Abstract
The treatment of diseases by respiratory drug delivery offers a noninvasive route to deliver either topically active medications or systemic drugs. Nose and lung are target organs which provide opportunities for aerosol drug delivery by deposition on the right surface. However, filter and clearance mechanisms of the body must be overcome in order to achieve successful applications. Basic mechanisms of deposition and their interplay with the particle size (aerodynamic diameters, approx. 40–80 μm (nose) and 2–5 μm (lung)) and the patient’s inhalation flow profile are discussed. The required particle size motivates the technological approaches for aerosol generation by different inhalers. Among them are nebulizers, dry powder inhalers (DPI), pressurized metered dose inhalers (p-MDI), and non-pressurized metered dose inhalers (np-MDI). Two recently designed examples of non-pressurized liquid inhalers are presented in more detail as they make direct use of microfluidic structures in their nozzle and filter designs.
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Wachtel, H. (2016). Respiratory Drug Delivery. In: Dietzel, A. (eds) Microsystems for Pharmatechnology. Springer, Cham. https://doi.org/10.1007/978-3-319-26920-7_9
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DOI: https://doi.org/10.1007/978-3-319-26920-7_9
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