15 Genetic and Metabolic Aspects of Primary and Secondary Metabolism of the Zygomycetes

  • Kerstin Voigt
  • Thomas Wolf
  • Katrin Ochsenreiter
  • Gábor Nagy
  • Kerstin Kaerger
  • Ekaterina Shelest
  • Tamás Papp
Part of the The Mycota book series (MYCOTA, volume III)


Basal lineages of the kingdom of fungi comprise terrestrial and aquatic fungi, which are traditionally summarized as Chytridiomycota and Zygomycota in a colloquial sense. The zygomycetes build up the most basal lineage among the terrestrial fungi. As the earliest fungi to conquer terrestrial habitats, they facilitated early coevolution with other land-dwelling microorganisms with implications on the primary and secondary metabolism which is adaptive to the life in soil. Advances in next-generation genome sequencing allow us to gain a new layer of knowledge with respect to their metabolism and its regulation. Recent revisions of the metabolic potential of zygomycetes using genome mining suggested a hidden potential for the production of secondary metabolites. First insights suggest a revision of our understanding of the importance and mode of action of metabolic pathways revealing a fascinating potential to produce novel natural compounds. The aim of this review is to draw attention to the zygomycetes as a unique fungal group and to inspire the scientific community to explore its potential as participants in complex ecosystems for innovative metabolic regulatory frameworks and novel compounds.


Fumaric Acid Carotenoid Biosynthesis Mucor Circinelloides Carotenoid Biosynthesis Gene Rhizopus Species 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Kerstin Voigt
    • 1
    • 2
  • Thomas Wolf
    • 3
  • Katrin Ochsenreiter
    • 4
  • Gábor Nagy
    • 5
  • Kerstin Kaerger
    • 6
  • Ekaterina Shelest
    • 3
  • Tamás Papp
    • 5
  1. 1.Jena Microbial Resource Collection, Leibniz Institute for Natural Product Research and Infection Biology – Hans-Knöll-InstituteJenaGermany
  2. 2.Department of Microbiology and Molecular Biology, Institute of MicrobiologyUniversity of JenaJenaGermany
  3. 3.Systems Biology/Bioinformatics, Leibniz Institute for Natural Product Research and Infection Biology – Hans-Knöll-InstituteJenaGermany
  4. 4.Karlsruhe Institute of Technology (KIT), Institute of Process Engineering in Life Sciences, Section II: Technical BiologyKarlsruheGermany
  5. 5.Faculty of Science and Informatics, Department of MicrobiologyUniversity of SzegedSzegedHungary
  6. 6.National Reference Center for Invasive Mycoses, Leibniz Institute for Natural Product Research and Infection Biology – Hans-Knöll-InstituteJenaGermany

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