The vascular system appears in the middle of week 3 of development from fixed primitive angiogenic cells which are mesodermal in origin. The first arteries to appear are the right and left primitive aortae which appear as a continuation of the endocardial heart tubes. The primitive aortae curve dorsally in the first pharyngeal arch, around the anterior part of the foregut, and then continue dorsally as the two dorsal aortae.
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