Arterial Stiffness pp 27-41 | Cite as
Implications of Arterial Stiffness
Abstract
The implications for increased arterial stiffness are just now beginning to be understood. However, there is still much unknown in this emerging field of study. In this chapter we overview several areas of clinical importance that influence arterial stiffness, which include aging, sex, race, body composition, and cardiorespiratory fitness, and the implications of these on cardiovascular health and target organ damage. These discussions merely highlight the complex interactions that occur with aging alone, which become increasingly convoluted with multiple pathologies. Thus, our discussion only begins to elucidate the very complex processes contributing to aortic stiffness and the overall health implications.
Keywords
Heart Kidney Brain VO2 peak Epidemiology AortaReferences
- 1.Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, de Ferranti S, Despres JP, Fullerton HJ, Howard VJ, Huffman MD, Judd SE, Kissela BM, Lackland DT, Lichtman JH, Lisabeth LD, Liu S, Mackey RH, Matchar DB, McGuire DK, Mohler ER III, Moy CS, Muntner P, Mussolino ME, Nasir K, Neumar RW, Nichol G, Palaniappan L, Pandey DK, Reeves MJ, Rodriguez CJ, Sorlie PD, Stein J, Towfighi A, Turan TN, Virani SS, Willey JZ, Woo D, Yeh RW, Turner MB (2015) Heart disease and stroke statistics—2015 update: a report from the American Heart Association. Circulation 131(4):e29–e322. doi: 10.1161/cir.0000000000000152 CrossRefPubMedGoogle Scholar
- 2.Ben-Shlomo Y, Spears M, Boustred C, May M, Anderson SG, Benjamin EJ, Boutouyrie P, Cameron J, Chen CH, Cruickshank JK, Hwang SJ, Lakatta EG, Laurent S, Maldonado J, Mitchell GF, Najjar SS, Newman AB, Ohishi M, Pannier B, Pereira T, Vasan RS, Shokawa T, Sutton-Tyrell K, Verbeke F, Wang KL, Webb DJ, Willum Hansen T, Zoungas S, McEniery CM, Cockcroft JR, Wilkinson IB (2014) Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects. J Am Coll Cardiol 63(7):636–646. doi: 10.1016/j.jacc.2013.09.063 CrossRefPubMedGoogle Scholar
- 3.Blacher J, Asmar R, Djane S, London GM, Safar ME (1999) Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients. Hypertension 33(5):1111–1117CrossRefPubMedGoogle Scholar
- 4.Boutouyrie P, Tropeano AI, Asmar R, Gautier I, Benetos A, Lacolley P, Laurent S (2002) Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study. Hypertension 39(1):10–15CrossRefPubMedGoogle Scholar
- 5.Koivistoinen T, Virtanen M, Hutri-Kahonen N, Lehtimaki T, Jula A, Juonala M, Moilanen L, Aatola H, Hyttinen J, Viikari JS, Raitakari OT, Kahonen M (2012) Arterial pulse wave velocity in relation to carotid intima-media thickness, brachial flow-mediated dilation and carotid artery distensibility: the Cardiovascular Risk in Young Finns Study and the Health 2000 Survey. Atherosclerosis 220(2):387–393. doi: 10.1016/j.atherosclerosis.2011.08.007 CrossRefPubMedGoogle Scholar
- 6.Laurent S, Katsahian S, Fassot C, Tropeano AI, Gautier I, Laloux B, Boutouyrie P (2003) Aortic stiffness is an independent predictor of fatal stroke in essential hypertension. Stroke 34(5):1203–1206. doi: 10.1161/01.str.0000065428.03209.64 CrossRefPubMedGoogle Scholar
- 7.Mattace-Raso FU, van der Cammen TJ, Hofman A, van Popele NM, Bos ML, Schalekamp MA, Asmar R, Reneman RS, Hoeks AP, Breteler MM, Witteman JC (2006) Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study. Circulation 113(5):657–663. doi: 10.1161/circulationaha.105.555235 CrossRefPubMedGoogle Scholar
- 8.Mitchell GF, Hwang SJ, Vasan RS, Larson MG, Pencina MJ, Hamburg NM, Vita JA, Levy D, Benjamin EJ (2010) Arterial stiffness and cardiovascular events: the Framingham Heart Study. Circulation 121(4):505–511. doi: 10.1161/circulationaha.109.886655 CrossRefPubMedPubMedCentralGoogle Scholar
- 9.Pereira T, Maldonado J, Pereira L, Conde J (2013) Aortic stiffness is an independent predictor of stroke in hypertensive patients. Arq Bras Cardiol 100(5):437–443. doi: 10.5935/abc.20130079 PubMedGoogle Scholar
- 10.Pereira T, Maldonado J, Polonia J, Silva JA, Morais J, Rodrigues T, Marques M (2014) Aortic pulse wave velocity and HeartSCORE: improving cardiovascular risk stratification. A sub-analysis of the EDIVA (Estudo de DIstensibilidade VAscular) project. Blood Press 23(2):109–115. doi: 10.3109/08037051.2013.823760 CrossRefPubMedGoogle Scholar
- 11.Regnault V, Lagrange J, Pizard A, Safar ME, Fay R, Pitt B, Challande P, Rossignol P, Zannad F, Lacolley P (2014) Opposite predictive value of pulse pressure and aortic pulse wave velocity on heart failure with reduced left ventricular ejection fraction: insights from an Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) substudy. Hypertension 63(1):105–111. doi: 10.1161/hypertensionaha.113.02046 CrossRefPubMedGoogle Scholar
- 12.Vlachopoulos C, Aznaouridis K, Stefanadis C (2010) Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. J Am Coll Cardiol 55(13):1318–1327. doi: 10.1016/j.jacc.2009.10.061 CrossRefPubMedGoogle Scholar
- 13.Vlachopoulos C, Ioakeimidis N, Aznaouridis K, Terentes-Printzios D, Rokkas K, Aggelis A, Panagiotakos D, Stefanadis C (2014) Prediction of cardiovascular events with aortic stiffness in patients with erectile dysfunction. Hypertension 64(3):672–678. doi: 10.1161/hypertensionaha.114.03369 CrossRefPubMedGoogle Scholar
- 14.Vasan RS (2006) Biomarkers of cardiovascular disease: molecular basis and practical considerations. Circulation 113(19):2335–2362. doi: 10.1161/circulationaha.104.482570 CrossRefPubMedGoogle Scholar
- 15.Vigen R, Maddox TM, Allen LA (2012) Aging of the United States population: impact on heart failure. Curr Heart Fail Rep 9(4):369–374. doi: 10.1007/s11897-012-0114-8 CrossRefPubMedPubMedCentralGoogle Scholar
- 16.North BJ, Sinclair DA (2012) The intersection between aging and cardiovascular disease. Circ Res 110(8):1097–1108. doi: 10.1161/circresaha.111.246876 CrossRefPubMedPubMedCentralGoogle Scholar
- 17.Laurent S (2012) Defining vascular aging and cardiovascular risk. J Hypertens 30(suppl):S3–S8. doi: 10.1097/HJH.0b013e328353e501 CrossRefPubMedGoogle Scholar
- 18.AlGhatrif M, Strait JB, Morrell CH, Canepa M, Wright J, Elango P, Scuteri A, Najjar SS, Ferrucci L, Lakatta EG (2013) Longitudinal trajectories of arterial stiffness and the role of blood pressure: the Baltimore Longitudinal Study of Aging. Hypertension 62(5):934–941. doi: 10.1161/hypertensionaha.113.01445 CrossRefPubMedGoogle Scholar
- 19.Laurent S, Boutouyrie P, Asmar R, Gautier I, Laloux B, Guize L, Ducimetiere P, Benetos A (2001) Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 37(5):1236–1241CrossRefPubMedGoogle Scholar
- 20.Meaume S, Benetos A, Henry OF, Rudnichi A, Safar ME (2001) Aortic pulse wave velocity predicts cardiovascular mortality in subjects >70 years of age. Arterioscler Thromb Vasc Biol 21(12):2046–2050CrossRefPubMedGoogle Scholar
- 21.McEniery CM, Yasmin, Hall IR, Qasem A, Wilkinson IB, Cockcroft JR (2005) Normal vascular aging: differential effects on wave reflection and aortic pulse wave velocity: the Anglo-Cardiff Collaborative Trial (ACCT). J Am Coll Cardiol 46(9):1753–1760. doi: 10.1016/j.jacc.2005.07.037 CrossRefPubMedGoogle Scholar
- 22.Redheuil A, Yu WC, Wu CO, Mousseaux E, de Cesare A, Yan R, Kachenoura N, Bluemke D, Lima JA (2010) Reduced ascending aortic strain and distensibility: earliest manifestations of vascular aging in humans. Hypertension 55(2):319–326. doi: 10.1161/hypertensionaha.109.141275 CrossRefPubMedPubMedCentralGoogle Scholar
- 23.Mitchell GF, Guo CY, Benjamin EJ, Larson MG, Keyes MJ, Vita JA, Vasan RS, Levy D (2007) Cross-sectional correlates of increased aortic stiffness in the community: the Framingham Heart Study. Circulation 115(20):2628–2636. doi: 10.1161/circulationaha.106.667733 CrossRefPubMedGoogle Scholar
- 24.Gepner AD, Korcarz CE, Colangelo LA, Hom EK, Tattersall MC, Astor BC, Kaufman JD, Liu K, Stein JH (2014) Longitudinal effects of a decade of aging on carotid artery stiffness: the multiethnic study of atherosclerosis. Stroke 45(1):48–53. doi: 10.1161/strokeaha.113.002649 CrossRefPubMedGoogle Scholar
- 25.Scuteri A, Morrell CH, Orru M, Strait JB, Tarasov KV, Ferreli LA, Loi F, Pilia MG, Delitala A, Spurgeon H, Najjar SS, AlGhatrif M, Lakatta EG (2014) Longitudinal perspective on the conundrum of central arterial stiffness, blood pressure, and aging. Hypertension 64(6):1219–1227. doi: 10.1161/hypertensionaha.114.04127 CrossRefPubMedPubMedCentralGoogle Scholar
- 26.Logan JG, Barksdale DJ (2013) Pulse wave velocity in Korean American men and women. J Cardiovasc Nurs 28(1):90–96. doi: 10.1097/JCN.0b013e3182376685 CrossRefPubMedPubMedCentralGoogle Scholar
- 27.Winham SJ, de Andrade M, Miller VM (2015) Genetics of cardiovascular disease: importance of sex and ethnicity. Atherosclerosis. doi: 10.1016/j.atherosclerosis.2015.03.021 PubMedPubMedCentralGoogle Scholar
- 28.Manson JE, Bassuk SS (2015) Biomarkers of cardiovascular disease risk in women. Metabolism 64(3 suppl 1):S33–S39. doi: 10.1016/j.metabol.2014.10.028 CrossRefPubMedGoogle Scholar
- 29.Coutinho T, Borlaug BA, Pellikka PA, Turner ST, Kullo IJ (2013) Sex differences in arterial stiffness and ventricular-arterial interactions. J Am Coll Cardiol 61(1):96–103. doi: 10.1016/j.jacc.2012.08.997 CrossRefPubMedGoogle Scholar
- 30.Regnault V, Thomas F, Safar ME, Osborne-Pellegrin M, Khalil RA, Pannier B, Lacolley P (2012) Sex difference in cardiovascular risk: role of pulse pressure amplification. J Am Coll Cardiol 59(20):1771–1777. doi: 10.1016/j.jacc.2012.01.044 CrossRefPubMedPubMedCentralGoogle Scholar
- 31.Stern R, Tattersall MC, Gepner AD, Korcarz CE, Kaufman J, Colangelo LA, Liu K, Stein JH (2015) Sex differences in predictors of longitudinal changes in carotid artery stiffness: the Multi-Ethnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol 35(2):478–484. doi: 10.1161/atvbaha.114.304870 CrossRefPubMedGoogle Scholar
- 32.Graham G (2014) Population-based approaches to understanding disparities in cardiovascular disease risk in the United States. Int J Gen Med 7:393–400. doi: 10.2147/ijgm.s65528 CrossRefPubMedPubMedCentralGoogle Scholar
- 33.Kuzawa CW, Sweet E (2009) Epigenetics and the embodiment of race: developmental origins of US racial disparities in cardiovascular health. Am J Hum Biol 21(1):2–15. doi: 10.1002/ajhb.20822 CrossRefPubMedGoogle Scholar
- 34.Heffernan KS, Jae SY, Wilund KR, Woods JA, Fernhall B (2008) Racial differences in central blood pressure and vascular function in young men. Am J Physiol Heart Circ Physiol 295(6):H2380–H2387. doi: 10.1152/ajpheart.00902.2008 CrossRefPubMedGoogle Scholar
- 35.Morris AA, Patel RS, Binongo JN, Poole J, Al Mheid I, Ahmed Y, Stoyanova N, Vaccarino V, Din-Dzietham R, Gibbons GH, Quyyumi A (2013) Racial differences in arterial stiffness and microcirculatory function between Black and White Americans. J Am Heart Assoc 2(2), e002154. doi: 10.1161/jaha.112.002154 CrossRefPubMedPubMedCentralGoogle Scholar
- 36.Din-Dzietham R, Couper D, Evans G, Arnett DK, Jones DW (2004) Arterial stiffness is greater in African Americans than in whites: evidence from the Forsyth County, North Carolina, ARIC cohort. Am J Hypertens 17(4):304–313. doi: 10.1016/j.amjhyper.2003.12.004 CrossRefPubMedGoogle Scholar
- 37.Feinstein M, Ning H, Kang J, Bertoni A, Carnethon M, Lloyd-Jones DM (2012) Racial differences in risks for first cardiovascular events and noncardiovascular death: the Atherosclerosis Risk in Communities study, the Cardiovascular Health Study, and the Multi-Ethnic Study of Atherosclerosis. Circulation 126(1):50–59. doi: 10.1161/circulationaha.111.057232 CrossRefPubMedPubMedCentralGoogle Scholar
- 38.Pierce GL, Zhu H, Darracott K, Edet I, Bhagatwala J, Huang Y, Dong Y (2013) Arterial stiffness and pulse-pressure amplification in overweight/obese African-American adolescents: relation with higher systolic and pulse pressure. Am J Hypertens 26(1):20–26. doi: 10.1093/ajh/hps014 CrossRefPubMedGoogle Scholar
- 39.Huynh Q, Blizzard L, Sharman J, Magnussen C, Schmidt M, Dwyer T, Venn A (2013) Relative contributions of adiposity in childhood and adulthood to vascular health of young adults. Atherosclerosis 228(1):259–264. doi: 10.1016/j.atherosclerosis.2013.02.022 CrossRefPubMedGoogle Scholar
- 40.Orr JS, Gentile CL, Davy BM, Davy KP (2008) Large artery stiffening with weight gain in humans: role of visceral fat accumulation. Hypertension 51(6):1519–1524. doi: 10.1161/hypertensionaha.108.112946 CrossRefPubMedPubMedCentralGoogle Scholar
- 41.Schouten F, Twisk JW, de Boer MR, Stehouwer CD, Serne EH, Smulders YM, Ferreira I (2011) Increases in central fat mass and decreases in peripheral fat mass are associated with accelerated arterial stiffening in healthy adults: the Amsterdam Growth and Health Longitudinal Study. Am J Clin Nutr 94(1):40–48. doi: 10.3945/ajcn.111.013532 CrossRefPubMedGoogle Scholar
- 42.Strasser B, Arvandi M, Pasha EP, Haley AP, Stanforth P, Tanaka H (2015) Abdominal obesity is associated with arterial stiffness in middle-aged adults. Nutr Metab Cardiovasc Dis 25(5):495–502. doi: 10.1016/j.numecd.2015.01.002 CrossRefPubMedGoogle Scholar
- 43.Anoop S, Misra A, Bhardwaj S, Gulati S (2015) High body fat and low muscle mass are associated with increased arterial stiffness in Asian Indians in North India. J Diabetes Complications 29(1):38–43. doi: 10.1016/j.jdiacomp.2014.08.001 CrossRefPubMedGoogle Scholar
- 44.Nordstrand N, Gjevestad E, Dinh KN, Hofso D, Roislien J, Saltvedt E, Os I, Hjelmesaeth J (2011) The relationship between various measures of obesity and arterial stiffness in morbidly obese patients. BMC Cardiovasc Disord 11:7. doi: 10.1186/1471-2261-11-7 CrossRefPubMedPubMedCentralGoogle Scholar
- 45.Wykretowicz A, Adamska K, Guzik P, Krauze T, Wysocki H (2007) Indices of vascular stiffness and wave reflection in relation to body mass index or body fat in healthy subjects. Clin Exp Pharmacol Physiol 34(10):1005–1009. doi: 10.1111/j.1440-1681.2007.04666.x CrossRefPubMedGoogle Scholar
- 46.Corden B, Keenan NG, de Marvao AS, Dawes TJ, Decesare A, Diamond T, Durighel G, Hughes AD, Cook SA, O’Regan DP (2013) Body fat is associated with reduced aortic stiffness until middle age. Hypertension 61(6):1322–1327. doi: 10.1161/hypertensionaha.113.01177 CrossRefPubMedGoogle Scholar
- 47.Czernichow S, Bertrais S, Oppert JM, Galan P, Blacher J, Ducimetiere P, Hercberg S, Zureik M (2005) Body composition and fat repartition in relation to structure and function of large arteries in middle-aged adults (the SU.VI.MAX study). Int J Obes (Lond) 29(7):826–832. doi: 10.1038/sj.ijo.0802986 CrossRefGoogle Scholar
- 48.Sutton-Tyrrell K, Newman A, Simonsick EM, Havlik R, Pahor M, Lakatta E, Spurgeon H, Vaitkevicius P (2001) Aortic stiffness is associated with visceral adiposity in older adults enrolled in the study of health, aging, and body composition. Hypertension 38(3):429–433CrossRefPubMedGoogle Scholar
- 49.Benetos A, Zervoudaki A, Kearney-Schwartz A, Perret-Guillaume C, Pascal-Vigneron V, Lacolley P, Labat C, Weryha G (2009) Effects of lean and fat mass on bone mineral density and arterial stiffness in elderly men. Osteoporos Int 20(8):1385–1391. doi: 10.1007/s00198-008-0807-8 CrossRefPubMedGoogle Scholar
- 50.Fantin F, Rossi AP, Cazzadori M, Comellato G, Mazzali G, Gozzoli MP, Grison E, Zamboni M (2013) Central and peripheral fat and subclinical vascular damage in older women. Age Ageing 42(3):359–365. doi: 10.1093/ageing/aft005 CrossRefPubMedGoogle Scholar
- 51.Tanaka H, DeSouza CA, Seals DR (1998) Absence of age-related increase in central arterial stiffness in physically active women. Arterioscler Thromb Vasc Biol 18(1):127–132CrossRefPubMedGoogle Scholar
- 52.Zhu W, Hooker SP, Sun Y, Xie M, Su H, Cao J (2014) Associations of cardiorespiratory fitness with cardiovascular disease risk factors in middle-aged Chinese women: a cross-sectional study. BMC Womens Health 14:62. doi: 10.1186/1472-6874-14-62 CrossRefPubMedPubMedCentralGoogle Scholar
- 53.Quan HL, Blizzard CL, Sharman JE, Magnussen CG, Dwyer T, Raitakari O, Cheung M, Venn AJ (2014) Resting heart rate and the association of physical fitness with carotid artery stiffness. Am J Hypertens 27(1):65–71. doi: 10.1093/ajh/hpt161 CrossRefPubMedGoogle Scholar
- 54.Otsuki T, Maeda S, Iemitsu M, Saito Y, Tanimura Y, Ajisaka R, Miyauchi T (2007) Vascular endothelium-derived factors and arterial stiffness in strength- and endurance-trained men. Am J Physiol Heart Circ Physiol 292(2):H786–H791. doi: 10.1152/ajpheart.00678.2006 CrossRefPubMedGoogle Scholar
- 55.Tarumi T, Gonzales MM, Fallow B, Nualnim N, Pyron M, Tanaka H, Haley AP (2013) Central artery stiffness, neuropsychological function, and cerebral perfusion in sedentary and endurance-trained middle-aged adults. J Hypertens 31(12):2400–2409. doi: 10.1097/HJH.0b013e328364decc CrossRefPubMedGoogle Scholar
- 56.Bertovic DA, Waddell TK, Gatzka CD, Cameron JD, Dart AM, Kingwell BA (1999) Muscular strength training is associated with low arterial compliance and high pulse pressure. Hypertension 33(6):1385–1391CrossRefPubMedGoogle Scholar
- 57.Miyachi M, Kawano H, Sugawara J, Takahashi K, Hayashi K, Yamazaki K, Tabata I, Tanaka H (2004) Unfavorable effects of resistance training on central arterial compliance: a randomized intervention study. Circulation 110(18):2858–2863. doi: 10.1161/01.cir.0000146380.08401.99 CrossRefPubMedGoogle Scholar
- 58.Kawano H, Tanimoto M, Yamamoto K, Sanada K, Gando Y, Tabata I, Higuchi M, Miyachi M (2008) Resistance training in men is associated with increased arterial stiffness and blood pressure but does not adversely affect endothelial function as measured by arterial reactivity to the cold pressor test. Exp Physiol 93(2):296–302. doi: 10.1113/expphysiol.2007.039867 CrossRefPubMedGoogle Scholar
- 59.Cook JN, DeVan AE, Schleifer JL, Anton MM, Cortez-Cooper MY, Tanaka H (2006) Arterial compliance of rowers: implications for combined aerobic and strength training on arterial elasticity. Am J Physiol Heart Circ Physiol 290(4):H1596–H1600. doi: 10.1152/ajpheart.01054.2005 CrossRefPubMedGoogle Scholar
- 60.Mero AA, Hulmi JJ, Salmijarvi H, Katajavuori M, Haverinen M, Holviala J, Ridanpaa T, Hakkinen K, Kovanen V, Ahtiainen JP, Selanne H (2013) Resistance training induced increase in muscle fiber size in young and older men. Eur J Appl Physiol 113(3):641–650. doi: 10.1007/s00421-012-2466-x CrossRefPubMedGoogle Scholar
- 61.Mitchell GF (2015) Arterial stiffness: insights from Framingham and Iceland. Curr Opin Nephrol Hypertens 24(1):1–7. doi: 10.1097/mnh.0000000000000092 CrossRefPubMedGoogle Scholar
- 62.Park JB, Schiffrin EL (2001) Small artery remodeling is the most prevalent (earliest?) form of target organ damage in mild essential hypertension. J Hypertens 19(5):921–930CrossRefPubMedGoogle Scholar
- 63.Palmieri V, Celentano A, Roman MJ, de Simone G, Lewis MR, Best L, Lee ET, Robbins DC, Howard BV, Devereux RB (2001) Fibrinogen and preclinical echocardiographic target organ damage: the strong heart study. Hypertension 38(5):1068–1074CrossRefPubMedGoogle Scholar
- 64.Desai AS, Mitchell GF, Fang JC, Creager MA (2009) Central aortic stiffness is increased in patients with heart failure and preserved ejection fraction. J Card Fail 15(8):658–664. doi: 10.1016/j.cardfail.2009.03.006 CrossRefPubMedGoogle Scholar
- 65.Celik T, Yuksel UC, Fici F, Celik M, Yaman H, Kilic S, Iyisoy A, Dell’oro R, Grassi G, Yokusoglu M, Mancia G (2013) Vascular inflammation and aortic stiffness relate to early left ventricular diastolic dysfunction in prehypertension. Blood Press 22(2):94–100. doi: 10.3109/08037051.2012.716580 CrossRefPubMedGoogle Scholar
- 66.Totaro S, Khoury PR, Kimball TR, Dolan LM, Urbina EM (2015) Arterial stiffness is increased in young normotensive subjects with high central blood pressure. J Am Soc Hypertens 9(4):285–292. doi: 10.1016/j.jash.2015.01.013 CrossRefPubMedGoogle Scholar
- 67.Coutinho T, Turner ST, Kullo IJ (2011) Aortic pulse wave velocity is associated with measures of subclinical target organ damage. JACC Cardiovasc Imaging 4(7):754–761. doi: 10.1016/j.jcmg.2011.04.011 CrossRefPubMedGoogle Scholar
- 68.Mitchell GF, van Buchem MA, Sigurdsson S, Gotal JD, Jonsdottir MK, Kjartansson O, Garcia M, Aspelund T, Harris TB, Gudnason V, Launer LJ (2011) Arterial stiffness, pressure and flow pulsatility and brain structure and function: the Age, Gene/Environment Susceptibility—Reykjavik study. Brain 134(pt 11):3398–3407. doi: 10.1093/brain/awr253 CrossRefPubMedPubMedCentralGoogle Scholar
- 69.Kidher E, Patel VM, Nihoyannopoulos P, Anderson JR, Chukwuemeka A, Francis DP, Ashrafian H, Athanasiou T (2014) Aortic stiffness is related to the ischemic brain injury biomarker N-methyl-D-aspartate receptor antibody levels in aortic valve replacement. Neurol Res Int 2014:970793. doi: 10.1155/2014/970793 CrossRefPubMedPubMedCentralGoogle Scholar
- 70.Brandts A, van Elderen SG, Westenberg JJ, van der Grond J, van Buchem MA, Huisman MV, Kroft LJ, Tamsma JT, de Roos A (2009) Association of aortic arch pulse wave velocity with left ventricular mass and lacunar brain infarcts in hypertensive patients: assessment with MR imaging. Radiology 253(3):681–688. doi: 10.1148/radiol.2533082264 CrossRefPubMedGoogle Scholar
- 71.Jia G, Aroor AR, Sowers JR (2014) Arterial stiffness: a nexus between cardiac and renal disease. Cardiorenal Med 4(1):60–71. doi: 10.1159/000360867 CrossRefPubMedPubMedCentralGoogle Scholar
- 72.Smith A, Karalliedde J, De Angelis L, Goldsmith D, Viberti G (2005) Aortic pulse wave velocity and albuminuria in patients with type 2 diabetes. J Am Soc Nephrol 16(4):1069–1075. doi: 10.1681/asn.2004090769 CrossRefPubMedGoogle Scholar
- 73.Townsend RR, Wimmer NJ, Chirinos JA, Parsa A, Weir M, Perumal K, Lash JP, Chen J, Steigerwalt SP, Flack J, Go AS, Rafey M, Rahman M, Sheridan A, Gadegbeku CA, Robinson NA, Joffe M (2010) Aortic PWV in chronic kidney disease: a CRIC ancillary study. Am J Hypertens 23(3):282–289. doi: 10.1038/ajh.2009.240 CrossRefPubMedGoogle Scholar
- 74.Yokoyama H, Aoki T, Imahori M, Kuramitsu M (2004) Subclinical atherosclerosis is increased in type 2 diabetic patients with microalbuminuria evaluated by intima-media thickness and pulse wave velocity. Kidney Int 66(1):448–454. doi: 10.1111/j.1523-1755.2004.00752.x CrossRefPubMedGoogle Scholar
- 75.Safar ME, London GM, Plante GE (2004) Arterial stiffness and kidney function. Hypertension 43(2):163–168. doi: 10.1161/01.HYP.0000114571.75762.b0 CrossRefPubMedGoogle Scholar