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Mechanisms of l-Arginine-Auxotrophic Response and Their Cancer Therapeutic Implications

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L-Arginine in Clinical Nutrition

Part of the book series: Nutrition and Health ((NH))

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Abstract

l-arginine (Arg) is a semi-essential amino acid. Because there is no specific storage system for the cellular l-Arg pool, Arg needs to be de novo synthesized or directly acquired from an extracellular source to meet physiological need. Different organs have different requirements of Arg. For example, sufficient Arg is synthesized in the liver and kidney of an adult but not sufficient to the growing child (Chaveroux et al. Biochimie 92:736–745, 2010). Arg is essential for fetuses and neonates.

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Author information

Authors and Affiliations

  1. Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, 2130 West Holcombe, Houston, TX, 77030, USA

    Wen-Bin Tsai PhD, Yan Long MD & Macus Tien Kuo PhD

  2. Hematology-Oncology Section, VA Medical Center, Sylvester Comprehensive Cancer Center, 1201 N.W. 16th Street, Miami, FL, 33125, USA

    Niramol Savaraj MD

  3. Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, FL, 33136, USA

    Lynn G. Feun MD

Authors
  1. Wen-Bin Tsai PhD
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  2. Yan Long MD
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  3. Niramol Savaraj MD
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  4. Lynn G. Feun MD
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  5. Macus Tien Kuo PhD
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Corresponding author

Correspondence to Wen-Bin Tsai PhD .

Editor information

Editors and Affiliations

  1. Faculty of Science & Technology Department of Biomedical Sciences, University of Westminster, London, United Kingdom

    Vinood B. Patel

  2. Department Nutrition and Dietetics Nutritional Sciences Division School of Biomedical & Health Sciences, King’s College London, London, United Kingdom

    Victor R. Preedy

  3. Nutritional Sciences Research Division Faculty of Life Science and Medicine, King’s College London, London, United Kingdom

    Rajkumar Rajendram

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Tsai, WB., Long, Y., Savaraj, N., Feun, L.G., Kuo, M.T. (2017). Mechanisms of l-Arginine-Auxotrophic Response and Their Cancer Therapeutic Implications. In: Patel, V., Preedy, V., Rajendram, R. (eds) L-Arginine in Clinical Nutrition. Nutrition and Health. Humana Press, Cham. https://doi.org/10.1007/978-3-319-26009-9_44

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  • DOI: https://doi.org/10.1007/978-3-319-26009-9_44

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  • Publisher Name: Humana Press, Cham

  • Print ISBN: 978-3-319-26007-5

  • Online ISBN: 978-3-319-26009-9

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