Rapid Prototyping of Biomedical Microsystems for Interacting at a Cellular Level

  • Andrés Díaz Lantada
  • Jeffrey Resnick
  • Javier Mousa
  • Miguel Ángel de Alba
  • Stefan Hengsbach
  • Milagros Ramos Gómez
Part of the Studies in Mechanobiology, Tissue Engineering and Biomaterials book series (SMTEB, volume 18)


The applications of microsystems in the biomedical field are indeed remarkable and continuously evolving thanks to recent extraordinary progresses in the area of micromanufacturing technologies, capable of manufacturing devices with details in the typical range of 1–500 μm. As living organisms are made up with cells, whose overall dimensions typically range from 5 to 100 μm, micro-manufactured devices (with details precisely in that range) are very well-suited to interacting at a cellular level for promoting innovative diagnostic and therapeutic approaches. This chapter provides an overview of the more relevant micromanufacturing technologies with special application to the development of advanced micro-medical devices and to the manufacture of rapid prototypes, as several of these manufacturing technologies will be applied thoroughly along the Handbook for the development of different cases of study linked to microfluidic biodevices for disease modeling, to cell culture platforms for understanding cell behavior, to labs-on-chips and organs-on-chips and to tissue engineering scaffolds. The different technologies detailed in present chapter are also illustrated by means of application examples related to the aforementioned types of biomedical microdevices aimed at interacting at a cellular level. The possibility of combining technologies for the promotion of multi-scale and biomimetic approaches is also analyzed in detail and some current research challenges are also discussed.


Rapid Prototype Additive Manufacturing Selective Laser Melting Selective Laser Sinter Tissue Engineering Scaffold 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We gratefully acknowledge the support of the Karlsruhe Nano Micro Facility (KNMF, a Helmholtz research infrastructure at the Karlsruhe Institute of Technology (KIT). Proposal KNMF-2013-010001542 (muFractal: Microsystem for studying the influence of fractal dimension on cell behaviour), linked to the rapid manufacture of microtextured microsystems, proposal KNMF-2013-010001541 (NanoAUX: Additive nanomanufacture of 3D auxetic metamaterials), linked to the nano-manufacture of auxetic metamaterials, and proposal KNMF-2012-009001145 (Replic-AS: Replication of advanced scaffolds with biomimetric fractal features), linked to replicating the presented multi-channelled microsystem with fractal channels, and the co-authors and their teams that made them possible are acknowledged. We acknowledge the support of the “Tomax: Tool-less manufacture of complex geometries” project, funded by the European Union Commission under grant nº: 633192 - H2020-FoF-2014-2015/H2020-FoF-2014 and led by Prof. Dr. Jürgen Stampfl from the Technical University of Vienna.


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Andrés Díaz Lantada
    • 1
  • Jeffrey Resnick
    • 1
  • Javier Mousa
    • 1
  • Miguel Ángel de Alba
    • 1
  • Stefan Hengsbach
    • 2
  • Milagros Ramos Gómez
    • 3
  1. 1.Mechanical Engineering Department – Product Development LaboratoryUniversidad Politécnica de MadridMadridSpain
  2. 2.Institute of Microstructure TechnologyKarlsruhe Institute of TechnologyEggenstein-LeopoldshafenGermany
  3. 3.Centre for Biomedical TechnologyUniversidad Politécnica de Madrid UPM Scientific and Technological ParkPozuelo de AlarcónSpain

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