Serotonin in the Cerebellum

Chapter
First Online:

Abstract

Serotonin (5-hydroxytryptamine, 5-HT) was first described as the ‘serum tonic factor’, and was therefore named serotonin. Serotonin is widely present in the brain, including in the cerebellum, which is richly innervated by serotonergic fibres. A variety of serotonin receptors mediate the effects of serotonin in the cerebellum. These serotonin receptors all have their own specialized role, but with some similar main effects. It is through the temporally and spatially restricted expression of these different serotonin receptors in the cerebellum that such a widely expressed neurotransmitter as serotonin can exert very specific functions. These functions include regulation of neuronal activity, synaptic transmission and cerebellar development.

Keywords

cerebellum serotonin 5-HT3 receptor development Lugaro cells neuromodulation synaptic plasticity circuit formation cerebellar cortex deep cerebellar nuclei 
This is a preview of subscription content, log in to check access.

References

  1. Bloom FE, Hoffer BJ, Siggins GR et al (1972) Effects of serotonin on central neurons: microiontophoretic administration. Fed Proc 31:97–106PubMedGoogle Scholar
  2. Daubert EA, Condron BG (2010) Serotonin: a regulator of neuronal morphology and circuitry. Trends Neurosci 33:424–434CrossRefPubMedPubMedCentralGoogle Scholar
  3. Dayer A (2014) Serotonin-related pathways and developmental plasticity: relevance for psychiatric disorders. Dialogues Clin Neurosci 16:29–41PubMedPubMedCentralGoogle Scholar
  4. Dean I, Robertson SJ, Edwards FA (2003) Serotonin drives a novel GABAergic synaptic current recorded in rat cerebellar Purkinje cells: a lugaro cell to Purkinje cell synapse. J Neurosci 23:4457–4469PubMedGoogle Scholar
  5. Dieudonné S, Dumoulin A (2000) Serotonin-driven long-range inhibitory connections in the cerebellar cortex. J Neurosci 20:1837–1848PubMedGoogle Scholar
  6. Gardette R, Krupa M, Crepel F (1987) Differential effects of serotonin on the spontaneous discharge and on the excitatory amino acid-induced responses of deep cerebellar nuclei neurons in rat cerebellar slices. Neuroscience 23:491–500CrossRefPubMedGoogle Scholar
  7. Geurts FJ, De Schutter E, Timmermans JP (2002) Localization of 5-HT2A, 5-HT3, 5-HT5A and 5-HT7 receptor-like immunoreactivity in the rat cerebellum. J Chem Neuroanat 24:65–74CrossRefPubMedGoogle Scholar
  8. Kitzman PH, Bishop GA (1994) The origin of serotoninergic afferents to the cat’s cerebellar nuclei. J Comp Neurol 340:541–550CrossRefPubMedGoogle Scholar
  9. Lainé J, Axelrad H (1998) Lugaro cells target basket and stellate cells in the cerebellar cortex. Neuroreport 9:2399–2403CrossRefPubMedGoogle Scholar
  10. Lainé J, Axelrad H (2002) Extending the cerebellar Lugaro cell class. Neuroscience 115:363–374Google Scholar
  11. Li SJ, Wang Y, Strahlendorf HK et al (1993) Serotonin alters an inwardly rectifying current (Ih) in rat cerebellar Purkinje cells under voltage clamp. Brain Res 617:87–95CrossRefPubMedGoogle Scholar
  12. Maura G, Roccatagliata E, Ulivi M et al (1988) Serotonin-glutamate interaction in rat cerebellum: involvement of 5-HT1 and 5-HT2 receptors. Eur J Pharmacol 145:31–38CrossRefPubMedGoogle Scholar
  13. Mitoma H, Kobayashi T, Song SY et al (1994) Enhancement by serotonin of GABA-mediated inhibitory synaptic currents in rat cerebellar Purkinje cells. Neurosci Lett 173:127–130CrossRefPubMedGoogle Scholar
  14. Murano M, Saitow F, Suzuki H (2011) Modulatory effects of serotonin on glutamatergic synaptic transmission and long-term depression in the deep cerebellar nuclei. Neuroscience 172:118–128CrossRefPubMedGoogle Scholar
  15. Oostland M, van Hooft JA (2013) The role of serotonin in cerebellar development. Neuroscience 248:201–212CrossRefPubMedGoogle Scholar
  16. Oostland M, Buijink MR, Teunisse GM et al (2014) Distinct temporal expression of 5-HT1A and 5-HT2A receptors on cerebellar granule cells in mice. Cerebellum 13:491–500CrossRefPubMedPubMedCentralGoogle Scholar
  17. Saitow F, Murano M, Suzuki H (2009) Modulatory effects of serotonin on GABAergic synaptic transmission and membrane properties in the deep cerebellar nuclei. J Neurophysiol 101:1361–1374CrossRefPubMedGoogle Scholar
  18. Strahlendorf JC, Strahlendorf HK, Barnes CD (1979) A possible interplay of GABA with serotonergic and noradrenergic systems in the cerebellum. Proc West Pharmacol Soc 22:219PubMedGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Swammerdam Institute for Life SciencesUniversity of AmsterdamAmsterdamThe Netherlands
  2. 2.Centre for Integrative PhysiologyUniversity of EdinburghEdinburghUK

Personalised recommendations