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Nelumbo nucifera

  • T. K. Lim
Chapter

Abstract

Lotus flowers, fruit and leaves

Keywords

Lotus Seed Betulinic Acid Maslinic Acid Lotus Leaf Aporphine Alkaloid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Selected References

  1. Agnihotri VK, ElSohly HN, Khan SI, Jacob MR, Joshi VC, Smillie T, Khan IK, Walker LA (2008) Constituents of Nelumbo nucifera leaves and their antimalarial and antifungal activity. Phytochem Lett 1(2):89–93CrossRefGoogle Scholar
  2. Ahn JH, Kim ES, Lee C, Kim S, Cho SH, Hwang BY, Lee MK (2013) Chemical constituents from Nelumbo nucifera leaves and their anti-obesity effects. Bioorg Med Chem Lett 23(12):3604–3608PubMedCrossRefGoogle Scholar
  3. Ahn YJ, Park SJ, Woo H, Lee HE, Kim HJ, Kwon G, Gao Q, Jang DS, Ryu JH (2014) Effects of allantoin on cognitive function and hippocampal neurogenesis. Food Chem Toxicol 64:210–216PubMedCrossRefGoogle Scholar
  4. Anitha A, Arunkumar D (2012) Fatty acid composition and antidermatophytic and antidiarrheal activity of Nelumbo nucifera seed oil. Int J Pharm Pharm Sci 4(4):264–270Google Scholar
  5. Arthur HR, Cheung HT (1959) An aporphine alkaloid, nuciferine, from Asiatic lotus cultivated in Hong Kong. Chem Abstr 53(20):19306gGoogle Scholar
  6. Backer CA, Bakhuizen van den Brink RC Jr (1963) Flora of Java, vol 1. Noordhoff, Groningen, 648 ppGoogle Scholar
  7. Bernauer K (1963) Pronuciferin, ein benzylisochinolin-alkaloid mit para-cyclohexadienon gruppierung. Helv Chim Acta 46(5):1783–1785 (In German)CrossRefGoogle Scholar
  8. Bernauer K (1964) Uber die isolierung von (+)-pronuciferin und (–)-anonain aus den keimlingen von Nelumbo nucifera Gaertn. Helv Chim Acta 47(8):2119–2122 (In German)CrossRefGoogle Scholar
  9. Borsch T, Barthlott W (1996) Classification and distribution of the genus Nelumbo Adans. (Nelumbonaceae). Beitr Biol Pflanzen 68:421–450Google Scholar
  10. Boustie J, Stigliani JL, Montanha J, Amoros M, Payard M, Girre L (1998) Antipoliovirus structure-activity relationships of some aporphine alkaloids. J Nat Prod 61(4):480–484PubMedCrossRefGoogle Scholar
  11. Brindha D, Arthi D (2010a) Antimicrobial activity of white and pink Nelumbo nucifera Gaertn flowers. J Pharm Res Health Care 2(2):147–155Google Scholar
  12. Brindha D, Arthi D (2010b) Evaluation of Antitumor and in vivo antioxidant potentials of Nelumbo nucifera Gaertn (white and pink) flowers in Ehrlich Ascites Carcinoma mice. J Pharm Res 3(10):2483–2487Google Scholar
  13. Burkill IH (1966) A dictionary of the economic products of the Malay Peninsula. Revised reprint, 2 vol. Ministry of agriculture and co-operatives, Kuala Lumpur, Malaysia. Vol 1 (A–H) pp 1–1240, Vol 2 (I–Z) pp 1241–2444Google Scholar
  14. Burkman AM, Cannon JG (1972) Screening nornuciferine derivatives for apomorphine-like activity. J Pharm Sci 61(5):813–814PubMedCrossRefGoogle Scholar
  15. Cai CH, Cai JW, Man JM, Yang Y, Wang ZF, Wei CX (2014) Allomorph distribution and granule structure of lotus rhizome C-type starch during gelatinization. Food Chem 142:408–415PubMedCrossRefGoogle Scholar
  16. Centre for Indigenous Peoples’ Nutrition and Environment (CINE) (2007) Asian case study – Miao Sichuan China. Community food system data tables. McGill University, Canada. http://www.mcgill.ca/cine/resources/data/miao/
  17. Chakravarthi PV, Gopakumar N (2009) Evaluation of analgesic activity of lotus seeds (Nelumbo nucifera) in albino rats. Vet World 2(9):355–357Google Scholar
  18. Chakravarthi PV, Gopakumar N (2010) Anti-inflammatory activity of red and white lotus seeds (Nelumbo nucifera) in albino rats. Vet World 3(4):157–159CrossRefGoogle Scholar
  19. Chao YC, Chou YL, Young PT, Chou TQ (1962) Studies on the alkaloids of embryo of loti Nelumbo nucifera. I. Isolation and characterization of liensinine. Sci China Math 5(2):215–219 (In Chinese)Google Scholar
  20. Chaudhuri PK, Singh D (2009) A new lipid and other constituents from the rhizomes of Nelumbo nucifera. J Asian Nat Prod Res 11(7):583–587PubMedCrossRefGoogle Scholar
  21. Chaudhuri PK, Singh D (2013) A new triterpenoid from the rhizomes of Nelumbo nucifera. Nat Prod Res 27(6):532–536PubMedCrossRefGoogle Scholar
  22. Chen WZ, Chu CC, Ting KS (1962) Hypotensive mechanism of the alkaloid NN-9 from Nelumbo nucifera. Yao Xue Xue Bao 13:271–276 (In Chinese)PubMedGoogle Scholar
  23. Chen Y, Fan GR, Wu HL, Wu YT, Mitchell A (2007) Separation, identification and rapid determination of liensine, isoliensinine and neferine from embryo of the seed of Nelumbo nucifera Gaertn. by liquid chromatography coupled to diode array detector and tandem mass spectrometry. J Pharm Biomed Anal 43:99–104PubMedCrossRefGoogle Scholar
  24. Chen J, Liu JH, Wang T, Xiao HJ, Yin CP, Yang J (2008) Effects of plant extract neferine on cyclic adenosine monophosphate and cyclic guanosine monophosphate levels in rabbit corpus cavernosum in vitro. Asian J Androl 10(2):307–312PubMedCrossRefGoogle Scholar
  25. Chen JX, Zhao HH, Yang Y, Liu B, Ni J, Wang W (2011) Lipid-lowering and antioxidant activities of Jiang-Zhi-Ning in Traditional Chinese Medicine. J Ethnopharmacol 134(3):919–930PubMedCrossRefGoogle Scholar
  26. Chen JX, Ma XL, Gao K, Wang Y, Zhao HH, Wu H, Wang J, Xie H, OuYang YL, Luo LT, Guo SZ, Han J, Liu B, Wang W (2012a) The active ingredients of Jiang-Zhi-Ning: study of the Nelumbo nucifera alkaloids and their main bioactive metabolites. Molecules 17(8):9855–9867PubMedCrossRefGoogle Scholar
  27. Chen S, Fang LC, Xi HF, Guan L, Fang JB, Liu YL, Wu BH, Li SH (2012b) Simultaneous qualitative assessment and quantitative analysis of flavonoids in various tissues of lotus (Nelumbo nucifera) using high performance liquid chromatography coupled with triple quad mass spectrometry. Anal Chim Acta 724:127–135PubMedCrossRefGoogle Scholar
  28. Chen S, Wu BH, Fang JB, Liu YL, Zhang HH, Fang LC, Guan L, Li SH (2012c) Analysis of flavonoids from lotus (Nelumbo nucifera) leaves using high performance liquid chromatography/photodiode array detector tandem electrospray ionization mass spectrometry and an extraction method optimized by orthogonal design. J Chromatogr A 1227:145–153PubMedCrossRefGoogle Scholar
  29. Chen S, Xiang Y, Deng J, Liu YL, Li SH (2013) Simultaneous analysis of anthocyanin and non-anthocyanin flavonoid in various tissues of different lotus (Nelumbo) cultivars by HPLC-DAD-ESI-MSn. PLoS One 8(4):1–13Google Scholar
  30. Chinese Pharmacopoeia Committee (2010) Pharmacopoeia of the People’s Republic of China, vol 1. Chemical Industry Press, Beijing, pp 193–195Google Scholar
  31. Chopra RN, Nayar SL, Chopra IC (1986) Glossary of Indian medicinal plants. (Including the Supplement). Council Scientific Industrial Research, New Delhi, 330 ppGoogle Scholar
  32. Chu P, Chen HH, Zhou YL, Li Y, Ding Y, Jiang LW, Tsang EWT, Wu KQ, Huang SZ (2012) Proteomic and functional analyses of Nelumbo nucifera annexins involved in seed thermotolerance and germination vigor. Planta 235(6):1271–1288PubMedCrossRefGoogle Scholar
  33. Council of Scientific and Industrial Research (CSIR) (1966) The wealth of India. A dictionary of Indian raw materials and industrial products. (Raw Materials 7). Publications and Information Directorate, New Delhi, IndiaGoogle Scholar
  34. Deng SG, Deng ZY, Fan YW, Li J, Liu R, Xiong DM (2009a) Application of high-speed counter-current chromatography coupled with high performance liquid chromatography for the separation and purification of Quercetin-3-O-sambubioside from the leaves of Nelumbo nucifera. Front Chem Eng Chin 3:375–382CrossRefGoogle Scholar
  35. Deng SG, Deng ZY, Fan YW, Peng Y, Li J, Xiong DM, Liu R (2009b) Isolation and purification of three flavonoid glycosides from the leaves of Nelumbo nucifera (Lotus) by high-speed counter-current chromatography. J Chromatogr B Analyt Technol Biomed Life Sci 877(24):2487–2492PubMedCrossRefGoogle Scholar
  36. Deng J, Chen S, Yin XJ, Wang K, Liu YL, Li SH, Yang PF (2013) Systematic qualitative and quantitative assessment of anthocyanins, flavones and flavonols in the petals of 108 lotus (Nelumbo nucifera) cultivars. Food Chem 139(1–4):307–312PubMedCrossRefGoogle Scholar
  37. Ding YF, Cheng HY, Song SQ (2008) Changes in extreme high-temperature tolerance and activities of antioxidant enzymes of sacred lotus seeds. Sci China C Life Sci 51(9):842–853 (In Chinese)PubMedCrossRefGoogle Scholar
  38. Ding H, Shi JH, Wang Y, Guo J, Zhao JH, Dong L (2011) Neferine inhibits cultured hepatic stellate cell activation and facilitates apoptosis: a possible molecular mechanism. Eur J Pharmacol 650(1):163–169PubMedCrossRefGoogle Scholar
  39. Do TC, Nguyen TD, Tran H, Stuppner H, Ganzera M (2012) Quantitative determination of phenolic compounds in lotus (Nelumbo nucifera) leaves by capillary zone electrophoresis. Planta Med 78(16):1796–1799PubMedCrossRefGoogle Scholar
  40. Do TCMV, Nguyen TD, Tran H, Stuppner H, Ganzera M (2013) Analysis of alkaloids in lotus (Nelumbo nucifera Gaertn.) leaves by non-aqueous capillary electrophoresis using ultraviolet and mass spectrometric detection. J Chromatogr A 1302:174–180PubMedCrossRefGoogle Scholar
  41. Du H, You JS, Zhao X, Park JY, Kim SH, Chang KJ (2010) Antiobesity and hypolipidemic effects of lotus leaf hot water extract with taurine supplementation in rats fed a high fat diet. J Biomed Sci 17(1):S42–S47PubMedCentralPubMedCrossRefGoogle Scholar
  42. Duan Y, Zhang H, Xie B, Yan Y, Li J, Xu F, Qin Y (2010) Whole body radioprotective activity of an acetone-water extract from the seedpod of Nelumbo nucifera Gaertn. Seedpod. Food Chem Toxicol 48(12):3374–3384PubMedCrossRefGoogle Scholar
  43. Duan XH, Pei L, Jiang JQ (2013) Cytotoxic alkaloids from stems of Nelumbo nucifera. Zhongguo Zhong Yao Za Zhi 38(23):4104–4108 (In Chinese)PubMedGoogle Scholar
  44. Duanmu QP, Li AF, Sun AL, Liu RM, Li XP (2010) Semi-preparative high-speed counter-current chromatography separation of alkaloids from embryo of the seed of Nelumbo nucifera Gaertn by pH-gradient elution. J Sep Sci 33(12):1746–1751PubMedCrossRefGoogle Scholar
  45. ENVIS (2008) Medicinal plants of conservation concern. Environmental information System (ENVIS) Centre, Foundation for Revitalisation of Local Health Traditions (FRLHT), Ministry of Environment and Forests, India. http://envis.frlht.org/about_envis.htm
  46. Fu D, Wiersema JH (2001) Nelumbonaceae dumortier. In: Wu ZY, Raven PH, Hong DY (eds) Flora of China, vol 6 (Caryophyllaceae through Lardizabalaceae). Science Press, Beijing, and Missouri Botanical Garden Press, St. LouisGoogle Scholar
  47. Furukawa H (1965a) On the alkaloids of Nucifera nucifera Gaertn. IX. Alkaloids of loti embryo. (2). Structure of neferine, a new biscoclaurine alkaloid. Yakugaku Zasshi 85(4):335–338 (In Japanese)PubMedGoogle Scholar
  48. Furukawa H (1965b) On the alkaloids of Nelumbo nucifera Gaertn. X. Alkaloids of loti embryo. (3). Domestic “lien tze hsin”. Yakugaku Zasshi 85(4):353–354 (In Japanese)PubMedGoogle Scholar
  49. Furukawa H (1966a) On the alkaloids of Nelumbo nucifera Gaertn. XII. Alkaloids of loti embryo. Yakugaku Zasshi 86(1):75–77 (In Japanese)PubMedGoogle Scholar
  50. Furukawa H (1966b) Studies on the alkaloids of Nelumbo nucifera Gaertn. NMR spectra of liensinine type alkaloids. Yakugaku Zasshi 86(10):883–886 (In Japanese)PubMedGoogle Scholar
  51. Furukawa H (1971) Studies on the alkaloids of Nelumbo nucifera Gaertn.: NMR spectra of liensinine type alkaloids. Yakugaku Zasshi 86(10):883–886 (In Japanese)Google Scholar
  52. Furukawa H, Yang TH, Lin TJ (1965) On the alkaloids of Nelumbo nucifera Gaertn. XI. Alkaloids of loti embryo. 4. Structure of lotusine, a new water-soluble quaternary base. Yakugaku Zasshi 85(5):472–475 (In Japanese)PubMedGoogle Scholar
  53. Gayathri K, Dhevi R, Niraimathi KL, Shabi MM, Subashini U, Rajamanickam GV, Dubhey GP (2009) Comparative evaluation of Nelumbo nucifera (Gaertn.) flowers and vitamin C in In vitro antioxidant activity. ICFAI J Life Sci 3(1):7–19Google Scholar
  54. Goo HR, Choi JS, Na DH (2009) Simultaneous determination of quercetin and its glycosides from the leaves of Nelumbo nucifera by reversed-phase high-performance liquid chromatography. Arch Pharm Res 32(2):201–206PubMedCrossRefGoogle Scholar
  55. Gu DF, Li XL, Qi ZP, Shi SS, Hu MQ, Liu DM, She CB, Lv YJ, Li BX, Yang BF (2009) Blockade of HERG K+ channel by isoquinoline alkaloid neferine in the stable transfected HEK293 cells. Naunyn Schmiedebergs Arch Pharmacol 380(2):143–151PubMedCrossRefGoogle Scholar
  56. Gu SY, Zhu GH, Wang YZ, Li Q, Wu X, Zhang JG, Liu GL, Li XY (2014) A sensitive liquid chromatography–tandem mass spectrometry method for pharmacokinetics and tissue distribution of nuciferine in rats. J Chromatogr B 961:20–28CrossRefGoogle Scholar
  57. Guo H (2009) Cultivation of lotus (Nelumbo nucifera Gaertn. ssp. nucifera) and its utilization in China. Genet Resour Crop Evol 56:323–330CrossRefGoogle Scholar
  58. Guo MD, Chen LG (1984) Studies on the alkaloids constituents of the embryo nelumbinis (Nelumbo nucifera) produced in China. Chin Tradit Herb Drugs 15:291–293 (In Chinese)Google Scholar
  59. Guo XF, Wang DJ, Duan WJ, Du JH, Wang X (2010) Preparative isolation and purification of four flavonoids from the petals of Nelumbo nucifera by high-speed counter-current chromatography. Phytochem Anal 21(3):268–272CrossRefGoogle Scholar
  60. Guo FC, Yang X, Li XX, Feng RN, Guan CM, Wang YW, Li Y, Sun CH (2013) Nuciferine prevents hepatic steatosis and injury induced by a high-fat diet in hamsters. PLoS One 8(5):e63770PubMedCentralPubMedCrossRefGoogle Scholar
  61. Gupta M, Mazumder UK, Mukhopadhyay RK, Sarkar S (1996) Antisteroidogenic effect of the seed extract of Nelumbo nucifera in the testis and the ovary of the rat. Indian J Pharm Sci 58:236–242Google Scholar
  62. Gupta S, Singh N, Jaggi AS (2014) Evaluation of in vitro aldose reductase inhibitory potential of alkaloidal fractions of Piper nigrum, Murraya koenigii, Argemone mexicana, and Nelumbo nucifera. J Basic Clin Physiol Pharmacol 25(2):255–265PubMedCrossRefGoogle Scholar
  63. Ha JY, Lee K, Park J, Dong A, Shin HS (2010) Cytoprotective activity of lotus (Nelumbo nucifera Gaertner) leaf extracts on the mouse embryonic fibroblast cell. Food Sci Biotechnol 19(5):1171–1176CrossRefGoogle Scholar
  64. Han X, Wang W, Wu CA, Liu S, Wang LY (2008) Effect of nuciferine on cholesterol metabolism in Bel-7402 cells. Progr Modern Biomed 9:1628–1630 (In Chinese)Google Scholar
  65. He LS, Meng FL, Diao XJ, Li YW, Meng R, Xi BD, Shu JM (2013) Allelopathic effect of Nelumbo nucifera stem and leaf tissue extract on the growth of Microcystis aeruginosa and Scenedesmus quadricanda. Huan Jing Ke Xue 34(7):2637–2641 (In Chinese)PubMedGoogle Scholar
  66. Ho HH, Hsu LS, Chan KC, Chen HM, Wu CH, Wang CJ (2010) Extract from the leaf of nucifera reduced the development of atherosclerosis via inhibition of vascular smooth muscle cell proliferation and migration. Food Chem Toxicol 48(1):159–168PubMedCrossRefGoogle Scholar
  67. Hsieh YY, Chen WC, Kao YS (1964a) Studies on the alkaloids of Nelumbo nucifera. III. Absolute configuration of liensinine. Sci China Math 13:2018–2019 (In Chinese)Google Scholar
  68. Hsieh YY, Pan PC, Chen WC, Kao YS (1964b) Alkaloids of Nelumbo nucifera. IV. Total synthesis of liensinine. Sci Sin 12(12):2020–2025 (In Chinese)Google Scholar
  69. Hu SY (2005) Food plants of China. The Chinese University Press, Hong Kong, 844 ppGoogle Scholar
  70. Hu M, Skibsted LH (2007) Antioxidative capacity of rhizome extract and rhizome knot extract of edible lotus (Nelumbo nuficera). Food Chem 76:327–333CrossRefGoogle Scholar
  71. Hu XM, Zhou BH, Luo SD, Cai HS, Yin WH (1993) Quantitative determination of liensinine in the embryo Nelumbinis (Nelumbo nucifera Gaertn.) by TLC-scanning. Zhongguo Zhong Yao Za Zhi 18(3):167–168, 192. (In Chinese)PubMedGoogle Scholar
  72. Hu LW, Xu W, Zhang X, Su J, Liu XR, Li HY, Zhang WD (2010) In-vitro and in-vivo evaluations of cytochrome P450 1A2 interactions with nuciferine. J Pharm Pharmacol 62(5):658–662PubMedCrossRefGoogle Scholar
  73. Huang B, Ban XQ, He JS, Tong J, Tian J, Wang YW (2010a) Comparative analysis of essential oil components and antioxidant activity of extracts of Nelumbo nucifera from various areas of China. J Agric Food Chem 58(1):441–448PubMedCrossRefGoogle Scholar
  74. Huang B, Ban XQ, He JS, Tong J, Tian J, Wang YW (2010b) Hepatoprotective and antioxidant activity of ethanolic extracts of edible lotus (Nelumbo nucifera Gaertn.) leaves. Food Chem 120(3):873–878CrossRefGoogle Scholar
  75. Huang CF, Chen YW, Yang CY, Lin HY, Way TD, Chiang W, Liu SH (2011a) Extract of lotus leaf (Nelumbo nucifera) and its active constituent catechin with insulin secretagogue activity. J Agric Food Chem 59(4):1087–1094PubMedCrossRefGoogle Scholar
  76. Huang Y, Zhao LB, Bai Y, Liu P, Wang JL, Xiang JZ (2011b) Simultaneous determination of liensinine, isoliensinine and neferine from seed embryo of Nelumbo nucifera Gaertn. in rat plasma by a rapid HPLC method and its application to a pharmacokinetic study. Arzneimittelforschung 61(6):347–352PubMedCrossRefGoogle Scholar
  77. Huang B, Zhu L, Liu S, Li D, Chen YX, Ma BX, Wang YW (2013) In vitro and in vivo evaluation of inhibition activity of lotus (Nelumbo nucifera Gaertn.) leaves against ultraviolet B-induced phototoxicity. J Photochem Photobiol B 121:1–5PubMedCrossRefGoogle Scholar
  78. Hutadilok-Towatana N, Chaiyamutti P, Panthong K, Mahabusarakam W, Rukachaisirikul V (2006) Antioxidative and free radical scavenging activities of some plants used in Thai folk medicine. Pharm Biol 44(3):221–228CrossRefGoogle Scholar
  79. Hyun SK, Jung YJ, Chung HY, Jung HA, Choi JS (2006) Isorhamnetin glycosides with free radical and ONOO-scavenging activities from the stamens of Nelumbo nucifera. Arch Pharm Res 29(4):287–292PubMedCrossRefGoogle Scholar
  80. Ibrahim N, El-Eraqy W (1996) Protein content and amino acid composition of Nelumbo nucifera seeds and its evaluation as hypoglycaemic agent. Egypt J Pharm Sci 37(1-6):635–664Google Scholar
  81. Im AR, Kim YH, Uddin MR, Chae SW, Lee HW, Jung WS, Kim YH, Kang BJ, Kim YS, Lee MY (2013) Protection from antimycin A-induced mitochondrial dysfunction by Nelumbo nucifera seed extracts. Environ Toxicol Pharmacol 36(1):19–29PubMedCrossRefGoogle Scholar
  82. Ishida H, Umino T, Tsuji K, Kosuge T (1988) Studies on the antihemorrhagic substances in herbs classified as hemostatics in Chinese medicine. VIII On the antihemorrhagic principle in Nelumbins Receptaculum. Chem Pharm Bull 36(11):4585–4587PubMedCrossRefGoogle Scholar
  83. Itoh A, Saitoh T, Tani K, Uchigaki M, Sugimoto Y, Yamada J, Nakajima H, Ohshiro H, Sun SJ, Tanahashi T (2011) Bisbenzylisoquinoline alkaloids from Nelumbo nucifera. Chem Pharm Bull 59(8):947–951PubMedCrossRefGoogle Scholar
  84. Jeong IY, Lee HY, Park YD, Jin CH, Choi DS, Byun MW (2009) Effects of gamma irradiation on total polyphenols, radical scavenging activities and decolourization of Nelumbo nucifera extracts. Radiat Phys Chem 78:575–577CrossRefGoogle Scholar
  85. Jiang JZ, Cao BS (2005) Cultivar types of aquatic vegetables and their utilization. Chin Food Nutr 9:21–24Google Scholar
  86. Jiang Y, Ng TB, Wang CR, Li N, Wen TY, Qiao WT, Zhang D, Cheng ZH, Liu F (2010) First isolation of tryptophan from edible lotus (Nelumbo nucifera Gaertn) rhizomes and demonstration of its antioxidant effects. Int J Food Sci Nutr 61(4):346–356PubMedCrossRefGoogle Scholar
  87. Jung HA, Kim JE, Chung HY, Choi JS (2003) Antioxidant principles of Nelumbo nucifera stamens. Arch Pharm Res 26(4):279–285PubMedCrossRefGoogle Scholar
  88. Jung HA, Jung YJ, Yoon NY, da Jeong M, Bae HJ, Kim DW, Na DH, Choi JS (2008) Inhibitory effects of Nelumbo nucifera leaves on rat lens aldose reductase, advanced glycation endproducts formation, and oxidative stress. Food Chem Toxicol 46(12):3818–3826PubMedCrossRefGoogle Scholar
  89. Jung HA, Jin SE, Choi RJ, Kim DH, Kim YS, Ryu JH, Kim DW, Son YK, Park JJ, Choi JS (2010a) Anti-amnesic activity of neferine with antioxidant and anti-inflammatory capacities, as well as inhibition of ChEs and BACE1. Life Sci 87(13-14):420–430PubMedCrossRefGoogle Scholar
  90. Jung HA, Jung YJ, Hyun SK, Min BS, Kim DW, Jung JH, Choi JS (2010b) Selective cholinesterase inhibitory activities of a new monoterpene diglycoside and other constituents from Nelumbo nucifera stamens. Biol Pharm Bull 33(2):267–272PubMedCrossRefGoogle Scholar
  91. Ka SM, Kuo YC, Ho PJ, Tsai PY, Hsu YJ, Tsai WJ, Lin YL, Shen CC, Chen A (2010) (S)-armepavine from Chinese medicine improves experimental autoimmune crescentic glomerulonephritis. Rheumatology (Oxford) 49(10):1840–1851CrossRefGoogle Scholar
  92. Kamaraj C, Rahuman AA, Bagavan A, Elango G, Zahir AA, Santhoshkumar T (2011) Larvicidal and repellent activity of medicinal plant extracts from Eastern Ghats of South India against malaria and filariasis vectors. Asian Pac J Trop Med 4(9):698–705PubMedCrossRefGoogle Scholar
  93. Karki R, Jung MA, Kim KJ, Kim DW (2012) Inhibitory effect of Nelumbo nucifera (Gaertn.) on the development of atopic dermatitis-like skin lesions in NC/Nga mice. Evid Based Complement Alternat Med 2012:153568PubMedCentralPubMedCrossRefGoogle Scholar
  94. Karki R, Jeon ER, Kim DW (2013) Nelumbo nucifera leaf extract inhibits neointimal hyperplasia through modulation of smooth muscle cell proliferation and migration. Nutrition 29(1):268–275PubMedCrossRefGoogle Scholar
  95. Kashiwada Y, Aoshima A, Ikeshiro Y, Chen YP, Furukawa H, Itoigawa M, Fujioka T, Mihashi K, Cosentino ML, Morris-Natschke SL, Lee KH (2005) Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera and structure-activity correlations with related alkaloids. Bioorg Med Chem 13(2):443–448PubMedCrossRefGoogle Scholar
  96. Khattak KF, Simpson TJ, Ihasnullah (2009) Effect of gamma irradiation on the microbial load, nutrient composition and free radical scavenging activity of Nelumbo nucifera rhizome. Radiat Phys Chem 78:206–212CrossRefGoogle Scholar
  97. Kim MJ, Shin HS (2012) Antioxidative effect of lotus seed and seedpod extracts. Food Sci Biotechnol 21(6):1761–1766CrossRefGoogle Scholar
  98. Kim SB, Rho SB, Rhyu DY, Kim DW (2005) Effect of Nelumbo nucifera leaves on hyperlipidemic atherosclerotic Bio F1B hamster. Korean J Pharmacogn 36(3):229–234 (In Korean)Google Scholar
  99. Kim HK, Park HR, Lee JS, Chung TS, Chung HY, Chung J (2007) Down-regulation of iNOS and TNF-alpha expression by kaempferol via NF-kappaB inactivation in aged rat gingival tissues. Biogerontology 8(4):399–408PubMedCrossRefGoogle Scholar
  100. Kim KH, Chang SW, Ryu SY, Choi SU, Lee KR (2009) Phytochemical constituents of Nelumbo nucifera. Nat Prod Sci 15(2):90–95Google Scholar
  101. Kim T, Kim HJ, Cho SK, Kang WY, Baek H, Jeon HY, Kim BY, Kim D (2011) Nelumbo nucifera extracts as whitening and anti-wrinkle cosmetic agent. Korean J Chem Eng 28(2):424–427Google Scholar
  102. Knipping K, Garssen J, van’t Land B (2012) An evaluation of the inhibitory effects against rotavirus infection of edible plant extracts. Virol J 9(1):137–144PubMedCentralPubMedCrossRefGoogle Scholar
  103. Koch K, Dommisse A, Barthlott W (2006) Chemistry and crystal growth of plant wax tubules of lotus (Nelumbo nucifera) and nasturtium (Tropaeolum majus) leaves on technical substrates. Cryst Growth Des 6(11):2571–2578CrossRefGoogle Scholar
  104. Koshiyama H, Ohkuma H, Kawaguchi H, Hsu HY, Chen YP (1970) Isolation of 1-(p-Hydroxybenzyl)-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline (demethylcoclaurine), an active alkaloid from Nelumbo nucifera. Chem Pharm Bull 18(12):2564–2568CrossRefGoogle Scholar
  105. Kredy HM, Huang DH, Xie BJ, He H, Yang ER, Tian BQ, Xiao D (2010) Flavonols of lotus (Nelumbo nucifera, Gaertn.) seed epicarp and their antioxidant potential. Eur Food Res Technol 231:387–394CrossRefGoogle Scholar
  106. Kunanusorn P, Panthong A, Pittayanurak P, Wanauppathamkul S, Nathasaen N, Reutrakul V (2011) Acute and subchronic oral toxicity studies of Nelumbo nucifera stamens extract in rats. J Ethnopharmacol 134(3):789–795PubMedCrossRefGoogle Scholar
  107. Kunimoto J, Kamimura M (1964) Studies on the alkaloids of Nelumbo nuciefera Gaertn. VII. Cleavage reaction of nuciferine and nornuciferine by metallic sodium in liquid ammonia. Yakugaku Zasshi 84(11):1100–1104Google Scholar
  108. Kunitomo J, Yamamoto C, Otsuki T (1964) Studies on the alkaloids of Nelumbo nucifera Gaertn. VI. Alkaloids of “gen-shi-hasu”. Yakugaku Zasshi 84(11):1141–1142 (In Japanese)PubMedGoogle Scholar
  109. Kunitomo J, Nagai Y, Okamoto Y, Furukawa H (1970) On the alkaloids of Nelumbo nucifera Gaertn. XIV. On the tertiary base. Yakugaku Zasshi 90(9):1165–1169 (In Japanese)PubMedGoogle Scholar
  110. Kunitomo J, Miyoshi M, Maruyama T, Yuge E (1971) Studies on the alkaloids of Nelumbo nucifera Gaertn. XV. Synthesis of dl-nornuciferine (dl-1-methoxy-2-hydroxyaporphine). Yakugaku Zasshi 91(8):896–900 (In Japanese)PubMedGoogle Scholar
  111. Kunitomo J, Yoshikawa Y, Tanaka S, Imori Y, Isoi K, Masada Y, Hashimoto K, Inoue T (1973) Alkaloids of Nelumbo nucifera. Phytochemistry 12(3):699–701CrossRefGoogle Scholar
  112. Kuo YC, Lin YL, Liu CP, Tsai WJ (2005) Herpes simplex virus type 1 propagation in HeLa cells interrupted by Nelumbo nucifera. J Biomed Sci 12(6):1021–1034PubMedCrossRefGoogle Scholar
  113. Kwon K, Kwon OY, Kang KH (2012) Anti-inflammatory effects of Nelumbo nucifera leaves extracts on the lipopolysaccharide-activated Raw 264.7 cells, pp 97–104. In: Green and smart technology with sensor applications. Springer, Berlin/HeidelbergGoogle Scholar
  114. La Cour B, Molgaard P, Yi Z (1995) Traditional Chinese medicine in treatment of hyperlipidaemia. J Ethnopharmacol 46(2):12–125Google Scholar
  115. Lee KS, Lee KY (2011) Effect of lotus (Nelumbo nucifera) leaf extract on serum and liver lipid levels of rats fed a high fat diet. J Korean Soc Food Sci Nutr 40:1544–1547CrossRefGoogle Scholar
  116. Lee HK, Choi YM, Noh DO, Suh HJ (2005) Antioxidant effect of Korean traditional lotus liquor (Yunyupju). Int J Food Sci Technol 40(7):709–715CrossRefGoogle Scholar
  117. Lee HJ, Chen CC, Chou FP, Wu CH, Lai FS, Yang MY, Wang CJ (2010) Water extracts from Nelumbo nucifera leaf reduced plasma lipids and atherosclerosis in cholesterol-fed rabbits. J Food Biochem 34:779–795CrossRefGoogle Scholar
  118. Li GR, Li XG, Lu FH (1989) Effects of neferine on transmembrane potential in rabbit sinoatrial nodes and clusters of cultured myocardial cells from neonatal rats. Zhongguo Yao Li Xue Bao 10(4):328–331 (In Chinese)PubMedGoogle Scholar
  119. Li GR, Qian JQ, Lu FH (1990) Effects of neferine on heart electromechanical activity in anaesthetized cats. Zhongguo Yao Li Xue Bao 11(2):158–161 (In Chinese)PubMedGoogle Scholar
  120. Li SS, Wu J, Chen LG, Du H, Xu YJ, Wang LJ, Zhang HJ, Zheng XC, Wang LS (2014) Biogenesis of C-glycosyl flavones and profiling of flavonoid glycosides in lotus (Nelumbo nucifera). PLoS One 9(10):e108860PubMedCentralPubMedCrossRefGoogle Scholar
  121. Liao CH, Lin JY (2012) Purification, partial characterization and anti-inflammatory characteristics of lotus (Nelumbo nucifera Gaertn) plumule polysaccharides. Food Chem 135(3):1818–1827PubMedCrossRefGoogle Scholar
  122. Liao CH, Lin JY (2013a) Lotus (Nelumbo nucifera Gaertn) plumule polysaccharide ameliorates pancreatic islets loss and serum lipid profiles in non-obese diabetic mice. Food Chem Toxicol 58:416–422PubMedCrossRefGoogle Scholar
  123. Liao CH, Lin JY (2013b) Purified active lotus plumule (Nelumbo nucifera Gaertn) polysaccharides exert anti-inflammatory activity through decreasing toll-like receptor-2 and -4 expressions using mouse primary splenocytes. J Ethnopharmacol 147(1):164–173PubMedCrossRefGoogle Scholar
  124. Lim SS, Jung YJ, Hyun SK, Lee YS, Choi JS (2006) Rat lens aldose reductase inhibitory constituents of Nelumbo nucifera stamens. Phytother Res 20(10):825–830PubMedCrossRefGoogle Scholar
  125. Lin HY, Kuo YH, Lin YL, Chiang W (2009a) Antioxidative effect and active components from leaves of lotus (Nelumbo nucifera). J Agric Food Chem 57(15):6623–6629PubMedCrossRefGoogle Scholar
  126. Lin MC, Kao SH, Chung PJ, Chan KC, Yang MY, Wang CJ (2009b) Improvement for high fat diet-induced hepatic injuries and oxidative stress by flavonoid-enriched extract from Nelumbo nucifera leaf. J Agric Food Chem 57(13):5925–5932PubMedCrossRefGoogle Scholar
  127. Lin RJ, Wu MH, Ma YH, Chung LY, Chen CY, Yen CM (2014) Anthelmintic activities of aporphine from Nelumbo nucifera Gaertn. cv. Rosa-plena against Hymenolepis nana. Int J Mol Sci 15(3):3624–3639PubMedCentralPubMedCrossRefGoogle Scholar
  128. Ling ZQ, Xie BJ, Yang EL (2005) Isolation, characterization, and determination of antioxidative activity of oligomeric procyanidins from the seedpod of Nelumbo nucifera Gaertn. J Agric Food Chem 53:2441–2445PubMedCrossRefGoogle Scholar
  129. Liu CP, Tsai WJ, Lin YL, Liao JF, Chen CF, Kuo YC (2004) The extracts from Nelumbo nucifera suppress cell cycle progression, cytokine genes expression, and cell proliferation in human peripheral blood mononuclear cells. Life Sci 75(6):699–716PubMedCrossRefGoogle Scholar
  130. Liu CP, Tsai WJ, Shen CC, Lin YL, Liao JF, Chen CF, Kuo YC (2006) Inhibition of (S)-armepavine from Nelumbo nucifera on autoimmune disease of MRL/MpJ-lpr/lpr mice. Eur J Pharmacol 531(1–3):270–279PubMedCrossRefGoogle Scholar
  131. Liu CP, Kuo YC, Shen CC, Wu MH, Liao JF, Lin YL, Chen CF, Tsai WJ (2007) (S)-armepavine inhibits human peripheral blood mononuclear cell activation by regulating Itk and PLCgamma activation in a PI-3K-dependent manner. J Leukoc Biol 81(5):1276–1286PubMedCrossRefGoogle Scholar
  132. Liu S, Wang B, Li XZ, Qi LF, Liang YZ (2009) Preparative separation and purification of liensinine, isoliensinine and neferine from seed embryo of Nelumbo nucifera Gaertn using high-speed counter-current chromatography. J Sep Sci 32(14):2476–2481PubMedCrossRefGoogle Scholar
  133. Liu S, Li D, Huang B, Chen YX, Lu XC, Wang YW (2013) Inhibition of pancreatic lipase, α-glucosidase, α-amylase, and hypolipidemic effects of the total flavonoids from Nelumbo nucifera leaves. J Ethnopharmacol 149(1):263–269PubMedCrossRefGoogle Scholar
  134. Liu SH, Lu TH, Su CC, Lay IS, Lin HY, Fang KM, Ho TJ, Chen KL, Su YC, Chiang WC, Chen YW (2014) Lotus leaf (Nelumbo nucifera) and its active constituents prevent inflammatory responses in macrophages via JNK/NF-κB signaling pathway. Am J Chin Med 42(4):869–889PubMedCrossRefGoogle Scholar
  135. Luo XB, Chen B, Liu JJ, Yao SZ (2005) Simultaneous analysis of N-nornuciferine, O-nornuciferine, nuciferine, and roemerine in leaves of Nelumbo nucifera Gaertn by high-performance liquid chromatography–photodiode array detection–electrospray mass spectrometry. Anal Chim Acta 538(1):129–133CrossRefGoogle Scholar
  136. Lv L, Jiang C, Li J, Zheng T (2012) Protective effects of lotus (Nelumbo nucifera Gaertn) germ oil against carbon tetrachloride-induced injury in mice and cultured PC-12 cells. Food Chem Toxicol 50(5):1447–1453PubMedCrossRefGoogle Scholar
  137. Ma WY, Lu YB, Hu RL, Chen JH, Zhang ZZ, Pan YJ (2010) Application of ionic liquids based microwave-assisted extraction of three alkaloids N-nornuciferine, O-nornuciferine, and nuciferine from lotus leaf. Talanta 80:1292–1297PubMedCrossRefGoogle Scholar
  138. Ma CJ, Wang JJ, Chu HM, Zhang XX, Wang ZH, Wang HL, Li G (2014) Purification and characterization of aporphine alkaloids from leaves of Nelumbo nucifera Gaertn and their effects on glucose consumption in 3T3-L1 adipocytes. Int J Mol Sci 15(3):3481–3494PubMedCentralPubMedCrossRefGoogle Scholar
  139. Macko E, Douglas B, Weisbach JA, Waltz DT (1972) Pharmacology of nuciferine and related aporphines. Arch Int Pharmacodyn Ther 197:261–273PubMedGoogle Scholar
  140. Man JM, Cai JW, Cai CH, Xu B, Huai HY, Wei CX (2012) Comparison of physicochemical properties of starches from seed and rhizome of lotus. Carbohydr Polym 88(2):676–683CrossRefGoogle Scholar
  141. Mani SS, Subramanian IP, Pillai SS, Muthusamy K (2010) Evaluation of hypoglycemic activity of inorganic constituents in Nelumbo nucifera seeds on streptozotocin-induced diabetes in rats. Biol Trace Elem Res 138(1–3):226–237PubMedCrossRefGoogle Scholar
  142. Mathew M, Subramanian S (2014) In vitro screening for anti-cholinesterase and antioxidant activity of methanolic extracts of ayurvedic medicinal plants used for cognitive disorders. PLoS One 9(1):e86804PubMedCentralPubMedCrossRefGoogle Scholar
  143. Mazumder UK, Gupta M, Pramanik G, Mukhopadhyay RK, Sarkar S (1992) Antifertility activity of seed of Nelumbo nucifera in mice. Indian J Exp Biol 30(6):533–534PubMedGoogle Scholar
  144. Mon AA (2000) Use of Lotus (Nelumbo nucifera) for nutrient retrieval from Pond Mud. M.Sc. thesis, Asian Institute of Technology, Bangkok, ThailandGoogle Scholar
  145. Mongkolrat S, Palanuvej C, Ruangrungsi N (2012) Quality assessment and liriodenine quantification of Nelumbo nucifera dried leaf in Thailand. Pharmacogn J 4(32):24–28CrossRefGoogle Scholar
  146. Morales MA, Bustamante SE, Brito G, Paz D, Cassels BK (1997) Cardiovascular effects of plant secondary metabolites norarmepavine, coclaurine and norcoclaurine. Phytother Res 12:103–109CrossRefGoogle Scholar
  147. Mukherjee PK, Balasubramanian R, Saha K, Saha BP, Pal M (1995a) Antibacterial efficiency of Nelumbo nucifera (Nymphaeaceae) rhizomes extract. Indian Drugs 32(6):274–276Google Scholar
  148. Mukherjee PK, Das J, Balasubramanian R, Kakali S, Pal M, Saha BP (1995b) Antidiarrhoeal evaluation of Nelumbo nucifera rhizome extract. Indian J Pharmacol 27(4):262–264Google Scholar
  149. Mukherjee PK, Pal SK, Saha K, Saha BP (1995c) Hypoglycaemic activity of Nelumbo nucifera Gaertn. (Fam. Nymphaeaceae) rhizome (methanolic extract) in streptozotocin‐induced diabetic rats. Phytother Res 9(7):522–524Google Scholar
  150. Mukherjee PK, Saha K, Giri S, Pal M, Saha B (1995d) Antifungal screening of Nelumbo nucifera (Nymphaeaceae) rhizome extract. Indian J Microbiol 35:327–330Google Scholar
  151. Mukherjee PK, Das J, Saha K, Giri SN, Pal M, Saha BP (1996a) Antipyretic activity of Nelumbo nucifera rhizome extract. Indian J Exp Biol 34(3):275–276PubMedGoogle Scholar
  152. Mukherjee PK, Pal M, Saha K, Saha BP, Das J (1996b) Diuretic activity of extract of the rhizomes of Nelumbo nucifera Gaertn. (Fam. Nymphaeaceae). Phytother Res 10(5):424–425CrossRefGoogle Scholar
  153. Mukherjee PK, Saha K, Balasubramanian R, Pal M, Saha BP (1996c) Studies on psychopharmacological effects of Nelumbo nucifera Gaertn. rhizome extract. J Ethnopharmacol 54(2–3):63–67PubMedCrossRefGoogle Scholar
  154. Mukherjee PK, Saha K, Das J, Pal M, Saha BP (1997a) Studies on the anti-inflammatory activity of rhizomes of Nelumbo nucifera. Planta Med 63(4):367–369PubMedCrossRefGoogle Scholar
  155. Mukherjee PK, Saha K, Saha BP (1997b) Effect of Nelumbo nucifera rhizome extract on blood sugar level in rats. J Ethnopharmacol 58(3):207–213PubMedCrossRefGoogle Scholar
  156. Mukherjee PK, Pal M, Pal SK, Shah K, Saha BP (1998) Pharmacognostical profiles of rhizomes of Nelumbo nucifera Gaertn. Anc Sci Life 17(4):273–279PubMedCentralPubMedGoogle Scholar
  157. Mukherjee PK, Kumar V, Houghton PJ (2007) Screening of Indian medicinal plants for acetylcholinesterase inhibitory activity. Phytother Res 21(12):1142–1145PubMedCrossRefGoogle Scholar
  158. Mukherjee PK, Mukherjee D, Maji AK, Rai S, Heinrich M (2009) The sacred lotus (Nelumbo nucifera) – phytochemical and therapeutic profile. J Pharm Pharmacol 61(4):407–422PubMedGoogle Scholar
  159. Mukherjee D, Biswas A, Bhadra S, Pichairajan V, Biswas T, Saha BP, Mukherjee PK (2010a) Exploring the potential of Nelumbo nucifera rhizome on membrane stabilization, mast cell protection, nitric oxide synthesis, and expression of costimulatory molecules. Immunopharmacol Immunotoxicol 32(3):466–472PubMedCrossRefGoogle Scholar
  160. Mukherjee D, Khatua TN, Venkatesh P, Saha BP, Mukherjee PK (2010b) Immunomodulatory potential of rhizome and seed extracts of Nelumbo nucifera Gaertn. J Ethnopharmacol 128(2):490–494PubMedCrossRefGoogle Scholar
  161. Mukherjee D, Kumar NS, Khatua T, Mukherjee PK (2010c) Rapid validated HPTLC method for estimation of betulinic acid in Nelumbo nucifera (Nymphaeaceae) rhizome extract. Phytochem Anal 21(6):556–560PubMedCrossRefGoogle Scholar
  162. Mutreja A, Agarwal M, Kushwaha S, Chauhan A (2008) Effect of Nelumbo nucifera seeds on the reproductive organs of female rats. Iranian J Reproduct Med 6(1):7–11Google Scholar
  163. Nadkarni KM, Nadkarni AK (1982) Indian Materia Medica with ayurvedic, Unani-Tibbi, siddha, allopathic, homeopathic, naturopathic & home remedies, vol 2, 2nd edn. Sangam Books, BombayGoogle Scholar
  164. Nakamura S, Nakashima S, Tanabe G, Oda Y, Yokota N, Fujimoto K, Matsumoto T, Sakuma R, Ohta T, Ogawa K, Nishida S, Miki H, Matsuda H, Muraoka O, Yoshikawa M (2013) Alkaloid constituents from flower buds and leaves of sacred lotus (Nelumbo nucifera, Nymphaeaceae) with melanogenesis inhibitory activity in B16 melanoma cells. Bioorg Med Chem 21(3):779–787PubMedCrossRefGoogle Scholar
  165. National Institute of Materia Medica (NIMM) (1999) Selected medicinal plants in Vietnam, vol 2. Science and Technology Publishing House, Hanoi, 460 ppGoogle Scholar
  166. Nguyen KH, Ta TN, Pham T, Nguyen QT, Pham H, Mishra S, Nyomba BL (2012) Nuciferine stimulates insulin secretion from beta cells – An in vitro comparison with glibenclamide. J Ethnopharmacol 142(2):488–495PubMedCrossRefGoogle Scholar
  167. Nishibe S, Tsukamoto H, Kinoshita H, Kitagawa S, Sakushima A (1986) Alkaloids from embryo of the seed of Nelumbo nucifera. J Nat Prod 49(3):547–548CrossRefGoogle Scholar
  168. Nishimura K, Horii S, Anahashi T, Sugimoto Y, Yamada J (2013) Synthesis and pharmacological activity of alkaloids from embryo of lotus, Nelumbo nucifera. Chem Pharm Bull 61(1):59–68PubMedCrossRefGoogle Scholar
  169. Niu CH, Wang Y, Liu JD, Wang JL, Xiao JH (2013) Protective effects of neferine on amiodarone-induced pulmonary fibrosis in mice. Eur J Pharmacol 714(1–3):112–119PubMedCrossRefGoogle Scholar
  170. Ochse JJ, Bakhuizen van den Brink RC (1980) Vegetables of the Dutch Indies, 3rd edn. Ascher & Co., Amsterdam, 1016 ppGoogle Scholar
  171. Ogle BM, Dao HTA, Mulokozi G, Hambraeus L (2001) Micronutrient composition and nutritional importance of gathered vegetables in Vietnam. Int J Food Sci Nutr 52:485–499PubMedCrossRefGoogle Scholar
  172. Oh JH, Choi BJ, Chang MS, Park SK (2009) Nelumbo nucifera semen extract improves memory in rats with scopolamine-induced amnesia through the induction of choline acetyltransferase expression. Neurosci Lett 461(1):41–44PubMedCrossRefGoogle Scholar
  173. Ohara K, Wakabayashi H, Taniguchi Y, Shindo K, Yajima H, Yoshida A (2013) Quercetin-3-O-glucuronide induces ABCA1 expression by LXRα activation in murine macrophages. Biochem Biophys Res Commun 441(4):929–934PubMedCrossRefGoogle Scholar
  174. Ohkoshi E, Miyazaki H, Shindo K, Watanabe H, Yoshida A, Yajima H (2007) Constituents from the leaves of Nelumbo nucifera stimulate lipolysis in the white adipose tissue of mice. Planta Med 73(12):1255–1259PubMedCrossRefGoogle Scholar
  175. Onishi E, Yamada K, Yamada T, Kaji K, Inoue H, Seyama Y, Yamashita S (1984) Comparative effects of crude drugs on serum lipids. Chem Pharm Bull 32(2):646–650PubMedCrossRefGoogle Scholar
  176. Ono Y, Hattori E, Fukaya Y, Imai S, Ohizumi Y (2006) Anti-obesity effect of Nelumbo nucifera leaves extract in mice and rats. J Ethnopharmacol 106(2):238–244PubMedCrossRefGoogle Scholar
  177. Ou M (1989) Chinese–English manual of common-used prescriptions in traditional Chinese medicine. Joint Publishing Co, Ltd., Hong Kong, 753 ppGoogle Scholar
  178. Pan PC, Chou YL, Sun TC, Kao YS (1962) Studies on the alkaloids of embryo of loti Nelumbo nucifera. II Structure of liensinine. Sci China Math 5(3):321–336 (In Chinese)Google Scholar
  179. Pan Y, Cai BC, Wang KL, Wang SM, Zhou SY, Yu XC, Xu B, Chen L (2009) Neferine enhances insulin sensitivity in insulin resistant rats. J Ethnopharmacol 124(1):98–102PubMedCrossRefGoogle Scholar
  180. Park YS, Towantakavanit K, Kowalska T, Jung ST, Ham KS, Heo BG, Cho JY, Yun JG, Kim HJ, Gorinstein S (2009) Bioactive compounds and antioxidant and antiproliferative activities of Korean white lotus cultivars. J Med Food 12(5):1057–1064PubMedCrossRefGoogle Scholar
  181. Peng ZY, Zhang SD, Liu S, He BM (2011) Protective effect of neferine on endothelial cell nitric oxide production induced by lysophosphatidylcholine: the role of the DDAH-ADMA pathway. Can J Physiol Pharmacol 89(4):289–294PubMedCrossRefGoogle Scholar
  182. Phillips R, Rix M (1993) Vegetables. Pan Books, London, 270ppGoogle Scholar
  183. Phonkot N, Wangsomnuk PP, Aromdee C (2008) Antioxidant activity and DNA fingerprint of four varieties of lotus stamens (Nelumbo nucifera Gaertn.). Songklanakarin J Sci Technol 30(1):55–58Google Scholar
  184. Phonkot N, Wangsomnuk PP, Aromdee C (2010) High-performance liquid chromatographic determination of β-carotene content in four varieties of lotus stamens. Songklanakarin J Sci Technol 32(4):373–377Google Scholar
  185. Poornima P, Quency RS, Padma VV (2013a) Neferine induces reactive oxygen species mediated intrinsic pathway of apoptosis in HepG2 cells. Food Chem 136(2):659–667PubMedCrossRefGoogle Scholar
  186. Poornima P, Weng CF, Padma VV (2013b) Neferine from Nelumbo nucifera induces autophagy through the inhibition of PI3K/Akt/mTOR pathway and ROS hyper generation in A549 cells. Food Chem 141(4):3598–3605PubMedCrossRefGoogle Scholar
  187. Poornima P, Weng CF, Padma VV (2014) Neferine, an alkaloid from lotus seed embryo, inhibits human lung cancer cell growth by MAPK activation and cell cycle arrest. Biofactors 40(1):121–131PubMedCrossRefGoogle Scholar
  188. Qian JQ (2002) Cardiovascular pharmacological effects of bisbenzylisoquinoline alkaloid derivatives. Acta Pharmacol Sin 23(12):1086–1092PubMedGoogle Scholar
  189. Rahman W, Ilyas M, Khan AW (1962) Flower pigments: Flavonoids from Nelumbo nucifera Gaerten. Naturwissenschaften 49(14):327CrossRefGoogle Scholar
  190. Rai S, Wahile A, Mukherjee K, Saha BP, Mukherjee PK (2006) Antioxidant activity of Nelumbo nucifera (sacred lotus) seeds. J Ethonopharmacol 104(3):322–327CrossRefGoogle Scholar
  191. Sakuljaitrong S, Buddhakala N, Chomko S, Talubmook C (2013) Effects of flower extract from lotus (Nelumbo nucifera) on hypoglycemic and hypolipidemic in streptozotocin-induced diabetic rats. J Sci Eng Res 4(7):1441–1446Google Scholar
  192. Santhoshkumar T, Rahuman AA, Rajakumar G, Marimuthu S, Bagavan A, Jayaseelan C, Zahir AA, Elango G, Kamaraj C (2011) Synthesis of silver nanoparticles using Nelumbo nucifera leaf extract and its larvicidal activity against malaria and filariasis vectors. Parasitol Res 108(3):693–702PubMedCrossRefGoogle Scholar
  193. Santhoshkumar T, Rahuman AA, Bagavan A, Kirthi AV, Marimuthu S, Jayaseelan C, Kamaraj C, Zahir AA, Elango G, Rajakumar G, Velayutham K (2012) Efficacy of adulticidal and larvicidal properties of botanical extracts against Haemaphysalis bispinosa, Hippobosca maculata, and Anopheles subpictus. Parasitol Res 111(4):1833–1840PubMedCrossRefGoogle Scholar
  194. Shad MA, Nawaz H, Hussain M, Yousuf B (2011) Proximate composition and functional properties of rhizomes of lotus (Nelumbo nucifera) from Punjab, Pakistan. Pak J Bot 43(2):895–904Google Scholar
  195. Shen-Miller J, Lindner P, Xie Y, Villa S, Wooding K, Clarke SG, Loo RRO, Loo JA (2013) Thermal-stable proteins of fruit of long-living sacred lotus Nelumbo nucifera Gaertn var. China Antique. Trop Plant Biol 6(2–3):69–84CrossRefGoogle Scholar
  196. Shim SY, Choi JS, Byun DS (2009) Kaempferol isolated from Nelumbo nucifera stamens negatively regulates FcepsilonRI expression in human basophilic KU812F cells. J Microbiol Biotechnol 19(2):155–160PubMedCrossRefGoogle Scholar
  197. Shoji N, Umeyama A, Saito N, Iuchi A, Takemoto T, Kajiwara A, Ohizumi Y (1987) Asimilobine and lirinidine, serotoninergic receptor antagonists, from Nelumbo nucifera. J Nat Prod 50(4):773–774PubMedCrossRefGoogle Scholar
  198. Shrestha MK, Knud-Hansen CF (1994) Increasing attached microorganism biomass as a management strategy for Nile tilapia (Oreochromis niloticus) production. Aquacult Eng 13:101–108CrossRefGoogle Scholar
  199. Siegner R, Heuser S, Holtzmann U, Söhle J, Schepky A, Raschke T, Stäb F, Wenck H, Winnefeld M (2010) Lotus leaf extract and l-carnitine influence different processes during the adipocyte life cycle. Nutr Metab 7:66–75CrossRefGoogle Scholar
  200. Sinha S, Mukherjee PK, Mukherjee K, Pal M, Mandal SC, Saha BP (2000) Evaluation of antipyretic potential of Nelumbo nucifera stalk extract. Phytother Res 14(4):272–274PubMedCrossRefGoogle Scholar
  201. Sittiwet C (2009) Antimicrobial activity of essential oil from Nelumbo nucifera Gaertn. Pollen. Int J Pharmacol 5(1):98–100CrossRefGoogle Scholar
  202. Smith RV, Sood SP (1971) In vitro metabolism of certain nornuciferine derivatives. J Pharm Sci 60(11):1654–1658PubMedCrossRefGoogle Scholar
  203. Sohn DH, Kim YC, Oh SH, Park EJ, Li X, Lee BH (2003) Hepatoprotective and free radical scavenging effects of Nelumbo nucifera. Phytomedicine 10(2–3):165–169PubMedCrossRefGoogle Scholar
  204. Sridhar KR, Bhat R (2007) Lotus-a potential nutraceutical source. J Agric Technol 3(1):143–155Google Scholar
  205. Subashini R, Ponmurugan P, Rajadurai M (2012) Nelumbo nucifera leaf extract ameliorates lipidperoxides and antioxidants in isoproterenolinduced myocardial infarction: biochemical and histological examination. J Pharm Res 5(7):3878–3882Google Scholar
  206. Sugimoto Y, Furutani S, Itoh A, Tanahashi T, Nakajima H, Oshiro H, Sun S, Yamada J (2008) Effects of extracts and neferine from the embryo of Nelumbo nucifera seeds on the central nervous system. Phytomedicine 15(12):1117–1124PubMedCrossRefGoogle Scholar
  207. Sugimoto Y, Furutani S, Nishimura K, Itoh A, Tanahashi T, Nakajima H, Oshiro H, Sun S, Yamada J (2010) Antidepressant-like effects of neferine in the forced swimming test involve the serotonin1A (5-HT1A) receptor in mice. Eur J Pharmacol 634(1–3):62–67PubMedCrossRefGoogle Scholar
  208. Sung JH, Sung JS, Shin HS (2011) Cytoprotective effects of lotus (Nelumbo nucifera Gaertner) seed extracts on oxidative damaged mouse embryonic fibroblast cell. Food Sci Biotechnol 20(6):1533–1537CrossRefGoogle Scholar
  209. Suthienkul O, Miyazaki O, Chulasiri M, Kositanont U, Oishi K (1993) Retroviral reverse transcriptase inhibitory activity in Thai herbs and spices: screening with Moloney murine leukemia viral enzyme. Southeast Asian J Trop Med Public Health 24(4):751–755PubMedGoogle Scholar
  210. Suzuki A, Kaneyama M, Shibanuma K, Takeda Y, Abe J, Hizukuri S (1992) Characterization of lotus starch. Cereal Chem 69(3):309–315Google Scholar
  211. Talukder MJ, Nessa J (1998) Effect of Nelumbo nucifera rhizome extract on the gastrointestinal tract of rat. Bangladesh Med Res Counc Bull 24(1):6–9PubMedGoogle Scholar
  212. Tanaka Y, Nguyen VK (2007) Edible wild plants of Vietnam: the bountiful garden. Orchid Press, Bangkok, 175 ppGoogle Scholar
  213. Tang CC, Lin WL, Lee YJ, Tang YC, Wang CJ (2014) Polyphenol-rich extract of Nelumbo nucifera leaves inhibits alcohol-induced steatohepatitis via reducing hepatic lipid accumulation and anti-inflammation in C57BL/6 J mice. Food Funct 5(4):678–687PubMedCrossRefGoogle Scholar
  214. Tang W, Eisenbrand G (1992) Chinese drugs of plant origin. Springer, Berlin/Heidelberg/New York/London/Paris/Tokyo/Hong Kong, 1065 ppCrossRefGoogle Scholar
  215. Thongtha S, Teamkao P, Boonapatcharoen N, Tripetchkul S, Techkarnjararuk S, Thiravetyan P (2014) Phosphorus removal from domestic wastewater by Nelumbo nucifera Gaertn. and Cyperus alternifolius L. J Environ Manage 137:54–60PubMedCrossRefGoogle Scholar
  216. Tian N, Liu Z, Huang J, Luo G, Liu S, Liu X (2007) Isolation and preparation of flavonoids from the leaves of Nelumbo nucifera Gaertn by preparative reversed-phase high performance liquid chromatography. Se Pu 25(1):88–92 (In Chinese)PubMedGoogle Scholar
  217. Tomita M, Furukawa H (1962) On the alkaloids of Nelumbo nucifera Gaertn. V. Alkaloids of Ohga-Hasu. Yakugaku Zasshi 82(10):1458–1460 (In Japanese)PubMedGoogle Scholar
  218. Tomita M, Watanabe Y, Furukawa H (1961a) On the alkaloids of Nelumbo nucifera Gaertn. II. Structure of nornuciferine. Yakugaku Zasshi 81(7):942–947 (In Japanese)Google Scholar
  219. Tomita M, Watanabe Y, Furukawa H (1961b) On the alkaloids of Nelumbo nucifera Gaertn. IV. Isolation of dl-armepavine. Yakugaku Zasshi 81(11):1644–1647 (In Japanese)Google Scholar
  220. Tomita M, Watanabe Y, Tomita M, Furukawa H (1961c) On the alkaloids of Nelumbo nucifera Gaertn. I. Yakugaku Zasshi 81(4):469–473 (In Japanese)Google Scholar
  221. Tomita M, Furukawa H, Yang TH, Lin TJ (1964) Studies on the alkaloids of loti embryo. I. Structure of isoliensinine. Tetrahedron Lett 5(37):2637–2642CrossRefGoogle Scholar
  222. Tomita M, Furukawa H, Yang TH, Lin TJ (1965) On the alkaloids of Nelumbo nucifera Gaertn. VIII. Studies on the alkaloids of loti embryo. (1). Structure of isoliensinine, a new biscoclaurine type alkaloid. Chem Pharm Bull 13(1):39–43PubMedCrossRefGoogle Scholar
  223. Tomita M, Kunitomo J, Miyoshi M, Maruyama T, Yuge E (1971) Studies on the Alkaloids of Nelumbo nucifera Gaertn. XV: synthesis of dl-Nornuciferine (dl-1-Methoxy-2-hydroxyaporphine). Yakugaku Zasshi 91(8):896–900 (In Japanese)Google Scholar
  224. Tsuruta Y, Nagao K, Kai S, Tsuge K, Yoshimura T, Koganemaru K, Yanagita T (2011) Polyphenolic extract of lotus root (edible rhizome of Nelumbo nucifera) alleviates hepatic steatosis in obese diabetic db/db mice. Lipids Health Dis 10(1):202–230PubMedCentralPubMedCrossRefGoogle Scholar
  225. Tsuruta Y, Nagao K, Shirouchi B, Nomura S, Tsuge K, Koganemaru K, Yanagita T (2012) Effects of lotus root (the edible rhizome of Nelumbo nucifera) on the development of non-alcoholic fatty liver disease in obese diabetic db/db mice. Biosci Biotechnol Biochem 76(3):462–466PubMedCrossRefGoogle Scholar
  226. U.S. Department of Agriculture, Agricultural Research Service (USDA-ARS) (2014) USDA national nutrient database for standard reference, release 26. Nutrient data laboratoryhome page. http://www.ars.usda.gov/ba/bhnrc/ndl
  227. Ushimaru T, Kanematsu S, Katayama M, Tsuji H (2001) Antioxidative enzymes in seedlings of Nelumbo nucifera germinated under water. Physiol Plant 112(1):39–46PubMedCrossRefGoogle Scholar
  228. Ushimaru T, Hasegawa T, Amano T, Katayama M, Tanaka S, Tsuji H (2003) Chloroplasts in seeds and dark-grown seedlings of lotus. J Plant Physiol 160(3):321–324PubMedCrossRefGoogle Scholar
  229. Velusami CC, Agarwal A, Mookambeswaran V (2013) Effect of Nelumbo nucifera petal extracts on lipase, adipogenesis, adipolysis, and central receptors of obesity. Evid Based Comp Alternat Med 2013. Article ID 145925Google Scholar
  230. Wan JD, Zhao LB, Xu C, Zhang SH, Zhang ZX, Zeng C, Chang MJ, Xiao JH, Wang JL (2011) Effects of neferine on the pharmacokinetics of amiodarone in rats. Biomed Chromatogr 25(8):858–866PubMedCrossRefGoogle Scholar
  231. Wang JL, Hu XM, Yin WH, Cai HS (1991) Studies on alkaloids of Plumula Nelumbinis. Zhongguo Zhong Yao Za Zhi (J Chin Mat Med) 16(11):673–675, 703. (In Chinese)Google Scholar
  232. Wang JL, Nong Y, Jing MX (1992) Effects of liensinine on haemodynamics in rats and the physiologic properties of isolated rabbit atria. Yao Xue Xue Bao 27(12):881–885 (In Chinese)PubMedGoogle Scholar
  233. Wang JL, Nong Y, Xia GJ, Yao WX, Jiang MX (1993) Effects of linesinine on slow action potentials in myocardium and slow inward current in canine cardiac Purkinje fibers. Yao Xue Xue Bao 28(11):812–816 (In Chinese)PubMedGoogle Scholar
  234. Wang YX, Liu B, Shi RB (2008) HPLC determination of 2-hydroxy-1-methoxyaporphine, pronuciferine, nuciferine and roemerine in Nelumbo nucifera and its alkaloid fraction. Zhongguo Zhong Yao Za Zhi 33(14):1713–1716 (In Chinese)PubMedGoogle Scholar
  235. Wang X, Liu JH, Geng YL, Wang DJ, Dong HJ, Zhang TY (2010) Preparative separation of alkaloids from Nelumbo nucifera Gaertn by pH-zone-refining counter-current chromatography. J Sep Sci 33(4–5):539–544PubMedCrossRefGoogle Scholar
  236. Wang HM, Yang WL, Yang SC, Chen CY (2011) Chemical constituents from the leaves of Nelumbo nucifera Gaertn. cv. Rosa-plena. Chem Nat Comp 47(2):316–318CrossRefGoogle Scholar
  237. Wassel G, Saeed A, Ibrahim N, El-Eraqy W (1996) Flavonoids of Nelumbo nucifera Gaertn and biological evaluation. Egypt J Pharm Sci 37(1–6):585–595Google Scholar
  238. Weng TC, Shen CC, Chiu YT, Lin YL, Kuo CD, Huang YT (2009) Inhibitory effects of armepavine against hepatic fibrosis in rats. J Biomed Sci 16:78PubMedCentralPubMedCrossRefGoogle Scholar
  239. Wongwattanasathien O, Kangsadalampai K, Tongyonk L (2010) Antimutagenicity of some flowers grown in Thailand. Food Chem Toxicol 48(4):1045–1051PubMedCrossRefGoogle Scholar
  240. Wu MJ, Wang L, Weng CY, Yen JH (2003) Antioxidant activity of methanol extract of the lotus leaf (Nelumbo nucifera Gertn.). Am J Chin Med 31(5):687–698PubMedCrossRefGoogle Scholar
  241. Wu SH, Sun CR, Cao XJ, Zhou H, Hong Z, Pan YJ (2004) Preparative counter-current chromatography isolation of liensinine and its analogues from embryo of the seed of Nelumbo nucifera GAERTN. using upright coil planet centrifuge with four multilayer coils connected in series. J Chromatogr A 1041(1–2):153–162PubMedCrossRefGoogle Scholar
  242. Wu CH, Yang MY, Chan KC, Chung PJ, Ou TT, Wang CJ (2010) Improvement in high-fat diet-induced obesity and body fat accumulation by a Nelumbo nucifera leaf flavonoid-rich extract in mice. J Agric Food Chem 58(11):7075–7081PubMedCrossRefGoogle Scholar
  243. Wu YB, Zheng LJ, Wu JG, Chen TQ, Yi J, Wu JZ (2012) Antioxidant activities of extract and fractions from receptaculum nelumbinis and related flavonol glycosides. Int J Mol Sci 13(6):7163–7173PubMedCentralPubMedCrossRefGoogle Scholar
  244. Wu YB, Zheng LJ, Yi J, Wu JG, Chen TQ, Wu JZ (2013) Quantitative and chemical fingerprint analysis for the quality evaluation of Receptaculum Nelumbinis by RP-HPLC coupled with hierarchical clustering analysis. Int J Mol Sci 14(1):1999–2010PubMedCentralPubMedCrossRefGoogle Scholar
  245. Xiao JH, Zhang JH, Chen HL, Feng XL, Wang JL (2005) Inhibitory effects of isoliensinine on bleomycin-induced pulmonary fibrosis in mice. Planta Med 71(3):225–230PubMedCrossRefGoogle Scholar
  246. Xiao JH, Zhang YL, Feng XL, Wang J, Qian JQ (2006) Effects of isoliensinine on angiotensin II-induced proliferation of porcine coronary arterial smooth muscle cells. J Asian Nat Prod Res 8(3):209–216PubMedCrossRefGoogle Scholar
  247. Xiao H, Chen AH, Ji AM, Li ZL, Song XD (2007) Isolation and identification of pronuciferine monomer. Zhong Yao Cai 30(3):289–291 (In Chinese)PubMedGoogle Scholar
  248. Xiao JS, Xie BJ, Cao YP, Wu H, Sun ZD, Xiao D (2012) Characterization of oligomeric procyanidins and identification of quercetin glucuronide from lotus (Nelumbo nucifera Gaertn.) seedpod. J Agric Food Chem 60(11):2825–2829PubMedCrossRefGoogle Scholar
  249. Xie B, Wan J, Wang WQ, Shi CY, Hou XL, Fang JG (2011) Nelumbo nucifera alkaloid inhibits 3 T3-L1 preadipocyte differentiation and improves high-fat diet-induced obesity and body fat accumulation in rats. J Med Plants Res 5(10):2021–2028Google Scholar
  250. Xu X, Dong J, Mu XF, Sun LP (2011a) Supercritical CO2 extraction of oil, carotenoids, squalene and sterols from lotus (Nelumbo nucifera Gaertn) bee pollen. Food Bioprod Process Trans Inst Chem Eng Part C 89(1):47–52CrossRefGoogle Scholar
  251. Xu X, Sun CR, Dai XJ, Hu RL, Pan YJ, Yang ZF (2011b) LC/MS guided isolation of alkaloids from lotus leaves by pH-zone-refining counter-current chromatography. Molecules 3:2551–2560CrossRefGoogle Scholar
  252. Xu SH, Sun Y, Jing F, Duan WJ, Du JH, Wang X (2011c) Separation and purification of flavones from Nelumbo nucifera Gaertn. by silica gel chromatography and high-speed counter-current chromatography. Se Pu 29(12):1244–1248 (In Chinese)PubMedGoogle Scholar
  253. Yan SL, Wang QZ, Peng GH (2009) Determination of catechin in lotus rhizomes by high-performance liquid chromatography. Int J Food Sci Nutr 60(5):432–438PubMedCrossRefGoogle Scholar
  254. Yang TH, Chen CM (1970a) Isolation of methylcorypalline from embryo loti. J Chin Chem Soc (Taipei) 17(1):54–56CrossRefGoogle Scholar
  255. Yang TH, Chen CM (1970b) On the alkaloids of Nelumbo nucifera Gaertn. Studies on the alkaloid of loti embryo. J Chin Chem Soc (Taipei) 17(4):113–120Google Scholar
  256. Yang TH, Chen CM, Lu CS, Liao CL (1972) Studies on the alkaloids of lotus receptacle. J Chin Chem Soc 19(3):143–147 (In Chinese)CrossRefGoogle Scholar
  257. Yang DM, Wang QS, Ke LQ, Jiang JM, Ying TJ (2007) Antioxidant activities of various extracts of lotus (Nelumbo nuficera Gaertn) rhizome. Asia Pac J Clin Nutr 16(Suppl 1):158–163PubMedGoogle Scholar
  258. Yang WM, Shim KJ, Choi MJ, Park SY, Choi BJ, Chang MS, Park SK (2008) Novel effects of Nelumbo nucifera rhizome extract on memory and neurogenesis in the dentate gyrus of the rat hippocampus. Neurosci Lett 443(2):104–107PubMedCrossRefGoogle Scholar
  259. Yang RZ, Wei XL, Gao FF, Wang LS, Zhang HJ, Xu YJ, Li CH, Ge YX, Zhang JJ, Zhang J (2009) Simultaneous analysis of anthocyanins and flavonols in petals of lotus (Nelumbo) cultivars by high-performance liquid chromatography-photodiode array detection/electro-spray ionization mass spectrometry. J Chromatogr A 1216:106–112PubMedCrossRefGoogle Scholar
  260. Yang MY, Chang YC, Chan KC, Lee YJ, Wang CJ (2011) Flavonoid-enriched extracts from Nelumbo nucifera leaves inhibits proliferation of breast cancer in vitro and in vivo. Eur J Integr Med 3(3):e153–e163CrossRefGoogle Scholar
  261. Yang ZD, Zhang X, Du J, Ma ZJ, Guo F, Li S, Yao XJ (2012) An aporphine alkaloid from Nelumbo nucifera as an acetylcholinesterase inhibitor and the primary investigation for structure–activity correlations. Nat Prod Res 26(5):387–392PubMedCrossRefGoogle Scholar
  262. Ye LH, He XX, Kong LT, Liao YH, Pan RL, Xiao BX, Liu XM, Chang Q (2014a) Identification and characterization of potent CYP2D6 inhibitors in lotus leaves. J Ethnopharmacol 153(1):190–196PubMedCrossRefGoogle Scholar
  263. Ye LH, He XX, Yan MZ, Chang Q (2014b) Identification of in vivo components in rats after oral administration of lotus leaf flavonoids using ultra fast liquid chromatography with tandem mass spectrometry. Anal Methods 6:6088–6094CrossRefGoogle Scholar
  264. Yen GC, Duh PD, Su HJ, Yeha CT, Wu CH (2006) Scavenging effects of lotus seed extracts on reactive nitrogen species. Food Chem 94(4):596–602CrossRefGoogle Scholar
  265. Yoo DY, Kim W, Yoo KY, Lee CH, Choi JH, Kang IJ, Yoon YS, Kim DW, Won MH, Hwang IK (2011) Effects of Nelumbo nucifera rhizome extract on cell proliferation and neuroblast differentiation in the hippocampal dentate gyrus in a scopolamine-induced amnesia animal model. Phytother Res 25(6):809–815PubMedCrossRefGoogle Scholar
  266. Yoon JS, Kim HM, Yadunandam AK, Kim NH, Jung HA, Choi JS, Kim CY, Kim GD (2013) Neferine isolated from Nelumbo nucifera enhances anti-cancer activities in Hep3B cells: molecular mechanisms of cell cycle arrest, ER stress induced apoptosis and anti-angiogenic response. Phytomedicine 20(11):1013–1022PubMedCrossRefGoogle Scholar
  267. You JS, Lee YJ, Kim KS, Kim SH, Chang KJ (2014a) Anti‐obesity and hypolipidaemic effects of Nelumbo nucifera seed ethanol extract in human pre‐adipocytes and rats fed a high‐fat diet. J Sci Food Agric 94(3):568–575PubMedCrossRefGoogle Scholar
  268. You JS, Lee YJ, Kim KS, Kim SH, Chang KJ (2014b) Ethanol extract of lotus (Nelumbo nucifera) root exhibits an anti-adipogenic effect in human pre-adipocytes and anti-obesity and anti-oxidant effects in rats fed a high-fat diet. Nutr Res 34(3):258–267PubMedCrossRefGoogle Scholar
  269. Youn UJ, Lee JH, Lee YJ, Nam JW, Bae H, Seo EK (2010) Regulation of the 5‐HT3A receptor‐mediated current by alkyl 4‐hydroxybenzoates isolated from the seeds of Nelumbo nucifera. Chem Biodivers 7(9):2296–2302PubMedCrossRefGoogle Scholar
  270. Yu J, Hu WS (1997) Effects of neferine on platelet aggregation in rabbits. Yaoxue Xuebao 32:1–4 (In Chinese)Google Scholar
  271. Yu HG, Cheng LB, Yin JJ, Yan SJ, Liu KJ, Zhang FM, Xu B, Li LJ (2013a) Structure and physicochemical properties of starches in lotus (Nelumbo nucifera Gaertn.) rhizome. Food Sci Nutr 1(4):273–283PubMedCentralPubMedCrossRefGoogle Scholar
  272. Yu LS, Shen Q, Zhou Q, Jiang HD, Bi HC, Huang M, Zhou H, Zeng S (2013b) In vitro characterization of ABC transporters involved in the absorption and distribution of liensinine and its analogs. J Ethnopharmacol 150(2):485–491PubMedCrossRefGoogle Scholar
  273. Zhang XY, Liu ZJ, Xu B, Sun ZL, Gong YQ, Shao CS (2012) Neferine, an alkaloid ingredient in lotus seed embryo, inhibits proliferation of human osteosarcoma cells by promoting p38 MAPK-mediated p21 stabilization. Eur J Pharmacol 677(1–3):47–54PubMedCrossRefGoogle Scholar
  274. Zhang Y, Wang Y, Zheng BD, Lu X, Zhuang WJ (2013a) The in vitro effects of retrograded starch (resistant starch type 3) from lotus seed starch on the proliferation of Bifidobacterium adolescentis. Food Funct 4(11):1609–1616PubMedCrossRefGoogle Scholar
  275. Zhang YJ, Hao XY, Liang ZS, Ke WD, Guo HB (2013b) Efficient isolation of high-quality RNA from lotus Nelumbo nucifera ssp nucifera tissues. Genet Mol Res 12(1):223–229PubMedCrossRefGoogle Scholar
  276. Zhang Y, Zeng HL, Wang Y, Zeng SX, Zheng BD (2014) Structural characteristics and crystalline properties of lotus seed resistant starch and its prebiotic effects. Food Chem 155:311–318PubMedCrossRefGoogle Scholar
  277. Zhao X, Shen J, Chang KJ, Kim SH (2013a) Analysis of Fatty acids and phytosterols in ethanol extracts of Nelumbo nucifera seeds and rhizomes by GC-MS. J Agric Food Chem 61(28):6841–6847PubMedCrossRefGoogle Scholar
  278. Zhao XL, Wang ZM, Ma XJ, Jing WG, Liu A (2013b) Chemical constituents from leaves of Nelumbo nucifera. Zhongguo Zhong Yao Za Zhi 38(5):703–708 (In Chinese)PubMedGoogle Scholar
  279. Zhao X, Shen J, Chang KJ, Kim SH (2014) Comparative analysis of antioxidant activity and functional components of the ethanol extract of lotus (Nelumbo nucifera) from various growing regions. J Agric Food Chem 62(26):6227–6235PubMedCrossRefGoogle Scholar
  280. Zheng ZJ, Wang ML, Wang DJ, Duan WJ, Wang X, Zheng CC (2010) Preparative separation of alkaloids from Nelumbo nucifera leaves by conventional and pH-zone-refining counter-current chromatography. J Chromatogr B Analyt Technol Biomed Life Sci 878(19):1647–1651PubMedCrossRefGoogle Scholar
  281. Zhong G, Chen ZD, WeYM (2007) Physicochemical properties of lotus (Nelumbo nucifera Gaertn.) and kudzu (Pueraria hirsuta Matsum.) starches. Int J Food Sci Technol 42(12):1449–1455CrossRefGoogle Scholar
  282. Zhou MG, Jiang M, Ying XH, Cui QX, Han YQ, Hou YY, Gao J, Bai G, Luo GA (2013a) Identification and comparison of anti-inflammatory ingredients from different organs of Lotus Nelumbo by UPLC/Q-TOF and PCA coupled with a NF-κB reporter gene assay. PLoS One 8(11):1Google Scholar
  283. Zhou YJ, Xiang JZ, Yuan H, Liu H, Tang Q, Hao HZ, Yin Z, Wang J, Ming ZY (2013b) Neferine exerts its antithrombotic effect by inhibiting platelet aggregation and promoting dissociation of platelet aggregates. Thromb Res 132(2):202–210PubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • T. K. Lim
    • 1
  1. 1.CanberraAustralia

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