGoogle Scholar
  35. 35.
    Hofmann-Wellenhof R. Special criteria for special locations 2: scalp, mucosal, and milk line. Dermatol Clin. 2013;31(4):625–36.PubMedCrossRefGoogle Scholar
  36. 36.
    Murzaku EC, Penn LA, Hale CS, Pomeranz MK, Polsky D. Vulvar nevi, melanosis, and melanoma: an epidemiologic, clinical, and histopathologic review. J Am Acad Dermatol. 2014;71(6):1241–9.PubMedCrossRefGoogle Scholar
  37. 37.
    Rigel DS, Russak J, Friedman R. The evolution of melanoma diagnosis: 25 years beyond the ABCDs. CA Cancer J Clin. 2010;60(5):301–16.PubMedCrossRefGoogle Scholar
  38. 38.
    Friedman RJ, Rigel DS, Kopf AW. Early detection of malignant melanoma: the role of physician examination and self-examination of the skin. CA Cancer J Clin. 1985;35:130–51.PubMedCrossRefGoogle Scholar
  39. 39.
    Abbasi NR, Shaw HM, Rigel DS, Friedman RJ, McCarthy WH, Osman I, et al. Early diagnosis of cutaneous melanoma: revisiting the ABCD criteria. JAMA. 2004;292(22):2771–6.PubMedCrossRefGoogle Scholar
  40. 40.
    Grob JJ, Bonerandi JJ. The “ugly duckling” sign: identification of the common characteristics of nevi in an individual as a basis for melanoma screening. Arch Dermatol. 1998;134:103–4.PubMedCrossRefGoogle Scholar
  41. 41.
    Marghoob AA, Scope A. The complexity of diagnosing melanoma. J Invest Dermatol. 2009;129(1):11–3.PubMedCrossRefGoogle Scholar
  42. 42.
    McGovern VJ, Mihm MC Jr, Bailly C, Booth C, Clark WH Jr, Cochran AJ, et al. The classification of malignant melanoma and its histologic reporting. Cancer. 1973;32:1446–57.PubMedCrossRefGoogle Scholar
  43. 43.
    Curtin JA, Fridlyand J, Kageshita T, Patel HN, Busman KJ, Kutzner H, et al. Distinct sets of genetic alterations in melanoma. N Engl J Med. 2005;353:2135–47.PubMedCrossRefGoogle Scholar
  44. 44.
    Kittler H, Pehamberger H, Wolff K, Binder M. Diagnostic accuracy of dermoscopy. Lancet Oncol. 2002;3(3):159–65.PubMedCrossRefGoogle Scholar
  45. 45.
    Bafounta ML, Beauchet A, Aegerter P, Saiag P. Is dermoscopy (epiluminescence microscopy) useful for the diagnosis of melanoma? Results of a meta-analysis using techniques adapted to the evaluation of diagnostic tests. Arch Dermatol. 2001;137(10):1343–50.PubMedCrossRefGoogle Scholar
  46. 46.
    Pizzichetta MA, Talamini R, Marghoob AA, Soyer HP, Argenziano G, Bono R, et al. Negative pigment network: an additional dermoscopic feature for the diagnosis of melanoma. J Am Acad Dermatol. 2013;68(4):552–9.PubMedCrossRefGoogle Scholar
  47. 47.
    Balagula Y, Braun RP, Rabinovitz HS, Dusza SW, Scope A, Liebman TN, et al. The significance of crystalline/chrysalis structures in the diagnosis of melanocytic and nonmelanocytic lesions. J Am Acad Dermatol. 2012;67(2):194.e1–8.CrossRefGoogle Scholar
  48. 48.
    Pizzichetta MA, Kittler H, Stanganelli I, Bono R, Cavicchini S, De Giorgi V, et al. Italian Melanoma Intergroup. Pigmented nodular melanoma: the predictive value of dermoscopic features using multivariate analysis. Br J Dermatol. 2015;173(1):10614.CrossRefGoogle Scholar
  49. 49.
    Kalkhoran S, Milne O, Zalaudek I, et al. Historical, clinical, and dermoscopic characteristics of thin nodular melanoma. Arch Dermatol. 2010;146:311–8.PubMedCrossRefGoogle Scholar
  50. 50.
    Argenziano G, Longo C, Cameron A, Cavicchini S, Gourhant JY, Lallas A, et al. Blue-black rule: a simple dermoscopic clue to recognize pigmented nodular melanoma. Br J Dermatol. 2011;165:1251–5.PubMedCrossRefGoogle Scholar
  51. 51.
    Lallas A, Argenziano G, Moscarella E, Longo C, Simonetti V, Zalaudek I. Diagnosis and management of facial pigmented macules. Clin Dermatol. 2014;32(1):94–100.PubMedCrossRefGoogle Scholar
  52. 52.
    Schiffner R, Schiffner-Rohe J, Vogt T, Landthaler M, Wlotzke U, Cognetta AB, et al. Improvement of early recognition of lentigo maligna using dermatoscopy. J Am Acad Dermatol. 2000;42:25–32.PubMedCrossRefGoogle Scholar
  53. 53.
    Stolz W, Schiffner R, Burgdorf WH. Dermatoscopy for facial pigmented skin lesions. Clin Dermatol. 2002;20:276–8.PubMedCrossRefGoogle Scholar
  54. 54.
    Pralong P, Bathelier E, Dalle S, Poulalhon N, Debarbieux S, Thomas L. Dermoscopy of lentigo malignant melanoma: report of 125 cases. Br J Dermatol. 2012;167:280–7.PubMedCrossRefGoogle Scholar
  55. 55.
    Jaimes N, Marghoob AA, Rabinovitz H, Braun RP, Cameron A, Rosendahl C, et al. Clinical and dermoscopic characteristics of melanomas on nonfacial chronically sun-damaged skin. J Am Acad Dermatol. 2015;72(6):1027–35.PubMedCrossRefGoogle Scholar
  56. 56.
    Vanden Daelen A, Ferreira I, Marot L, Tromme I. A digital dermoscopy follow-up illustration and a histopathologic correlation for angulated lines in extrafacial lentigo maligna. JAMA Dermatol. 2016;152(2):200–3.CrossRefGoogle Scholar
  57. 57.
    Jaimes N, Braun RP, Thomas L, Marghoob AA. Clinical and dermoscopic characteristics of amelanotic melanomas that are not of the nodular subtype. J Eur Acad Dermatol Venereol. 2012;26(5):591–6.PubMedCrossRefGoogle Scholar
  58. 58.
    Argenziano G, Zalaudek I, Hofmann-Wellenhof R, Bakos RM, Bergman W, Blum A, et al. Total body skin examination for skin cancer screening in patients with focused symptoms. J Am Acad Dermatol. 2012;66:212–9.PubMedCrossRefGoogle Scholar
  59. 59.
    Zalaudek I, Kittler H, Marghoob AA, Balato A, Blum A, Dalle S, et al. Time required for a complete skin examination with and without dermoscopy: a prospective, randomized multicenter study. Arch Dermatol. 2008;144:509–13.PubMedGoogle Scholar
  60. 60.
    Argenziano G, Giacomel J, Zalaudek I, Blum A, Braun RP, Cabo H, et al. A clinicodermoscopic approach for skin cancer screening: recommendations involving a survey of the International Dermoscopy Society. Dermatol Clin. 2013;31(4):525–34.PubMedCrossRefGoogle Scholar
  61. 61.
    Argenziano G, Catricala C, Ardigo M, Buccini P, De Simone P, Eibenschutz L, et al. Dermoscopy of patients with multiple nevi: improved management recommendations using a comparative diagnostic approach. Arch Dermatol. 2011;147:46–9.PubMedCrossRefGoogle Scholar
  62. 62.
    Salerni G, Carrera C, Lovatto L, Puig-Butille JA, Badenas C, Plana E, et al. Benefits of total body photography and digital dermatoscopy (“twostep method of digital follow-up”) in the early diagnosis of melanoma in patients at high risk for melanoma. J Am Acad Dermatol. 2011;67(1):e17–27.PubMedCentralPubMedCrossRefGoogle Scholar
  63. 63.
    Salerni G, Lovatto L, Carrera C, Puig S, Malvehy J. Melanomas detected in a follow-up program compared with melanomas referred to a melanoma unit. Arch Dermatol. 2011;147:549–55.PubMedCrossRefGoogle Scholar
  64. 64.
    Argenziano G, Mordente I, Ferrara G, Sgambato A, Annese P, Zalaudek I. Dermoscopic monitoring of melanocytic skin lesions: clinical outcome and patient compliance vary according to follow-up protocols. Br J Dermatol. 2008;159:331–6.PubMedCrossRefGoogle Scholar
  65. 65.
    Valencia D, Neil A, Ken K. Benign epithelial tumors, hamartomas, and hyperplasias. In: Fitzpatrick. Dermatología en medicina general. Madrid: Panamericana. 2008; p. 1054–76.Google Scholar
  66. 66.
    Lin J, Han S, Cui L, Song Z, Gao M, Yang G, et al. Evaluation of dermoscopic algorithm for seborrheic keratosis: a prospective study in 412 patients. J Eur Acad Dermatol Venereol. 2014;28:957–62.PubMedCrossRefGoogle Scholar
  67. 67.
    Ruiz AB, Quiñones R, Domínguez AE. Dermatoscopía de las queratosis seborreicas y sus diferentes caras. Dermatol Rev Mex. 2012;56(3):193–200.Google Scholar
  68. 68.
    Braun RP, Scope A, Marghoob AA. The “blink sign” in dermoscopy. Arch Dermatol. 2011;147(4):520.PubMedCrossRefGoogle Scholar
  69. 69.
    Malvehy J, Puig S, Braun R, Marghoob A, Kopf A. Manual de Dermatoscopía. Barcelona: Editorial BCN Art Directe; 2006. p. 1–20.Google Scholar
  70. 70.
    Cabo H, Argenziano G, Sabban C, et al. Lesiones no melanocíticas en Dermatoscopía. 2nd ed. Argentina: Ediciones Journal; 2008. p. 83–117.Google Scholar
  71. 71.
    Carrera C, Zaballos P, Puig S, Malvehy J, Mascaró-Galy JM, Palou J. Correlación histológica en dermatoscopía; lesiones melanocíticas y no melanocíticas. Criterios dermatoscópicos de nevus melanocíticos. Med Cut Iber Lat Am. 2004;32(2):47–60.Google Scholar
  72. 72.
    Basset-Séguin N, Chaussade V, Vilmer C. Carcinomas basocelulares. EMC. Dermatología. Paris: Elsevier Masson SAS; 2011.Google Scholar
  73. 73.
    Nelson SA, Scope A, Rishpon A, Rabinovitz HS, Oliviero MC, Laman SD, et al. Accuracy and confidence in the clinical diagnosis of basal cell cancer using dermoscopy and reflex confocal microscopy. Int J Dermatol. 2016; doi: https://doi.org/10.1111/ijd.13361.
  74. 74.
    Wong CSM, Strange RC, Lear JT. Basal cell carcinoma. BMJ. 2003;327(7418):794–8.PubMedCentralPubMedCrossRefGoogle Scholar
  75. 75.
    Mackiewicz-Wysocka M, Bowszyc-Dmochowska M, Strzelecka-Węklar D, Dańczak-Pazdrowska A, Adamski Z. Basal cell carcinoma – diagnosis. Contemp Oncol (Pozn). 2013;17(4):337–42.Google Scholar
  76. 76.
    Chinem PV, Miot HA. Epidemiologia do carcinoma basocelular. An Bras Dermatol. 2011;86(2):292–305.PubMedCrossRefGoogle Scholar
  77. 77.
    Lallas A, Tzellos T, Kyrgidis A, Apalla Z, Zalaudek I, Karatolias A, et al. Accuracy of dermoscopic criteria for discriminating superficial from other subtypes of basal cell carcinoma. J Am Acad Dermatol. 2014;70(2):303–11.PubMedCrossRefGoogle Scholar
  78. 78.
    González V, Gramajo M, Escobar C, Romero Costas L, Ruzzi I, Picardi N, et al. Dermatoscopía del carcinoma basocelular: criterios clásicos y actuales. Arch Argent Dermatol. 2012;62:87–91.Google Scholar
  79. 79.
    Menzies SW, Westerhoff K, Rabinovitz H, Kopf AW, McCarthy WH, Katz B. Surface microscopy of pigmented basal cell carcinoma. Arch Dermatol. 2000;136(8):1012–6.PubMedCrossRefGoogle Scholar
  80. 80.
    Puspok-Schwarz M, Steiner A, Binder M, Partsch B, Wolff K, Pehamberger H. Statistical evaluation of epiluminiscence microscopy criteria in the differential diagnosis of malignant melanoma and pigmented basal cell carcinoma. Melanoma Res. 1997;7:307–11.CrossRefPubMedGoogle Scholar
  81. 81.
    Altamura D, Menzies S, Argenziano G, Zalaudek I, Soyer P, Sera F, et al. Dermatoscopy of basal cell carcinoma: morphologic variability of global and local features and accuracy of diagnosis. J Am Acad Dermatol. 2010;62:67–75.CrossRefPubMedGoogle Scholar
  82. 82.
    Quiñones R, Verduzco AP, Guevara E. Hallazgos dermatoscópicos del carcinoma basocelular en relación con su tamaño. Dermatol Rev Mex. 2012;56(3):172–6.Google Scholar
  83. 83.
    Zaballos P, Puig S, Llambrich A, Malvehy J. Dermoscopy of dermatofibromas: a prospective morphological study of 412 cases. Arch Dermatol. 2008;144(1):75–83.CrossRefPubMedGoogle Scholar
  84. 84.
    Laureano A, Fernandes C, Cardoso J. Hemosiderotic dermatofibroma: clinical and dermoscopic presentation mimicking melanoma. J Dermatol Case Rep. 2015;9(2):39–41.PubMedCentralPubMedCrossRefGoogle Scholar
  85. 85.
    Ferrari A, Argenziano G, Buccini P, Cota C, Sperduti I, De Simone P, et al. Typical and atypical dermoscopic presentations of dermatofibroma. JEADV. 2013;27(11):1375–80.PubMedGoogle Scholar
  86. 86.
    Zaballos P, Daufí C, Puig S, Argenziano G, Moreno-Ramirez D, Cabo H, et al. Dermoscopy of solitary angiokeratomas. A morphological study. Arch Dermatol. 2007;143(3):318–25.PubMedCrossRefGoogle Scholar
  87. 87.
    Kim JH, Kim MR, Lee S-H, Lee SE, Lee SH. Dermoscopy: a useful tool for the diagnosis of angiokeratoma. Ann Dermatol. 2012;24(4):468–71.PubMedCentralPubMedCrossRefGoogle Scholar
  88. 88.
    Malvehy J. A new vision of actinic keratosis beyond visible clinical lesions. JEADV. 2015;29(Suppl. 1):3–8.PubMedGoogle Scholar
  89. 89.
    Zalaudek I, Ferrara G, Leinweber B, Mercogliano A, D’ Ambrosio A, Argenziano G. Pitfalls in the clinical and dermoscopic diagnosis of pigmented actinic keratosis. J Am Acad Dermatol. 2005;53:1071–4.PubMedCrossRefGoogle Scholar
  90. 90.
    Aviles JA, Suárez R, Lázaro P. Diagnostic utility of dermoscopy in pigmented actinic keratosis. Actas Dermosifiliogr. 2011;102(8):623–6.CrossRefPubMedGoogle Scholar
  91. 91.
    Rigel DS, Stein Gold LF. The importance of early diagnosis and treatment of actinic keratosis. J Am Acad Dermatol. 2013;68:S20–7.CrossRefPubMedGoogle Scholar
  92. 92.
    Giacomel J, Lallas A, Argenziano G, Bombonato C, Zalaudek I. Dermoscopic “signature” pattern of pigmented and nonpigmented facial actinic keratoses. Am Acad Dermatol. 2015;72:e57–9.CrossRefGoogle Scholar
  93. 93.
    Zalaudek I, Argenziano G. Dermoscopy of actinic keratosis, intraepidermal carcinoma and squamous cell carcinoma. Curr Probl Dermatol. Basel, Karger. 2015;46:70–6.CrossRefPubMedGoogle Scholar
  94. 94.
    Kittler H, Marghoob AA, Argenziano G, Carrera C, Curiel-Lewandrowski C, Hofmann-Wellnhof R, et al. Standardization of terminology in dermoscopy/dermatoscopy: results of the third consensus conference of the International Society of Dermoscopy. J Am Acad Dermatol. 2016;74:1093–106.PubMedCentralPubMedCrossRefGoogle Scholar
  95. 95.
    Martín JM, Bella-Navarro R, Jordaa E. Vascular patterns in dermoscopy. Actas Dermosifiliogr. 2012;103(5):357–75.CrossRefPubMedGoogle Scholar
  96. 96.
    Lallas A, Giacomel J, Argenziano G, García-García B, González-Fernández D, Zalaudek I, et al. Dermoscopy in general dermatology: practical tips for the clinician. Br J Dermatol. 2014;170(3):514–26.CrossRefPubMedGoogle Scholar
  97. 97.
    Mun J, Ko H, Kim B, Kim MB. Dermoscopy of giant molluscum contagiosum. J Am Acad Dermatol. 2013;69:e287–8.CrossRefPubMedGoogle Scholar
  98. 98.
    Mical G, Lacarruba F, Massimino D, Schwartz RA. Dermatoscopy: alternative uses in daily clinical practice. J Am Acad Dermatol. 2011;64(6):1136–46.Google Scholar
  99. 99.
    Ianhez M, da Costa P. Cestari S, Yoshiaki Enokihara M, Bandeira de Paiva Melo Seize M. Dermoscopic patterns of molluscum contagiosum: a study of 211 lesions confirmed by histopathology. An Bras Dermatol. 2011;86(1):79–4.CrossRefGoogle Scholar
  100. 100.
    Segura Tigell S. Dermatoscopia en el diagnóstico de las infecciones cutáneas. Dermoscopy in the diagnosis of skin infections. Piel (barc). 2014;29(1):20–8.CrossRefGoogle Scholar
  101. 101.
    Michajłowski I, Michajłowski J, Sobjanek M, Włodarkiewicz A, Matuszewski M, Krajk K. Usefulness of dermoscopy for differentiation of pearly penile papules and genital warts. Eur Urol Supl. 2008;8:567–605.Google Scholar
  102. 102.
    Zalaudek I, Giacomel J, Schmid K, Bondino S, Rosendahl S, Cavicchini S. Dermatoscopy of facial actinic keratosis, intraepidermal carcinoma, and invasive squamous cell carcinoma: a progression model. J Am Acad Dermatol. 2012;66:589–97.CrossRefPubMedGoogle Scholar
  103. 103.
    Rhee DY, Won KH, Lee YJ, Won CH, Chang SE, Lee MW. Successful treatment of multiple vemurafenib-induced keratoacanthomas by topical application of imiquimod cream: confirmation of clinical clearance by dermoscopy. J Dermatolog Treat. 2016;19:1–2.Google Scholar
  104. 104.
    Woltsche N, Schwab C, Deinlein T, Hofmann-Wellenhof R, Zalaudek I. Dermoscopy in the era of dermato-oncology: from bed to bench side and retour. Expert Rev Anticancer Ther. 2016;16(5):531–41.CrossRefPubMedGoogle Scholar
  105. 105.
    Pozzobon FC, Puig-Butille JA, Gonzalez-Alvarez T, Carrera C, Aguilera P, Alos L, et al. Dermoscopic criteria associated with BRAF and NRAS mutation status in primary cutaneous melanoma. Br J Dermatol. 2014;171(4):754–9.CrossRefPubMedGoogle Scholar
  106. 106.
    De Giorgi V, Savarese I, D’Errico A, Gori A, Papi F, Colombino M, et al. CDKN2A mutations could influence the dermoscopic pattern of presentation of multiple primary melanoma: a clinical dermoscopic genetic study. J Eur Acad Dermatol Venereol. 2015;29(3):574–80.CrossRefPubMedGoogle Scholar
  107. 107.
    Guitera P, Menzies SW, Argenziano G, Longo C, Losi A, Drummond M, et al. Dermoscopy and in vivo confocal microscopy are complimentary techniques for the diagnosis of difficult amelanotic and light colored skin lesions. Br J Dermatol. doi: https://doi.org/10.1111/bjd.14749.

Recommended Reading

  1. 108.
    Malvhey J, Puig S. Handbook of dermoscopy. 1st ed. Barcelona: Taylor and Francis Group, CRC Press; 2006.Google Scholar
  2. 109.
    Malvehy J, Puig S. Principios de dermatoscopia. 1st ed. Barcelona; 2011.Google Scholar
  3. 110.
    Kittler H, Rosendahl C, Cameron A, Tschandl P. Dermatoscopía. Un método algorítimico basado en el análisis de patrones. 1st ed. Gdansk; 2015.Google Scholar
  4. 111.
    Cabo H. Dermatoscopía. 2ª ed. Buenos Aires: Ediciones Journal; 2012.Google Scholar
  5. 112.
    Rezze G., Paschoal, FM., Hirata, S. Atlas de Dermatoscopia aplicada. 1era Edición. San Pablo: Lemar Livraria e editora Marina; 2014.Google Scholar
  6. 113.
    Larre Borges A, Nicoletti S, Salerni G. Dermatoscopía elemental: lesiones pigmentadas. Primera Edición. Montevideo; 2013.Google Scholar

Copyright information

© Springer International Publishing Switzerland 2018

Authors and Affiliations

  • Alejandra Larre Borges
    • 1
  • Sofía Nicoletti
    • 1
  • Lídice Dufrechou
    • 1
  • Andrea Nicola Centanni
    • 1
  1. 1.Hospital de Clínicas“Dr. Manuel Quintela”MontevideoUruguay

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