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Precursor Lesions of Skin Cancer

  • Majoriê Mergen SegattoEmail author
  • Eloísa Unfer Schmitt Botton
Chapter
First Online:

Abstract

Skin cancer is more common than any other type of cancer. In view of the impact of skin cancer on public health, this chapter is dedicated to recognizing and treating precursor lesions of melanoma and nonmelanoma skin cancer. We divide the precursor lesions into three main groups. In the cutaneous melanoma precursor lesions group we discuss congenital melanocytic nevus, dysplastic nevus, and acquired melanocytic nevus. In the basocellular carcinoma precursor lesions group we discuss nevus sebaceus, and in the spinocellular carcinoma precursor lesions group we discuss actinic keratosis, porokeratosis, cutaneous horn, chronic scars, oral leukoplakia and erythroplakia, oral lichen planus, lichen sclerosus, and precursor lesions of skin cancer related to human papillomavirus.

Keywords

Acquired melanocytic nevus Actinic keratoses Atypical nevus Basocellular carcinoma Burn scars Common nevi Congenital melanocytic nevus Cutaneous horn Cutaneous melanoma Chronic scars Dysplastic nevus Giant congenital melanocytic nevus Erythroplakia Lichen sclerosus Lichen sclerosus et atrophicus Marjolin’s ulcer Melanocytic nevus Nevus sebaceus Nevus sebaceus of Jadassohn Nonmelanoma skin cancer Nevus Scars Skin cancer Oral lichen planus Oral leukoplakia Porokeratosis Premalignant lesions Precursor lesions Spinocellular carcinoma Squamous cell carcinoma 
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Notes

Glossary

Actinic keratoses

Epidermal lesions at the initial clinical stage of a biological continuum that may culminate in spinocellular carcinoma. They generally result from prolonged exposure to nonionizing radiation, especially ultraviolet. It has been characterized as a premalignant or precursor lesion of skin cancer, because it presents atypical keratinocytes confined in the epidermis.

Congenital melanocytic nevus

Melanocytic nevus that is present at birth or rarely up to 2 years of age. It is believed to result from the rapid proliferation of melanocytic lineage cells due to some morphologic error of the neuroectoderm, during the migration of the melanoblasts from the neural crest to the skin.

Cutaneous horn

A clinical term for a firm, white to yellow, conical, keratotic papule or plaque ranging from a few millimeters to several centimeters in size. Spinocellular carcinoma is the most common neoplasia associated with malignant-based horn.

Dysplastic nevus

Described as a continuum between the common acquired nevus and the melanoma, since it is morphologically and biologically the intermediate between these two entities.

Erythroplakia

A fiery red patch that cannot be characterized clinically or pathologically as any other definable disease. It is classified as an oral potentially malignant disorder.

Giant congenital melanocytic nevus

Congenital melanocytic nevus of ≥20 cm that generally presents as a brownish lesion with defined margins and hypertrichosis. The association with melanoma is well established.

Human papillomaviruses

Consist of a heterogeneous group of nonenveloped, double-stranded DNA viruses that display a distinct tropism for mucosal or cutaneous squamous epithelia. They are associated with development of malignancies, particularly high-risk HPV types.

Lichen sclerosus

An autoimmune, inflammatory dermatosis, characterized by a lymphocytic response that has a predilection for the genital skin in both sexes, and an association with several other autoimmune diseases.

Marjolin’s ulcer

This term refers to carcinomas arising both from chronically inflamed and scarred skin.

Nevus sebaceus

A hamartoma of epithelial and nonepithelial origin that is often referred to as an organoid nevus because it may contain any or all components of the skin.

Oral leukoplakia

A white plaque of questionable risk having excluded (other) known diseases or disorders that carry no risk. It is classified as an oral potentially malignant disorder.

Porokeratosis

A group of cutaneous entities characterized by disordering of epidermal keratinization, presence of a cornoid lamella, and a predisposition to develop malignant transformation.

References

  1. 1.
    IARC Working Group on the Evaluation of Cancer-preventive Agents. Sun, skin and cancer prevention. In: IARC handbooks of cancer prevention volume 5: Sunscreens. Lyon: International Agency for Research on Cancer; 2001. p. 1–15.Google Scholar
  2. 2.
    Chen ST, Geller AC, Tsao H. Update on the epidemiology of melanoma. Curr Dermatol Rep. 2013;2(1):24–34.PubMedPubMedCentralCrossRefGoogle Scholar
  3. 3.
    Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):E359–86.PubMedCrossRefGoogle Scholar
  4. 4.
    Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S, Coebergh JWW, Comber H, et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer. 2013;49(6):1374–403.PubMedCrossRefPubMedCentralGoogle Scholar
  5. 5.
    American Cancer Society. Cancer facts & figures 2015. Atlanta: American Cancer Society; 2015.Google Scholar
  6. 6.
    Rogers HW, Weinstock MA, Harris AR, Hinckley MR, Feldman SR, Fleischer AB, et al. Incidence estimate of nonmelanoma skin cancer in the United States, 2006. Arch Dermatol. 2010;146(3):283–7.PubMedCrossRefGoogle Scholar
  7. 7.
    Housman TS, Feldman SR, Williford PM, Fleischer AB Jr, Goldman ND, Acostamadiedo JM, et al. Skin cancer is among the most costly of all cancers to treat for the Medicare population. J Am Acad Dermatol. 2003;48(3):425–9.PubMedCrossRefGoogle Scholar
  8. 8.
    Kauvar ANB, Cronin T, Roenigk R, Hruza G, Bennett R. Consensus for nonmelanoma skin cancer treatment: basal cell carcinoma, including a cost analysis of treatment methods. Dermatol Surg. 2015;41(5):550–71.PubMedCrossRefGoogle Scholar
  9. 9.
    Noto G. On the clinical significance of cutaneous melanoma’s precursors. Indian Dermatol Online J. 2012;3(2):83–8.PubMedPubMedCentralCrossRefGoogle Scholar
  10. 10.
    Tsao H, Bevona C, Goggins W, Quinn T. The transformation rate of moles (Melanocytic Nevi) into cutaneous melanoma. Arch Dermatol. 2003;139(3):282–8.PubMedCrossRefGoogle Scholar
  11. 11.
    Gruber SB, Barnhill RL, Stenn KS, Roush GC. Nevomelanocytic proliferations in association with cutaneous malignant melanoma: a multivariate analysis. J Am Acad Dermatol. 1989;21(4):773–80.PubMedCrossRefGoogle Scholar
  12. 12.
    Marks R, Dorevitch AP, Mason G. Do all melanomas come from “moles”? A study of the histological association between melanocytic naevi and melanoma. Aust J Dermatol. 1990;31(2):77–80.CrossRefGoogle Scholar
  13. 13.
    Kruger S, Garbe C, Buttner P, Stadler R, Guggenmoos-Holzmann I, Orfanos CE. Epidemiologic evidence for the role of melanocytic nevi as risk markers and direct precursors of cutaneous malignant melanoma: results of a case control study in melanoma patients and nonmelanoma control subjects. J Am Acad Dermatol. 1992;26(6):920–6.PubMedCrossRefGoogle Scholar
  14. 14.
    Viana ACL, Gontijo B, Bittencourt FV. Giant congenital melanocytic nevus. An Bras Dermatol. 2013;88(6):863–78.PubMedPubMedCentralCrossRefGoogle Scholar
  15. 15.
    Barnhill RL, Rabinovitz H. Benign melanocytic neoplasms. In: Bolognia JL, Jorizzo JL, Rapini RP, editors. Dermatology. 2nd ed. Rio de Janeiro: Elsevier; 2008. p. 1713–40.Google Scholar
  16. 16.
    Kopf A, Bart R, Hennessey P. Congenital nevocytic nevi and malignant melanomas. J Am Acad Dermatol. 1979;1:123–30.PubMedCrossRefGoogle Scholar
  17. 17.
    Marghoob AA. Congenital melanocytic nevi. Eval Manag Dermatol Clin. 2002;20:607–16.CrossRefGoogle Scholar
  18. 18.
    Takayama H, Nagashima Y, Hara M, Takagi H, Mori M, Merlino G, et al. Immunohistochemical detection of the c-met proto-oncogene product in the congenital melanocytic nevus of an infant with neurocutaneous melanosis. J Am Acad Dermatol. 2001;44:538–40.PubMedCrossRefGoogle Scholar
  19. 19.
    Saida T. Histogenesis of congenital and acquired melanocytic nevi: a unifying concept. Am J Dermatopathol. 2006;28:377–9.PubMedCrossRefGoogle Scholar
  20. 20.
    Sahin S, Levin L, Kopf AW, Rao BK, Triola M, Koenig K, et al. Risk of melanoma in medium-sized congenital melanocytic nevi: a follow-up study. J Am Acad Dermatol. 1998;39(3):428–33.PubMedCrossRefGoogle Scholar
  21. 21.
    Swerdlow AJ, English JS, Qiao Z. The risk of melanoma in patients with congenital nevi: a cohort study. J Am Acad Dermatol. 1995 Apr;32(4):595–9.PubMedCrossRefGoogle Scholar
  22. 22.
    Alikhan A, Ibrahimi OA, Eisen DB. Congenital melanocytic nevi: Where are we now? Part I. Clinical presentation, epidemiology, pathogenesis, histology, malignant transformation, and neurocutaneous melanosis. J Am Acad Dermatol. 2012;67(4):495.PubMedCrossRefGoogle Scholar
  23. 23.
    Hale EK, Stein J, Ben-Porat L, Panageas KS, Eichenbaum MS, Marghoob AA, et al. Association of melanoma and neurocutaneous melanocytosis with large congenital melanocytic naevi – results from the NYU-LCMN registry. Br J Dermatol. 2005;152:512–7.PubMedCrossRefGoogle Scholar
  24. 24.
    Rhodes AR, Wood WC, Sober AJ, Mihm MC Jr. Nonepidermal origin of malignant melanoma associated with a giant congenital nevocellular nevus. Plast Reconstr Surg. 1981;67:782–90.PubMedCrossRefGoogle Scholar
  25. 25.
    Trozak DJ, Rowland WD, Hu F. Metastatic malignant melanoma in prepubertal children. Pediatrics. 1975;55:191–204.PubMedGoogle Scholar
  26. 26.
    DeDavid M, Orlow SJ, Provost N, Marghoob AA, Rao BK, Huang CL, et al. A study of large congenital melanocytic nevi and associated malignant melanomas: review of cases in the New York University Registry and the world literature. J Am Acad Dermatol. 1997;36:409–16.PubMedCrossRefGoogle Scholar
  27. 27.
    Ibrahimi OA, Alikhan A, Eisen DB. Congenital melanocytic nevi: where are we now? Part II. Treatment options and approach to treatment. J Am Acad Dermatol. 2012 Oct;67(4):515.PubMedCrossRefGoogle Scholar
  28. 28.
    Goldstein AM, Tucker MA. Dysplastic nevi and melanoma. Cancer Epidemiol Biomark Prev. 2013;22(4):528–32.CrossRefGoogle Scholar
  29. 29.
    Clark WH Jr, Reimer RR, Greene M, Ainsworth AM, Mastrangelo MJ. Origin of familial malignant melanomas from heritable melanocytic lesions. ‘The B-K mole syndrome’. Arch Dermatol. 1978;114:732–8.PubMedCrossRefGoogle Scholar
  30. 30.
    Duffy K, Grossman D. The dysplastic nevus: from historical perspective to management in the modern era: part I. Historical, histologic, and clinical aspects. J Am Acad Dermatol. 2012;67(1):1.e1–1.e16.CrossRefGoogle Scholar
  31. 31.
    Farber MJ, Heilman ER, Friedman RJ. Dysplastic nevi. Dermatol Clin. 2012;30(3):389–404.PubMedCrossRefGoogle Scholar
  32. 32.
    Elder DE. Dysplastic naevi: an update. Histopathology. 2010;56(1):112–20.PubMedCrossRefGoogle Scholar
  33. 33.
    Tucker MA, Halpern A, Holly EA, Hartge P, Elder DE, Sagebiel RW, et al. Clinically recognized dysplastic nevi. A central risk factor for cutaneous melanoma. JAMA. 1997;277(18):1439–44.PubMedCrossRefGoogle Scholar
  34. 34.
    Gandini S, Sera F, Cattaruzza MS, Pasquini P, Abeni D, Boyle P, et al. Meta-analysis of risk factors for cutaneous melanoma: I. Common and atypical naevi. Eur J Cancer. 2005;41:28–44.PubMedCrossRefGoogle Scholar
  35. 35.
    Naeyaert JM, Brochez L. Dysplastic nevi. N Engl J Med. 2003;349(23):2233–40.PubMedCrossRefGoogle Scholar
  36. 36.
    NIH Consensus conference. Diagnosis and treatment of early melanoma. JAMA. 1992;268:1314–9.CrossRefGoogle Scholar
  37. 37.
    Clemente C, Cochran AJ, Elder DE, Levene A, MacKie RM, Mihm MC, et al. Histopathologic diagnosis of dysplastic nevi: concordance among pathologists convened by the World Health Organization Melanoma Programme. Hum Pathol. 1991;22:313–9.PubMedCrossRefGoogle Scholar
  38. 38.
    Arumi-Uria M, McNutt NS, Finnerty B. Grading of atypia in nevi: correlation with melanoma risk. Mod Pathol. 2003;16(8):764–71.PubMedCrossRefGoogle Scholar
  39. 39.
    Shors A, Kim S, White E, Argenyi Z, Barnhill RL, Duray P, et al. Dysplastic naevi with moderate to severe histological dysplasia: a risk factor for melanoma. Br J Dermatol. 2006;155(5):988–93.PubMedCrossRefGoogle Scholar
  40. 40.
    Kittler H, Pehamberger H, Wolff K, Binder M. Diagnostic accuracy of dermoscopy. Lancet Oncol. 2002;3(3):159–65.PubMedCrossRefGoogle Scholar
  41. 41.
    Feit NE, Dusza SW, Marghoob AA. Melanomas detected with the aid of total cutaneous photography. Br J Dermatol. 2004;150(4):706–14.PubMedCrossRefGoogle Scholar
  42. 42.
    Sober AJ, Chuang TY, Duvic M, Farmer ER, Grichnik JM, Halpern AC, et al. Guidelines of care for primary cutaneous melanoma. J Am Acad Dermatol. 2001;45(4):579–86.PubMedCrossRefGoogle Scholar
  43. 43.
    Tran KT, Wright NA, Cockerell CJ. Biopsy of the pigmented lesion – when and how. J Am Acad Dermatol. 2008;59(5):852–71.PubMedCrossRefGoogle Scholar
  44. 44.
    Bataille V, Bishop JA, Sasieni P, Swerdlow AJ, Pinney E, Griffiths K, et al. Risk of cutaneous melanoma in relation to the numbers, types and sites of naevi: a case-control study. Br J Cancer. 1996 Jun;73(12):1605–11.PubMedPubMedCentralCrossRefGoogle Scholar
  45. 45.
    Grulich AE, Bataille V, Swerdlow AJ, Newton-Bishop JA, Cuzick J, Hersey P, et al. Naevi and pigmentary characteristics as risk factors for melanoma in a high-risk population: a case-control study in New South Wales. Aust Int J Cancer. 1996 Aug;67(4):485–91.CrossRefGoogle Scholar
  46. 46.
    Whiteman DC, Pavan WJ, Bastian BC. The melanomas: a synthesis of epidemiological, clinical, histopathological, genetic, and biological aspects, supporting distinct subtypes, causal pathways, and cells of origin. Pigment Cell Melanoma Res. 2011;24:879–97.PubMedPubMedCentralCrossRefGoogle Scholar
  47. 47.
    Lin WM, Luo S, Muzikansky A, Lobo AZ, Tanabe KK, Sober AJ, et al. Outcome of patients with de novo versus nevus-associated melanoma. J Am Acad Dermatol. 2015;72:54–8.PubMedCrossRefGoogle Scholar
  48. 48.
    Kaddu S, Smolle J, Zenahlik P, Hofmann-Wellenhof R, Kerl H. Melanoma with benign melanocytic naevus components: reappraisal of clinicopathological features and prognosis. Melanoma Res. 2002;12(3):271–8.PubMedCrossRefGoogle Scholar
  49. 49.
    Bevona C, Goggins W, Quinn T, Fullerton J, Tsao H. Cutaneous melanomas associated with nevi. Arch Dermatol. 2003;139(12):1620–4.PubMedCrossRefGoogle Scholar
  50. 50.
    Kraft S, Tsao H. Melanoma-associated naevi: precursors or coincidence? Br J Dermatol. 2015 Sep;173(3):633–4.PubMedCrossRefGoogle Scholar
  51. 51.
    Skender-Kalnenas TM, English DR, Heenan PJ. Benign melanocytic lesions: risk markers or precursors of cutaneous melanoma? J Am Acad Dermatol. 1995 Dec;33(6):1000–7.PubMedCrossRefGoogle Scholar
  52. 52.
    Shitara D, Tell-Marti G, Badenas C, Enokihara MM, Alós L, Larque AB, et al. Mutational status of naevus-associated melanomas. Br J Dermatol. 2015;173(3):671–80.PubMedPubMedCentralCrossRefGoogle Scholar
  53. 53.
    Hidvegi NC, Kangesu L, Wolfe KQ. Squamous cell carcinoma complicating naevus sebaceous of Jadassohn in a child. Br J Plast Surg. 2003;56(1):​50–2.PubMedCrossRefGoogle Scholar
  54. 54.
    Ball EA, Hussain M, Moss AL. Squamous cell carcinoma and basal cell carcinoma arising in a naevus sebaceous of Jadassohn: case report and literature review. Clin Exp Dermatol. 2005;30(3):259–60.PubMedCrossRefGoogle Scholar
  55. 55.
    Davison SP, Khachemoune A, Yu D, Kauffman LC. Nevus sebaceus of Jadassohn revisited with reconstruction options. Int J Dermatol. 2005;44(2):145–50.PubMedCrossRefGoogle Scholar
  56. 56.
    Aslam A, Salam A, Griffiths CEM, McGrath JA. Naevus sebaceus: a mosaic RASopathy. Clin Exp Dermatol. 2014;39(1):1–6.PubMedCrossRefGoogle Scholar
  57. 57.
    Moody MN, Landau JM, Goldberg LH. Nevus sebaceous revisited. Pediatr Dermatol. 2012;29(1):15–23.PubMedCrossRefGoogle Scholar
  58. 58.
    Chun K, Vazquez M, Sanchez JL. Nevus sebaceus: clinical outcome and considerations for prophylactic excision. Int J Dermatol. 1995;34(8):538–41.PubMedCrossRefGoogle Scholar
  59. 59.
    Cribier B, Scrivener Y, Grosshans E. Tumors arising in nevus sebaceus: a study of 596 cases. J Am Acad Dermatol. 2000;42(2 Pt 1):263–8.PubMedCrossRefGoogle Scholar
  60. 60.
    Idriss MH, Elston DM. Secondary neoplasms associated with nevus sebaceus of Jadassohn: a study of 707 cases. J Am Acad Dermatol. 2014;70(2):332–7.PubMedCrossRefGoogle Scholar
  61. 61.
    Mundi JP, Rose AE, Boyd KP, Patel RR, Lipkin G. Syringocystadenoma. Dermatol Online J. 2013;​19(12):20722.PubMedGoogle Scholar
  62. 62.
    Salache SJ. Epidemiology of actinic keratoses and squamous cell carcinoma. J Am Acad Dermatol. 2000;42:4–7.CrossRefGoogle Scholar
  63. 63.
    Rigel DS, Cockerell CJ, Carucci J, Wharton J. Actinic keratosis, basal cell carcinoma and squamous cell carcinoma. In: Bolognia JL, Jorizzo JL, Rapini RP, editors. Dermatology. 2nd ed. Rio de Janeiro: Elsevier; 2008. p. 1641–59.Google Scholar
  64. 64.
    Gupta AK, Cooper EA, Feldman SR, Fleischer AB Jr. A survey of office visits for actinic keratosis as reported by NAMCS, 1990–1999. National Ambulatory Medical Care Survey. Cutis. 2002;70(Suppl 2):8–13.PubMedGoogle Scholar
  65. 65.
    Marks R, Rennie G, Selwood TS. Malignant transformation of solar keratoses to squamous cell carcinoma. Lancet. 1988;1:795–7.PubMedCrossRefGoogle Scholar
  66. 66.
    Dodson JM, DeSpain J, Hewett JE, Clark DP. Malignant potential of actinic keratoses and the controversy over treatment. A patient-oriented perspective. Arch Dermatol. 1991;127:1029–31.PubMedCrossRefGoogle Scholar
  67. 67.
    Hurwitz RM, Monger LE. Solar keratosis: an evolving squamous cell carcinoma: Benign or malignant? Dermatol Surg. 1995;21:184.PubMedCrossRefGoogle Scholar
  68. 68.
    Werner RN, Sammain A, Erdmann R, Hartmann V, Stockfleth E, Nast A. The natural history of actinic keratosis: a systematic review. Br J Dermatol. 2013;169:502–18.PubMedCrossRefGoogle Scholar
  69. 69.
    Werner RN, Stockfleth E, Connolly SM, Correia O, Erdmann R, Foley P, et al. Evidence- and consensus-based (S3) guidelines for the treatment of actinic keratosis – International League of Dermatological Societies in cooperation with the European Dermatology Forum – Short version. J Eur Acad Dermatol Venereol. 2015;29(11):​2069–79.PubMedCrossRefGoogle Scholar
  70. 70.
    McIntyre WJ, Downs MR, Bedwell SA. Treatment options for actinic keratoses. Am Fam Physician. 2007;76:667–71.PubMedGoogle Scholar
  71. 71.
    Rapini RP. Dermatopatologia prática. 1st ed. Rio de Janeiro: Di Livros; 2007.Google Scholar
  72. 72.
    Arranz-Salas I, Sanz-Trelles A, Ojeda DB. p53 alterations in porokeratosis. J Cutan Pathol. 2003;30(7):455–8.PubMedCrossRefGoogle Scholar
  73. 73.
    Maubec E, Duvillard P, Margulis A, Bachollet B, Degois G, Avril MF. Common skin cancers in porokeratosis. Br J Dermatol. 2005;152:1389–91.PubMedCrossRefGoogle Scholar
  74. 74.
    Palleschi GM, Torchia D. Porokeratosis of Mibelli and superficial disseminated porokeratosis. J Cutan Pathol. 2008;35:253–5.PubMedCrossRefGoogle Scholar
  75. 75.
    Koley S, Sarkar J, Choudhary S, Dhara S, Choudhury M, Bhattacharya S. Different morphological variants of hypertrophic porokeratosis and disseminated lesions of porokeratosis of Mibelli: a rare co-existence. Indian J Dermatol Venereol Leprol. 2011;77(2):199–202.PubMedCrossRefGoogle Scholar
  76. 76.
    Leow YH, Soon YH, Tham SN. A report of 31 cases of porokeratosis at the National Skin Centre. Ann Acad Med Singap. 1996;25(6):837–41.PubMedGoogle Scholar
  77. 77.
    Lee HR, Han TY, Son S, Lee JH. Squamous cell carcinoma developing within lesions of disseminated superficial actinic porokeratosis. Ann Dermatol. 2011;23:536–8.PubMedPubMedCentralCrossRefGoogle Scholar
  78. 78.
    Cockerell CJ, Larsen F. Benign epidermal tumors and proliferations. In: Bolognia JL, Jorizzo JL, Rapini RP, editors. Dermatology. 2nd ed. Rio de Janeiro: Elsevier; 2008. p. 1661–80.Google Scholar
  79. 79.
    Sasson M, Krain AD. Porokeratosis and cutaneous malignancy. A review. Dermatol Surg. 1996;22:339–42.PubMedGoogle Scholar
  80. 80.
    Happle R. Cancer proneness of linear porokeratosis may be explained by allelic loss. Dermatology. 1997;195(1):20–5.PubMedCrossRefGoogle Scholar
  81. 81.
    Vani T, Ramamohan CH, Nageswaramma S, Swarnakumari G, V Sivaramakrishna T, Rajunaidu DS, et al. Giant porokeratosis of mibelli with squamous cell carcinomas. J Dent Med Sci. 2015;14(2):44–6.Google Scholar
  82. 82.
    Kanitakis J. Porokeratoses: an update of clinical, aetiopathogenic and therapeutic features. Eur J Dermatol. 2014;24(5):533–44.PubMedGoogle Scholar
  83. 83.
    Dereli T, Ozyurt S, Ozturk G. Porokeratosis of Mibelli: successful treatment with cryosurgery. J Dermatol. 2004;31(3):223–7.PubMedCrossRefGoogle Scholar
  84. 84.
    Garg T, Ramchander T, Varghese B, Barara M, Nangia A. Generalized linear porokeratosis: a rare entity with excellent response to acitretin. Dermatol Online J. 2011;17(5):3.PubMedGoogle Scholar
  85. 85.
    Arun B, Pearson J, Chalmers R. Disseminated superficial actinic porokeratosis treated effectively with topical imiquimod 5% cream. Clin Exp Dermatol. 2011;36:509–11.PubMedCrossRefGoogle Scholar
  86. 86.
    Kneitz H, Motschenbacher S, Wobser M, Goebeler M. Giant cutaneous horn associated with squamous cell carcinoma. J Dermatol Case Rep. 2015;9:27–8.PubMedPubMedCentralCrossRefGoogle Scholar
  87. 87.
    Fernandes NF, Sinha S, Lambert WC, Schwartz RA. Cutaneous horn: a potentially malignant entity. Acta Dermatovenerol Alp Pannonica Adriat. 2009;18:189–93.PubMedGoogle Scholar
  88. 88.
    Solanki LS, Dhingra M, Raghubanshi G, Thami GP. An innocent giant. Indian J Dermatol. 2014;59:633.PubMedPubMedCentralCrossRefGoogle Scholar
  89. 89.
    Yu RC, Pryce DW, Macfarlane AW, Stewart TW. A histopathological study of 643 cutaneous horns. Br J Dermatol. 1991;24:449–52.CrossRefGoogle Scholar
  90. 90.
    Schosser RH, Hodge SJ, Gaba CR, Owen LG. Cutaneous horns: a histopathologic study. South Med J. 1979;72(9):1129–31.PubMedCrossRefGoogle Scholar
  91. 91.
    Mantese SA, Diogo PM, Rocha A, Berbert AL, Ferreira AK, Ferreira TC. Cutaneous horn: a retrospective histopathological study of 222 cases. An Bras Dermatol. 2010;85(2):157–63.PubMedCrossRefGoogle Scholar
  92. 92.
    Pyne J, Sapkota D, Wong JC. Cutaneous horns: clues to invasive squamous cell carcinoma being present in the horn base. Dermatol Pract Conc. 2013;3(2):3–7.Google Scholar
  93. 93.
    Kowal-Vern A, Criswell BK. Burn scar neoplasms: a literature review and statistical analysis. Burns. 2005;31:403–13.PubMedCrossRefGoogle Scholar
  94. 94.
    Phillips TJ, Salman SM, Bhawan J, Rogers GS. Burn scar carcinoma. Diagn Manag Dermatol Surg. 1998;24(5):561–5.CrossRefGoogle Scholar
  95. 95.
    Opara KO, Otene IC. Marjolin’s ulcer: a review. Niger Health J. 2011;11:107–11.Google Scholar
  96. 96.
    Yu N, Long X, Lujan-Hernandez JR, Hassan KZ, Bai M, Wang Y, et al. Marjolin’s ulcer: a preventable malignancy arising from scars. World J Surg Oncol. 2013;11:313.PubMedPubMedCentralCrossRefGoogle Scholar
  97. 97.
    Huang CY, Feng CH, Hsiao YC, Chuang SS, Yang JY. Burn scar carcinoma. J Dermatol Treat. 2010;21:350–6.CrossRefGoogle Scholar
  98. 98.
    Sakatani S, Kusakabe H, Kiyokane K, Suzuki K. P53 gene mutations in squamous cell carcinoma occurring in scars: comparison with p53 protein immunoreactivity. Am J Dermatopathol. 1998;20:463–7.PubMedCrossRefGoogle Scholar
  99. 99.
    Lee SH, Shin MS, Kim HS. Somatic mutations of Fas (Apo-1/CD95) gene in cutaneous cell carcinomas arising from a burn scar. J Invest Dermatol. 2000;114:122–6.PubMedCrossRefGoogle Scholar
  100. 100.
    Warnakulasuriya S, Johnson NW, van der Waal I. Nomenclature and classication of potentially malignant disorders of the oral mucosa. J Oral Pathol Med. 2007;36(10):575–80.PubMedCrossRefGoogle Scholar
  101. 101.
    Dionne KR, Warnakulasuriya S, Zain RB, Cheong SC. Potentially malignant disorders of the oral cavity: current practice and future directions in the clinic and laboratory. Int J Cancer. 2015;136:503–15.PubMedGoogle Scholar
  102. 102.
    Farah CS, Woo S, Zain RB, Sklavounou A, McCullough MJ, Lingen M. Oral cancer and oral potentially malignant disorders. Int J Dent. 2014;2014:853479.PubMedPubMedCentralCrossRefGoogle Scholar
  103. 103.
    Petti S. Pooled estimate of world leukoplakia prevalence: a systematic review. Oral Oncol. 2003;39:770–80.PubMedCrossRefGoogle Scholar
  104. 104.
    Yardimci G, Kutlubay Z, Engin B, YaTuzun Y. Precancerous lesions of oral mucosa. World J Clin Cases. 2014;2(12):866–72.PubMedPubMedCentralCrossRefGoogle Scholar
  105. 105.
    Napier SS, Speight PM. Natural history of potentially malignant oral lesions and conditions: an overview of the literature. J Oral Pathol Med. 2008;37(1):1–10.PubMedCrossRefGoogle Scholar
  106. 106.
    Villa A, Villa C, Abati S. Oral cancer and oral erythroplakia: an update and implication for clinicians. Aust Dent J. 2011;56(3):253–6.PubMedCrossRefGoogle Scholar
  107. 107.
    Reichart PA, Philipsen HP. Oral erythroplakia – a review. Oral Oncol. 2005;41(6):551–61.PubMedCrossRefGoogle Scholar
  108. 108.
    Panwar A, Lindau R, Wieland A. Management for premalignant lesions of the oral cavity. Expert Rev Anticancer Ther. 2014;14(3):349–57.PubMedCrossRefGoogle Scholar
  109. 109.
    Rhodus LN, Kerr AR, Patel K. Oral cancer leukoplakia, premalignancy, and squamous cell carcinoma. Dent Clin N Am. 2014;58:315–40.PubMedCrossRefGoogle Scholar
  110. 110.
    Warnakulasuriya S. Squamous cell carcinoma and precursor lesions: prevention. Periodontol. 2011;57(1):38–50.CrossRefGoogle Scholar
  111. 111.
    Sousa FA, Rosa LE. Oral lichen planus: clinical and histopathological considerations. Br J Otorhinolaryngol. 2008;74:284–92.CrossRefGoogle Scholar
  112. 112.
    De Rossi SS, Ciarrocca K. Oral lichen planus and lichenoid mucositis. Dent Clin N Am. 2014;58(2):299–313.PubMedCrossRefGoogle Scholar
  113. 113.
    Sousa FA, Paradella TC. Malignant potential of oral lichen planus: a meta-analysis. Revista Odonto Ciência. 2009;24(2):194–7.Google Scholar
  114. 114.
    Estimate/2016 – Cancer Incidence in Brazil. Rio de Janeiro: Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA); 2015. Portuguese.Google Scholar
  115. 115.
    Sugerman PB, Savage NW. Oral lichen planus: causes, diagnosis and management. Aust Dent J. 2002;47:290–7.PubMedCrossRefGoogle Scholar
  116. 116.
    Edwards PC, Kelsch R. Oral lichen planus: clinical presentation and management. J Can Dent Assoc. 2002;68(8):494–9.PubMedGoogle Scholar
  117. 117.
    Gainza-Cirauqui ML, Nieminen MT, Novak Frazer L, Aguirre-Urizar JM, Moragues MD, Rautemaa R. Production of carcinogenic acetaldehyde by Candida albicans from patients with potentially malignant oral mucosal disorders. J Oral Pathol Med. 2013;42(3):243–9.PubMedCrossRefGoogle Scholar
  118. 118.
    Lo Muzio L, della Valle A, Mignogna MD, Pannone G, Bucci P, Bucci E, et al. The treatment of oral aphthous ulceration or erosive lichen planus with topical clobetasol propionate in three preparations: a clinical and pilot study on 54 patients. J Oral Pathol Med. 2001;30(10):611–7.PubMedCrossRefGoogle Scholar
  119. 119.
    Neill SM, Lewis FM, Tatnall FM, Cox NH. British Association of Dermatologists’ guidelines for the management of lichen sclerosus 2010. Br J Dermatol. 2010;163:672–82.PubMedCrossRefGoogle Scholar
  120. 120.
    Powell JJ, Wojnarowska F. Lichen sclerosus. Lancet. 1999;353(9166):1777–83.PubMedCrossRefGoogle Scholar
  121. 121.
    Gutiérrez-Pascual M, Vicente-Martín FJ, López-Estebaranz JL. Lichen sclerosus and squamous cell carcinoma. Acta Dermosifiliogr. 2012;103(1):21–8.CrossRefGoogle Scholar
  122. 122.
    Kirtschig G, Becker K, Günthert A, Jasaitiene D, Cooper S, Chi CC, et al. Evidence-based (S3) guideline on (anogenital) lichen sclerosus. J Eur Acad Dermatol Venereol. 2015;29(10):e1–43.PubMedCrossRefGoogle Scholar
  123. 123.
    Babu CS, Morgan E. Squamous cell carcinoma in a patient with lichen sclerosus. Trends Urol Gynecol Sexual Health. 2008;13:30–1.CrossRefGoogle Scholar
  124. 124.
    Downes MR. Review of in situ and invasive penile squamous cell carcinoma and associated non-neoplastic dermatological conditions. J Clin Pathol. 2015;68(5):333–40.PubMedCrossRefGoogle Scholar
  125. 125.
    Rocken M, Ghoreschi K. Morphea and lichen sclerosus. In: Bolognia JL, Jorizzo JL, Rapini RP, editors. Dermatology. 2nd ed. Rio de Janeiro: Elsevier; 2008. p. 1469–83.Google Scholar
  126. 126.
    Henquet C. Anogenital malignancies and pre-malignancies. J Eur Acad Dermatol Venereol. 2011;25:885–95.PubMedCrossRefGoogle Scholar
  127. 127.
    Leibowitch M, Neill S, Pelisse M, Moyal-Baracco M. The epithelial changes associated with squamous cell carcinoma of the vulva: a review of the clinical, histological and viral findings in 78 women. Br J Obstet Gynaecol. 1990;97:1135–9.PubMedCrossRefGoogle Scholar
  128. 128.
    Trietsch MD, Nooij LS, Gaarenstroom KN, van Poelgeest MIE. Genetic and epigenetic changes in vulvar squamous cell carcinoma and its precursor lesions: a review of the current literature. Gynecol Oncol. 2015;136:143–57.PubMedCrossRefGoogle Scholar
  129. 129.
    Barbagli G, Palminteri E, Mirri F, Guazzoni G, Turini D, Lazzeri M. Penile carcinoma in patients with genital lichen sclerosus: a multicenter survey. J Urol. 2006;175(4):1359–63.PubMedCrossRefGoogle Scholar
  130. 130.
    Perceau G, Derancourt C, Clavel C, Durlach A, Pluot M, Lardennois B, Bernard P. Lichen sclerosus is frequently present in penile squamous cell carcinomas but is not always associated with oncogenic human papillomavirus. Br J Dermatol. 2003;​148(5):934–8.PubMedCrossRefGoogle Scholar
  131. 131.
    Nasca MR, Innocenzi D, Micali G. Association of penile lichen sclerosus and oncogenic human papillomavirus infection. Int J Dermatol. 2006;45(6):681–3.PubMedCrossRefGoogle Scholar
  132. 132.
    Ghittoni R, Accardi R, Chiocca S, Tommasino M. Role of human papillomaviruses in carcinogenesis. Ecancermedicalscience. 2015;29:9–526.Google Scholar
  133. 133.
    McLaughlin-Drubin ME. Human papillomaviruses and non-melanoma skin cancer. Semin Oncol. 2015;42(2):284–90.PubMedCrossRefGoogle Scholar
  134. 134.
    Ljubojevic S, Skerlev M. HPV-associated diseases. Clin Dermatol. 2014;32:227–34.PubMedCrossRefGoogle Scholar
  135. 135.
    Villain P, Gonzalez P, Almonte M, Franceschi S, Dillner J, Anttila A, et al. European code against cancer 4th edition: infections and cancer. Cancer Epidemiol. 2015;39(Supl1):120–38.CrossRefGoogle Scholar
  136. 136.
    IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Biological agents. Volume 100 B. A review of human carcinogens. IARC Monogr Eval Carcinog Risks Hum. 2012;100(Pt B):1–441.PubMedCentralGoogle Scholar
  137. 137.
    Workowski KA, Bolan GA, Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep. 2015;64(RR-03):1–137.PubMedPubMedCentralGoogle Scholar
  138. 138.
    Li N, Franceschi S, Howell-Jones R, Snijders PJ, Clifford GM. Human papillomavirus type distribution in 30,848 invasive cervical cancers worldwide: variation by geographical region, histological type and year of publication. Int J Cancer. 2011;128(4):927–35.PubMedCrossRefGoogle Scholar
  139. 139.
    Lacey CJN, Woodhall SC, Wikstrom A, Ross J. 2012 European guideline for the management of anogenital warts. JEADV. 2013;27:e263–70.PubMedGoogle Scholar

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© Springer International Publishing Switzerland 2018

Authors and Affiliations

  • Majoriê Mergen Segatto
    • 1
    Email author
  • Eloísa Unfer Schmitt Botton
    • 2
  1. 1.Private PracticePorto AlegreBrazil
  2. 2.Private PracticePorto AlegreBrazil

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