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Basal Cell Carcinoma

  • Roberto Gomes Tarlé
  • Wagner Bertolini
  • Luciano José Biasi
  • José Roberto Toshio Shibue
Chapter

Abstract

Basal cell carcinoma (BCC) is the most incident type of skin cancer, having been related etiologically to chronic sun exposure and genetic predisposition. The classical clinical presentation of BCC is a slow-growing pearly papule, showing telangiectatic vessels that can progress to nodules. Different clinical and histologic subtypes are described, whose recognition is of great importance in arriving at the correct therapeutic decision and oncologic cure.

Keywords

Basal cell carcinoma Skin cancer Nonmelanoma skin cancer 

Notes

Glossary

Confocal microscopy

Noninvasive imaging technique that enables in vivo visualization of the skin structure in real time.

Dermoscopy

Noninvasive diagnostic technique for the in vivo observation of skin lesions with a dermatoscope, allowing magnification of the lesion.

Gorlin’s syndrome

Also known as nevoid basal cell carcinoma syndrome, it is characterized by developmental anomalies, such as odontogenic keratocysts of the mandible, bifid ribs, palmoplantar pits and tumors, and especially multiple BCCs.

Mohs micrographic surgery

A microscopically controlled surgery used to treat different types of skin cancer, developed in 1938 by Frederic Mohs.

Optical coherence tomography

Noninvasive imaging examination that uses light waves to take cross-sectional pictures of the skin structure.

Photodynamic therapy

Treatment that uses a photosensitizer or photosensitizing agent that will be absorbed by the target cell, and a particular type of light that will react with the photosensitizer and cause cellular death.

PTCH1, patched 1 gene

This gene encodes the protein receptor for the sonic hedgehog, a molecule implicated in the formation of embryonic structures and in tumorigenesis. Mutations of this gene have been associated with basal cell nevus syndrome and sporadic BCC.

Telangiectasias

Dilated capillaries that appear clinically as red linear vessels with spidery appearance on the surface of the skin.

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Copyright information

© Springer International Publishing Switzerland 2018

Authors and Affiliations

  • Roberto Gomes Tarlé
    • 1
  • Wagner Bertolini
    • 2
  • Luciano José Biasi
    • 3
  • José Roberto Toshio Shibue
    • 4
  1. 1.Santa Casa de Misericórdia Pontifical Catholic University of Paraná – PUCPRCuritibaBrazil
  2. 2.Santa Casa HospitalPorto AlegreBrazil
  3. 3.Instituto de Oncologia do ParanáCuritibaBrazil
  4. 4.Santa Casa de Curitiba, Instituto de Neurologia de CuritibaCuritibaBrazil

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