l-Arginine in the Uterus and Placenta and During Gestation in Mammals

  • Jonathan M. GreeneEmail author
  • Peter L. Ryan
Part of the Nutrition and Health book series (NH)


Often considered to be one of the most versatile amino acids, l-arginine is classified as a basic, cationic amino acid with three amine groups comprising a guanidino group in the side chain. l-arginine was first isolated from lupin seedlings by Schulze and Steiger (Z Physiol Chem 11:43–65, 1886), and shortly thereafter, Hedin (Z Physiol Chem 21:297–305, 1895) discovered that l-arginine is a component of animal proteins (as reviewed by Wu and Morris, Biochem J 336(Pt 1):1–17, 1998). Following the discovery of l-arginine, many efforts to determine its essentiality or dispensability were undertaken with a definitive answer still being debated today. The results from Scull and Rose (J Biol Chem 89(1):109–123, 1930) suggested that l-arginine was a dispensable or nonessential amino acid. This finding was repeated in humans by Rose and colleagues (J Biol Chem 206(1):421–430, 1954) who reported that removal of l-arginine from the diet did not result in a negative nitrogen balance in adult males.


l-arginine Nitric oxide Polyamines Uterus Placenta Pregnancy Gestation 


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© Springer International Publishing Switzerland 2017

Authors and Affiliations

  1. 1.Department of Pathobiology and Population Medicine, Department of Animal and Dairy SciencesMississippi State UniversityMississippi StateUSA
  2. 2.Department of Pathobiology and Population Medicine, Department of Animal and Dairy SciencesMississippi State UniversityMississippi StateUSA

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