Pharmacology of Drugs in Aging

  • Louise MalletEmail author


General principles for appropriate prescribing for the elderly are described in this chapter. Age-related changes in pharmacokinetics (absorption, distribution, metabolism, and distribution) with normal aging and in frail elderly patients are presented. Tools to identify potentially inappropriate medications in the elderly, including the American Geriatrics Society Beers Criteria and the STOPP/START criteria, are described. The prescription cascade, where a side effect of a medication is misinterpreted as a new medical condition leading to the introduction of another drug, is also described. The association between geriatric syndromes and medication use is presented as well as strategies to reduce fall risk-increasing medications. Assessment and review of medications in frail elderly patients should be done every 6 months.


Fall Risk Clinical Decision Support System Serum Creatinine Concentration Inappropriate Medication Medication Reconciliation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Adverse drug events


Activity of daily living


American Geriatrics Society


Fall risk-increasing drug


Institute for Safe Medication Practices


Medication appropriateness index


Potentially inappropriate medication


Screening tool to alert doctors to right treatment


Screening tool of older person’s prescriptions


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Faculty of PharmacyUniversity of MontréalMontréalCanada
  2. 2.Department of PharmacyMcGill University Health CenterMontréalCanada

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