What Is the Risk? Dental Amalgam, Mercury Exposure, and Human Health Risks Throughout the Life Span

  • John KallEmail author
  • Amanda Just
  • Michael Aschner


All dental amalgam fillings contain approximately 50 % elemental mercury by weight. Concerns about health risks due to continual emissions of mercury vapor from this tooth restorative material have been addressed by dentists, scientists, and government authorities worldwide and have resulted in a range of recommended practices and regulations. By reviewing articles collected by a literature search of the International Academy of Oral Medicine and Toxicology (IAOMT) database and the PubMed database, we identify health risks associated with dental mercury amalgam. We present the science of potential harm as applicable to the general population, pregnant women, fetuses, children, and dental professionals. We specifically address genetic predispositions, mercury allergies, Alzheimer’s disease, multiple sclerosis, amyotrophic lateral sclerosis, and other health conditions pertinent to dental mercury exposure. We conclude that reviews and studies of dental amalgam mercury risk should assess biocompatibility with special consideration for all populations and all risk factors.


Multiple Sclerosis Autism Spectrum Disorder Amyotrophic Lateral Sclerosis Chronic Fatigue Syndrome Mercury Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Minimal funding for administrative costs of this work was provided by the International Academy of Oral Medicine and Toxicology (IAOMT). However, the views expressed in this publication do not necessarily reflect the views of the IAOMT, its Executive Council, Scientific Advisory Board, administration, membership, employees, contractors, etc.

The authors of this review are affiliated with the IAOMT in the following capacities: Dr. John Kall is the Chairperson of the Board and Accredited Master of the IAOMT, Amanda Just is the Program Director and a writer and researcher for the IAOMT, and Dr. Michael Aschner is a member of the Scientific Advisory Board for the IAOMT. Dr. Aschner was supported in part by grants from the NIH R01 ES07331 and R01 ES020852

Portions of this document were adapted from two documents created by the IAOMT:

Haley, B. E., Love, J. M., Virtue, W. E. (2012, October 10). Position statement of the International Academy of Oral Medicine and Toxicology in response to the ‘Call for Information’ extended by the Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR) European Commission. ChampionsGate, FL: IAOMT.

Kall, J., Robertson, K., Sukel, P., Just, A. (2013, April 16). International Academy of Oral Medicine and Toxicology (IAOMT) Position Statement against Dental Mercury Amalgam Fillings for Medical and Dental Practitioners, Dental Students, and Patients. ChampionsGate, FL: IAOMT.

The authors also wish to thank the Executive Council, Scientific Advisory Board, and the administration and membership of the IAOMT, especially Dr. Boyd Haley; James Love, Esq.; Dr. William Virtue; Dr. Kindal Robertson; and Dr. Phillip Sukel, for their research and writings that led to the publication of this article.


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.International Academy of Oral Medicine and ToxicologyChampionsGateUSA
  2. 2.Department of Molecular PharmacologyAlbert Einstein College of MedicineBronxUSA
  3. 3.Vanderbilt Kennedy Center for Research on Human DevelopmentNashvilleUSA

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