Cell Therapy for Vascular Diseases in Israel

  • Yael Porat
  • Michael Belkin
  • Shlomo Bulvik
  • Michael Frogel
  • Offer Galili
  • Mark Niven
Chapter
First Online:

Abstract

In Israel, as elsewhere in the world, people with vascular disease suffer severe complications, including critical limb ischemia, which can result in gangrene and amputation. This chapter describes the step-wise progression in translational medical research as a scientific breakthrough progresses from a laboratory invention to the start of a clinical trial. The novel idea is a method whereby a sub-population of non-mobilized peripheral blood cells can be turned, within a day, into a cellular therapeutic product code-named BGC101, composed of endothelial progenitor cells (EPCs) and Stem/progenitor cell (SPCs). In addition, the benefits of collaboration between an Israeli biotechnology company and an Israeli medical center in overcoming the hurdles of bringing the idea to fruition will be described.

Keywords

Diabetes complications Peripheral artery disease Ischemia Cardiovascular diseases dendritic cells Stem/progenitor cell therapy Endothelial progenitor cells 
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Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  • Yael Porat
    • 1
    • 2
  • Michael Belkin
    • 1
    • 3
  • Shlomo Bulvik
    • 4
  • Michael Frogel
    • 1
    • 5
    • 6
  • Offer Galili
    • 7
  • Mark Niven
    • 8
  1. 1.BioGenCell, Ltd.NetanyaIsrael
  2. 2.Hematology Stem Cell Research Center, Sanz Medical CenterLaniado HospitalNetanyaIsrael
  3. 3.Eye Research Institute, Sheba Medical CenterTel-Aviv UniversityTel-AvivIsrael
  4. 4.Department of Hematology, Sanz Medical CenterLaniado HospitalNetanyaIsrael
  5. 5.Cohen’s Children’s Medical CenterNew Hyde ParkUSA
  6. 6.NY Pediatric Disaster Coalition, Department of PediatricsMaimonides Infant and Children’s Hospital of BrooklynBrooklynUSA
  7. 7.Hillel Yaffe Medical CenterHaderaIsrael
  8. 8.Department of Endocrinology and Diabetes, Sanz Medical CenterLaniado HospitalNetanyaIsrael

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