Advances in Management of Complications for Head and Neck Cancer Therapy

  • Barbara Murphy
  • Jie Deng
  • Mark J. Stavas
  • Heidi Ganzer
  • Joel B. Epstein
Chapter
First Online:

Abstract

Increased use of the multimodality head and neck cancer (HNC) therapy has led to improvement in the local control, larynx preservation, and overall survival rates, leaving many HNC patients at risk for developing acute and late effects from treatment. The acute and late effects have resulted in substantial symptom burden and functional deficits in HNC population. The symptom control and functional issues associated with HNC and its aggressive treatment are complex, evolve over time, persist long term, and require frequent and ongoing assessment. In recent years, research efforts have focused on better understanding the supportive care needs in HNC patients across the trajectory of the disease treatment and recovery and developing new interventions to improve HNC patients’ overall quality of life. The aim of this chapter is to review symptom control issues in HNC, emphasizing areas in which interventions are feasible and have demonstrated improvement in patients’ outcome. Due to space limit, this chapter particularly focuses on the following areas: (1) nutrition and swallow function, (2) oral health, (3) acute and late musculoskeletal impairment (MSI), and (4) systemic effects.

Keywords

Head and neck cancer Complication Survivorship Late effects Symptom Nutrition Swallow Oral health Musculoskeletal impairment Systemic effects 
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References

  1. 1.
    Carlsson E, Ehrenberg A, Ehnfors M. Stroke and eating difficulties: long-term experiences. J Clin Nurs. 2004;13(7):825–34.PubMedCrossRefGoogle Scholar
  2. 2.
    Vissink A, Jansma J, Spijkervet FK, Burlage FR, Coppes RP. Oral sequelae of head and neck radiotherapy. Crit Rev Oral Biol Med. 2003;14(3):199–212.PubMedCrossRefGoogle Scholar
  3. 3.
    Ottosson S, Laurell G, Olsson C. The experience of food, eating and meals following radiotherapy for head and neck cancer: a qualitative study. J Clin Nurs. 2013;22(7-8):1034–43.PubMedCrossRefGoogle Scholar
  4. 4.
    Ganzer H, Touger-Decker R, Parrott JS, Murphy BA, Epstein JB, Huhmann MB. Symptom burden in head and neck cancer: impact upon oral energy and protein intake. Support Care Cancer. 2013;21(2):495–503.PubMedCrossRefGoogle Scholar
  5. 5.
    Silander E, Jacobsson I, Bertéus-Forslund H, Hammerlid E. Energy intake and sources of nutritional support in patients with head and neck cancer—a randomised longitudinal study. Eur J Clin Nutr. 2013;67(1):47–52.PubMedCrossRefGoogle Scholar
  6. 6.
    van den Berg MG, Rütten H, Rasmussen-Conrad EL, et al. Nutritional status, food intake, and dysphagia in long-term survivors with head and neck cancer treated with chemoradiotherapy: a cross-sectional study. Head Neck. 2014;36(1):60–5.PubMedCrossRefGoogle Scholar
  7. 7.
    Arthur AE, Peterson KE, Rozek LS, et al. Pretreatment dietary patterns, weight status, and head and neck squamous cell carcinoma prognosis. Am J Clin Nutr. 2013;97(2):360–8.PubMedCrossRefGoogle Scholar
  8. 8.
    Orell-Kotikangas H, Schwab U, Österlund P, Saarilahti K, Mäkitie O, Mäkitie AA. High prevalence of vitamin D insufficiency in patients with head and neck cancer at diagnosis. Head Neck. 2012;34(10):1450–5.PubMedCrossRefGoogle Scholar
  9. 9.
    da Cruz EP, Toporcov TN, Rotundo LD, et al. Food restrictions of patients who are undergoing treatment for oral and oropharyngeal cancer. Eur J Oncol Nurs. 2012;16(3):253–7.CrossRefGoogle Scholar
  10. 10.
    Britton B, Clover K, Bateman L, et al. Baseline depression predicts malnutrition in head and neck cancer patients undergoing radiotherapy. Support Care Cancer. 2012;20(2):335–42.PubMedCrossRefGoogle Scholar
  11. 11.
    Kiss NK, Krishnasamy M, Loeliger J, Granados A, Dutu G, Corry J. A dietitian-led clinic for patients receiving (chemo) radiotherapy for head and neck cancer. Support Care Cancer. 2012;20(9):2111–20.PubMedCrossRefGoogle Scholar
  12. 12.
    Sheth CH, Sharp S, Walters ER. Enteral feeding in head and neck cancer patients at a UK cancer centre. J Hum Nutr Diet. 2013;26(5):421–8.PubMedCrossRefGoogle Scholar
  13. 13.
    Nugent B, Lewis S, O’Sullivan JM. Enteral feeding methods for nutritional management in patients with head and neck cancers being treated with radiotherapy and/or chemotherapy. Cochrane Database Syst Rev. 2013;1:CD007904.PubMedGoogle Scholar
  14. 14.
    Langmore S, Krisciunas GP, Miloro KV, Evans SR, Cheng DM. Does PEG use cause dysphagia in head and neck cancer patients? Dysphagia. 2012;27(2):251–9.PubMedCrossRefGoogle Scholar
  15. 15.
    Galloway TJ, Amdur RJ, Liu C, Yeung AR, Mendenhall WM. Revisiting unnecessary larynx irradiation with whole-neck IMRT. Pract Radiat Oncol. 2011;1(1):27–32.PubMedCrossRefGoogle Scholar
  16. 16.
    Peponi E, Glanzmann C, Willi B, Huber G, Studer G. Dysphagia in head and neck cancer patients following intensity modulated radiotherapy (IMRT). Radiat Oncol. 2011;6:1.PubMedPubMedCentralCrossRefGoogle Scholar
  17. 17.
    Cousins N, MacAulay F, Lang H, MacGillivray S, Wells M. A systematic review of interventions for eating and drinking problems following treatment for head and neck cancer suggests a need to look beyond swallowing and trismus. Oral Oncol. 2013;49(5):387–400.PubMedCrossRefGoogle Scholar
  18. 18.
    Zhen Y, Wang JG, Tao D, Wang HJ, Chen WL. Efficacy survey of swallowing function and quality of life in response to therapeutic intervention following rehabilitation treatment in dysphagic tongue cancer patients. Eur J Oncol Nurs. 2012;16(1):54–8.PubMedCrossRefGoogle Scholar
  19. 19.
    Lang H, France E, Williams B, Humphris G, Wells M. The psychological experience of living with head and neck cancer: a systematic review and meta-synthesis. Psychooncology. 2013;22(12): 2648–63.PubMedCrossRefGoogle Scholar
  20. 20.
    Robinson CA. Managing life with a chronic condition: the story of normalization. Qual Health Res. 1993;3(1):6–28.PubMedCrossRefGoogle Scholar
  21. 21.
    Winkler MF, Wetle T, Smith C, Hagan E, O’Sullivan Maillet J, Touger-Decker R. The meaning of food and eating among home parenteral nutrition-dependent adults with intestinal failure: a qualitative inquiry. J Am Diet Assoc. 2010;110(11):1676–83.PubMedCrossRefGoogle Scholar
  22. 22.
    Winkler MF. 2009 Lenna Frances Cooper Memorial Lecture: living with enteral and parenteral nutrition: how food and eating contribute to quality of life. J Am Diet Assoc. 2010;110(2):169–77.PubMedCrossRefGoogle Scholar
  23. 23.
    Bisogni CA, Connors M, Devine CM, Sobal J. Who we are and how we eat: a qualitative study of identities in food choice. J Nutr Educ Behav. 2002;34(3):128–39.PubMedCrossRefGoogle Scholar
  24. 24.
    McQuestion M, Fitch M, Howell D. The changed meaning of food: physical, social and emotional loss for patients having received radiation treatment for head and neck cancer. Eur J Oncol Nurs. 2011;15(2):145–51.PubMedCrossRefGoogle Scholar
  25. 25.
    Röing M, Hirsch JM, Holmström I. The uncanny mouth—a phenomenological approach to oral cancer. Patient Educ Couns. 2007;67(3):301–6.PubMedCrossRefGoogle Scholar
  26. 26.
    Semple CJ, Dunwoody L, George Kernohan W, McCaughan E, Sullivan K. Changes and challenges to patients’ lifestyle patterns following treatment for head and neck cancer. J Adv Nurs. 2008;63(1):85–93.PubMedCrossRefGoogle Scholar
  27. 27.
    Mortensen GL, Paaske PB. Patients perceive tonsil cancer as a strike at psycho-socially “vital organs”. Dan Med J. 2012; 59(9):A4504.PubMedGoogle Scholar
  28. 28.
    Swore Fletcher B, Cohen MZ, Schumacher K, Lydiatt W. A blessing and a curse: head and neck cancer survivors’ experiences. Cancer Nurs. 2012;35(2):126–32.PubMedCrossRefGoogle Scholar
  29. 29.
    Larsson M, Hedelin B, Athlin E. Lived experiences of eating problems for patients with head and neck cancer during radiotherapy. J Clin Nurs. 2003;12(4):562–70.PubMedCrossRefGoogle Scholar
  30. 30.
    Donovan M, Glackin M. The lived experience of patients receiving radiotherapy for head and neck cancer: a literature review. Int J Palliat Nurs. 2012;18(9):448–55.CrossRefPubMedGoogle Scholar
  31. 31.
    Murphy B. Late treatment effects: reframing the questions. Lancet. 2009;10:530.PubMedCrossRefGoogle Scholar
  32. 32.
    Murphy B, Ridner S, Wells N, Dietrich M. Quality of life research in head and neck cancer: a review of the current state of science. Crit Rev Oncol Hematol. 2007;62:251–67.PubMedCrossRefGoogle Scholar
  33. 33.
    Deboni AL, Giordani AJ, Lopes NN, et al. Long-term oral effects in patients treated with radiochemotherapy for head and neck cancer. Support Care Cancer. 2012;20(11):2903–11.PubMedCrossRefGoogle Scholar
  34. 34.
    Roh JL, Kim AY, Cho MJ. Xerostomia following radiotherapy of the head and neck affects vocal function. J Clin Oncol. 2005;23(13):3016–23.PubMedCrossRefGoogle Scholar
  35. 35.
    Navazesh M, Wood GJ, Brightman VJ. Relationship between salivary flow rates and Candida albicans counts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995;80(3):284–8.PubMedCrossRefGoogle Scholar
  36. 36.
    Porter SR, Fedele S, Habbad KM. Xerostomia in head and neck malignancy. Oral Oncol. 2010;46(6):460–3.PubMedCrossRefGoogle Scholar
  37. 37.
    Wagner W, Prott FJ, Schonekas KG. Amifostine: a radioprotector in locally advanced head and neck cancer. Oncol Rep. 1998;5(5): 1255–7.PubMedGoogle Scholar
  38. 38.
    Rankin KV, Jones DL, Redding SW. Oral health in cancer therapy: a guide for health care professionals. file:///C:/Users/dengj/Desktop/MANU-MUST-New/working%20folder/Validation%20Article/Oral_Health_in_Cancer_Therapy_-_A_Guide_for_Health_Care_Professionals_3rd_edition.pdf. Accessed 1 Mar 2015.Google Scholar
  39. 39.
    Jha N, Seikaly H, Harris J, et al. Prevention of radiation induced xerostomia by surgical transfer of submandibular salivary gland into the submental space. Radiother Oncol. 2003;66(3):283–9.PubMedCrossRefGoogle Scholar
  40. 40.
    Rieger J, Seikaly H, Jha N, et al. Submandibular gland transfer for prevention of xerostomia after radiation therapy: swallowing outcomes. Arch Otolaryngol Head Neck Surg. 2005;131(2):140–5.PubMedCrossRefGoogle Scholar
  41. 41.
    Cassolato SF, Turnbull RS. Xerostomia: clinical aspects and treatment. Gerodontology. 2003;20(2):64–77.PubMedCrossRefGoogle Scholar
  42. 42.
    Scarantino C, LeVeque F, Swann RS, et al. Effect of pilocarpine during radiation therapy: results of RTOG 97-09, a phase III randomized study in head and neck cancer patients. J Support Oncol. 2006;4(5):252–8.PubMedGoogle Scholar
  43. 43.
    Chambers MS, Posner M, Jones CU, et al. Cevimeline for the treatment of postirradiation xerostomia in patients with head and neck cancer. Int J Radiat Oncol Biol Phys. 2007;68(4):1102–9.PubMedCrossRefGoogle Scholar
  44. 44.
    Simcock R, Fallowfield L, Monson K, et al. ARIX: a randomized trial of acupuncture v oral care sessions in patients with chronic xerostomia following treatment of head and neck cancer. Ann Oncol. 2013;24(3):776–83.PubMedCrossRefGoogle Scholar
  45. 45.
    Meng Z, Garcia MK, Hu C, et al. Randomized controlled trial of acupuncture for prevention of radiation-induced xerostomia among patients with nasopharyngeal carcinoma. Cancer. 2012;118(13):3337–44.PubMedCrossRefGoogle Scholar
  46. 46.
    Furness S, Bryan G, McMillan R, Birchenough S, Worthington HV. Interventions for the management of dry mouth: non-pharmacological interventions. Cochrane Database Syst Rev. 2013;9:CD009603.PubMedGoogle Scholar
  47. 47.
    Towler P, Molassiotis A, Brearley SG. What is the evidence for the use of acupuncture as an intervention for symptom management in cancer supportive and palliative care: an integrative overview of reviews. Support Care Cancer. 2013;21(10):2913–23.PubMedCrossRefGoogle Scholar
  48. 48.
    Schiødt M, Hermund NU. Management of oral disease prior to radiation therapy. Support Care Cancer. 2002;10(1):40–3.PubMedCrossRefGoogle Scholar
  49. 49.
    Eliyas S, Al-Khayatt A, Porter RW, Briggs P. Dental extractions prior to radiotherapy to the jaws for reducing post-radiotherapy dental complications. Cochrane Database Syst Rev. 2013;2:CD008857.PubMedGoogle Scholar
  50. 50.
    Epstein JB, Murphy BA. Late effects of cancer and cancer therapy on oral health and quality of life. J Mass Dent Soc. 2010;59(3):22–7.PubMedGoogle Scholar
  51. 51.
    Fischer DJ, Epstein JB. Management of patients who have undergone head and neck cancer therapy. Dent Clin North Am. 2008;52(1):39–60, viii.PubMedCrossRefGoogle Scholar
  52. 52.
    Chambers MS, Garden AS, Kies MS, Martin JW. Radiation-induced xerostomia in patients with head and neck cancer: pathogenesis, impact on quality of life, and management. Head Neck. 2004;26(9):796–807.PubMedCrossRefGoogle Scholar
  53. 53.
    Friedman PK, Isfeld D. Xerostomia: the “invisible” oral health condition. J Mass Dent Soc. 2008;57(3):42–4.PubMedGoogle Scholar
  54. 54.
    Barker GJ, Epstein JB, Williams KB, Gorsky M, Raber-Durlacher JE. Current practice and knowledge of oral care for cancer patients: a survey of supportive health care providers. Support Care Cancer. 2005;13(1):32–41.PubMedCrossRefGoogle Scholar
  55. 55.
    Husein AB, Butterworth CJ, Ranka MS, Kwasnicki A, Rogers SN. A survey of general dental practitioners in the North West of England concerning the dental care of patients following head and neck radiotherapy. Prim Dent Care. 2011;18(2):59–65.PubMedCrossRefGoogle Scholar
  56. 56.
    Lyons A, Osher J, Warner E, Kumar R, Brennan PA. Osteoradionecrosis—a review of current concepts in defining the extent of the disease and a new classification proposal. Br J Oral Maxillofac Surg. 2014;52(5):392–5.PubMedCrossRefGoogle Scholar
  57. 57.
    Marx RE, Johnson RP. Studies in the radiobiology of osteoradionecrosis and their clinical significance. Oral Surg Oral Med Oral Pathol. 1987;64(4):379–90.PubMedCrossRefGoogle Scholar
  58. 58.
    Lyons A, Ghazali N. Osteoradionecrosis of the jaws: current understanding of its pathophysiology and treatment. Br J Oral Maxillofac Surg. 2008;46(8):653–60.PubMedCrossRefGoogle Scholar
  59. 59.
    Lyons AJ, West CM, Risk JM, et al. Osteoradionecrosis in head-and-neck cancer has a distinct genotype-dependent cause. Int J Radiat Oncol Biol Phys. 2012;82(4):1479–84.PubMedCrossRefGoogle Scholar
  60. 60.
    Scully C, Epstein JB. Oral health care for the cancer patient. Eur J Cancer B Oral Oncol. 1996;32B(5):281–92.PubMedCrossRefGoogle Scholar
  61. 61.
    Nguyen NP, Vock J, Chi A, et al. Effectiveness of intensity-modulated and image-guided radiotherapy to spare the mandible from excessive radiation. Oral Oncol. 2012;48(7):653–7.PubMedCrossRefGoogle Scholar
  62. 62.
    Delanian S, Chatel C, Porcher R, Depondt J, Lefaix JL. Complete restoration of refractory mandibular osteoradionecrosis by prolonged treatment with a pentoxifylline-tocopherol-clodronate combination (PENTOCLO): a phase II trial. Int J Radiat Oncol Biol Phys. 2011;80(3):832–9.PubMedCrossRefGoogle Scholar
  63. 63.
    Bennett MH, Feldmeier J, Hampson N, Smee R, Milross C. Hyperbaric oxygen therapy for late radiation tissue injury. Cochrane Database Syst Rev. 2012;16(5), CD005005.Google Scholar
  64. 64.
    Epstein JB, Barasch A. Taste disorders in cancer patients: pathogenesis, and approach to assessment and management. Oral Oncol. 2010;46(2):77–81.PubMedCrossRefGoogle Scholar
  65. 65.
    Marunick MT, Seyedsadr M, Ahmad K, Klein B. The effect of head and neck cancer treatment on whole salivary flow. J Surg Oncol. 1991;48(2):81–6.PubMedCrossRefGoogle Scholar
  66. 66.
    Nelson GM. Biology of taste buds and the clinical problem of taste loss. Anat Rec. 1998;253(3):70–8.PubMedCrossRefGoogle Scholar
  67. 67.
    Nguyen HM, Reyland ME, Barlow LA. Mechanisms of taste bud cell loss after head and neck irradiation. J Neurosci. 2012;32(10):3474–84.PubMedPubMedCentralCrossRefGoogle Scholar
  68. 68.
    Fernando IN, Patel T, Billingham L, et al. The effect of head and neck irradiation on taste dysfunction: a prospective study. Clin Oncol. 1995;7(3):173–8.CrossRefGoogle Scholar
  69. 69.
    de Graeff A, de Leeuw JR, Ros WJ, Hordijk GJ, Blijham GH, Winnubst JA. Long-term quality of life of patients with head and neck cancer. Laryngoscope. 2000;110(1):98–106.PubMedCrossRefGoogle Scholar
  70. 70.
    Cooperstein E, Gilbert J, Epstein JB, et al. Vanderbilt head and neck symptom survey version 2.0: report of the development and initial testing of a subscale for assessment of oral health. Head Neck. 2012;34(6):797–804.PubMedCrossRefGoogle Scholar
  71. 71.
    Shi HB, Masuda M, Umezaki T, et al. Irradiation impairment of umami taste in patients with head and neck cancer. Auris Nasus Larynx. 2004;31(4):401–6.PubMedCrossRefGoogle Scholar
  72. 72.
    Ripamonti C, Zecca E, Brunelli C, et al. A randomized, controlled clinical trial to evaluate the effects of zinc sulfate on cancer patients with taste alterations caused by head and neck irradiation. Cancer. 1998;82(10):1938–45.PubMedCrossRefGoogle Scholar
  73. 73.
    Halyard MY, Jatoi A, Sloan JA, et al. Does zinc sulfate prevent therapy-induced taste alterations in head and neck cancer patients? Results of phase III double-blind, placebo-controlled trial from the North Central Cancer Treatment Group (N01C4). Int J Radiat Oncol Biol Phys. 2007;67(5):1318–22.PubMedCrossRefGoogle Scholar
  74. 74.
    Büntzel J, Glatzel M, Mücke R, Micke O, Bruns F. Influence of amifostine on late radiation-toxicity in head and neck cancer—a follow-up study. Anticancer Res. 2007;27(4A):1953–6.PubMedGoogle Scholar
  75. 75.
    Jham BC, Chen H, Carvalho AL, Freire AR. A randomized phase III prospective trial of bethanechol to prevent mucositis, candidiasis, and taste loss in patients with head and neck cancer undergoing radiotherapy: a secondary analysis. J Oral Sci. 2009;51(4):565–72.PubMedCrossRefGoogle Scholar
  76. 76.
    Epstein JB, Huhmann MB. Dietary and nutritional needs of patients after therapy for head and neck cancer. J Am Dent Assoc. 2012;143(6):588–92.PubMedCrossRefGoogle Scholar
  77. 77.
    Cheville AL. Cancer rehabilitation. Semin Oncol. 2005;32(2):19–24.CrossRefGoogle Scholar
  78. 78.
    Bornbaum CC, Fung K, Franklin JH, Nichols A, Yoo J, Doyle PC. A descriptive analysis of the relationship between quality of life and distress in individuals with head and neck cancer. Support Care Cancer. 2012;20(9):2157–65.PubMedCrossRefGoogle Scholar
  79. 79.
    McNeely M, Parliament M, Seikaly H, et al. Predictors of adherence to an exercise program for shoulder pain and dysfunction in head and neck cancer survivors. Support Care Cancer. 2012;20(3): 515–22.PubMedCrossRefGoogle Scholar
  80. 80.
    Teymoortash A, Hoch S, Eivazi B, Werner JA. Postoperative morbidity after different types of selective neck dissection. Laryngoscope. 2010;120(5):924–9.PubMedGoogle Scholar
  81. 81.
    Deng J. The impact of secondary lymphedema after head and neck cancer treatment on symptoms, functional status, and quality of life. Dissertation. Nashville: Vanderbilt University; 2010.Google Scholar
  82. 82.
    Dijkstra PU, Kalk WW, Roodenburg JL. Trismus in head and neck oncology: a systematic review. Oral Oncol. 2004;40(9):879–89.PubMedCrossRefGoogle Scholar
  83. 83.
    Hsiung CY, Huang EY, Ting HM, Huang HY. Intensity-modulated radiotherapy for nasopharyngeal carcinoma: the reduction of radiation-induced trismus. Br J Radiol. 2008;81(970):809–14.PubMedCrossRefGoogle Scholar
  84. 84.
    Bensadoun RJ, Riesenbeck D, Lockhart PB, Elting LS, Spijkervet FK, Brennan MT. A systematic review of trismus induced by cancer therapies in head and neck cancer patients. Support Care Cancer. 2010;18(8):1033–8.PubMedCrossRefGoogle Scholar
  85. 85.
    Stubblefield M, O’Dell M. Cancer rehabilitation: principles and practice. New York: Demos; 2009.Google Scholar
  86. 86.
    McNeely M, Parliament M, Seikaly H, et al. Effect of exercise on upper extremity pain and dysfunction in head and neck cancer survivors. Cancer. 2008;113(1):214–22.PubMedCrossRefGoogle Scholar
  87. 87.
    Nibu K, Ebihara Y, Ebihara M, et al. Quality of life after neck dissection: a multicenter longitudinal study by the Japanese Clinical Study Group on Standardization of Treatment for Lymph Node Metastasis of Head and Neck Cancer. Int J Clin Oncol. 2010;15(1):33–8.PubMedCrossRefGoogle Scholar
  88. 88.
    Crevenna R, Maehr B, Fialka-Moser V, Keilani M. Strength of skeletal muscle and quality of life in patients suffering from “typical male” carcinomas. Support Care Cancer. 2009;17(10):1325–8.PubMedCrossRefGoogle Scholar
  89. 89.
    Shih Y-CT XY, Cormier JN, et al. Incidence, treatment costs, and complications of lymphedema after breast cancer among women of working age: a two-year follow-up study. J Clin Oncol. 2009;27:1–8.CrossRefGoogle Scholar
  90. 90.
    Horney DJ, Smith HE, McGurk M, et al. Associations between quality of life, coping styles, optimism, and anxiety and depression in pretreatment patients with head and neck cancer. Head Neck. 2011;33(1):65–71.PubMedCrossRefGoogle Scholar
  91. 91.
    Murphy BA, Gilbert J, Ridner SH. Systemic and global toxicities of head and neck treatment. Expert Rev Anticancer Ther. 2007;7(7):1043–53.PubMedCrossRefGoogle Scholar
  92. 92.
    Smith BG, Lewin JS. Lymphedema management in head and neck cancer. Curr Opin Otolaryngol Head Neck Surg. 2010;18(3): 153–8.PubMedPubMedCentralCrossRefGoogle Scholar
  93. 93.
    Carr SD, Bowyer D, Cox G. Upper limb dysfunction following selective neck dissection: a retrospective questionnaire study. Head Neck. 2009;31(6):789–92.PubMedCrossRefGoogle Scholar
  94. 94.
    Lauchlan DT, McCaul JA, McCarron T, Patil S, McManners J, McGarva J. An exploratory trial of preventative rehabilitation on shoulder disability and quality of life in patients following neck dissection surgery. Eur J Cancer Care (Engl). 2011;20(1):113–22.CrossRefGoogle Scholar
  95. 95.
    Lauchlan DT, McCaul JA, McCarron T. Neck dissection and the clinical appearance of post-operative shoulder disability: the post-operative role of physiotherapy. Eur J Cancer Care (Engl). 2008;17(6):542–8.Google Scholar
  96. 96.
    Stuiver MM, van Wilgen CP, de Boer EM, et al. Impact of shoulder complaints after neck dissection on shoulder disability and quality of life. Otolaryngol Head Neck Surg. 2008;139(1):32–9.PubMedCrossRefGoogle Scholar
  97. 97.
    van Wouwe M, de Bree R, Kuik DJ, et al. Shoulder morbidity after non-surgical treatment of the neck. Radiother Oncol. 2009;90(2):196–201.PubMedCrossRefGoogle Scholar
  98. 98.
    Umeda M, Shigeta T, Takahashi H, et al. Shoulder mobility after spinal accessory nerve-sparing modified radical neck dissection in oral cancer patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109(6):820–4.PubMedCrossRefGoogle Scholar
  99. 99.
    Deng J, Murphy BA, Dietrich MS, et al. The impact of secondary lymphedema after head and neck cancer treatment on symptoms, functional status, and quality of life. Head Neck. 2013;35(7): 1026–35.PubMedCrossRefGoogle Scholar
  100. 100.
    van Wilgen CP, Dijkstra PU, van der Laan BF, et al. Morbidity of the neck after head and neck cancer therapy. Head Neck. 2004;26(9):785–91.PubMedCrossRefGoogle Scholar
  101. 101.
    Ahlberg A, Nikolaidis P, Engström T, et al. Morbidity of supraomohyoidal and modified radical neck dissection combined with radiotherapy for head and neck cancer: a prospective longitudinal study. Head Neck. 2012;34(1):66–72.PubMedCrossRefGoogle Scholar
  102. 102.
    Hoebers F, Heemsbergen W, Moor S, et al. Reirradiation for head-and-neck cancer: delicate balance between effectiveness and toxicity. Int J Radiat Oncol Biol Phys. 2011;81(3):e111–8.PubMedCrossRefGoogle Scholar
  103. 103.
    Montejo ME, Shrieve DC, Bentz BG, et al. IMRT with simultaneous integrated boost and concurrent chemotherapy for locoregionally advanced squamous cell carcinoma of the head and neck. Int J Radiat Oncol Biol Phys. 2011;81(5):e845–52.PubMedCrossRefGoogle Scholar
  104. 104.
    Melchers LJ, Van Weert E, Beurskens CHG, et al. Exercise adherence in patients with trismus due to head and neck oncology: a qualitative study into the use of the therabite. Int J Oral Maxillofac Surg. 2009;38(9):947–54.PubMedCrossRefGoogle Scholar
  105. 105.
    Tsang KL, Fong KY, Ho SL, et al. Localized neuromyotonia of neck muscles after radiotherapy for nasopharyngeal carcinoma. Mov Disord. 1999;14(6):1047–9.PubMedCrossRefGoogle Scholar
  106. 106.
    Terrell JE, Welsh DE, Bradford CR, et al. Pain, quality of life, and spinal accessory nerve status after neck dissection. Laryngoscope. 2000;110(4):620–6.PubMedCrossRefGoogle Scholar
  107. 107.
    Laverick L, Lowe D, Brown JS, et al. The impact of neck dissection on health-related quality of life. Arch Otolaryngol Head Neck Surg. 2004;130(2):149–54.PubMedCrossRefGoogle Scholar
  108. 108.
    Cheng PT, Hao SP, Lin YH, et al. Objective comparison of shoulder dysfunction after three neck dissection techniques. Ann Otol Rhinol Laryngol. 2000;109:761–6.PubMedCrossRefGoogle Scholar
  109. 109.
    Inoue H, Nibu K, Saito A, et al. Quality of life after neck dissection. Arch Otolaryngol Head Neck Surg. 2006;132(6):662–6.PubMedCrossRefGoogle Scholar
  110. 110.
    Kuntz AL, Weymuller EA. Impact of neck dissection on quality of life. Laryngoscope. 1999;109(8):1334–8.PubMedCrossRefGoogle Scholar
  111. 111.
    Erisen L, Basel B, Irdesel J, et al. Shoulder function after accessory nerve-sparing neck dissections. Head Neck. 2004;26(11):967–71.PubMedCrossRefGoogle Scholar
  112. 112.
    Sobol S, Jensen C, Sawyer W, et al. Objective comparison of physical dysfunction after neck dissection. Am J Surg. 1985;150(4):503–9.PubMedCrossRefGoogle Scholar
  113. 113.
    van Wilgen CP. Morbidity after neck dissection in cancer. Dutch J Phys Ther. 2007;117:116–7.Google Scholar
  114. 114.
    Ülger Ö, Yağlı NV. Effects of yoga on balance and gait properties in women with musculoskeletal problems: a pilot study. Complement Ther Clin Pract. 2011;17(1):13–5.PubMedCrossRefGoogle Scholar
  115. 115.
    Chen KM, Chen MH. Physical fitness of older adults in senior activity centres after 24-week silver yoga exercises. J Clin Nurs. 2008;17(19):2634–46.PubMedCrossRefGoogle Scholar
  116. 116.
    Lennox AJ, Shafer JP, Hatcher M, Beil J, Funder SJ. Pilot study of impedance-controlled microcurrent therapy for managing radiation-induced fibrosis in head-and-neck cancer patients. Int J Radiat Oncol Biol Phys. 2002;54(1):23–34.PubMedCrossRefGoogle Scholar
  117. 117.
    Pfister DG, Cassileth BR, Deng GE, et al. Acupuncture for pain and dysfunction after neck dissection: results of a randomized controlled trial. J Clin Oncol. 2010;28(15):2565–70.PubMedPubMedCentralCrossRefGoogle Scholar
  118. 118.
    Stubblefield MD, Manfield L, Riedel ER. A preliminary report on the efficacy of a dynamic jaw opening device (Dynasplint Trismus System) as part of the multimodal treatment of trismus in patients with head and neck cancer. Arch Phys Med Rehabil. 2010;91(8):1278–82.PubMedCrossRefGoogle Scholar
  119. 119.
    Louise Kent M, Brennan MT, Noll JL, et al. Radiation-induced trismus in head and neck cancer patients. Support Care Cancer. 2008;16(3):305–9.PubMedCrossRefGoogle Scholar
  120. 120.
    Silver HJ, Dietrich MS, Murphy BA. Changes in body mass, energy balance, physical function, and inflammatory state in patients with locally advanced head and neck cancer treated with concurrent chemoradiation after low-dose induction chemotherapy. Head Neck. 2007;29(10):893–900.PubMedCrossRefGoogle Scholar
  121. 121.
    Berger AM, Abernethy AP, Atkinson A, et al. Cancer-related fatigue. J Natl Compr Canc Netw. 2010;8(8):904–31.PubMedGoogle Scholar
  122. 122.
    Spratt DE, Sakae M, Riaz N, et al. Time course and predictors for cancer-related fatigue in a series of oropharyngeal cancer patients treated with chemoradiation therapy. Oncologist. 2012;17(4): 569–76.PubMedPubMedCentralCrossRefGoogle Scholar
  123. 123.
    Bansal M, Mohanti BK, Shah N, Chaudhry R, Bahadur S, Shukla NK. Radiation related morbidities and their impact on quality of life in head and neck cancer patients receiving radical radiotherapy. Qual Life Res. 2004;13(2):481–8.PubMedCrossRefGoogle Scholar
  124. 124.
    Jereczek-Fossa BA, Santoro L, Alterio D, et al. Fatigue during head-and-neck radiotherapy: prospective study on 117 consecutive patients. Int J Radiat Oncol Biol Phys. 2007;68(2):403–15.PubMedCrossRefGoogle Scholar
  125. 125.
    Mallinson T, Cella D, Cashy J, Holzner B. Giving meaning to measure: linking self-reported fatigue and function to performance of everyday activities. J Pain Symptom Manage. 2006;31(3):229–41.PubMedCrossRefGoogle Scholar
  126. 126.
    Curt GA, Breitbart W, Cella D, et al. Impact of cancer-related fatigue on the lives of patients: new findings from the Fatigue Coalition. Oncologist. 2000;5(5):353–60.PubMedCrossRefGoogle Scholar
  127. 127.
    Vogelzang NJ, Breitbart W, Cella D, et al. Patient, caregiver, and oncologist perceptions of cancer-related fatigue: results of a tripart assessment survey. The Fatigue Coalition. Semin Hematol. 1997;34(3 suppl 2):4–12.PubMedGoogle Scholar
  128. 128.
    Neuenschwander H, Bruera E, Cavalli F. Matching the clinical function and symptom status with the expectations of patients with advanced cancer, their families, and health care workers. Support Care Cancer. 1997;5(3):252–6.PubMedCrossRefGoogle Scholar
  129. 129.
    Berger AM, Parker KP, Young-McCaughan S, et al. Sleep-wake disturbances in people with cancer and their caregivers: state of the science. Oncol Nurs Forum. 2005;32(6):98–126.CrossRefGoogle Scholar
  130. 130.
    Oldervoll LM, Loge JH, Lydersen S, et al. Physical exercise for cancer patients with advanced disease: a randomized controlled trial. Oncologist. 2011;16(11):1649–57.PubMedPubMedCentralCrossRefGoogle Scholar
  131. 131.
    Sinard RJ, Tobin EJ, Mazzaferri EL, et al. Hypothyroidism after treatment for nonthyroid head and neck cancer. Arch Otolaryngol Head Neck Surg. 2000;126(5):652–7.PubMedCrossRefGoogle Scholar
  132. 132.
    Minton O, Richardson A, Sharpe M, Hotopf M, Stone PC. Psychostimulants for the management of cancer-related fatigue: a systematic review and meta-analysis. J Pain Symptom Manage. 2011;41(4):761–7.PubMedCrossRefGoogle Scholar
  133. 133.
    Jean-Pierre P, Morrow GR, Roscoe JA, et al. A phase 3 randomized, placebo-controlled, double-blind, clinical trial of the effect of modafinil on cancer-related fatigue among 631 patients receiving chemotherapy: a University of Rochester Cancer Center Community Clinical Oncology Program Research base study. Cancer. 2010;116(14):3513–20.PubMedPubMedCentralCrossRefGoogle Scholar
  134. 134.
    Morrow GR, Hickok JT, Roscoe JA, et al. Differential effects of paroxetine on fatigue and depression: a randomized, double-blind trial from the University of Rochester Cancer Center Community Clinical Oncology Program. J Clin Oncol. 2003;21(24):4635–41.PubMedCrossRefGoogle Scholar
  135. 135.
    Roscoe JA, Morrow GR, Hickok JT, et al. Effect of paroxetine hydrochloride (Paxil) on fatigue and depression in breast cancer patients receiving chemotherapy. Breast Cancer Res Treat. 2005;89(3):243–9.PubMedCrossRefGoogle Scholar
  136. 136.
    Welsh LC, Dunlop AW, McGovern T, et al. Neurocognitive function after (chemo)-radiotherapy for head and neck cancer. Clin Oncol (R Coll Radiol). 2014;26(12):765–75.CrossRefGoogle Scholar
  137. 137.
    Bjordal K, Kaasa S. Psychological distress in head and neck cancer patients 7–11 years after curative treatment. Br J Cancer. 1995;71:592–7.PubMedPubMedCentralCrossRefGoogle Scholar
  138. 138.
    Lee PWH, Hung BKM, Woo EKW, et al. Effects of radiation therapy on neuropsychological functioning in patients with nasopharyngeal carcinoma. J Neurol Neurosurg Psychiatry. 1989;52: 488–92.PubMedPubMedCentralCrossRefGoogle Scholar
  139. 139.
    Woo E, Lam K, Yu YL, et al. Temporal lobe and hypothalamic-pituitary dysfunctions after radiotherapy for nasopharyngeal carcinoma: a distinct clinical syndrome. J Neurol Neurosurg Psychiatry. 1988;51:1302–7.PubMedPubMedCentralCrossRefGoogle Scholar
  140. 140.
    Meyers CA, Geara F, Wong PF, et al. Neurocognitive effects of therapeutic irradiation for base of skull tumors. Int J Radiat Oncol Biol Phys. 2000;46:51–5.PubMedCrossRefGoogle Scholar
  141. 141.
    Hsiao KY, Yeh SA, Chang CC, et al. Cognitive function before and after intensity-modulated radiation therapy in patients with nasopharyngeal carcinoma: a prospective study. Int J Radiat Oncol Biol Phys. 2010;77:722–6.PubMedCrossRefGoogle Scholar
  142. 142.
    Cheung MC, Chan AS, Law SC, et al. Cognitive function of patients with nasopharyngeal carcinoma with and without temporal lobe radionecrosis. Arch Neurol. 2000;57:1347–52.PubMedGoogle Scholar
  143. 143.
    Lam LCW, Leung SF, Chan YL. Progress of memory function after radiation therapy in patients with nasopharyngeal carcinoma. J Neuropsychiatry Clin Neurosci. 2003;15:90–7.PubMedCrossRefGoogle Scholar
  144. 144.
    Bond SM, Dietrich MS, Murphy BA. Neurocognitive function in head and neck cancer patients prior to treatment. Support Care Cancer. 2012;20(1):149–57.PubMedCrossRefGoogle Scholar
  145. 145.
    Bond SM, Dietrich MS, Murphy BA. Patterns of self-reported neurocognitive deficits in head and neck cancer patients during concurrent chemoradiation. J Clin Oncol. 2010;28:e16015.Google Scholar
  146. 146.
    Bond SM, Hawkins DK, Murphy BA. Caregiver-reported neuropsychiatric symptoms in patients undergoing treatment for head and neck cancer: a pilot study. Cancer Nurs. 2014;37(3):227–35.PubMedPubMedCentralCrossRefGoogle Scholar
  147. 147.
    Abayomi OK. Pathogenesis of cognitive decline following therapeutic irradiation for head and neck tumors. Acta Oncol. 2002;41:346–51.PubMedCrossRefGoogle Scholar
  148. 148.
    Cheung MC, Chan AS, Law SC, et al. Impact of radionecrosis on cognitive dysfunction in patients after radiotherapy for nasopharyngeal carcinoma. Cancer. 2003;97:2019–26.PubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Barbara Murphy
    • 1
  • Jie Deng
    • 2
  • Mark J. Stavas
    • 3
  • Heidi Ganzer
    • 4
  • Joel B. Epstein
    • 5
    • 6
    • 7
  1. 1.Department of OncologyVanderbilt UniversityNashvilleUSA
  2. 2.School of NursingVanderbilt UniversityNashvilleUSA
  3. 3.Department of Radiation OncologyVanderbilt University Medical CenterNashvilleUSA
  4. 4.MelbourneUSA
  5. 5.Samuel Oschin Comprehensive Cancer InstituteCedars-Sinai Medical CenterLos AngelesUSA
  6. 6.Department of SurgeryCedars-Sinai Medical CenterLos AngelesUSA
  7. 7.Department of SurgeryCity of Hope National Medical CenterLos AngelesUSA

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