Autoimmune Bullous Dermatoses
Autoimmune bullous dermatoses are acquired diseases associated with pathogenic autoantibodies against structural proteins that maintain cell–cell and cell–matrix adhesions in the skin and mucous membranes. They are classified as acantholytic (or intraepidermal) bullous dermatoses or non-acantholytic (or subepidermal) bullous dermatoses. Etiopathogenic, clinical, and therapeutic aspects are discussed in this chapter.
KeywordsDesmosome Hemidesmosome Acantholysis Immunofluorescence Immunosuppression
Loss of epithelial intercellular contact, showing isolated round keratinocytes.
Blistering dermatoses without acantholysis, caused by hemidesmosomal lesions.
Cell structure that adheres epithelial cells to each other, composed of two plaques, one in each cell, connected by transmembranous proteins.
Laboratory investigation to detect antibodies in tissues.
Cell structure that adheres the basal keratinocyte to the basement membrane, composed of one plaque, also connected by transmembranous proteins.
Blistering dermatoses with acantholysis caused by desmosomal lesions.
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