Malignant Peripheral Nerve Sheath Tumors

  • Yazgi Koy
  • Tarik Tihan


Malignant peripheral nerve sheath tumors (MPNSTs) (ICD-O 9540/3) are rare soft-tissue sarcomas that arise predominantly from Schwann cells. A malignant spindle-cell tumor with histological, immunohistochemical, and ultrastructural features of Schwann cell differentiation, they usually arise in the setting of neurofibromatosis 1 (NF1) or may be seen sporadically in children.


Malignant neurofibroma Malignant schwannoma Peripheral nerve sheath tumor MPNST Schwann cell 


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Copyright information

© Springer International Publishing AG 2016

Authors and Affiliations

  1. 1.Department of PathologyBagcilar Research and Training HospitalIstanbulTurkey
  2. 2.Department of PathologyNeuropathology DivisionSan FranciscoUSA

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