Skip to main content

Multiple sclerosis therapies and pregnancy

  • Chapter
  • First Online:
Case Studies in Multiple Sclerosis
  • 1007 Accesses

Abstract

A 24-year-old patient (see Case 16) with relapsing-remitting multiple sclerosis (RRMS) returned 6 months after diagnosis with sub-acute diplopia. She described difficulty moving her eyes to the right and horizontal, binocular diplopia, maximal in leftward gaze. There were no other neurological symptoms. Examination revealed conjugate horizontal gaze palsy to the right and limited adduction of the right eye, constituting the ‘one-and-a-half syndrome.’ A repeat MRI scan revealed a new lesion in the right pons affecting the region of the abducens nucleus and the ipsilateral medial longitudinal fasciculus. There was no enhancement. The overall burden of lesions on MRI was otherwise stable, and the enhancing right frontal lesion previously seen was less prominent.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Gold R, Theodore Phillips J, Havrdova E, et al. P839 Delayed-release dimethyl fumarate and pregnancy: preclinical studies and pregnancy outcomes from clinical trials and postmarketing experience. Neurol Ther. 2015;1-12.

    Google Scholar 

  2. Wei QR, Runrong G, Xiangdong S. Studies on teratogenicity of dimethyl fumarate. J Hyg Res. 1990;19:28-31.

    Google Scholar 

  3. Karlsson G, Francis G, Koren G, et al. Pregnancy outcomes in the clinical development program of fingolimod in multiple sclerosis. Neurology. 2014;82:674-680.

    Google Scholar 

  4. Novartis Pharmaceuticals Corporation. Gilenya (fingolimod) prescribing information (2010). Revised August 2015. www.accessdata.fda.gov/drugsatfda_docs/label/2015/022527s019lbl.pdf. Accessed April 6, 2016.

  5. Kieseier BC, Benamor M, Truffinet P, Henson LJ. Pregnancy outcomes for female patients and partners of male patients in the teriflunomide clinical development program. Presented at: ACTRIMS-ECTRIMS; September 12, 2014; Boston, Massachusetts, USA. Poster P846.

    Google Scholar 

  6. Genzyme Corporation. Aubagio (teriflunomide) prescribing information. Revised October 2014a. http://products.sanofi.us/aubagio/aubagio.pdf. Accessed April 6, 2016.

  7. Cristiano L, Friend S, Bozic C, Bloomgren G. Evaluation of pregnancy outcomes from the TYSABRI (Natalizumab) pregnancy exposure registry. Neurology. 2013;80(Meeting Abstracts 1):P02.127.

    Google Scholar 

  8. Biogen Idec Inc. Tysabri (natalizumab) prescribing information. Revised May 2015. www.tysabri.com/prescribingInfo. Accessed April 6, 2016.

  9. Genzyme Corporation. Lemtrada (alemtuzumab) prescribing information. Revised November 2014. http://products.sanofi.us/lemtrada/lemtrada.pdf. Accessed April 6, 2016.

  10. McCombe P, Achiron A, Brinar B, et al. Pregnancy outcomes in the alemtuzumab multiple sclerosis clinical development program. Presented at: ACTRIMS-ECTRIMS; September 12, 2014; Boston, Massachusetts, USA. Poster P842.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Lincoln, M.R., Oh, J. (2017). Multiple sclerosis therapies and pregnancy. In: Giacomini, P. (eds) Case Studies in Multiple Sclerosis. Adis, Cham. https://doi.org/10.1007/978-3-319-31190-6_17

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-31190-6_17

  • Published:

  • Publisher Name: Adis, Cham

  • Print ISBN: 978-3-319-31188-3

  • Online ISBN: 978-3-319-31190-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics