Sepsis, Severe Sepsis, and Septic Shock

  • Andrew C. GauglerEmail author
  • Nicholas Namias


The sepsis syndrome represents the wide spectrum of the deleterious inflammatory response to an infectious insult. As the most common cause of mortality in the surgical intensive care unit, understanding the diagnosis and management of sepsis is critical for the surgical ICU physician. Early identification and aggressive resuscitation of the septic patient, combined with adequate surgical source control, can be lifesaving. Surgeons and critical care physicians who care for septic patients should be familiar with current evidence-based practices in the management of sepsis. Patients with organ system dysfunction and failure should be identified and appropriate support initiated. As more patients survive severe sepsis and septic shock, a syndrome of persistent inflammation, immune suppression, and catabolism has been identified and presents a new and difficult challenge for physicians.


Sepsis Systemic inflammatory response syndrome Septic shock Infection Severe sepsis Multi-organ failure 


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Authors and Affiliations

  1. 1.Trauma and Surgical Critical Care, DeWitt Daughtry Family Department of SurgeryJackson Memorial Hospital, Ryder Trauma CenterMiamiUSA
  2. 2.Department of SurgeryUniversity of Miami Hospital/Jackson Memorial Hospital/Ryder Trauma CenterMiamiUSA

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