A Risk-Adapted Approach to Breast Radiation Using Targeted Intraoperative Radiotherapy (TARGIT)

  • Jayant S. Vaidya
  • Jeffrey S. Tobias
  • Frederik Wenz
  • Samuele Massarut
  • Max Bulsara
  • Christobel Saunders
  • Henrik Flyger
  • Michael Alvarado
  • Wolfgang Eiermann
  • Tammy Corica
  • David Joseph
  • Michael Baum
Chapter

Abstract

Whole-organ detailed three-dimensional pathological analysis of mastectomy specimens vis-à-vis the results of breast-conserving surgery trials demonstrates a remarkable phenomenon: in addition to the main tumor, the mastectomy specimen reveals often multiple foci of cancer distributed widely in the breast volume. This is in contrast with the location of a local recurrence, which mostly occurs in the area around the original tumor – thus, it makes sense to focus radiation only around the original tumor. Based on this insight, the targeted intraoperative radiotherapy technique and the device to deliver it were developed in the late 1990s, the first case treated at the Middlesex Hospital, University College London, UK, on 2 July 1998. Pilot studies confirmed feasibility and safety, and in March 2000, the TARGIT-A randomized trial was launched.

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Jayant S. Vaidya
    • 1
  • Jeffrey S. Tobias
    • 2
  • Frederik Wenz
    • 3
  • Samuele Massarut
    • 4
  • Max Bulsara
    • 5
  • Christobel Saunders
    • 6
  • Henrik Flyger
    • 7
  • Michael Alvarado
    • 8
  • Wolfgang Eiermann
    • 9
  • Tammy Corica
    • 10
  • David Joseph
    • 10
  • Michael Baum
    • 11
  1. 1.Professor of Surgery and Oncology, Clinical Trials Group, Division of Surgery and Interventional ScienceUniversity College LondonLondonUK
  2. 2.Department of Clinical OncologyUniversity College London HospitalsLondonUK
  3. 3.Department of Radiation OncologyUniversity Medical Centre Mannheim, University of HeidelbergHeidelbergGermany
  4. 4.Department of SurgeryCentro di Riferimento OncologicoAvianoItaly
  5. 5.Department of BiostatisticsUniversity of Notre DameWAAustralia
  6. 6.School of SurgeryUniversity of Western AustraliaWAAustralia
  7. 7.Department of Breast SurgeryUniversity of CopenhagenCopenhagenDenmark
  8. 8.Department of SurgeryUniversity of CaliforniaCAUSA
  9. 9.Department of Gynecology and ObstetricsRed Cross HospitalMunichGermany
  10. 10.Department of Radiation OncologySir Charles Gairdner HospitalWAAustralia
  11. 11.Clinical Trials Group, Division of Surgery and Interventional ScienceUniversity College LondonLondonUK

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