• Theodore NicolaidesEmail author
  • Biljana Horn
  • Anuradha Banerjee
Part of the Pediatric Oncology book series (PEDIATRICO)


Chemotherapy is increasingly used in the multimodal management of childhood brain tumors, with the therapeutic goals of optimizing survival and reducing radiation-related morbidity. The numerous chemotherapy treatment protocols for pediatric brain tumors reflect the extreme heterogeneity of these neoplasms. For example, in the setting of average-risk medulloblastoma and germinoma, which have high cure rates with radiation treatment alone, chemotherapy is used to reduce radiation doses, yet maintain high cure rates. For infants with malignant brain tumors, who are particularly vulnerable to radiation-related morbidity, chemotherapy has been used to delay radiation treatment. Similarly, in the setting of unresectable, low-grade astrocytoma, chemotherapy can provide prolonged disease stabilization, perhaps allowing for delay or deferral of radiation.


Central Nervous System Tumor Malignant Brain Tumor Pediatric Brain Tumor Stem Cell Rescue Childhood Brain Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer International Publishing 2017

Authors and Affiliations

  • Theodore Nicolaides
    • 1
    Email author
  • Biljana Horn
    • 2
  • Anuradha Banerjee
    • 3
  1. 1.Division of Hematology/Oncology, Departments of Pediatrics and Neurological SurgeryUniversity of California San Francisco & UCSF Benioff Children’s HospitalSan FranciscoUSA
  2. 2.Blood and Marrow Transplant Program, Department of PediatricsUniversity of California San Francisco & UCSF Benioff Children’s HospitalSan FranciscoUSA
  3. 3.Division of Hematology/Oncology, Departments of PediatricsUniversity of California San Francisco & UCSF Benioff Children’s HospitalSan FranciscoUSA

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