International Workshop on Machine Learning in Medical Imaging

MICCAI 2015: Machine Learning in Medical Imaging pp 178-185 | Cite as

Group-Constrained Laplacian Eigenmaps: Longitudinal AD Biomarker Learning

  • R. Guerrero
  • C. Ledig
  • A. Schmidt-Richberg
  • D. Rueckert
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 9352)

Abstract

Longitudinal modeling of biomarkers to assess a subject’s risk of developing Alzheimers disease (AD) or determine the current state in the disease trajectory has recently received increased attention.Here, a new method to estimate the time-to-conversion (TTC) of mild cognitive impaired (MCI) subjects to AD from a low-dimensional representation of the data is proposed. This is achieved via a combination of multilevel feature selection followed by a novel formulation of the Laplacian Eigenmaps manifold learning algorithm that allows the incorporation of group constraints.Feature selection is performed using Magnetic Resonance (MR) images that have been aligned at different detail levels to a template. The suggested group constraints are added to the construction of the neighborhood matrix which is used to calculate the graph Laplacian in the Laplacian Eigenmaps algorithm.The proposed formulation yields relevant improvements for the prediction of the TTC and for the three-way classification (control/MCI/AD) on the ADNI database.

Keywords

Feature Selection Mild Cognitive Impaired Linear Discriminant Analysis Local Binary Pattern Mini Mental State Examination Score 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • R. Guerrero
    • 1
  • C. Ledig
    • 1
  • A. Schmidt-Richberg
    • 1
  • D. Rueckert
    • 1
  1. 1.Biomedical Image Analysis GroupImperial College LondonLondonUK

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