Preservatives for Topical Ocular Drug Formulations

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Abstract

Although, the use of eye medications are known for their prolonged presence in the history, the concept of using preservatives in ocular drug formulations came to practice only after second World War. Usage of preservatives restricts the microbial growth in the opened ophthalmic drug formulations which are meant for multiple dosing. Preservatives used for ophthalmic formulations are not free from hurdles. This chapter explains the physical, chemical and biological preservation methods employed in ophthalmic dosage forms and the adverse effect of preservatives on eye.

Keywords

Ocular Surface Ophthalmic Solution Quaternary Ammonium Compound Benzalkonium Chloride Acanthamoeba Castellanii 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Ocular Pharmacology and PharmacyDr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical SciencesNew DelhiIndia

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