Contact Dermatitis

  • Stefan F. MartinEmail author
  • Thilo Jakob


Our skin is exposed daily to a large number of chemicals in household products, cosmetics, in the environment and in the workplace. Many of these chemicals can cause irritant or allergic contact dermatitis. Allergic contact dermatitis is an inflammatory skin disease that is mediated by our immune system. In this chapter we summarize current methods for the diagnosis of contact dermatitis and treatment strategies. In addition we review our current understanding of the cellular and molecular pathomechanisms and its implications for the development of novel diagnostic and treatment strategies and of animal-free testing strategies for contact allergen identification.


Allergic contact dermatitis ACD Antigen presenting cell APC Hypersensitivity Damage-associated molecular pattern T cell Mononuclear cell Local Lymph Node Assay LLNA Contact dermatitis Heterologous innate immunity 



Allergic contact dermatitis


Antigen presenting cell


Contact hypersensitivity


Damage-associated molecular pattern


2,4-dinitrobenzene sulfonic acid










Hyaluronic acid


Human T cell priming assay


Irritant contact dermatitis


Local Lymph Node Assay


Low zone tolerance


Microbe-associated molecular pattern


Major histocompatibility complex


Pathogen-associated molecular pattern


Peripheral blood mononuclear cell


Pattern recognition receptor


T cell receptor


2,4,6-trinitrobenzene sulfonic acid




Toll-like receptor


Regulatory T cell


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Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  1. 1.Department of DermatologyMedical Center – University of FreiburgFreiburgGermany
  2. 2.Department of Dermatology and AllergologyJustus Liebig Universtiy Gießen, Universtiy Medical Center GießenMarburgGermany

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