Metabolic Rhythm of Hepatic Lipogenesis: Regulation and Roles in Metabolism
Hepatic lipid metabolism is modulated by multiple pathways, including hormones (e.g., insulin and glucagon), energy/nutrient-sensing signaling, and circadian rhythm. The latter constitutes a pre-programmed transcriptional mechanism in anticipation of upcoming feeding/fasting metabolic cycles. Although the central clock is controlled by light, the peripheral clock, such as that in the liver, is very sensitive to the nutrient status. As such, studies in mice and humans have demonstrated that disrupted circadian rhythm is linked to metabolic diseases. This chapter will describe roles of the molecular clock and downstream nuclear receptors in the control of liver lipid metabolism. Potential mechanisms through which hepatic lipogenesis may affect peripheral metabolic homeostasis via lipid metabolites will also be discussed.
KeywordsCircadian rhythm Lipid metabolism Inter-organ communication Hepatic de novo lipogenesis Lipid mediator
Work in the laboratory of the authors is supported by National Institutes of Health grant R01DK075046 and American Diabetes Association grant 1-14-BS-122 (C-.H.L). H.J.C and R.K.A are supported by Herchel Smith Graduate Fellowship.
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