Cardiovascular Interventional and Implantable Devices

  • M. Whitt
  • P. Senarith
  • R. Handy
  • M. J. JacksonEmail author


Cardiovascular interventional and implantable devices must be safe and efficacious, as well as biocompatible. Surface treatment is of importance to the design and function of these devices. Lubricity, wear resistance, thrombogenicity, inflammation, and infections can all be affected significantly by surface treatments. The surfaces of cardiovascular interventional and implantable devices can either be modified with active or passive coating. Devices with active coating such as drug eluting stents (DES) deliver therapeutic agents that can enhance the mechanical function and modulate long-term vascular responses. In some implantable devices such as vascular grafts, endothelial cell growth is desirable. This is achievable with the addition of a coating or a modification to the surface properties of the device. This chapter reviews some of the most commonly used cardiovascular interventional and implantable devices with an overview of the role that surface treatments have in their functionality and safety.


Cardiovascular devices Medical devices Surgical tools Angioplasty Surface treatments 


  1. 1.
    Blake, D. M., & Maness, P. C. (1999). Separation and Purification Methods, 28(1), 1–50.CrossRefGoogle Scholar
  2. 2.
    Byrne, J. A., Eggins, B. R., Brown, N. M. D., McKinney, B., & Rouse, M. (1998). Applied Catalysis, B: Environmental, 1998(17), 25–36.CrossRefGoogle Scholar
  3. 3.
    Byrne, J. A., Davidson, A., Dunlop, P. S. M., & Eggins, B. R. (2002). Journal of Photochemistry and Photobiology A: Chemistry, 148, 365–374.CrossRefGoogle Scholar
  4. 4.
    Byrne, J. A., Hamilton, J. W. J., McMurray, T. A., Dunlop, P. S. M., Jackson, V., Donaldson, A., et al. (2006). Abstracts of the NSTI conference, Boston. Google Scholar
  5. 5.
    Coleman, H. M., Routledge, E. J., Sumpter, J. P., Eggins, B. R., & Byrne, J. A. (2004). Water Research, 38, 3233–3240.CrossRefGoogle Scholar
  6. 6.
    Cosnier, S., Gondran, C., Senillou, A., Gratzel, M., & Vlachopoulos, N. (1997). Electroanalysis, 9(18), 1387–1392.CrossRefGoogle Scholar
  7. 7.
    Dunlop, P. S. M., Byrne, J. A., Manga, N., & Eggins, B. R. (2002). Journal of Photochemistry and Photobiology A: Chemistry, 148, 355–363.CrossRefGoogle Scholar
  8. 8.
    Fujishima, A., & Honda, K. (1972). Nature, 238, 37–38.CrossRefGoogle Scholar
  9. 9.
    Fujishima, A., Rao, T. N., & Tryk, D. A. (2000). Journal of Photochemistry and Photobiology C: Photochemistry Reviews, 1, 1–21.CrossRefGoogle Scholar
  10. 10.
    Giavaresi, G., Ambrosio, L., Battiston, G. A., Casellato, U., Gerbasi, R., Finia, M., et al. (2004). Biomaterials, 25, 5583–5591.CrossRefGoogle Scholar
  11. 11.
    Hoffman, M. R., Martin, S. T., Choi, W., & Bahnemann, D. W. (1995). Chemical Reviews, 95, 69–96.CrossRefGoogle Scholar
  12. 12.
    Holgers, K. M., & Ljungh, A. (1999). Biomaterials, 20, 1319–1326.CrossRefGoogle Scholar
  13. 13.
    Huang, N., Yang, P., Leng, Y. X., Chen, J. Y., Sun, H., Wang, J., et al. (2003). Biomaterials, 24, 2177–2187.CrossRefGoogle Scholar
  14. 14.
    Kuhn, K. P., Chaberny, I. F., Massholder, K., Stickler, M., Benz, V. W., Sonntag, H.-G., & Erdinger, L. (2003). Chemosphere, 53, 71–77.CrossRefGoogle Scholar
  15. 15.
    Lee, S.-H., Kim, H.-W., Lee, E.-J., Li, L.-H., & Kim, H.-E. (2006). Journal of Biomaterials Applications, 20, 195–208.CrossRefGoogle Scholar
  16. 16.
    Liu, X., Zhao, X., Ding, C., & Chu, P. K. (2006). Applied Physics Letters, 88, 13905.CrossRefGoogle Scholar
  17. 17.
    McMurray, T. A., Byrne, J. A., Dunlop, P. S. M., Winkelman, J. G. M., Eggins, B. R., & McAdams, E. T. (2004). Applied Catalysis, A: General, 262(1), 105–110.CrossRefGoogle Scholar
  18. 18.
    McMurray, T. A., Byrne, J. A., Dunlop, P. S. M., & McAdams, E. T. (2005). Journal of Applied Electrochemistry, 35, 723–731.CrossRefGoogle Scholar
  19. 19.
    Mills, A., & Le Hunte, S. (1997). Journal of Photochemistry and Photobiology A: Chemistry, 108, 1–35.CrossRefGoogle Scholar
  20. 20.
    Nygren, H., Tengvall, P., & Lundstrom, I. (1997). Journal of Biomedical Materials Research, 34, 487–492.CrossRefGoogle Scholar
  21. 21.
    Ohko, Y., Utsumi, Y., Niwa, C., Tatsuma, T., Kobayakawa, K., Satoh, Y., et al. (2001). Journal of Biomedical Materials Research (Applied Biomaterials), 58, 97–101.CrossRefGoogle Scholar
  22. 22.
    Pan, J., Leygraf, C., Thierry, D., & Ektessabi, A. M. (1997). Journal of Biomedical Materials Research, 35, 309–318.CrossRefGoogle Scholar
  23. 23.
    Ramires, P. A., Romito, A., Cosentino, F., & Milella, E. (2001). Biomaterials, 22, 1467–1474.CrossRefGoogle Scholar
  24. 24.
    Shani Sekler, M., Levi, Y., Polyak, B., Dunlop, P. S. M., Byrne, J. A., & Marks, R. S. (2004). Journal of Applied Toxicology, 24, 395–400.CrossRefGoogle Scholar
  25. 25.
    Yang, Y., Glover, R., & Ong, J. L. (2003). Colliods and Surfaces B: Biointerfaces, 30, 291–297.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2016

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 2.5 International License (, which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

The images or other third party material in this chapter are included in the chapter's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the chapter's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

Authors and Affiliations

  • M. Whitt
    • 1
  • P. Senarith
    • 2
  • R. Handy
    • 3
  • M. J. Jackson
    • 4
    Email author
  1. 1.California State PolytechnicSan Luis-ObispoUSA
  2. 2.Medtronic CorporationMinneapolisUSA
  3. 3.School of MedicineThe University of UtahSalt Lake CityUSA
  4. 4.Kansas State UniversitySalinaUSA

Personalised recommendations