Assessment of Tissue Injury in Severe Brain Trauma

  • Christophe Maggia
  • Senan Doyle
  • Florence Forbes
  • Olivier Heck
  • Irène Troprès
  • Corentin Berthet
  • Yann Teyssier
  • Lionel Velly
  • Jean-François Payen
  • Michel DojatEmail author
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 9556)


We report our methodological developments to investigate, in a multi-center study using mean diffusivity, the tissue damage caused by a severe traumatic brain injury (GSC \(<9\)) in the 10 days post-event. To assess the diffuse aspect of the injury, we fuse several atlases to parcel cortical, subcortical and WM structures into well identified regions where MD values are computed and compared to normative values. We used P-LOCUS to provide brain tissue segmentation and exclude voxels labeled as CSF, ventricles and hemorrhagic lesion and then automatically detect the lesion load. Preliminary results demonstrate that our method is coherent with expert opinion in the identification of lesions. We outline the challenges posed in automatic analysis for TBI.


Traumatic Brain Injury Apparent Diffusion Coefficient Diffusion Tensor Imaging Mean Diffusivity Severe Traumatic Brain Injury 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Grenoble MRI facility IRMaGe was partly funded by the French program Investissement d\(^{\prime }\) avenir run by the Agence Nationale pour la Recherche; grant Infrastructure d\(^{\prime }\) avenir en Biologie Santé - ANR-11-INBS-0006. Research funded by French ministry of research and education under the Projet Hospitalier de Recherche Clinique grant OXY-TC to JFP.


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Christophe Maggia
    • 1
    • 2
  • Senan Doyle
    • 3
  • Florence Forbes
    • 4
  • Olivier Heck
    • 5
  • Irène Troprès
    • 1
    • 5
    • 6
    • 7
  • Corentin Berthet
    • 5
  • Yann Teyssier
    • 5
  • Lionel Velly
    • 8
  • Jean-François Payen
    • 1
    • 2
    • 5
  • Michel Dojat
    • 1
    • 2
    Email author
  1. 1.Grenoble Institut des Neurosciences, GINUniv. Grenoble AlpesGrenobleFrance
  2. 2.INSERM, U1216GrenobleFrance
  3. 3.PixylGrenobleFrance
  4. 4.INRIA Grenoble, LJKGrenobleFrance
  5. 5.CHU de GrenobleGrenobleFrance
  6. 6.CNRS, UMR 3552GrenobleFrance
  7. 7.INSERM, US 017GrenobleFrance
  8. 8.Hôpital de la TimoneMarseilleFrance

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