Genus: Calanthe to Cyrtosia
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This large chapter describe the herbal usage and pharmacology of 73 species in 12 genera (Calanthe, Callostylis, Cephalanthera, Cleisostoma, Coelogyne, Conchidium, Corymborkhis, Cremastra, Crepidium, Cymbidium, Cypripedium and Cyrtosia). A good percentage of the orchids are commonly cultivated as ornamental plants and many hybrids have been produced with Calanthe and Cymbidium. TCM makes use of 14 species of Calanthe and Rumphius who authored Hut Amboinesche Kruidboek [the Amboinese Herbal, Volumes 1–6 (1741–1750), published posthumously] described Calanthe triplicata. Calanthe species contain compounds with antitumour and hair-restoring properties. Fourteen species of Coelogyne are medicinal and several have been studied phytochemically by Majumder’s group in Calcutta. Another large group, Cymbidium, with 17 medicinal species, is also much studied. Lectins present in some species suppress replication of coronaviruses, toroviruses and viruses. An interesting compound that suppresses angiogenesis has been discovered in Cremastra appendiculata and it may find a role in preventing blindness and spread of cancers. Cyrtosia is a homomycotrophic genus and should be an interesting subject for phytochemical studies.
KeywordsSide Lobe Flower Season Entire Plant Improve Blood Flow Terrestrial Orchid
Genus: Calanthe Brown
Chinese name: Xiaji Lan (prawn spine orchid)
Japanese name: Ebine
Calanthe are sympodial orchids with short stems and several plicate, elliptical leaves that are spirally arranged, or arranged in two rows, ensheathing the stem. Inflorescences arise at the side or from the base and carry many showy flowers on a short raceme. Approximately 100 species of Calanthe are distributed across tropical Asia to the Pacific Islands, tropical and southern Africa. A single species occurs in Central America. They are mainly terrestrial, with a few epiphytic members and occur at low to high elevations. Some species are deciduous, others evergreen. The plant and its flowers turn bluish when they are bruised.
Calanthe is the first orchid species to be artificially hybridised by man. Many species have attractive flowers. Indeed, the name, Calanthe, was derived from two Greek words, kalos (beautiful) and anthe (bloom), meaning ‘beautiful flower’. The shape of the lip is an important criterion for distinguishing among species.
Calanthe alismifolia Lindl.
Chinese names: Zexiexiaji Lan (glossy prawn spine orchid), Xidiangenjie Lan (small spots segmented root orchid); in Taiwan: black-spotted Calanthe; white flower Calanthe
Chinese medicinal name: Zongyeqi
Herbal Usage: Plants are harvested in summer and autumn, washed clean and sun-dried for future use. The herb is acrid in taste, slightly bitter and considered to be cool in nature. In Traditional Chinese Medicine (TCM), the whole plant is antipyretic and it detoxifies, removes gas and humidity, reduces stasis of blood, reduces swellings, improves blood circulation, and heals ulcers, scrofula, haematuria and traumatic injuries, the last being its principal usage. For consumption, decoction is made with 6–12 g of the whole dried plant (Wu 1994; Zhongyao Bencao 2000; Ou et al. 2003).
Calanthe alpina Hook. f. ex Lindl.
Chinese name: Liusuxiaji Lan (tassels prawn spine orchid)
Medicinal names: Mayaqi (horse teeth seven)—the name is shared with Calanthe davidii; Jiuxilian (nine son lotus), Daxiancao (large divine herb)
Description: Plant is 30–50 cm tall. Pseudobulbs are small, 7 mm in diameter, conical, and terminating in a short pseudo-stem which is ensheathed by three or four thin, elliptic leaves with undulating margins. Leaves are 11–26 by 3–6 cm. Inflorescence is axillary, erect, 3–12 cm tall. Up to a dozen, nodding, pink flowers are carried on the erect inflorescence. Flowers are 3–4 cm across and are darker-coloured on the dorsal surface than on the under-surface of the petals and sepals. Lip is white or pale yellow veined with purplish-red (Chen et al. 1999; Perner and Luo 2007). Flowering period is June to September.
C. alpina is widespread in northern Sichuan in mixed broad-leaved, evergreen forest at 2200–2450 m but it is not common (Rathore 1983; Perner and Luo 2007). The species is distributed in southern Shaanxi, southern Gansu, Sichuan, west Yunnan and southern Xizang to Sikkim, Taiwan and Japan. It occurs in montane forests or on grassy slopes at 1500–3500 m (Chen et al. 1999).
Herbal Usage: The herb is collected in summer from Hebei, Shanxi, Hunan, Hubei, Guizhou, Yunnan and Sichuan (Wu 1994). Roots and stem are used to remove “heat” and toxins, relieve pain, and dispel “wind” or to hasten the disappearance of ecchymosis. C. alpina is prescribed for stomach ulcer, acute distension of the stomach, hepatitis, scrofula, toothache, sore throat, common colds, painful joints, fatique, snake bite, and traumatic and chest injuries (Zhongyao Da Cidian 1986; Wu 1994; Zhonghua Bencao 2000). It can be used in three ways: (1) by itself in decoction, using 15–30 g fresh herb; (2) to treat chronic pharyngitis, also in decoction, Mayaqi (C. fimbriata/C. alpina) 30 g together with Ba zhao long 60 g; and (3) as a paste for external application, just grinding a suitable amount of Mayaqi. These prescriptions were originally published in Shaanxi Chinese Herbs (Zhongyao Da Cidian 1986).
(Illustration: see Flora of China Orchids, p. 136, Fig. 28/29)
Calanthe brevicornu Lindl.
Chinese name: Shenchunxiaji Lan (kidney lips prawn spine orchid)
Description: This is a pretty Calanthe. Pseudobulb is conical, 2 cm thick, bearing 3 or 4 elliptic, plicate leaves, 10 by 5–11 cm sheathing a pseudo-stem, 5–8 cm in length. Scape is up to 30 cm long with many widely-spaced flowers of white to yellowish-green (brick red in the Indian varieties), 2–3 cm across, well expanded. Lip is trilobed and carries prominent, symmetrical kidney-shaped red patches on its large mid-lobe. It flowers from May to June. The species is distributed from northeast India, Bhutan and Nepal to Xizang, Yunnan, Sichuan, Hubei and Guangxi in China (Chen et al. 1999). At Huanglong in Sichuan Province, it occurs at 1800–2300 m in open scrub. Flowers in some clones smell of cinnamon (Perner and Luo 2007).
Usage: CHM employs the root to counter ‘heat’, promote diuresis, arrest bleeding, reduce swelling, and to treat nephritis or the presence of blood in the urine. It is usedused to promote expulsion of an incompletely delivered placenta, recovery after a stillbirth, or to stop abdominal pain caused by ‘poor air flow’ (Wu 1994). There is no mention of the herb in Zhongyao Bencao (2000).
Calanthe cardioglossa Schltr.
Thai names: Ueang namton, Uang liam
Herbal Usage: The stem is used as a tonic in Thailand (Chuakul 2002).
Calanthe ceciliae Rchb. f.
Malay name: Sebueh
Calanthe davidii Franch.
Chinese name: Jianyexiaji Lan (sword leaf prawn spine orchid) Changyegenjie Lan
Chinese medicinal name: Mayaqi (the name is shared with Calanthe alpina)
Description: Plant is 30–50 cm tall with 6–10 long and narrow, ensiform or lorate, membranous leaves, 20–60 by 1–4 cm. Inflorescence is 60–80 cm tall but may reach a height of 120 cm (Perner and Luo 2007). Flowers are numerous, crowded, randomly orientated, pale green or white with reflexed petals and sepals. Lip is white, three-lobed, and quite variable in shape and size. C. davidii usually flowers in June and July (Chen et al. 2009a).
C. davidii is distributed from India across southern China to Taiwan and southern Japan, occurring in forests at 1200–2000 m. However, the last time it was collected in India was in July 1899 (Rathore 1983). It is probably seriously endangered or extinct in the Himalayas. Perner (2007) found it growing and flowering in between Cypripedium wardii at 1620 m in pine forest in Sichuan in late May. Plants were most luxuriant at the grass borders.
Herbal Usage: Herb (Mayaqi) refers to both C. alpina and C. davidii although the vegetative appearance of the two species is dissimilar. They are generally supplied by the same provinces, Hebei, Shanxi, Hunan, Hubei Guizhou, Yunnan and Sichuan. Guangxi also supplies C. alipina but does not produce C. davidii. Stems and roots of C. davidii are used in the same manner and for the same conditions as those of C. alpina in Chinese Herbal Medicine (Wu 1994; Zhongyao Bencao 2000).
Calanthe densiflora Lindl.
Chinese name: Zhuyegenjie Lan (bamboo leaf segmented root orchid), Mihuaxiaji Lan (prawn spine flower orchid)
Description: A terrestrial herb found in shaded hardwood forests. Rhizomes are long, terete, about 8 mm in diameter, from which arise 7–9 cm tall shoots bearing 2–3 lanceolate or narrowly elliptic leaves of 20–40 by 2.3–6.5 cm, and 5-ribbed. Scape is 20 cm tall, arising from the rhizome adjacent to a mature shoot, and carries a crowded head of yellow flowers at the apex, each about 1.5 cm across. Lip is trilobed: side lobes ovate, middle lobe large, oblong and with two large keels at the base. The species is found in the southern Himalayas, China, Indochina and Japan: in Taiwan, below 1500 m throughout the island. It is the last Calanthe to flower in Taiwan, flowering from October to December (Lin 1975).
Herbal Usage: The Taiwanese Chinese Herbal states that the whole plant improves blood circulation, and reduces stasis of blood and swellings. It removes gas and humidity and is usedused to treat rheumatism, backache, pain affecting the lower limbs, running sores and traumatic injuries (Lin et al. 2003).
Calanthe discolor Lindl.
Chinese names: Xiaji Lan (prawn spine orchid)
Chinese medicinal names: Jiuzilianhuancao (nine united sons flowering herb)—this name also refers to Calanthe tricarinata; zhu chuan zhu (string of beads); ye baiji (night white chicken); Roulainhuan (meat in circles); Jiujiechong (nine segment bug); Yichuanniuzi (string of buttons).
Description: C. discolor is a robust Calanthe, 40–65 cm tall, with 3 elliptic-oblong leaves, 13–25 by 3–9 cm, not deciduous. Pseudobulbs are small, 1 cm in diameter. Inflorescence is axillary, erect, 20–30 cm tall, densely pubescent bearing 10 round, nodding, purplish-brown to pale maroon flowers with a white lip. Flowers may be clustered or spaced out. They are 2 cm across and appear from April to May. C. discolor grows in considerable profusion on the forest floor, preferring sloping terrain, at 700–1500 m in an arc in southeastern China from Guizhou to Guangdong, Fujian and Zhejiang to Japan. It is widespread throughout most of the Japanese islands (Japan Calanthean Society 1987).
Phytochemistry: Calanthoside (a novel indole, S,O-bisdesmoside), glucoindican, calaliukiuenoside, calaphenanthrenol, tryptanthrin, indirubin, isatin and indicant were obtained by methanolic extraction of C. discolor and C. liukiuensis. The first four compounds improved blood flow through the skin and promoted hair growth (Yoshikawa et al. 1998).
Acid hydrolysis of calanthoside yielded indirubin and isatin, whereas enzymatic hydrolysis with beta-glucosidase furnished tryptanthrin and small amounts of indirubin and isatin. Judging from their relative concentrations in fresh and dried plants of the two Calanthe species, the investigators postulate that calanthoside may be a common, genuine glycoside of tryptanthrin, indirubin and isatin in the plants (Yoshikawa et al. 1998).
1. Indication: skin ulcers,
(a) Mix Jiuzilianhuacao with vinegar and apply three times a day.
(b) Cook C. discolor 15 g with meat and consume. Additionally, mix C. discolor 6 g with chives 3 g for external application.
2. Indication: hemorrhoids and prolapsed piles
Mix powdered C. discolor 15 g in vegetable oil for application.
3. For swelling and pain in the throat, rheumatism, trauma and hepatitis
Use 9 g Jiuzilianhuancao in decoction
Calanthe fimbriata Franch. [see Calanthe alpina (Hook. f. ex Lindl.)]
Calanthe graciliflora Hayata
Chinese names: Goujuxiaji Lan (splayed hooks prawn spine orchid), Xiyegenjie Lan (fine leaved, segmented root orchid), Xihuagenjie Lan (fine flowered, segmented root orchid), Zhihuagenjie Lan (brocade flower segmented root orchid), Goujuxiaji Lan (hooked prawn spine orchid): in Taiwan: slender flower Calanthe
Chinese medicinal name: Silima
Description: A robust terrestrial orchid, C. gracifolia has tufted, ovoid pseudobulbs, 2 cm in diameter, which bears 3–4 large, lustrous, lanceolate leaves with undulating edges that taper towards the base, 30–50 by 4–7 cm. Inflorescence is slender, 45–60 cm in length, nodding, with 9–20 flowers, 2 cm across, also nodding, and loosely arranged: the petals and sepals are pale maroon dorsally, yellowish ventrally. Lip is white and flat. It flowers in June and July (Chen et al. 2009a).
It is found in shady, moist locations in forests and along ravines at 600–1500 m in southern China from Yunnan and Sichuan in the west to Zhejiang, Guangdong, Hong Kong and Taiwan in the east (Chen et al. 1999). In Taiwan, it is found in broad-leaf forests at 1000–1500 m (Su 1985).
Herbal Usage: In Taiwan, the entire plant of C. graciliflora (syn. C. hamata) is usedused to relieve fever and for detoxification. It boosts yin elements, benefits the lungs, improves blood flow, reduces stasis of blood, detumescence, and stops pain and coughing (Ou et al. 2003).
On the mainland, the entire plant of C. hamata is used to treat rheumatism, bone pain, traumatic injuries. Herb is obtained from Hunan Province (Wu 1994). Several prescriptions are provided in Zhonghua Bencao (2000).
Calanthe hamata Hand. Mazz. (see C. graciliflora)
Calanthe lamellosa Rolfe (see C. brevicornu)
Calanthe mannii Hook. f.
Local Name: Xihuaxiaji Lan (Small Flowers Prawn Spine Orchid)
Description: Plants are 18–35 cm tall with small, conical pseudobulbs and 4–5 thin, narrowly elliptic, 5-veined, plicate leaves, 18–35 by 3–4.5 cm. Inflorescence is axillary. Rachis is erect, many-flowered, the flowers closely arranged all round. Sepals and petals are brownish; lip yellow, trilobed, mid-lobe splaying distally into 2 lobules which are rounded at their apices (Jin et al. 2009). Flowering season is May in China (Chen et al. 2009a); April to June in Bhutan (Gurong 2006); and April to May in Nepal (Raskoti 2009). C. manii is found in the Himalayas, Nepal, Myanmar, southern China, Vietnam and Kyushu Island in Japan in dense, broad-leaved evergreen forests at 600–2600 m (Gurong 2006; Chen et al. 2009a; Raskoti 2009).
Herbal Usage: Herb is obtained from Sichuan, Yunnan and Guizhou. In Chinese herbal medicine, C. manii is used for stomach heat, scrofula and abscess (Wu 1994).
Calanthe masuca (D. Don) Lindl.
Chinese names: Changjuxiaji Lan (long spur prawn spine orchid), Zihuaxiaji Lan (purple flower prawn spine orchid), Shankala, Shanzhizhu (mountain spider)
Myanmar Name: Thazin gyi myo kywe
Nepali Name: Pakha phul
Description: The “species is widely known as C. masuca in mainland Asia” (Seidenfaden and Wood 1992), but numerous taxonomists working in Asia named the species as C. sylvatica (Thou.) Lindl. (Seidenfaden and Wood 1992; Chen et al. 1999; Matthew 1995; Comber 2001; Gurong 2006; Raskoti 2009). However, according to the Kew Monocot List, the Asian species is C. masuca (D. Don) Lindl. C. sylvatica is distributed in Africa and in some islands in the south of the Indian Ocean but it does not occur in mainland Asia. For the sake of consistency and easy reference, the present volume follows the accepted names given in the Kew Monocot List, so the name of this species is C. masuca.
At one time, this pretty, moderate-sized, montane, pink Calanthe was a popular orchid in Europe. It has the distinction of being one of the parents of the first hybrid orchid to be bred by man.
C. masuca enjoys a wide distribution from Japan across southern China (Taiwan, Hunan, Guangxi, Guangdong, Hong Kong, southern Yunnan and southeast Xizang), Bhutan, Nepal, Sikkim, India, Sri Lanka to Madagascar and South Africa. Its northern-most distribution is in a few scattered southern islands at the southern tip of Japan and on Mikurajima Island just below 34°N latitude and south of Tokyo (Japan Calanthean Society 1987). In the south, it is found in Thailand, Malaysia and Indonesia. It occurs at an elevation of 800–2000 m in shaded, moist locations, in broad-leaved low montane forests.
Herbal Usage: Herb is obtained from Fujian, Jiangxi, Yunnan, Hunan, Guangxi, Guangdong and Xizang. The entire plant is used as an anodyne. It also reduces swellings, removes toxins and repairs wounded tissues. It is usedused in the treatment of abscesses especially if foreign bodies in the body are not surgically removed (Wu 1994). In Nepal, a paste made from the stem is applied to treat dislocated bones (Manandhar and Manandhar 2002). The flowers are used to arrest epistaxis (Rao 2004; Singh and Duggal), Pseudobulbs are also used to treat nose bleeds (Baral and Kurmi 2006).
Calanthe plantaginea Lindl.
Herbal Usage: Harvested tubers are washed, sun-dried and rendered into powder form. In Nepal, the powder is mixed with milk is consumed as a tonic and aphrodisiac (Pant and Raskoti 2013).
Calanthe puberula Lindl.
Chinese names: Lianexiaji Lan (sickle lip orchid), Fanjuangenjie Lan (counter folding root segment orchid), Juanegenjie Lan (folding calyx root segment orchid), Lianyexiaji Lan (sickle leaf prawn spine orchid): Jiaxiaji Lan (fake prawn spine orchid), Xiangsixiaji Lan (similar prawn spine orchid) Zigenjie Lan (purple root orchid)
Chinese medicinal name: Lianexiaji Lan (sickle lip orchid)
C. puberula grows in mixed broad-leaved evergreen forests at 1200–2500 m in western Yunnan and adjacent southeastern Tibet; in Sikkim and northeast India at 2000 m; in Taiwan at 1300–2500 m; and in Vietnam. It is widely distributed in Japan with a northern limit at Okushiri Island (Japan Calanthean Society 1987).
Herbal Usage: Herb is obtained from Yunnan, Guangxi and Guandong. The whole plant is usedused in Chinese Herbal Medicine (CHM) to treat scrofula, and sores that itch (Wu 1994). It is antipyretic and detoxifies. Used for running sores, it improves blood flow and stops pain. It is used to treat ulcers, scrofula, mange, scarlet fever, amenorrhoea, trauma and dysentery in Taiwan (Ou et al. 2003). C. puberla Lindl. and C. similes Schltr. are mentioned as separate species by Wu (1994), but botanically they are not different and the first name has precedence.
Calanthe similis Schltr. (see C. puberula Lindl.)
Calanthe sylvatica (Thou.) Lindl. [see Calanthe masuca (D. Don) Lindl.]
Calanthe tricarinata Lindl.
Chinese name: Sanlengxiaji Lan (triangular prism prawn spine orchid)
Chinese medicinal name: Jiuzilianhuancao (nine united sons flowering herb) This name also refers to Calanthe discolor; Roulianhuan
Description: Stem of this attractive, evergreen Calanthe is sheathed in bracts and leaves in its lower half and bears 2–3 elliptic leaves 30 by 7 cm. Flowers are 2.5 cm in diameter, opening widely, and are loosely arranged in the lower part of the raceme. Sepals are greenish, petals white. Lip is rose purple with a white border; large, oblong and trilobed with barely any space between the large middle lobe and the two smaller lateral lobes. It flowers in April to June in Indian Himalaya, Bhutan and at Gaoligongshan in western Yunnan (Bose and Bhattacharjee 1980; Japan Calanthean Society 1987; Pearce and Cribb 2002; Jin et al. 2009). C. tricarinata grows in the shade on the forest floor at an altitude of 2000 m in Pakistan, Kashmir, Sikkim, western China and Japan, being widespread in the Japanese islands.
Herbal Usage: Herb is obtained from Shanxi, Hubei, Sichuan, Yunnan, Guangxi, Guizhou and Xizang. In China, the root is used to stimulate blood circulation, relax muscles and joints, remove wind and stop bleeding. It is usedused in the treatment of stomachache, arthritis, lumbar muscle degeneration and traumatic injuries. Its use is contra-indicated during pregnancy (Wu 1994; Zhonghua Bencao 2000). Leaf paste is used to treat wounds and eczema in Nepal. In that country, leaves and pseudobulbs are valued as aphrodisiacs (Pant and Raskoti 2013). In Uttarakhand, West Himalaya, roots and leaves are usedused to treat jaundice and typhoid (Maikhuri et al. 2014).
Calanthe triplicata (Willimet) Ames
Chinese names: Sanzhexiaji Lan (three layered shrimp’s spine), Baihe Lan (white crane orchid), Shishangjiao (leaf on the stone), Roulianhuan (meaty chain of rings); Paiwan (put in order and bend in a stream), embossed banana leaf orchid
Chinese medicinal name: Shishangjiao (leaf on the stone)
Japanese name: Tsuru Ran (crane orchid)
Thai name: Ueang Kao Tog
Indonesian names: Lau Bawang in Kalimantan Barat; Angkrek Popotjongan, Ahan Malona (Amboin); Bunga Tiga Lapis (Maluku); Guru ni Hambing (Batak Toba) Lumbu Hutan (Sumatra and Timor); Seugeundeu (Gajo Singkut in Batak Karo) Anggrek bayi tidur (Sulawesi)
Flowering period is April to September in Singapore–Malaysia (O’Byrne 2001) but the author’s plants in Singapore are still putting out new inflorescences in October, March to September in the Shan state of Myanmar, April to May on the Chinese mainland (Chen et al. 1999), March to July on Hong Kong and Lantau Islands (Wu et al. 2001), June in Thailand (Vaddhanaphuti 2001), April to June at the Western Ghats in southern India (Bose and Bhattacharjee 1980), May to July in southern India (Abraham and Vatsala 1981; Joseph 1982) or May to October (Misra 2007), and April to May and July to December in Bhutan (Pearce and Cribb 2002).
Phytochemistry: Leaves of C. triplicata produce indigo when bruised. Alkaloid is present (Luning 1967).
Herbal Usage: Chinese herbalists in Taiwan use the root to treat rheumatism, backache and traumatic injuries including fractures (Ou et al. 2003). The whole plant is a diuretic.
Ananda Rao and Sridhar (2007) reported that in Karnataka the roots are used for diarrhoea and toothache. In Arunachal Pradesh, the roots are an ingredient in a remedy for swollen hands, and, in a separate combination, usedused for treating diarrhea. Various parts of the plant are usedused to treat toothache. Pseudobulbs are a masticatory for a variety of gastro-intestinal disorders while flowers are used to relieve toothache (Rao 2004). Root extract is usedused to treat diarrhoea and toothache (Das 2004).
Rumphius (late seventeenth century) who lived on the island of Amboin (Sulawesi) observed that the plant was “quite sharp” and cautioned regarding its use. Initially, the taste of the roots is insipid, but suddenly it becomes quite sharp, “like some Gentiana, burning the mouth, so that one’s lips will swell, one’s throat gets hoarse, and one even feels this sharpness in the leaves, wherein it differs from all Angreks”. The roots were used together with nutmeg, cloves and two types of ginger “rubbed together and tied to” the swollen hands. “The natives have such tough mouths, that they dare to take these sharp roots internally, and chew it along with pinang (betel-nut), nutmeg and ginger, against persistent diarrhoea caused by cold or raw dampness” (quotations from Beekman’s translation, 2002) (Rumphius 1741–1750). In Sumatra, the flowers are used to relieve pain from caries (Heyne (1927). In Sulawesi, the rhizome is a cure for toothache (Yuzammi and Hidayat 2002).
Calanthe vestita Wall ex Lindl.
Thai name: Khao Malila
Myanmar name: Thazin gyi ahphyu
Phytochemistry: Leaves of C. vestita contain flavone C-glycosides (Williams 1979).
Herbal Usage: In Vietnam, crushed bulbs are rubbed over aching bones of people suffering from rheumatism (Petelot quoted by Perry). Six bacterial strains belonging to the genera Athrobacter, Bacillus, Mycobacterium and Pseudomonas have been isolated from the underground roots of C. vestita var. rubrooculata (Tsavkelova et al. 2001), but whether this impacts on its medicinal usage is unknown.
There is discordance between the traditional medical usage and the modern scientific/pharmaceutical interest in this genus of orchids.
In Chinese herbal medicine, 14 Calanthe species provide a remedy for a variety of conditions, in particular swellings of different aetiology (abscess, trauma, arthritis), and pain (painful joints, pain at the extremities, toothache, pharyngitis, pain from stomach ulcers or abdominal distension, snake bites and trauma). Calanthe reduces stasis of blood, improves blood circulation and detoxifies. A number of species (C. alismaefolia, C. davidii, C. gracilifolia, C. fimbriata, C. lamellose and C. puberula) are said to be antipyretic. Several Calanthe are used for treating wounds and infected skin (C. alismaefolia, C. densiflora, C. discolor, C. manii, C. mascula, C. puberula and C. similes) (Wu 1994; Lin et al. 2003). Among the ways of using the orchid, wine fortified by the roots of some Calanthe species was reportedly usedused in China to treat traumatic injuries and internal bleeding (Hu and Cheo, quoted by Perry and Metzger 1980). Interestingly, use of C. tricarinata is contra-indicated during pregnancy (Wu 1994).
C. vestita which is common in the limestone areas of Southeast Asia is usedused in Vietnam to treat rheumatism. This usage is probably derived from a Chinese tradition set during the Chinese Tang Dynasty’s (618–907) suzerain over Vietnam (Annam).
Another common Southeast Asian species, C. triplicata (C. veratrifolia) has similar uses in Ayervedic medicine and in Indonesia. It is used to treat rheumatism, backache and trauma. More unique is its alleged ability to correct intractable diarrhoea. In Amboin, the root of C. triplicata is a component of a remedy for swollen hands (Rumphius, late seventeenth cent.). In Sumatra, its flowers are used to relieve pain from dental caries (Heyne, quoted by Perry and Metzger 1980).
Contemporary research completely ignores the traditional usage of Calanthe and focuses on two areas: (1) a hair-restoring property, and (2) a possible anticancer agent. Both areas have tremendous economic potential but there is no report of any relevant drug trial. Calanthoside, glucoindican, calaliukiuenoside and calaphenanthrenol present in C. discolor and C. liukieuensis (= C. lyroglossa var. lyroglossa) improved blood flow through the skin and promoted hair growth (Yoshikawa et al. 1998).
Calanquinone A from C. arisanensis exhibited potent antitumour activity against lung (A549), prostate (PC-3 and DU145), colon (HCT-8), breast (MCF7), nasopharyngeal (KB) and vincristine-resistant nasopharyngeal (KB-VIN) cancer cell lines. Most exciting was the finding that this compound showed an improved drug resistance profile compared to paclitaxel. (The latter is a highly effective cytotoxic agent from the Pacific yew that has saved so many women suffering from ovarian cancer.) Lee and his co-workers have managed the total synthesis of Calaquionone A (Lee et al. 2008). Calanquinone A induces s-phase arrest and apoptosis of glioblastoma (brain tumour) cell types A172, T98 and U87 by decreasing cellular glutathione. Glioblastoma is resistent to radiotherapy and chemotherapy, so it would be helpful if this action of calantquinone can be translated into antiglioblastoma therapy (Liu et al. 2014a).
C. arisanensis also contains other calanquinones (B and C). Four new 9,10-dihydrophenanthrenes, calanhydroquinones A, B, C and calanphenanthrene A, and several known compounds are also present in C. arisanensis. Calanquinones B and C, and calanhydroquinones A, B and C, all showed cytotoxic activity against several human cancer cell lines. Calanquinone B exhibited the highest potency (EC(50) < 0.5 mg/mL) against seven cancer cell lines (human lung A549, prostate PC-3 and DU145, colon HCT-8, breast MCF-7, nasopharyngeal KB and vincristine-resistant nasopharyngeal KBVIN cancer, with the greatest activity against breast cancer MCF-7 cells [EC(50) <0.02 μg/mL] (Lee et al. 2009). Alkaloids are present in C. triplicata, C. vestita and several other species. Indoles are present in C. triplicata and flavone C-glycoside in C. vestita (Williams 1979; Veitch and Grayer 2007a).
Genus: Callostylis Blume
Chinese name: mei zhu lan
A small genus with only five or six species distributed from the Himalayan region to China and southwards to Myanmar, Thailand, Indochina, Malaysia and Indonesia, these are epiphytic orchids that were once included under Eria. Pseudobulbs are bulbous or terete, with base loosely covered by dry sheaths, leafy on the upper part, and are well spaced along a stout, creeping rhizome. Leaves are leathery, 2–5, arising at or near the apex of the stem. Inflorescence is axillary, with many cream-coloured or yellow flowers. Sepals are covered with brown hairs abaxially.
Callostylis bambusifolia (Lindl.) S.C. Chen & J.J. Wood
Indian name: Mundabai
Herbal Usage: The entire plant is used to treat stomach upsets in India. A plant of Callostylis bambusifolia (syn. Eria bambusifolia) and another of Aegle marmelos (not an orchid) are separately burnt to ashes in earthen pots, and thereafter their ash is mixed in a 1:1 ratio. Half a tablespoon is administered on an empty stomach twice a day for one week to treat hyperacidity and stomach upsets. This is the practice of the Dongria Kandha hill tribe in the southwest of Orissa State in India (Dash et al. 2008).
Genus: Cephalanthera Rich.
Chinese name: Tourui Lan
Cephalanthera is a genus made up by a dozen species of robust, terrestrial orchids generally inhabiting the temperate regions of Eurasia to the Himalayas and North Africa. There is one species in Taiwan (Tang and Su 1978) and another in Laos (Schuiteman and de Vogel 2000). Plants have underground rhizomes and erect stems sheathed with ovate-lanceolate leaves. Inflorescences are terminal and carry several small, resupinate, white, red, or green flowers. Lips are trilobed and do not possess spurs. In some species, the flowers do not open widely (Chen et al. 2009b).
The generic name is derived from the Greek kephale (head) and refers to the fanciful impression that its anther is held high like a head. Cephalanthera are not present in orchid collections.
Cephalanthera erecta (Thunb.) Blume
Chinese name: Yin Lan (silver orchid)
Chinese medicinal name: Yin Lan (silver orchid)
Description: C. erecta is native to the Eastern Himalaya, China and Japan, growing amidst grasses and low shrubbery. Tubers are paired, irregular and underground. Stems are slender, 30–40 cm tall with 3–4 lanceolate leaves near the apex, 3–6 cm long, plicate and pointed. The Huanglong variety is small, generally only 15 cm tall. Inflorescence is short with up to 8 flowers, loosely arranged. Flowers are 1–1.2 cm long, green or white, barely opening, and appear in April to June (Hawkes 1965; Perner and Luo 2007; Jin et al. 2009).
This species resembles C. longifolia but the plant is smaller. Chin-shaped spur is a prominent characteristic of the flowers (Perner and Luo 2007).
Herbal Usage: Herb is obtained from Shanxi, Hubei, Zhejiang, Jiangxi, Guangdong and Sichuan. Plant is used to treat fever, thirst, urinary infection. It is diuretic (Wu 1994).
Cephalanthera falcata (Thunb.) Lindl.
Chinese names: Jin Lan (gold orchid), Lianyetourui Lan (pistal above sickle leaf orchid)
Chinese medicinal name: Jin Lan (gold orchid)
Description: C. falcata is a lowland terrestrial orchid of the temperate zone. Its slender stems arise from slender, creeping rhizomes with numerous roots. Stem is 25–35 cm tall, with 4–6 broadly elliptic or lanceolate, plicate, pointed leaves, 5–8 cm long. Inflorescence is up to 15 cm long, loosely 9–18 flowered. Flowers are 1.6 cm long, a clear golden yellow in Japan, or white or green flushed with white, and are fragrant. The golden Japanese variety is quite handsome (Kanda 1977).
The species is found in Yunnan Province in China, and in Korea and Japan. It flowers in April and May at Gaoligongshan in Yunnan (Jin et al. 2009), appearing a bit later, from May to July, further north (Kanda 1977). Accelerated growth observed when the orchid exists in tripartate symbiosis with Telephoraceae fungi, and Quercus serrata in pot culture in Sapporo suggests that under inclement conditions C. falcata may become mycoheterotrophic or even purely mixotrophic (Yagame and Yamato 2013).
Herbal Usage: Herb is obtained from Hubei, Hunan, Guangdong, Guangxi, Yunnan and Sichuan. The entire plant is antiheat, and relieves fever. It is used to treat sore throat and toothache (Wu 1994).
Cephalanthera longifolia (L.) Fritsch.
Chinese names: Changyetourui Lan (pistal above the long leaf orchid), Tourui Lan
Significant amounts of alkaloid were not detected when a single species of Cephalanthera was screened by Luning’s Swedish team (Luning 1974a, b). The newly discovered saprophytic species might be more promising as a source of secondary metabolites (Chen and Lang 1986). Antibiotics might be present in the mixotrophic C. falcata which is used to treat toothache and sore throat.
C. longifolia is on the red list of endangered orchid species (Duffy et al. 2009) and attempts to germinate the seeds and propagate C. longifolia were uniformly unsuccessful (Rasmussen 1995). However, Yamazaki and Miyoshi (2006) succeeded in the asymbiotic germination of C. falcata which is reported to be endangered in Japan, using green pod culture 70 days from pollination. They found that after this date the viability of the seeds declined and minimal germination was seen in seeds harvested 100 days post-pollination or later (Yamazaki and Miyoshi 2006).
Recently, it was shown that light intensity is the decisive factor influencing autotrophic versus heterotrophic behaviour in adult Cephalanthera plants. When the light intensity is low, for instance during winter, the orchid may switch to strong dependency on fungi for its carbon nutrition (Preiss et al. 2010). C. falcata photosynthesises but simultaneously obtains carbon supplies from mycorrhiza (Thelephraceae fungi growing on oak), i.e. it is mixotrophic (Yagame and Yamato 2013). C. longifolia obtains 33 % of its carbon and 86 % of its nitrogen from Thelephraceae fungi (Abadie et al. 2006). Tripartate symbiosis should be considered when attempts are being made to conserve terrestrial orchids growing in deep shade or in temperate regions.
Genus: Changnienia Chien
Chinese name: Duhua Lan (solitary flower orchid)
Changnienia is a recently discovered, monotypic, terrestrial genus which belongs to the subtribe Calypsoeae. It is endemic in China and enjoys a wide distribution in the central provinces at elevations of 400–1500 m. Pseudobulbs are subellipsoid or ovoid, 1.5 cm, cloaked with numerous membranous sheaths. Leaf is apical, solitary, broadly ovate-elliptic to broadly elliptic. Flowers are pink; however, if the soil is alkaline (pH 4.5–5.0), they are blue.
The fleshy, corm-like, subterranean pseudobulb sends up a single elliptic leaf in September. Inflorescence appears in November but the solitary flower does not open until March or April and fruit is set in May to June. There is considerable variation within the species, allegedly an adaptive mechanism for pollination (Sun et al. 2005). Bumblebees of the species Bombus trifaciatus Smithi pollinate the orchid. Visits by other species of insects have also been observed in Shenggongjia, but their visits do not result in pollination (Sun et al. 2003).
The species is named for Chang-nien Chen, a botanical collector of the early twentieth century who worked for the Academia Sinica (now renamed the Chinese Academy of Sciences) in Nanjing.
Changnienia amoena Chien
Chinese names: Duhua Lan (solitary flower orchid); elder blue*
Chinese medicinal name: Changnian Lan
Description: This terrestrial orchid is found in humus-rich soil in shady spots along ravines at 700–1800 m in southern Shaanxi, Jiangsu, Anhui, Zhejiang, Jiangxi, Hubei, Hunan and Sichuan Provinces in China. Pseudobulbs are subterranean, corm-like, fleshy, ovoid, pale yellowish-white, 1.5–2.5 cm long and 1–2 cm in diameter. It bears a single, terminal broadly elliptic, undulate leaf at the end of a 3.5–8 cm petiole thrust above the humus and ground cover. Leaf is green on its upper surface, reddish-purple on the under-surface, 6.5–11.5 by 5–8 cm. Scape is terminal, 10–17 cm long and carries a single pink flower which is 5–6 cm across. Dorsal sepal and lateral petals are close together and form a hood over the lip. Lateral sepals are linear and well extended at a 160° angle. Lip has three lobes. Side lobes are erect and form a hood over the column; mid-lobe is broad and irregularly undulate, extending backwards into an iron-shaped spur. Lip is white with pink spots on the three keels in the throat and at the edges; spur is long and pointed. Flowers appear in April (Chen et al. 1999).
Herbal Usage: Herb is obtained from Zhejiang, Jiangsu, Hunan and Sichuan. The whole plant together with its roots is regarded as antiheat and antitoxic. It cools the blood. It is usedused in the treatment of coughs, blood-streaked sputum, sores and furuncles (Wu 1994). To treat bloody phlegm, a decoction is prepared with 15–30 g of dried or 60–90 g of fresh herb, then sweetened with white sugar and drunk day and night before meals.
To treat sores, a poultice is made by mixing fresh pulverised plant with salt. The dressing is changed at least every day (Zhonghua Bencao 2000).
Only discovered and botanically published in 1935, it is remarkable that it already has a herbal use. The reason being that Chinese herbalists have long recognised C. amoena as a distinctive species but botanists were not aware of its existence. A similar explanation exists for many medicinal orchid species long known to tribal people and much later “discovered” and described in journals.
There is no pharmacological information on the species.
This genus is now included under Bulbophyllum
Cirrhopetalum andersonii Hook. f. (see Bulbophyllum andersonii Hook f.)
Cirrhopetalum vaginatum Lindl. (see Bulbophyllum vaginatum (Lindl.) Rchb. f.)
Genus: Cleisostoma Blume
Chinese name: Geju Lan
Cleisostoma is a large genus of small to medium-sized epiphytic, monopodial orchids with some 90 members. It enjoys a widespread distribution from Sri Lanka and India through China to Japan and across Southeast Asia to Papua New Guinea and the Pacific Islands. Many species formerly classified as Sarcanthus are now in Cleisostoma, whereas numerous others formerly in Cleisostoma have been moved to other genera (Seidenfaden and Wood 1992). The epicenter for the genus is Thailand. They are rarely cultivated as garden plants.
Stems may be short or long, erect or pendant, with leaves that are terete, semi-terete or flat. Flowers are small with spreading petals and sepals of equal size. Lip is trilobed, with a spur and the conspicuous callus that distinguishes the species. The name Cleisostoma is constituted by two Greek words, kleistos (closed) and stoma (mouth), referring to the calli blocking the entrance to the spur thus producing a narrowed mouth.
Cleisostoma birmanicum (Schltr.) Garay
Laotian name: Ka dam phi
Herbal Usage: The orchid was used to treat orchitis in Laos (Vidal 1963).
Cleisostoma flagelliforme (Rolfe ex Downie) Garay (see Cleisostoma fuerstenbergianum Kraenzl.)
Cleisostoma fuerstenbergianum Kraenzl.
Chinese name: Changyegeju Lan (long leaf separate distance orchid)
Thai names: Kloi nam thai in Ubon Ratchathani; kang pla
Herbal Usage: Herb is obtained from Hainan and Yunnan. The whole plant is used as a remedy for heat and toxins, sore throat and tonsillitis in China (Wu 1994). Leaves are used to treat diabetes in Thailand (Chuakul 2002).
Cleisostoma hongkongense (Rolfe) Garay [see C. williamsoni (Rchb .f.) Garay]
Cleisostoma paniculatum (Ker-Gawl) Garay
Local names: big centipede orchid; tiger stripes; Taiwan centipede; purple stripes
Description: Its local name is curious, seeing that this species has small yellow flowers only 7 mm across. Plant is 20 cm tall, intermediate in size among medicinal Chinese species of Cleisostoma. The slim, erect stem is sometimes branched and carries numerous flat, linear, oblong leaves, 10–25 by 0.8–2 cm. Sepals and petals are yellow-green with brown lines. Lip is yellow with a brownish tinge at the edge of the side lobes. Inflorescence is axillary, branching with 10–15 flowers. Flowering season is June. The species is distributed from Taiwan southwards to Fujian, southern Guangdong, Hong Kong, Guangxi, Hainan, Jiangxi, Sichuan and Xizang; also Vietnam, northeastern and central Thailand and northeast India (Vaddhanaphuti 2001).
Herbal Usage: The entire plant is used to boost yin, treat coughs and to strengthen the lungs in Taiwan (Lin et al. 2003).
Cleisostoma scolopendrifolium (Makino) Garay [see Pelantheria scolopendrifolium (Makino) Aver.]
Cleisostoma tenuifolium (L.) Garay
Common name: delicate leafed Cleisostoma
Old Malabarese name: Mau Tsjerou Maravara, Ambo keli; Kolli Tsjerou Mava-maravara, Abo-tia
Herbal Usage: The whole plant was used in western peninsular India to treat kidney disorders, leucorrhoea, gonorrhoea and scalds (van Rheede 1703). Made into a poultice, Kolli Tsjerou Mava-maravara was used to reduce pain and swelling of abscesses and to promote their rupture. Plant was also blended in vinegar and administered to expel kidney stones, treat dysuria, gonorrhoea, other forms of white vaginal discharge and heavy menstrual loss (Van Rheede 1703).
Cleisostoma williamsonii (Reichb. f.) Garay
Common Name: Dianmiangeju Lan (Yunnan - Myanmar separate distance orchid)
Chinese medicinal name: Longjiaocao
Herbal Usage: The Chinese herb is obtained from Guangdong, Guangxi and Yunnan. Plants can be harvested throughout the year, washed and sun-dried. Taste is mildly sweet and sour, and it is neutral in nature. The whole plant is used to improve blood circulation, relax muscles and joints, clear phlegm and stop coughs. It is usedused in treating pulmonary tuberculosis, viral encephalitis, stroke, polio, backache and indigestion in children (Wu 1994).
The herb may be harvested at any time during the year and the entire plant is sun-dried for future use. It is mildly sweet and sour in flavour, neutral in nature. It simulates circulation, relaxes muscles and joints, stops coughing and is an expectorant. A Guangxi Materia Medica mentioned that it was usedused during epidemics of encephalitis B and to treat patients with tuberculosis or paralysis resulting from stroke or poliomyelitis, and malnourished children. A simple decoction is prepared by boiling 9–15 g of the herb. Alternatively, a soup may be prepared by boiling 9–15 g of Lionjiaocao (C. williamsonii), 9 g of Zanthoxylum bungeanum Maxim. (Chinese prickly ash, Sichuan pepper) root bark and lean pork. The preparation can alternatively be turned into a stew (Zhaoyao Bencao 2000).
In A Concise Edition of Medicinal Plants in China, Wu Xiu Ren listed C. hongkongense as a separate species from C. williamsonii and the two are given different Chinese names; Honghuageju Lan (red flower separate distance orchid) for C. hongkongense and Dianmiangeju Lan for C. williamsonii with Longjiaocao as the medicinal name for the latter. Botanically, however, these two species are identical. There may be varietal differences between the two, but both herbs are reported to be obtained from Guangdong, Guangxi and Yunnan. Furthermore, the fact that the ‘two’ Cleisostoma are similar in their usage shows that Chinese herbalists do recognise that they are one and the same species.
Although a widespread genus, Cleisostoma does not appear to have a medicinal use outside China, apart from some limited usage in the region of the Western Ghats during the early seventeenth century (van Rheede 1703). In the latter region, it was not mentioned again when Caius compiled his description of medicinal plants in the region of Bombay (Mumbai) in 1936. Most Chinese medicinal books make no mention of the orchid, and it is only in Wu’s (1994) extensive listing that some species are listed and their usage described. There is much overlap and confusion over taxonomic identification, but the different species appear to have a similar usage in a wide spectrum of unrelated illnesses.
The earliest search for medicinally active compounds focused on alkaloids (Luning 1974a, b, 1980; Slaytor 1977), those bitter compounds produced by plants, the most famous one of which is possibly quinine. Five Cleisostoma species were screened for alkaloids and none were found to have at least 0.1 % alkaloid content which was designated as the diagnostic criterion for classification as an alkaloid-accumulating species. However, several non-medicinal species (C. appendiculata, C. discolor, C. racemiferum, C. subulatum) contained small amount (0.01–0.1 % dry weight) of alkaloid (Luning 1974a, b).
Coeloglossum viride Hartm. [see Dactylorhiza viridis (Linn.) R.M. Bateman, Pridgeon and M.W. Chase]
Genus: Coelogyne Lindl.
Chinese name: Beimu Lan (pearl shell orchid)
Six Chinese species and two Thai species are used for medicinal purposes, while C. ovalis is used in India as Jeevanti (a substance which promotes life). Eight species from Nepal are medicinal (Pant and Raskoti 2013).
Coelogyne barbata Lindl. ex Griff.
Local name: Xuchunbeimu Lan (beard and lip pearl shell orchid), Ranmaobeimu Lan
Chinese medicinal name: Fengian
Description: Plants are epiphytic or lithophytic. Pseudobulbs are clustered, pale green, almost round, up to 10 cm in diameter, and carry 2 leathery, narrowly lanceolate, stalked leaves; up to 45 by 6 cm. Inflorescence is arching with few, crowded, white, musk-scented flowers, 5–7.5 cm across. Lip is white and bears three deep sepia-brown, fringed crests at the centre: it is fringed around the distal third with similarly coloured projections. Flowering season is autumn to winter. The species is distributed in Nepal, Bhutan, the Khasia Hills in Bangladesh, Myanmar and Gaoligongshan in Yunnan (Hawkes 1965; Jin et al. 2009).
Prescriptions employing Feng Lan (Coelogyne barbata Lindl. ex Griff.) Reference: Zhonghua Bencao 2000
Preparation: for decoction, use 15–30 g Feng Lan (C. barbata)
For external use: an appropriate amount, pulverise and apply
1. Indications: Cough with “lung heatiness”
Decoction with Plantain 30 g
2. Indication: sore throat
Decoction with Plantain 30 g, Prunella 15 g
3. Indication: Pain associated with hernia or scrotal swelling
Decoction with Plantain 30 g, Tangerine seed 15 g
4. Indication: Bruises and Sprains
Prepare paste with C. barbata and Plantain, and apply fresh to wounded part
5. Indication: Chapped hands and feet.
Prepare paste with equal amounts of C. barbata and Plantain and apply to wounds.
(Source: Xizang Chinese Materia Medica)
Coelogyne corymbosa Lindl.
Chinese name: Yanbanbeimu Lan (eye spotted pearl shell orchid), Beimu Lan (pearl shell orchid), Zhixueguo (haemostatic fruit); Shibajiao (stone palm leaves); Duiyeguo (fruit with a pair of leaves); Xiaoluji (small green Chinese elder)
Chinese medicinal name: Beimu Lan (pearl shell orchid); Guoshangye (leaves above the fruit)
Newari name: Tuyu kenbu swan
C. corymbosa is distributed from Yunnan to southern Tibet into Myanmar, Sikkim, Bhutan, Nepal and northern India. It is epiphytic on the tree trunks at the edge of forests and wet cliffs at 1300–3100 m.
1. Indication: bronchitis, flu
Use entire plant 15–30 g in decoction
(Source: Yunnan Selected Chinese Herbs)
2. Indication: soft tissue injuries
Use sheaths from base of pseudobulbs. Apply as powder or paste externally.
(Source: Yunnan Selected Chinese Herbs)
3. Indication: fractures
Grind Coelogyne corymbosa 100 g with Pteris multifidapoir 1 g
Apply to site of fracture after reduction and splinting.
Then add Man Shan Xiang powder to wound directly and apply another layer of the mixture.
Change medicine daily or on alternate days
(Source: Quan Zhan Selected Chapters)
4. Indication: bleeding from external wounds
Apply powdered, or a paste of grounded, fresh Coelogyme corymbosa to the wound
(Source: Wen Shan Chinese Herbs)
In India and Nepal, paste made with pseudobulbs is applied on the forehead to relieve headaches (Manandhar and Manandhar 2002; Baral and Kurmi 2006; Pant and Raskoti 2013). Juice of pseudobulbs is applied on wounds for pain relief and to treat burns (Das 2004; Baral and Kurmi 2006; Pant and Raskoti 2013).
Coelogyne cristata Lindl.
Chinese name: Beimu Lan (pearl shell orchid). Note that this name does not distinguish it from the preceding species.
Indian name: Hadjojen (bone joiner)
Nepali names: ban maiser, jhyanpate in Chepang dialect; chandi gabha (Nepali), syabal (Tamang)
Phytochemistry: Ethanolic extract of C. cristata is strongly bacteriostatic against Staphylococcus aureus and moderately against Escherichia coli (Marasini and Joshi 2012), a property which supports its usage in animal husbandry. Coelogin and coeloginin, and two novel 9,10-dihydrophenanthrene derivatives, coeloginanthridin and coeloginanthrin, were isolated from air-dried, finely-ground whole plant of C. cristata by Majumder’s group (Majumder et al. 1982a, 2001). The four compounds possess the biological activities of phytoalexins and endogenous plant growth regulators. Sensitivity testing of soil and other bacteria to individual phytoalexins should be performed to determine which compounds, if any, could be reasonable remedies for superficial infections, but such data are not available.
Ethanolic extract of C. cristata also restored trabecular bone without producing uterine changes when fed to mice rendered oestrogen-deficient by oophorectomy. Coelogin promoted surrogate markers of osteoblastic differentiation and activity in vitro (elevated alkaline phosphatase; increased calcium nodule formation). Together, they support the notion that the folk tradition of using C. cristata to treat fractured bones in the Kumaon region of Uttarakhand may have a rational basis. Perhaps there might be a role for compounds present in C. critsta for managing post-menopausal osteoporosis (Sharma et al. 2014).
Herbal Usage: Hadjogen (Indian, bone joiner; C. cristata) is used in the Himalaya to treat fractured bones in animals (Jaiswal et al. 2004). It is used to treat dysentery and diarrhoea in Myanmar (Naing et al. 2010) whereas in Nepal an infusion of pseudobulbs is used to correct constipation. Nepalese also use this orchid as an aphrodisiac (Pant and Raskoti 2013). Fresh juice or paste made with Coelogune cristata is consumed to relieve headache, fever and indigestion (Subedi et al. 2013). Juice squeezed from the pseudobulbs is applied to boils and to wounds on the hooves of animals (Manandhar and Manandhar 2002).
Coelogyne elata Lindl. [see Coelogyne stricta (D. Don) Schltr.]
Coelogyne fimbriata Lindl.
Chinese name: Liusubeimu Lan (tassels pearl shell orchid)
Myanmar name: Ngwe hnin phyu myo kywe
Herbal Usage: Herb is obtained from Hainan, Guangdong, Yunnan and Xizang. In Chinese herbal medicine, the whole plant is used to reduce heat (Wu 1994).
Coelogyne flaccida Lindl.
Chinese names: Lilinbeimu Lan (chestnut scales pearl shell orchid), Guishangye (the leaf above fruits)
Chinese medicinal name: Jidatui
Nepali name: Thur gava
Phytochemistry: Phenanthrenes and stilbenoids have been isolated from this species: flaccidin in 1988 (Majumder and Maiti 1988), and soflaccidin and isooxoflaccidin in 1991 (Majumbder and Maiti 1991). Callosin originally isolated from the orchid, Agrostophyllum callosum, was discovered in C. flaccida in 1995 (Majumder et al. 1995; Kovacs et al. 2007).
Herbal Usage: Herb is collected from Guizhou and Yunnan. Known as Guoshangye, C. flaccida is a popular medicine among the minority tribes in both provinces. In China, the whole plant is used to clear heat, counter dryness, promote the production of body fluids, and to clear phlegm and stop coughs (Wu 1994; Zhonghua Benco 2000). Pseudobulbs are made into a paste in Nepal and applied to the forehead to treat headache, while the juice treats indigestion (Manandhar and Manandhar 2002). The paste is also used for boils (Baral and kurmi 2006).
Coelogyne flavida Hook. f. (see Coelogyne prolifera Lindl.)
Coelogyne fuscescens Lindl.
Chinese name: Hechunbeimu Lan
Thai names: Sing to, phaya rat, phao hin
Description: Pseudobulbs are clustered, narrowly sub-oblong, 2–3 cm long and 5–7 mm in diameter, with two elliptic leaves, 12 by 1.5–2 cm (Chen and Clayton 2009). In Bhutan, C. fuscescens Lindl. var. fuscescens is much larger. Pseudobulbs are 8–14.5 by 1–3.2 cm (Pearce and Cribb 2002; Gurong 2006). Inflorescence carries only one or two pale yellow flowers which are 5 cm across, with golden brown edges at the sidelobes of the lip and three golden brown keels on the mid-lobe. It flowers in December in Thailand (Vaddhanaphuti 2001), October to November in Nepal (Raskoti 2009), June in Yunnan (Chen and Clayton 2009). This epiphytic or saxicolous species is found in northern and northeastern Thailand, Laos, Vietnam, Myanmar, southern Yunnan Sikkim, Bhutan and Nepal at 1300 m. It is lithophytic in Yunnan.
Herbal Usage: The whole plant is a Thai aphrodisiac. When the plant was shown to ten Thai herbalists, three stated that it was an aphrodisiac, but seven did not. Stems are also used to treat burns and otitis media (Chuakul 2002). In Nepal, abdominal pain is treated with juice extracted from pseudobulbs or a poultice made with it (Baral and Kurmi 2006; Pant and Raskoti 2013).
Coelogyne leucantha W.W. Sm.
Chinese name: Baihuabeimu Lan (white flower pearl shell orchid)
Description: Pseudobulbs are ovoid-oblong, 1.5–5 cm long and 8–15 mm in diameter, spaced 1–2 cm apart. Two leaves at the apex are oblong-lanceolate, 5–15 by 1.1–3 cm wide, with a long, narrow petiole. Inflorescence is apical, on matured pseudobulbs, erect, 15–20 cm tall, with 3–11 slightly droopy flowers on raceme. Flowers are 3–5 cm across, not fully opened, white with yellow blotch on the lip. Petals are filiform (Chen et al. 1999). Flowering season is May to July in China (Chen and Clayton 2009).
C. leucantha is epiphytic or saxicolous in broad-leaved evergreen forests below 2500 m in south and northwest Yunnan, southwest Sichuan, Myanmar and Vietnam. In the Gaoligongshan area, it is found on so many trees that, from May to June when the Coelogyne is in bloom, the trees are beautifully garlanded with their white flowers (Yang et al. 1998).
Herbal Usage: Herb is obtained from Yunnan. Pseudobulbs and sometimes the entire plant is used to lessen heat, stop coughs, improve blood flow, reduce pain, promote the union of fractured bones and repair torn tendons (Wu 1994).
Coelogyne nitida (Wall ex D. Don) Lindl.
Chinese name: Mijingbeimu Lan
Nepali names: Silver Orchid in English, bhyan pat (Chepang), Salida, Sanit (Gurung), Chandi gabha, para phul (Nepali)
Phytochemistry: Ochrolide, a phenanthropyrone, and Ochrone A, a novel 9.10-dihydro-1,4-phenanthraquinone together with coelonin are present in C. ochracea (= C. nitida) (Bhaskar et al. 1989, 1991). Ochrolic, a monomeric phenanthrene derivative and a precursor to phenanthropyrones, was isolated from C. nitida (Anuradha et al. 1994).
Coelogyne occultata Hook. f.
Chinese name: Luanyebeimu Lan (ovate leaf pearl shell orchid)
Chinese medicinal names: Luanyebeimu Lan (ovate leaf pearl shell orchid); Youguashihu (squashed epiphyte)
Description: Plant has small pseudobulbs 1.5–5 cm by 0.5–1.5 cm with two ovate, coriaceous leaves at the apex, 1.5–6 by 1–2.5 cm. Flowers are relatively large, 5–6 cm across; white with two large yellow eyes connected by a transverse band on the proximal half of the lip whose side lobes are streaked with brown veins. It grows on tree trunks or cliffs at 1300–3000 m in Yunnan, Tibet, Myanmar, Sikkim and Bhutan. Flowering season is June to August (Chen et al. 1999; Chen and Clayton 2009).
Usage: Herb is obtained from Yunnan and Xizang. It nourishes yin, protects the kidney, nourishes the stomach and promotes the production of body fluids. Plant is used to treat hot flushes, fever, nocturnal emission, backache, anorexia and gastritis (Wu 1994; Zhonghua Bencao 2000). Decoction is prepared with 6–9 g of the herb for consumption to promote yin, relieve thirst and dry throat, or to treat tuberculosis, night sweats, chronic gastritis, lack of gastric acid, anorexia, nocturnal emission, waist pain, fatigue and haemorrhoids (Zhongyao Da Cidian 1986). It helps digestion (Chen and Tang 1982).
Coelogyne ochracea Lindl. [see Coelogyne nitida (Wall ex D. Don) Lindl.]
Coelogyne ovalis Lindl.
Chinese name: Changlinbeimu Lan
Indian name: Jeevanti
Phytochemistry: 2,7-dihydroxy-3,4,6-trimethoxy-9,10-dihydrophenanthrene, coelogin, coeloginin, flavidin, flavidinin, batatasin III, imbricatin, beta-sitosterol and its glycoside and a new bibenzyl compound, 3′-o-methylbatatasin III, are present in C. ovalis (Majumder and laha 1981; Majumder et al. 1982c; Majumder 1984; Sachdev and Kulshreshtha 1986). An alcoholic extract of the orchid pseudobulbs which contained flavidin and coelogin showed spasmolytic activity. Flavidin produced 50 % and 90 % inhibition of barium chloride-induced spasm of the guinea pig ileum at 1.0 and 2.0 mcg/ml doses. Coelogin showed 50 and 51 % activity at 0.5 and 1.0 mcg/ml (Sachdev and Kulshreshtha 1986).
Herbal Usage: It is known as Jeevanti which means ‘promoting life’, and in this respect it is usedused as a tonic. In Nepal, pseudobulbs are regarded as aphrodisiacs (Pant and Raskoti 2013), hence the name Jeevanti. However, Jeevanti may also refer to other popular “aphrodisiac” orchids, Flickingeria fugax (= Dendrobium fugax) and Flickingeria fimbriata (= Dendrobium plicatile) in eastern India, or to Leptadenia reticulata in northern India and Holostemma annulare in southern India, these last two being plants that are not orchids (Sarin 1995). Baral and Kurmi (2006) reported that paste made with pseudobulbs is used as aphrodisiac!
The entire plant of C. ovalis is also usedused in western and southern India to treat coughs, urine infections and eye disorders (Rao 2004).
Coelogyne prolifera Lindl.
Chinese name: Huanglubeimu Lan
Nepali names: Liso in Gurong dialect, Thurgaujo (Nepali)
Description: An epiphytic orchid, its pseudobulbs are spaced 2.5–4 cm apart and measure 2.2.–3.7 long and 1 cm in diameter. Leaves are paired, oblong to lanceolate, 8–13 by 1.6–2.1 cm, with a 2–2.5 cm long petiole. Inflorescence is borne apically on leafy pseudobulbs, 10–15 cm long with 4–6 greenish-white to yellow green flowers, 1 cm in diameter. Sepals are oblong, petals linear. Flowering period is June in China (Chen et al. 1999; Jin et al. 2009), January in Thailand (Vaddhanaphuti 2005), April to June in Nepal (Raskoti 2009), March to July in Bhutan (Pearce and Cribb 2002; Gurong 2006) and May to June in South India (Abraham and Vatsala 1981). C. prolifera is found on rocks and trees at 1100–2200 m in west and southern Yunnan, Myanmar, Thailand, Laos, Bangladesh, Sikkim, Bhutan and Nepal.
Phytochemistry: Flavidin, a novel 9,10-dihydrophenanthrene derivative, has been isolated from C. flavida Hook. f. (syn. C. prolifera Lindl.). This phytoalexin also occurs in two other Himalayan orchids, namely Pholidota articulata and Otochilus fuscus (Majumder et al. 1982b). Four related compounds, flavidinin and oxoflavidinin (Majumder and Datta 1982), a 9,10-dihydrophenanthropyran named flaccidin (Majumder and Maiti 1988) and imbricatin are also present in the orchid. The last compound had earlier been isolated from Pholidota imbricata: hence its name (Majumder and Sarkar 1982).
Coelogyne punctulata Lindl.
Description: Psedobulbs are contiguous on a stout, rigid rhizome. They are oblong, 2.5–4 by 0.7–1.3 cm, bright yellow when dried. There are 2 leaves at the apex and papery sheatchs at the base. Leaf is lanceolate, 8–14 by 1.3–2.5 cm, petiolated. Inflorescence is 8–15 cm long, carrying 2–4 white flowers 4 cm across. Lip is trilobed and bears a central white keel. A bright yellow patch outlined with a thin, orange rim is present on either side of the keel and on the medial aspect of the side lobes. Flowering season is November in China (Chen and Clayton 2009). C. punctulata is distributed from central Himalaya to Bangladesh, Myanmar, Thailand, southeastern China (SE Xizang and West Yunnan), Thailand and Vietnam. It is epiphytic or lithophytic in forests at 100–2900 m.
Usage: Pseudobulbs are dried and made into powder for use to treat wounds and burns in northern India (Das 2004). It is usedused to treat dry coughs and bleeding resulting from trauma in Vietnam (Hung 2014).
Coelogyne stricta (D. Don) Schltr.
Indian name: Harjojan
Description: C. elata is an epiphyte with cylindrical to narrowly ovoid pseudobulbs, 15 by 2.5–6.5 cm, carrying 2 lanceolate, leathery leaves marked by prominent veins, 18–30 by 4–7 cm. Inflorescence is erect, up to 60 cm long with 4–10 flowers. Flowers are fragrant, 2.5–6 cm across, white, with a forked yellow central band on the lip. It flowers in March to June in Bhutan (Pearce and Cribb 2002; Gurong 2006), rarely also in October to November (Gurong 2006) and in Nepal, April to June (Raskoti 2009). C. stricta is found between 1100 to 2000 m in Yunnan, Myanmar and Indochina (Chen and Clayton 2009), 1400 and 2000 m in Nepal (Raskoti) and over a wide range of elevations, from 500–3300 m, in Bhutan (Pearce and Cribb 2002; Gurong 2006).
Phytochemistry: A 9,10-dihydrophenanthropyrone was isolated from C. elata (correct name: C. stricta) and C. nitida (Majumder et al. 1982c), and a 9,10-dihydrophenanthrene named coelonin was obtained from C. elata (= C. stricta) (Majumder and Datta 1984). The phytoalexins exhibit bacterostatic and fungistatic activities (Marasini and Joshi 2012).
Usage: In northeast India, it is used to promote healing of bones and is applied externally to fractured limbs (Trivedi, Dixit and Lal 1980). Poultice made with pseudobulbs is applied to relieve headache and fever in Nepal (Baral and Kurmi 2006; Pant and Raskoti 2013).
Coelogyne trinervis Lindl.
Thai name: Ueang mak
Description: Pseudobulbs are ovoid, 9 cm long, yellow green, with two narrow leaves, 40 by 3.5 cm that taper to a stalk towards the base. There are 5–6 white to creamy, fragrant flowers, 4–6 cm across, on the inflorescence. Tepals are narrow, 2.2 cm by 2.5 mm. Lip is marked with brown lines and three keels on the mid-lobe. Flowering period is November (Seidenfaden and Wood 1992; Vaddhanaphuti 2001). C. trinervis is found throughout Thailand, in Assam, Myanmar, Indochina, Peninsular Malaysia, Java and Maluku at 700–1000 m (Handoyo 2010).
Herbal Usage: In Thailand, the tuber is used to treat fractures and sprains (Chuakul 2002).
Coelogyne is a huge genus with a wide distribution, and it is surprising that only the few species in China, Nepal and Thailand, at the periphery of its distribution, should find medicinal usage, whereas in Malesia, where the genus has the most number of species, there is not much medicinal application. C. asperata is sacred in some parts of Indonesian Borneo (Kalimantan) and here it was believed that the abundance of the rice harvest could be predicted by seasonal profusion of its flowers (Lawler 1986).
C. cristata is used to treat dysentery and diarrhoea in Myanmar whereas infusion of its pseudobulbs is used to treat constipation or indigestion in Nepal (Pant and Raskoti 2013; Subedi et al. 2013). This apparent paradox suggests that the pseudobulbs of the orchid may contain heat-labile and heat-stable compounds with opposing actions, as is the well-known case with Angelica sinensis. C. cristata contains coelogin (a 9,10-dihydrophenanthrene derivative) which has been shown to reduce intestinal spasms (Sachdev and Kulshreshtha 1986). The observation supports the Burmese herbal usage of the orchid.
C. cristata is sometimes usedused to treat headache and fever in Nepal (Subedi et al. 2013). Three species of Coelogyne are regarded as aphrodisiacs: C. cristata and C. ovalis in Nepal (Pant and Raskoti 2013) and C. fuscescens Lindl. var. brunnea Lindl. in Thailand (Chuakul 2002). This usage is probably not widespread because the three species are still not endangered.
Majumder’s group in India have been most active in the investigating the chemical constituents of Coelogyne. In 1982, they reported the isolation of coelonin and coeloginin, two 9,10-dihydrophenanthrenes from C. ochracea (= C. nitida) and C. elata [= C. stricta (D. Don) Schltr.] known in Chinese as Shuangzhebeimu Lan] (Majumder et al. 1982c). C. nitida had not been reported as a medicinal plant at that time, and the isolation of coelonin in both C. nitida and C. stricta demonstrates the value of examining many species when searching for pharmacologically active compounds within a genus. This is standard practice.
Micropropagation of C. cristata with the intent of conserving this medicinal plant for Myanmar was achieved through the assistance of a scientific team led by Ki Byung Lim in Korea (Naing et al. 2010).
Genus: Conchidium Griff.
Concidium are dwarfed, epiphytic herbs that were until fairly recently listed under Eria. There are ten species distributed from the Himalayas to southern China, Japan, and continental Southeast Asia excluding Peninsular Malaysia. Plants are epiphytic or saxicolous, often forming mats on tree trunks or rocks (caespitose). Pseudobulbs have a single internode and bear 1–4 obvate, lanceolate leaves at the apex. Inflorescence is terminal with a few or a single white, pale green or yellow flower.
Conchidium muscicola (Lindl.) Rausch.]
Sanskrit Name: Jivanti
Herbal Usage: Lawler (1984) reported that the Sanskrit name for this orchid is Jivanti, a name that is more commonly applied to Flickingeria fimbriata (Dendrobium plicatile). The Sanskrit word Jiva means ‘life’ and the term Jivanti is used for many herbs which are considered to be powerful tonics possessing rejuvenating and life-prolonging properties. They also act as aphrodisiacs. For comparison, some members of the contemporary medical fraternity assign a similar role to testosterone. Apart from this usage, the pseudobulbs of Eria muscicola are usedused in India to treat diseases of the heart and lungs, disorders of the nervous system, eye, ear and skin, facial tumours, fever and rabies (Hoernle, quoted by Lawler 1984). Usage in Nepal is fairly similar: it is usedused to treat heart, lungs and psychiatric disorders (Baral and Kurmi 2006).
Genus: Corymborkis Thouars.
Chinese name: Guanhua Lan
Corymborkis veratrifolia (Reinw.) Blume
Chinese name: Guanhua Lan
Malaysian name: Kayu Hok in aboriginal Semang
Phytochemistry: Alkaloid is present in Corymborkhis veratrifolia (Lawler and Slaytor 1969).
Herbal Usage: In 1906, Ridley received a specimen of Corymbokis veratrifolia with a note from Dr. J.D. Gimlette who was the British Resident Physician in Kelantan, the most northeastern state of the Malay Peninsula. The note read: “Collect the green leaves; bruise them in quantity; administer the juice either alone or with fine scrapings of Akar Bertak (which is not an orchid). It will cause vomiting. Use for ague (Demum kura), especially in children. No water to be mixed with juice. It is customary to cultivate a plant for the occasion” (Ridley 1906; Gimlette and Thomson 1939). In India, juice freshly extracted from the leaves is usedused as an emetic (Rao 2007). It is usedused to treat cuts on the feet in the British Solomon Islands (Henderson and Hancock 1988).
The instruction given by Gimlette recalls Li Shizhen’s prescription for Artemesia. Since C. veratrifolia is also usedused to treat ague (malaria or some other illness characterised by fever and rigors, perhaps dengue), it might be worthwhile to test the orchid against Plasmodium falciparum. It should be remembered that artemisinin (Chinese Qinghaosu) is heat-labile and any active ingredient in C. veratrifolia may also be destroyed by heat. There are currently no published pharmacological data on this orchid.
Genus: Cremastra Lindl.
Chinese name: Dujuan Lan (Azalea orchid)
The generic name is derived from Greek kremastra (flower stalk) which is the conspicuous feature of the genus.
Cremastra appendiculata (D. Don) Makino
Chinese name: Mabian Lan (horse whip orchid), Dujuan Lan (Azalea orchid); Shancigu (kind mountain lady), Maocigu (kind furry lady), Sandangu (three layer hoop)
Japanese: Sai-hai ran (purple orchid standard), Sanjiko
Korean: Sanjago, Yaknancho
Medicinal names: The Chinese Shancigu also refers to Pleione bulbocoides. It is Sanjiko in Japanese, and Sanjago in Korean (Kimura et al. 2001). Their similarity denotes a ancient common origin.
C. appendiculata is endangered because of habitat disturbance. At the Guizhou Biotechnology Institute, in vitro methods are being developed for mass propagation of the orchid from seed and meristems (Mao et al. 2007).
Recently, an additional 11 new and 23 known compounds were isolated from C. appendiculata. They include 20 phenanthrene or 9,10 dihydrophenanthrene derivatives, five bibenzyls, seven glucosides, adenosine and gastrodin. When tested for cytotoxic activity, only one compound showed moderate activity against A549 tumour cell line (Wang et al. 2013).
In the hexosan present in tubers of C. variabilis [= C. appendiculata var. variabilis (Bl.)I.D. Lund], the ratio of d-mannose to d-glucose is 3:1 (Ernst and Rodriguez 1984).
1. For reduction of swelling, dissolution of phlegm, detoxification, carbuncle, tuberculous lymphadenitis, throat numbness, swelling and pain, snake bites, and (?) rabies:
Wen Ha (a species of frog?) 90 g,
Cremastra. variabilis (Shan Ci Gu) 60 g,
Moschus moschiferns 900 mg,
Qian Jin Zi 30 g,
Euphorbia Perkinensis 45 g.
Cook with glutinous rice and make 40 tablets.
Take one tablet each time.
Original Source: Essentials of External Diseases
2. For carbuncle, jaundice:
Grind Cremastra. variabilis with roots and Can Er Cao,
Mix and take with wine, 9 g each time.
Original Source: Qiankun Sheng Yi
3. For ulcers, sores, scrofula, snake bite
Shancigu 9–15 g in decoction for oral consumption and also applied to affected part
4. For malignant sores and jaundice
(a) Shancigu with roots
Xanthium sibiricum (Siberian cocklebur)
Pulverise. Mix the two ingredients with wine; filter. Filtrate is the medication.
(b) Render into powder Shancigu. Add 9 g to wine for consumption
5. For cracked skin
Pulverise the sheath of the stems and apply to affected part
Decoction made with 9–15 g of Shancigu
7. To treat cancer of the oesophagus
Shancigu 9 g
Cloves 9 g
Diospyros kaki (persimmom) 5
Boil and drink.
Neovascularisation (an overgrowth of new blood vessels) in the eye is the commonest cause of blindness. It occurs in premature retinopathy, diabetic retinopathy, age-related macular degeneration and sickle cell anaemia. Jeong Hun Kim and his colleagues found that, in a rat model, the compound, a homoisoflavanone, extracted from C. appendiculata significantly reduces retinal neovascularisation. The scientists proposed that the compound might be useful for the treatment of vaso-proliferative retinopathies (Kim, Kim, Kim et al. 2007; Kim et al. 2008). A synthetic isomer of this homoisoflvanone code-named SH-11052 exhibits antiproliferative activity against human umbilical vein endothelial cells and human retinal microvascular endothelial cells. Although it did not induce apoptosis, it might be able to complement existing anti-angiogenic drugs usedused in the treatment of neovascular eye diseases (Basavarajappa et al. 2014). An ethanol extract of Dendrobium chrysotoxum was also found to be capable of alleviating retinal angiogenesis in streptozotocin-induced diabetic rats (Gong et al. 2014), but the identity of the compounds with this property was not defined.
Homoisoflavonoids exhibit a broad range of bioactivities that include antimicrobial, antimutagenic, anti-oxidant, immunomodulatory, antidiabetic, cytotoxic, anti-angiogenesis, vaso-relaxant, anti-inflammatory and anti-allergic effects (Lin, Liu, Ye 2014; Lee et al. 2014a, b; Basavarajappa et al. 2015). Therefore, there is still much about C. appendiculata that could be explored. Perhaps homoisoflavanone would also find a use in the treatment of tumours. There is a single case report of a 74-year-old patient with metastatic bladder cancer who refused chemotherapy and was treated with oral and nebuliser Korean herbal therapy which included C. appendiculata tubers. Serial X-rays showed diminution of the multiple metastatic nodules in the lungs and his symptoms disappeared. The herbal remedy is complex and, besides C. appendiculata, it contained Cordyceps militaris, Panax ginseng radix, Commiphora myrrha, Calculus bovis, margarita, Boswellia carteri, Panax notoginseng radix; the nebuliser solution was made with wild ginseng and Cordyceps sinensis distillate (Lee, Kim, Seong, et al. 2014). The Korean team is also studying other compounds from herbs with similar properties, for instance decursin extracted from roots of the non-orchidaceous plant, Angelica gigas Nakai (Kim, Kim, Lee, et al. 2009).
The anti-angiogenic homoisoflavanone, cremastranone, has now been synthesised. This synthetic compound was shown to inhibit proliferation, migration and tube formation of human retinal microvascular endothelial cells (Basavarajappa et al. 2014; Lee et al. 2014a).
In Japan, C. appendiculata is mixotrophic. Plants usually occur on the heavily shaded forest floor which rather limits their capacity for photosynthesis despite the presence of green leaves. However, the cortical cells of its underground rhizomes are heavily colonised by fungi (Coprinellus, Psathyrellaceae) which supply the orchid with additional carbon (Yagame et al. 2013). Orchids which associate with saprobic mycobionts like Gastrodia elata have been shown to contain neuroprotective compounds. Gastrodin has been isolated from C. appendiculata, but such therapeutic possibilities of the orchid for neuroprotection have not been explored.
Pleione bulbocodiodes (Franch.) Rolfe and Pleione yunnansis Rolfe are substitutes for C. wallachii when the term Shancigu is used (Zhonghua Bencao 2000; Bensky, Clavey, Stoger, Gamble 2004). Japanese and Korean medicinal names for C. appendiculata are derived from the Chinese. Shancigu entered the Chinese Pharmacopoeia around 720 during the height of the Tang Dynasty (618–907), a period which saw an active transfer of Chinese learning and culture to Korea and thence to Japan. The similar sounding Korean and Japanese names, Sanjaco and Sanjiko, respectively, for the medicine reflect the timing of C. appendiculata’s entry into Korean and Japanese herbal medicine.
Syn. Genus: Seidenfia Szlach.
Crepidium (syn. Seidenfia Szlach) is an Indo-Sri Lankan genus with 280 species of terrestrial herbs with hairy roots that were generally classified under Malaxis or Liparis. Six species are present in Peninsular India, and there is one in Seychelles. The genus was named by Blume and revived by Szlachetko.
Crepidium acuminatum (D. Don.) Szlach.
Indian names: Jeevak in Hindi, Jivak (Tamil), Jivakam (Malayalam), Jivakam (Tekugu, Jivakamu (Kannada), Jivaka (Sankrit): Lahsunia (vernacular name in Kumaun Himalaya)
Ayurvedic names: Jivak, Rishvak, Rishbhaka, Bandhura, Dhira, Durdhara, Gopati, Indraksa, Kakuda, Matrika, Visani, Vrisa, Vrisnabha
The preceding description fits the Indian variety. In Thailand, leaves are lanceolate-elliptic, thin, plicate, 5–9 by 2–3 cm, 4–6 leaves per plant. Thai flowers are 1 cm across (Nankorn and Watthana 2008). The orchid is also found at Gaoligongshan in western Yunnan where it blooms from May to July (Jin et al. 2009).
C. acuminatum is widely distributed from the southern Himalayas to Myanmar, Thailand, southern China (Xizang, Yunnan, Guizhou, Guangdong and Taiwan), Indochina and the Philippines to Australia at 300–2100 m. It is found mostly in pine or oak forests in the Himalayas (Jain 2003). Considered a medicinal plant and a protected species which is seriously threatened in India, it was discovered growing in the Haat Kali sacred grove in Uttarakhand in Central Himalaya (Singh 2010), and at 1800–2300 m in Garhwal (Dhayani et al. 2011).
Herbal Usage: C. acuminatum (syn. Malaxis acuminata) is one of eight component of ashtavarga (Dhayani et al. 2011). It is one of several herbs that could be considered as Jivak, another being Pueraria tuberosa (Indian name: kudzu) which is not an orchid (Puri 1970a). In Ayurvedic classification, it is sweet in taste (as a matter of fact, it is slightly bitter), cold in potency, pacifies vata and aggravates kapha. It is cooling, thus causing fever to abate, and promotes sperm formation. It is administered to men whose wives are unable to conceive. Pseudobulbs are used to treat bleeding disorders, fever, tuberculosis and a sensation of heat, emaciation, dysentery, rheumatism and insect bites (Pushpa et al. 2001). Sometimes, they are substituted with Pueraria tuberosa (Singh and Duggal 2009). Pseudobulbs of Crepdium acuminatum (syn. Microstylis wallichi) were considered to be simultaneously a tonic and an aphrodisiac (Duggal 1971). Dried pseudobulbs of C. acuminatum are incorporated into the Ayervedic tonic “Chyavanprash”, a popular herbal preparation for promoting health and preventing illness (Lawler 1984; Bhattacharjee 1998; Cheruvathur et al. 2010). It is a diuretic in addition to being a tonic (Pandey et al. 2003). In Bangladesh, it is used as a tonic to treat tuberculosis (Musharof Hossain 2009).
Jeevak or Jivak (C. acuminatum) features in the following formulations: Astavargha churna, Chyanprash rasayan, Chitrakadi taila, Vachadi taila, Mahakalyan ghrita, Mahamayura ghrita, Mahapadma taila, JIvaniya ghrita, Vajkaran ghrita, Brahini gutika and Himvana agada. Malaxis cylindrostachya (Lindl.) Kuntze and Malaxis mackinnoni (Duthie) Ames are sometimes usedused when C. acuminatum is not available. Other substitutes are Pueraria tuberosa (Vidara kand), Centaurea behen (Safed behmen), Centaurium roxburghii (D. Don) Druce (or Lal behmen) and Tinospora cordifolia (Guruchi). The last four herbs are not orchids (Chinmay et al. 2011; Balakrishna et al. 2012).
In Ayurvedic practice, to prepare the tonic for increasing sperm production and improving the reproductive tissues, 1 g of powdered C. acuminatum pseudobulb is mixed with the powdered Malaxis monophyllos (syn. Malaxis muscifera) pseudobulb, Lilium polyphyllum bulb, Fritillaria roylei bulb and Asparagus racemossus. This is consumed in the morning (Dhayani et al. 2011). Crepdium acuminatum has become rare in Kamaun Himalaya due to overexploitation (Jain 2003).
Crepidium resupinatum (G. Forst.) Szlach.
Syn. Seidenfia rheedii (Sw.) Szlach. (see Liparis rheedii Sw.); Seidenfia versicolor Marg. & Szlach.
Description: This is a variable, terrestrial herb with stems 8–21 cm long, 1.5–2 cm in diameter, with pseudobulbs along its length supporting 2–3 sessile, thin, lanceolate, plicate leaves 6–10 by 3–5.5 cm, and 7 veined. Inflorescence is erect and carries numerous small greenish-yellow to orange or purple flowers, 3.4 mm across. It continues to lengthen and produces new flowers which open successively over a long period. Flowers are non-resupinate. Lip is large, semicircular, with dentate margin, the teeth long and pronounced in some varieties, and barely visible in others (Abraham and Vatsala 1981). Plants are found in shaded locations between 400 and 1800 m (Jayaweera 1981).
The colour of the plant and flowers is influenced by light intensity: pure green in bright light, deep purple in the shade, and yellowish inbetween. It is because of this variation in colour that Lindley gave the species the epithet vesicolor (Santapau and Kapadia 1966). It was formerly referred to as Microstylis vesicolor, then as Seidenfia rheedii, and now as C. resupinatum. The species occurs in southern India (Karnataka, Kerala and Tamil Nadu) and in Sri Lanka.
Phytochemistry: Pseudobulb of C. acuminatum contains an alkaloid, glycosides, flavonoids, beta sitosterol, piperitone, 0-methylbatatasin, 1,8-cineole, citroenelal, eugenol, glucose, rhamnose, coline, limonene, p-cymene and ceryl alcohol (Pushpa et al. 2001; Balakrishna et al. 2012).
Herbal Usage: In the western part of the Indian peninsula, a potion made with the plant is used to treat fever, biliousness and infantile epilepsy (Delgardo, quoted by Lawler 1984).
C. acuminatum is an ingredient of the popular Indian rejuvenating tonic, Asthavarga in Uttarakhand in the western Himalayas and in many other parts of the country (Jalal et al. 2008). On account of its popularity as an ingredient in such Ayurvedic preparations and its rapid disappearance from its natural Indian habitat, Cheruvathur et al. (2010) undertook to propagate C. acuminatum in tissue culture by inducing adventitious shoots in cultured internodal explants. Meanwhile, Deb and Temjensangba (2006) succeeded with in vitro immature seed germination of another threatened terrestrial Indian Crepidium species, C. khasianum (Hook f.) Szlach. [syn. Malaxis khasiana (Hook f.) Kuntz.]. The plantlets showed 65 % survival under field conditions. Although this is not a medicinal species, it would appear that the medicinal C. acuminatum could also be seed-germinated.
Pseudobulb extracts of C. acuminatum contain polyphenols which possess anti-oxidant activity. This has been successfully exploited for the green synthesis of gold nanoparticles which will have applications in nanobiodiagnostics, pharmaceuticals, catalysis, and other applications of nanoscience (Gopal et al. 2014). However, they neither explain nor support the herbal usage of Crepidum acuminatum as a tonic and aphrodisiac.
An alkaloid, grandifoline, isolated from C. grandifolium (Schltr.) Szlach. (syn. Malaxis grandifolia Schltr.) is a glycosidic derivative of nervogenic acid esterified with laburnine (Lindstrom et al. 1971). Grandiflorine has also been isolated from Delphinium geyeri (low larkspur). It is closely related to the neurotoxin methyllycaconitine, and it has comparable neurotoxicity in mouse bioassays, whereas its synthetic monoacetate is significantly less toxic (Manners et al. 1998). Grandiflorine is one of several alkaloids in low larkspurs which are sometimes fatally ingested by cattle in the western USA (Gardner and Pfister 2009).
Genus: Cymbidium Sw.
Chinese name: Lan (orchid)
Cymbidiums are epiphytic or terrestrial orchids with extremely short rhizomes and pseudobulbs which carry many long, often arching, lanceolate, duplicate leaves which ensheath the pseudobulb at their base. Inflorescence arises laterally and carries several to numerous, showy, medium-sized to large flowers. Cymbidium is distributed in tropical East Asia from India eastwards to China, Japan and Southeast Asia in lowland and montane forests. Its hybrids play an important role in the cut flower industry but they are not grown extensively in Southeast Asia because the large, showy types require cool temperatures to initiate flowering. Approximately 68 species have been described, with 49 occurring in China. The generic name is derived from Greek kymbos (boat–shaped cup), alluding to the lip of the flower.
Cymbidium aloifolium (L.) Sw.
Chinese name: Wenban Lan (stripe petal orchid), Yingyediao Lan (stiff leaf hanging Cymbidium), Chuihuadiao Lan (pendulant flower Cymbidium), Diao Lan (hanging Cymbidium), Dabi Lan (lean-on-the-wall Cymbidium)
Chinese medicinal name: Yingyediao Lan (stiff leaf hanging Cymbidium)
Thai name: Ka Re Ka Ron
Vietnamese Name: Kim bien
Laotian names: Lung khao, Huan so pet, Kin loum, Khi mot top
Indian name: Supurn in Orissa State, boat orchid; panaipulluruvi (Valaiyans in Tamil Nadu)
Myanmar name: Thit tet lin nay
Nepalese name: Harjor in Tharu
English name: boat orchid
Santapau and Kapadia (1966) highlighted the confusion between this species and C. pendulum and with C. bicolor. C. aloifolium is sometimes confused with C. paucifolium in China, but the latter is distinguishable by its shorter, broader leaves and few flowers (usually 6–11), and also with C. mannii, but in the latter the leaves are thinner and the two lamellae of the lip are not broken in the middle (Liu et al. 2006). There is also confusion between this species and C. finlaysonianum Lindl., a common lowland orchid in Malaysia and Indonesia (Du Puy and Cribb 2007). The latter has pendulous scapes which commonly reach 90–100 cm in length with widely spaced flowers.
Phytochemistry: C. aloifolium contains several phenanthrenes: aloifol I and II, coelonin and 6-methoxycoelonin (Juneja et al. 1987), cymbinodin A (Barua et al. 1990), cymbinodin B (Ghosh et al. 1992), a novel polyoxygenated phenanthrene derivative designated pendulin, and a 3,7-dihydroxy-2,4,8-trimethoxyphenanthrene named denthyrsinin, the last which had earlier been isolated from Eulophia nuda and Dendrobium thyrsiflorum (Majumder and Sen 1991). An ethanolic extract of C. aloifolium leaves produced an anti-inflammatory and analgesic effect in mice (Howlader et al. 2011). It would be good to know which of any of the six phenanthrenes isolated so far have anti-infammatory, analgesic or haemostatic effects.
Pendulin, a polyoxygenated phenanthrene derivative, was isolated from C. pendulum (Majumder and Sen 1991). Unfortunately, the publication did not permit specific identification of the species because the orchid name might refer to any of the following: C. pendulum (Roxb. Sw. [= C. aloifolium (L.) Sw.); C. pendulum var. atropurpureum Lindl. [= C. atropurpureum (Lindl.) Rolfe]; C. pendulum var. brevilabre Lindl [= C. finlaysonianum Lindl.] or C. pendulum var. purpureum W. Watson [= C. crassifolium Herb.].
Herbal Usage: In Indian traditional medicine, juice is extracted from the whole plant by pounding it with ginger and a small amount of water is usedused to induce vomiting and diarrhoea (Caius 1936), or to cure chronic illness, weakness of the eyes, vertigo and paralysis (Lawler 1984). Reddy et al. (2005) who researched the region of the Eastern Ghats found that aboriginal Konda reddis of East Godavari district used the aerial roots of the orchid to make a paste for treating cracks on the feet, whereas aboriginal Koyas of Khammam district usedused a similar preparation for setting fractures. On the other side of the Deccan in the Uttara Kannada district, roots of C. aloifolium are added to tubers of a common terrestrial orchid, Zeuxine strataeumatica, to prepare a tonic (Rao 2004). Tribal residents at Kudremukh National Park in Karnataka use the mucilage extracted from the orchid leaves to stop bleeding from leech bites, as the sap is said to promote blood coagulation. Powdered pseudobulb is made into a drink to cause vomiting and purging by the same tribes (Rao 2007). C. aloifolium also forms an ingredient of medicinal oil that is usedused to treat both benign and malignant tumours. To treat paralysis, the Dongria Kandha tribe in Southwestern Orissa uses a twice-daily dose of a mixture of cow’s milk with powdered root of the orchid, ginger and black pepper for a period of 2 months (Dash et al. 2008). Santapau and Kapadia (1966) reported that the leaf sap had styptic properties. This useful medicinal property caused the plant to be collected to such an extent that it disappeared from some areas. Crushed leaves are used to stop bleeding from leech bites (Rao and Sridhar 2007). It is sometimes used as a vegetable aphrodisiac or as salep in India (Puri 1970b, c). Valaiyans living in the Vellimalai Hills of Tamil Nadu heat the leaves over a fire and administer the hot juice into the ear to relieve earache (Ganesan and Kesaavan 2003).
C. aloifolium is a constituent of a Sri Lankan oily embrocation usedused in the treatment of tumours (Soysa, quoted by Lawler 1984). In Indochina, a decoction of the plant is used as a medicinal bath for sickly children, or to treat women suffering from irregular menstruation (Petelot, quoted by Perry and Metzger 1980). Pseudobulbs are also used to treat cuts, sores and burns in Luang Prabang (Spire 1907, quoted by Vidal 1963). In Thailand, the leaves are used to treat ear infection while the root is usedused for kidney disorders (Chuakul 2002). In Myanmar, pseudobulbs are used to treat earache, stomach ache and dysentery, whereas leaves are usedused for fractures (Kurzweil and Lwin 2014).
In Nepal, a country which has imbibed many Indian traditions, the plant is used as an emetic, purgative and demulcent. It is also usedused in the form of a paste to treat dislocated bones (albeit many other orchids are also usedused for such purposes; see Calanthe masuca) (Manandhar and Manandhar 2002; Baral and Kurmi 2006; Pant and Raskoti 2013).
Chinese herbalists use the whole plant and its seeds to improve the condition of the lungs, stop coughs, establish regular menstruation, and to treat haemetemesis, discharge and bleeding from injuries. The medicinal plants are collected from Guangdong, Guangxi, Guizhou and Yunnan (Wu 1994).
Cymbidium bicolor Lindl.
Sri Lankan name: Visa Dhooli (Poison Dust); Beyudhuru (not specific; also used forPholidota imbricata)
Herbal Usage: Leaves are used for treating fractures in southern China (Wu 1994).
Cymbidium crassifolium Herb.
Chinese name: Rouye Lan (tender leaf Cymbidium)
Description: This epiphytic orchid has thick, duplicate, coriaceous leaves 20–90 cm by 1–3 cm. sheathing at the base. Inflorescence is lateral, pendulous with 10–20 flowers, 3–4.5 cm across, well spaced on the raceme. Sepals and petals are narrow, whitish or a pale yellow to brown, with a broad central streak of crimson. Petals are not well extended. Lip is trilobed, crimson with two longitudinal, yellow-coloured lamellae. It flowers in March and April in China, January to May in Thailand (Vaddhanaphuti 2005) and April to May elsewhere. The species is distributed from Yunnan eastwards across Guizhou and Guangxi to Guangdong and Hainan, southwards to Myanmar, Thailand, Indochina and Indonesia, and westwards to Nepal, Bhutan and Bangladesh, from 100 to 1600 m. It thrives in sunny locations, on trees in forests or in thickets. The medicinal plant is collected from Guangxi and Yunnan.
Herbal Usage: Leaves of C. bicolor are used for treating fractures (Wu 1994).
Cymbidium devonianum Paxton
Chinese name: Fu Lan
Nepali name: Thir gava
Vietnamese name: Gam ngu sac
Herbal Usage: In Nepal, a paste of the root is applied on boils. Plant is decocted until the liquid volume is reduced to half, salt is added and the decoction is consumed in small amounts three times a day for coughs and colds. Proportions are not stated (Manandhar and Manandhar 2002).
Cymbidium elegans Lindl. var. elegans
Chinese name: Suocao Lan
This species varies from the type in having more numerous flowers on the rachis. Lamellae on the lip are without any appendages (Chen and Cribb 2009).
Herbal Usage: Salep made with the plant is usedused as demulcent or emetic in India (Das 2004; Jalal et al. 2010). Fresh juice extracted from the leaves is usedused to arrest bleeding, especially from deep wounds (Baral and Kurmi 2006).
Cymbidium ensifolium (L.) Sw.
Chinese names: Lan (orchid), Guo Lan (National Orchid), Gog Lan (Nation’s Orchid), Jian Lan (Jian orchid), Dajing Lan (large, lush orchid), Jinbaolisuxin Lan (golden centered, quietly elegant orchid), Suxin Lan (quietly elegant heart orchid), Guanlanhua (official orchid flower), Lancao (orchid herb, orchid grass), Shanlanhua (mountain orchid flower), Kienlan (Fukien or Fujian Orchid), four season orchid, rock orchid, etc.
Medicinal names: Jian lan hua (famous orchid flower); Jian lan gen; Qiu Lan (autumn Cymbidium); Ba Yue Lan (Eighth month Cymbidium); Guan Lan (official Cymbidium)
Thai name: Chu lan
Description: This is the popular, fragrant Cymbidium which many oriental scholars identified with Confucius when he likened the company of good friends to a room full of fragrant orchids. It is frequently featured in Chinese paintings of the orchid that suggest grace and contentment. A standard advice to aspiring Chinese artists is to “Paint Cymbidium ensifolium when you are happy; bamboo when you are angry.”
C. ensifolium has numerous Chinese names (not including those of prized cultivated varieties). It is referred to as the National Orchid (Guo Lan) in Taiwan (Ou et al. 2003). However, it is not China’s national flower (Guo hua)—that is the peony (Paeonia).
The species is widely distributed throughout subtropical Asia, China south of the Yangzi, Japan, Indochina, Thailand, Malaysia, Philippines and Sri Lanka at 500–1800 m. It favours sparsely wooded, grassy slopes and open, hardwood forests which are not too humid.
1. Indication: chronic cough,
Prepare decoction with 14 flowers of Jian Lan Hua
(Xiamen New Treatment and Selected Chapters of Chinese Herbs)
2. Indication: tuberculosis with cough and haemoptysis
Squeeze juice from fresh Jian Lan Gen and cook with rock sugar.
Take 15–24 g each time.
3. Indication: hematuria or dysuria
Boil Jian Lan Gen 45 g, onion 3–5 bulbs, and take with brown sugar
4. Indication: leucorrhea
Cook Jian Lan Gen, Tian Dong, Lilium brownii, Bai Jie Ou with chicken
(Records of Sichuan Chinese Medicine)
5. Indication: feminine ‘dryness’
Cook Jian Lan Gen, Bai Jie Ou, Shi Zhu Gen, and Polygonatum chinense with pork
(Records of Sichuan Chinese Medicine)
In Indochina, the flowers were used as an ophthalmic wash, leaves as a diuretic, and roots for chest ailments (Petelot, quoted by Perry and Metzger 1980). Decoction of the flowers has a similar usage in Indonesia (Usher 1971), and to treat sore eyes in India (Das 2004). Also in India, rhizomes are boiled and the extract is consumed to treat gonorrhoea (Das 2004).
Cymbidium faberi Rolfe
Chinese names: Jiuhua Lan (nine flower orchid), Yijingjiuhua (nine splendour flower), Tubaibu (wild hundred steps); Taiwanyijingjiuhua (Taiwan Jiuhua blossom), Hui Lan (pure heart orchid), Changye Lan (long leaf orchid), Huaqi Lan (clearing gas orchid) . In Taiwan: multi-flowered orchid
Medicinal name: hua qi lan
Description: C. faberi is a large terrestrial herb with inconspicuous pseudobulbs and 6–10 linear, grass-like leaves, 60–90 cm long and 8–12 mm wide with serrated margins. Raceme carries 12–18 loosely arranged, fragrant flowers of pale green or yellow tinged with light purple, with purplish-red patches on the lip (Liu et al. 2006). Some varieties are very fragrant. Flowering period is February to May. In cultivation, it likes dampness but a well-drained medium. C. faberi occurs south of the Yellow River in China, in Taiwan, and in Nepal, Bhutan and northeast India, in sunny grassland or sparse forests at 700–3000 m, often in association with Miscanthus spp. (a perennial grass) or the Bhutan white pine, Pinus bhutanica (Gurong 2006).
Herbal Usage: Herb is collected in autumn. After washing, leaves and roots are removed from the pseudobulbs which are sun-dried for storage. The root is bitter, sweet, mild and slightly poisonous. C. faberi is used for the relief of headache or coughs, and to destroy insects, worms and lice. A decoction is taken for headache, while 6 g in decoction is consumed with white wine once a day to relieve coughs. To clear the bowel of ascaris (round worms), 500 g of C. faberi pseudobulb is added to wheat powder and made into buns. These are consumed over 3 days (Zhongyao Da Cidian 1986).
Cymbidium finlaysonianum Lindl.
Malay name: Sepuleh
Thai name: Ka Re ka Ron Pak Pet
Phytochemistry: 7-O-glycosides of vitexin and isovitexin was identified from C. finlaysonianum (Williams 1979).
Herbal Usage: Burkhill and Haniff (1930) reported that the Malay medicine men used it to remove bewitchment in Telok Anson, in the northwest of Peninsular Malaysia. At that time, malevolent spirits were thought to be the cause of numerous serious illnesses. Such employment of C. finlaysonianum and other orchids in the Malay magical approach to treating illness is indicated by their common Malay name, sepuleh which ranslates as “restorative”, i.e. restoring to health.
Cymbidium flaccidum Schltr. (see: Cymbidium crassifolium Herb.)
Cymbidium floribundum Lindl.
Local name: Duohua Lan (many flowered Cymbidium)
Description: Pseudobulbs are ovoid and a little flattened, 2.5–3.5 cm long, carrying 5 or 6 thin, coriaceous leaves, 50 by 0.8–1.8 cm. Inflorescence is suberect, lateral, with numerous flowers on the raceme. Flowers are well arranged and displayed, 3–4 cm across, of variable coloration, reddish-brown to green or brownish-grey with a white lip that is spotted with red. Flowering season is April to August. A large clump is very handsome when it produces numerous sprays of reddish flowers (Liu et al. 1969, 2006).
This epiphytic, occasionally terrestrial or saxicolous Cymbidium is widely distributed through central and southern China (Zhejiang, Jiangxi, Fujian, Taiwan, Guangdong, Guangxi, Hunan, Guizhou, Hubei, Sichuan, Yunnan and Xizang) at 100–3300 m. Plants are found in forests, at the edge of forests or on sunny cliffs and along ravines, and very rarely on rocky soil.
Herbal Usage: Herb is obtained from Huadong (Gouangdong Province), Huanan (Heilongjiang Province) and Tibet. Entire plant is used in the same manner as C. ensifolium (Zhongyao Da Cidian 1986; Wu 1994).
Japanese honey bees (workers, drones, queens and absconding bees) are attracted by fragrances emitted by C. floribundum which resemble compounds present in their mandibular glands. These are a mixture of 3-hydroxy octanoic acid and 10-hydroxy (E)-2-decenoic acid (Sugahara et al. 2013). Shiseido markets a perfume that contains the scent of Cymbidium. The French perfume Diorissimo ® attracts Euglossine bees in South America (Pijl and Dodson 1966) but we are not able to determine whether Shiseido’s perfume attracts Japanese honey bees.
Cymbidium floribundum Lindl. var. pumilum (Rolfe) Y.S. Wu et S.C. Chen (see Cymbidium floribundum Lindl.)
This variety is given different species status in the Chinese Materia Medica (2000), but it is not separated from C. floribundum Lindl. in Flora of China (Liu et al. 1969). Its medicinal usage is similar to that of C. floribundum (Zhongyao Da Cidian 1986; Wu 1994).
Cymbidium goeringii (Rchb. f) Rchb. f.
Local names: Chun Lan (spring orchid), Riben Chun Lan (Japanese spring orchid),
Diaolanhua (hanging orchid flowers); Cao Lan (grass orchid); Shan Lan (mountain orchid); Shuangfeiyan (twin flying sparrow)
Japanese: Hokuro (black seeds/age spots); Jiji-baba (grandpa and grandma)
Widely distributed throughout most of China (excluding the very northern provinces in Manchuria, Inner Mongolia, Xinjiang and Xizang), it is also found in Bhutan (at 500–3000 m with Pinus bhutanica, P. roxburghii, Quercus lanata and in mixed broad-leaved forests), in India, Korea and Japan (Liu and Nakayama 2007). It prefers stony habitats, shrubby slopes or sparse forests, at 300–2200 m. The southern regions of Korea represent its northernmost distribution, and here the clumps face south where they are exposed to wind speeds of 3 m/s. The swift wind cools the leaves in summer. In winter, wind blowing from the south maintains leaf temperature above minus 6 °C. Elsewhere in Korea, these conditions are not met and Cymbidium goeringii can barely survive in the wild (Cho and Beyoung 1995).
Phytochemistry: Cymbidine A, a monomeric peptidoglycan-related compound isolated from C. goeringii, possesses diuretic and hypotensive activities (Watanabe et al. 2007). Gigantol isolated from whole plants of C. goeringii by Won et al. (2006) exhibits inhibitory effects of LPS-induced nitric oxide and prostaglandin E2 (PGE2) production in macrophages. It is a potent inhibitor of tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6(IL-6) release, and it influences mRNA expression of these cytokines in a dose-dependent manner. These effects are produced through its ability to block nuclear factor kappa B (NF-kappaB) activation (Won et al. 2006).
Three new diketopiperazines were recently isolated from the fungus Chaetomonium cochliodes 88194 recovered from C. goeringii collected from Xinning in Hunan Province, China in 2008. Of the three compounds, only chaetocochin G arrested cell proliferation and induced apoptosis of MCF-7 human breast cancer cells in vitro. The other two compounds did not exhibit cytotoxicity (Wang et al. 2015).
C. goeringii is admired for its faint floral fragrance. This is constituted by a blend of methyl-cis(z)-dehydrojasmonate, (E) neroldol, 1,2,4-trimethoxybenzene, 1,2,3,5-tetramethoxybenzene and other jasmonates (Kaiser 1993).
Herbal Usage: According to TCM, roots improve blood flow, cool the blood and detoxify. The herb is used to treat traumatic injuries, bleeding from such injuries, and fractures, clear heat in the lungs, and relieve coughs and sore throat, stop the production of blood streaked phlegm, and treat haematuria and rabies. The entire plant is used to treat fever, large round worm infestation (ascariasis), abdominal colic associated with worm infestation, poor health, weak kidneys, dizziness, backache, sweating and piles (Zhongyao Da Cidian 1986).
Cymbidium hookerianum Rchb. f.
Chinese name: Hutou Lan
Chinese medicinal name: Hutou Lan
Herbal Usage: Seeds are applied on cuts and injuries as a haemostatic in India (Rao 2004). The Chinese herb which consists of the whole plant obtained from Yunnan is used to treat fractures and traumatic soft tissue injuries (Wu 1994).
Cymbidium iridioides D. Don
Chinese name: Huang chan Lan
Description: Plant is epiphytic or saxicolous. Pseudobulbs are ovoid, with 6–10 linear-lanceolate leaves 70–90 by 2–4 cm, pointed at the tips. Inflorescence is suberect, raceme laxly many-flowered. Flowers are reddish-brown, 7.5 cm across, lasting for months on the plant. Flowering season is September to December in Nepal (Raskoti 2009), August to December in China (Liu et al. 1969). C. iridioides is distributed in a narrow band from central and eastern Nepal (at 1500–2800 m) to northern Vietnam across Bhutan, Sikkim, Myanmar, SE Xizang, SW Sichuan, NW and SE Yunnan and SW Guizhou at 900–2800 m (Liu et al. 1969).
Phytochemistry: C. iridioides contains a triterpene glucoside, cymbidoside (Dahmen and Leander 1978) and a taraxerane triterpenoid, taraxerone, gigantol and sitosterol (Juneja et al. 1985). Taraxerone was inactive against leukaemia, or renal and ovarian cancer cell lines (Pub Chem CID 392170).
Herbal Usage: In Nepal, juice from the leaves of C. iridioides is used as a haemostatic on wounds (Baral and Kurmi 2006; Pant and Raskoti 2013). In the Khasi Hills in India, leaf juice is usedused to stop bleeding from wounds and for diarrhoea (Jalal et al. 2010).
Cymbidium kanran Makino
Local Name: Han lan (frigid Cymbidium orchid), winter orchid, Cao Lan (grass orchid)
This magnificent species enjoys much popularity among Chinese growers on account of its elegant form and strong fragrance.
(line drawing, Chen and Tsi 1998)
Herbal Usage: Herb is obtained from Huadong, Huanan and Yunnan. Chinese herbalists employ the entire plant to “purify the heart”, smooth the lungs, or to stop coughs and asthma. Roots are used for treating gastroenteritis and ascariasis (infestation of large intestinal round worms) (Wu 1994).
Cymbidium lancifolium Hook.
Chinese names: Soushan Hu (searching mountain tiger), Zhupo Lan (bamboo and pine Cymbidium orchid): Tuer Lan (rabbit ear orchid); Diqingmei (green floor plum); Xuli Cao (Through-the-ages herb, everlasting Herb). In Taiwan: white bamboo-leaf orchid.
Indonesian name : Ki Adjag in Sunda
Description: C. lancifolium is a small, terrestrial or saxicolous, and sometimes epiphytic, species found at low to moderate elevations (at 300–2200 m) throughout China south of the Yangzi and in Southeast Asia. It also occurs in southern Japan, south-eastern Tibet, Bhutan and northeast India. It is found in open forests, broad-leaved forests, bamboo forests, on the edge of forests and on humus-rich rocks along valleys.
Phytochemistry: Saponins are present in C. lancifolium. Alkaloids are absent (Boorsma 1902).
Herbal Usage: In China, the entire plant is used to relieve rheumatism, improve blood flow, and to treat traumatic injuries (Wu 1994).
Cymbidium longifolium D. Don (see Cymbidium elegans Lindl. var . elegans)
Cymbidium mannii Rchb. f. (see: Cymbidium crassifolium Herb.)
Cymbidium pendulum (Roxb) Sw. [see Cymbidium aloifolium (Linn) Sw.]
Cymbidium pumilum Rolfe (see Cymbidium floribudnum Lindl.)
Cymbidium macrorhizon Lindl.
Cymbidium sinense (Jacks.) Willd.
Chinese names: Baisui Lan (New Year Greeting Orchid, Pay a New Year’s Call Orchid), Baosui Lan (Congratulations for the New Year), Chun Lan (spring orchid), Mo Lan (dark orchid)
Description: This is a large terrestrial species with ovoid pseudobulbs, 2.5–6 by 1.5–2.5 cm that carry 3–4 lustrous, dark green, coriaceous, linear, lanceolate leaves, 60–90 by 2–3.5 cm. The tall, erect inflorescence bears 10–20 or more deep purple or purplish-brown flowers, that are strongly fragrant. They smell like violets (Nakamura, Tokuda and Omata 1990). Sepals and petals are narrow and pointed. Lip is cream, striped with red on the side lobes, and splashed with a border of red on the mid-lobe. It grows in shady, moist, well-drained soil in forests and along ravines at 300–2000 m. Its distribution extends from India to Myanmar, northern Thailand, Vietnam and east China to the Ryukyu Islands of Japan. In China, it has a long flowering period that extends from October to March (Chen et al. 1999) or to May (Chen, Liu, Chu, et al. 2009) with a peak around Chinese New Year, but in Thailand the chartreuse-coloured variety flowers in August (Vaddhanaphuti 2001) and the dark purplish-brown variety flowers from October to December (Nanakorn and Watthana 2008).
The typical Chinese variety is known as the var. sinense. C. sinense var. albo-juncundissimum (Hayata) Masamune, the Ink Orchid, is native to Hong Kong, occurring at Tai Mo Shan and Sunset Peak (Wu et al. 2002). The var. haematodes which has a more southerly distribution which extends to Sri Lanka, Indonesia and Papua New Guinea has broader leaves and scapes that are longer than the leaves. The floral morphology is similar, with red or green forms. Chinese and Japanese collectors admire Cymbidium for the shape of its leaves, and they are fascinated by the dark green leaves which carry fine yellow or white lines. Such Golden Thread Orchids are worth a king’s ransom. Peloric floral forms also occur.
Herbal Usage: The whole plant or just the roots may be usedused. Roots are collected in autumn and sun-dried for storage. They purify the heart and lungs, and stop coughs and asthma. A decoction prepared with 30 g of the herb is usedused to treat dry coughs (Li 1994).
Cymbidium wilsonii (Rolfe ex De Cock) Rolfe
Chinese names: Duanyechutou Lan (short leaf tiger head orchid), Diannanhutou Lan
Description: This epiphytic Cymbidium has ovoid, flattened pseudobulbs 4–6 by 2.5–3.5 cm. Leaves are slim, pointed, 70–100 by 1.3–3.2 cm. Inflorescence is 25–70 cm long and arching, with 5–15 chartreuse flowers, 9–10 cm across. Petals and sepals are narrow and pointed. Lip is cream, with chestnut stripes on the side lobes and purplish blotches along the edges of the mid-lobe. The lip becomes purplish-red after pollination. Flowering season is February to April. It is found in southern Yunnan and Vietnam at 2000 m (Liu et al. 2006).
Herbal Usage: Herb is collected from Yunnan. Roots used to treat weak lungs, coughs, bronchitis, tonsillitis and body ache (Wu 1994).
C. goeringii is the first orchid to receive the attention of mankind. It was mentioned in the Book of Odes (collated in the sixth century BC) under its ancient Chinese name “Wild Grass”. Confucius likened the character of gentlemen to the nature of Cymbidium—simple in its needs, modest, discreet, Spartan, resilient, reclusive and disdainful of honours, noble. When Kubulai Khan conquered China and instituted the most horrendous genocide, Zhen Xuxiao (1250–1300) expressed his grief by painting uprooted C. goeringii. This painting is now in the National Palace Museum in Taipei, but there are similar paintings in the collection of the Osaka Municipal Museum. It is one of the four seasonal flowers, and represents spring (Teoh 1982). Although many writers make the mistake of linking C. ensifolium with spring, that species flowers from June to October. Chun Lan (Spring Orchid) is the Chinese name for C. goeringii.
Cymbidiums have been cultivated as house plants in the Far East for more than 2000 years. In the course of time, new varieties have appeared, possessing variegated leaves, multiple flowers and various colour forms, such as narrow central purple streaks along the dorsal sepal and petals, or an orange-coloured flower (the variety Takahime or Martial Princess in Japan). Every one of the popular cultivated species (C. goeringii, C. ensifolium, C. kanran, C. faberi, C. tortisepalum, C. sinense, C. serratum, C. cyperifolium, C. hookerianum, C. floribundum) have produced mutations and there are several books in the Chinese language dedicated to describing such mutations. However, in so far as the aesthetic appreciation of Cymbidium emphasises simplicity and gracefulness of form and delicacy of fragrance, this should immediately disqualify most of the mutants.
Hybrids of Cymbidium enjoy a favoured position in the orchid cut flower trade because of the flower’s thick texture and longevity. Classified into four coloured groups, pink, yellow, green and white, their pigmentation is strongest in the lip, and even white forms carry a trace of pigment there. Six anthocyanins were isolated from 8 Cymbidium hybrids of four colours by Wang et al. 2014 working in New Zealand. The anthocyanins are: cyanidin-3-O-glucoside; cyanidin-3-O-rutinoside; peonidin-3-O-glucoside; peonidin-3-O-rutinoside; cyaniding-3-O(malonyl)-glucoside; and peonidin-3-O(malonyl)-glucoside. Anthocyanin, which is responsible for the lip coloration, is also present in high concentration in the tepals of pink flowers, but only trace to small amounts occur in flowers of other hues. Chlorophyll and its green breakdown products, pheophytin a and b responsible for the colour of green flowers, are also present in small amounts in yellow flowers. Yellow flowers carry beta-carotenoid and some additionally contain lutein. Three flavonols, glucosides of kaempferol, quercetin and isohamnetin, are present in all flowers. They are co-pigments that determine the final colour in association with anthocyanins (Wang et al. 2014).
Shiseido offers a perfume, Tentatrice, which carries the scent of Cymbidium. Ten aromatic glycosides were isolated from fresh flowers of the hybrid Cymbidium Great Flower ‘Marie Laurencin’, and two of these were new discoveries, namely marylaurensinosides D and E (Yoshikawa et al. 2014). Methyl cis(Z) dehydrojasmonate and related compounds are responsible for the fragrance of C. goeringii (Kaiser 1993), the orchid whose pleasant scent was usedused as a simile for friendship.
When a Cymbidium is used medicinally in TCM, the following names apply:
Lanhua refers to C. ensifolium, C. goeringii, C. faberi, C. floribundum and C. kanran;
Lanhuaye and Lanhuagen refer to C. ensifolium, C. kanran and C. floribundum var. pumilum;
Huaqilan and Huishi refer to C. faberi;
Niujiaosanqi refers to C. floribundum;
Hutoulan refers to C. hookerianum;
Yingyediaolan refers to C. pendulum.
Although coughs and tummy upsets are common conditions for which various Cymbidium species are a traditional medicinal remedy, there is no actual extensive usage of Cymbidium in TCM. This is probably due to the ready availability of many alternative remedies that have a longer history of usage, are less fancy, cheaper, and perhaps more efficacious. Four strains of mycorrhiza isolated from wild strains of C. goeringii showed strong inhibitory activity when tested against two pathogenic bacteria, Escherichia coli and Sarcina lutea (Min et al. 2012), but presently, mycorrhiza have not been usedused as probiotics.
Whereas C. aloifolium with its more southerly distribution enjoys many medicinal usages in the Indian sub-continent and Myanmar, it is totally ignored in TCM despite the orchid being present in several Chinese provinces (Yunnan, Guizhou, Guangxi, Guangdong and Hong Kong). Two Australian Cymbidium species are usedused by Queensland aborigines. Delicate children are reared on the readily available C. canaliculatum when accidents deny alternative supplies. The Australian aboriginal name for this useful plant is “dampy-ampy”. White Australians call it “native arrowroot” (Hedley 1888). Seeds of C. madidum are usedused as an oral contraceptive. The aborigines also chew on bulbs of any Cymbidium when afflicted by dysentery (Lawler and Slaytor 1970).
Ephemeranthroquinone B derived from a Cymbidium hybrid, Cymbidium Great Flower Marie Laurencin, inhibits Bacillus subtilis and has moderate cytoroxicity on lung promyeolcytic leukaemia (HL60) cells in vitro (Yoshikawa et al. 2012). Two new phenanthrenes, marylaurencinols C and D, and a new phenylpropanoid, ephermeranthoquinone, were isolated from Cymbidium Great Flower “Marylaurencin” and tested for antimicrobial activity against Bacillus subtilis, Klebsiella pneumonia and Grichophyton rubrum (Yoshikawa et al. 2014a).
An interesting group of compounds in Cymbidium are the lectins, a conceptionally new class of antivirals which bind to N-linked oligosaccharide elements of enveloped viruses (van de Meer et al. 2007). Test tube experiments showed that mannose-specific lectins from a Cymbidium hybrid and Epipactis helleborine prevent human immunodeficiency (AIDS) viruses (HIV-1 and HIV-2) and cytomegalovirus (CMV) from reproducing themselves. The 50 % effective concentration of the Cymbidium hybrid agglutinin (CA) and Epipactus helliborine agglutinin for HIV ranged from 0.04 to 0.08 mcg/ml, which is about 3 orders of magnitude below their toxic threshold (Balzarini et al. 1992). This suggests that they would not be poisonous when administered at the proper therapeutic dosage. However, they would need to be tested on laboratory animals and later on human volunteers before they can be medicine.
Large-scale National Cancer Institute (NCI) screening of 20,000 plant extracts for possible anti-HIV activity showed that approximately 5 % of organic plant extracts tested positive (Cragg and Boyd 1996). Some agents which show promise in vitro may not be usable because either they are not bio-available by oral administration, are only effective in high/near-toxic concentrations, or they possess serious side effects.
Nevertheless, the team from the Rega Institute for Medical Research at Ghent in Belgium and their associates have repeatedly stated that the properties of the plant lectins, which include Cymbidium agglutinin, among others, should be taken into consideration in the eventual choice of moving microbiocide candidate drugs into the clinical setting (Balzarini et al. 2004; Turville et al. 2005; Balzarini 2007; Balzarini et al. 2007; Pollicita et al. 2008; Auwerx et al. 2009).
Perhaps more importantly, Cymbidium agglutinin (CA) and a number of plant lectins strongly inhibited coronaviruses (transmissible gastroenteritis virus, infectious bronchitis virus, feline coronaviruses serotypes I and II, mouse hepatitis virus), arteriviruses (equine arteritis virus and procine respiratory and reproductive syndrome virus) and torovirus (equine Berne virus) (van de Meer et al. 2007). Scientists at Utrecht University in the Netherlands usedused three antiviral tests based on different evaluation principles to study the plant lectins: (1) cell viability (MTT-based colorimetric assay); (2) the number of infected cells (immunoperoxidase assay); and (3) the amount of viral protein expression (luciferase-based assay). These findings are important because there are no antivirals to combat infection with the Nidovirales (the Order grouping which includes the toroviruses, arteriviruses, roniviruses and coronaviruses). A coronavirus was the cause of the sudden SARS outbreak that caused numerous deaths and brought havoc to the Far East in 2002–2003. In their review, World Health Organization (WHO) experts on SARS from the Centre for Disease Control (CDC) concluded that, after they had examined 54 SARS treatment studies, “it was not possible to determine whether treatments benefited patients during the SARS outbreak. Some may have been harmful” (Stockman et al. 2006). Finding an effective antiviral agent is important. Can Cymbidium lectins provide an answer?
Cymibidium macrorhizon, being a holomycotrophic geophyte, should contain some interesting compounds. Unfortunately, published data have not appeared. There are altogether 170 species of holomycotrophic orchids within Asia (including eastern Russia) and the western Pacific (Campbell 2014) which can provide enormous opportunities for new discoveries. Chaetocochin, a diketopiperazine produced by Chaetomium cochliodes, isolated from C. goeringii, was recently shown to possess cytotoxic activity againt breast cancer cells in vitro (Wang et al. 2015).
Epiphytes absorb nutrients from the atmosphere. C. aloifolium growing in the environment of Kaiga, on the southwest coast of India where two nuclear power reactors were being constructed in 2001, contained elevated levels of the radionuclide 137 V. Higher fallout occurred when it rained (Karunakara et al. 2001). Cymbidium and other orchids may therefore be useful for minitoring the effects of environmental pollution: epiphytes for atmospheric contamination of radioactive elements, terrestrials for soil pollution of heavy metals and radioactive compounds. The findings further suggest that medicinal herbs harvested in contaminated localities might contain undesirable compounds.
Genus: Cypripedium Linn.
Chinese name: Shao Lan
The generic name is derived from Cyprus and pedium (Latin, slipper), the slipper of Cyprus. In Greek mythology, Cyprus (alternatively referred to as Paphos; hence Paphipedilum) is the island home of Aphrodite who is most beautiful among Greek goddesses.
Cypripedium cordigerum D. Don
Chinese name: Baichunshao Lan
Nepali Name: Jibri
Cypripedium cordigerum occurs in grassland, meadows and pine forests at 2800–3800 m in central and western Nepal, southern Tibet, Bhutan, Kashmir and Pakistan (Chen and Cribb 2009; Pant and Raskoti 2013).
Cypripedium corrugatum Franch. (see Cypripedium tibeticum King ex Rolfe)
Cypripedium debile Reichb. f.
Chinese names: Duiyeshao Lan (two leafed spoon orchid), Xiaoxipuxie Lan (small Xipu shoe orchid), Shuangyeshao Lan (two leaf spoon orchid), Erye Lan (two leaf orchid)
Description: A small terrestrial herb, it is probably the least impressive Cypripedium. Stem is thin, 8–15 cm tall. Leaves 2, directly opposite each other, small, 2.5–4 by 1–2 cm. A slim, 3-cm-long scape arises from the apex and curls downwards from the weight of the single, 2-cm, pale green flower of typical Cypripedium form. Lip is marked with maroon stripes. Flowering season is May to July. It grows on the forest floor in humus or litter-rich soil at 2000–3000 m, and has a restrictive distribution, being found only in southern Gansu, west and northeast Sichuan, western Hubei, at Mount Shenmachen in Taiwan and in Japan (Chen et al. 1999).
Herbal Usage: The entire plant is used in Taiwan. It improves blood flow, reduces swelling, relieves pain and is diuretic (Ou et al. 2003).
Cypripedium elegans, Rchb. f.
Chinese name: Yazhishao Lan
Description: Cypripedium elegans is a small plant, 10 cm tall with an erect stem that is densely covered with fine, white hairs. Plant bears 2 sub-opposite, sessile, ovate, apple-green, spreading leaves, 4–5 cm by 3–3.5 cm, laxly pubescent on both surfaces, and marked by 3 prominent veins underneath. Inflorescence is erect, 3–4 cm tall, with a single small flower, 1.5–2 cm long by 0.6–1.0 cm across. Petals and sepals are yellow-green, striped with maroon. Lip is white to yellowish-green and striped with crimson. Flowering period is June to July. It is found in humus-rich habitats on the edge of forests or in thickets at 3600–3700 m in northwest Yunnan and south to southeast Xizang, Nepal, Bhutan, Sikkim and northeast India (Chen et al. 1999)
Herbal Usage: In India, the root is used to treat disorders of the nervous system (Vij 1995). It is used as a nerve tonic and also in hysteria, spasms, fits, insanity, and epilepsy, and in rheumatism in the Himalayan region (Duggal 1971; Das 2004; Baral and Kurmi 2006; Jalal et al. 2010; Pant and Raskoti 2013).
Cypripedium fasciolatum Franch.
Chinese name: Dayezhuo Lan (big leaf spoon orchid)
Chinese medicinal name: Wugongqi
Description: Plant is robust 35–40 cm tall with a few, well-spaced, cordate, plicated leaves that measure 15–20 by 6–12 cm. Flowers are the largest among the Chinese Cypripediums, 10–12 cm across, of a cream to yellow colour, and marked by longitudinal reddish stripes over the synsepalum, petals and pouch. They have a sweet scent when newly open, but the smell becomes pungent when they age (Perner and Luo 2007). Flowering period is May to July. Cypripedium fasciolatum is endemic to China and has a small distribution in Sichuan, Hebei and Shanxi, growing in grassland and scrub or in forests at 1650–2100 m.
Herbal Usage: Herb is collected from Sichuan, Hebei and Shanxi. Roots and stems are diuretic and they are usedused to reduce swelling, improve blood flow, clear phlegm and stop pain, in particular joint pains. It is often used to treat generalised oedema, swelling of the lower extremities, fractures and other traumatic injuries (Wu 1994).
Cypripedium formosanum Hayata
Chinese name: Taiwanshao Lan (Taiwan spoon orchid), Taiwanpuxie Lan (Taiwan ordinary shoe orchid), Yidianhong (One Spot of Red), Taiwanjiapuxie Lan (Taiwan ordinary shoe orchid)
Description: Plant is 30–40 cm tall. Stem is erect, clothed at the base by the sheath of paired fan-shaped, plicate, finely hirsute, membranous leaves, 8–11 cm wide, and resembling a fan palm. Single, pale pink flowers finely spotted with red, and pubescent towards the base and peduncle, about 8 cm across, are borne on a 10-cm-long peduncle decorated by a few leafy bracts. Lip is pink, dotted with red spots. Flowering season is April to May (Chen and Cribb 2009). Cypripedium formosanum is found in forests of the Central Range of mountains in Taiwan (formerly known as Formosa) at 2500–3000 m, in moist sunny locations (Su 1985). It is an endemic, terrestrial species.
Herbal Usage: The entire plant improves blood flow, regulates the menses, expels gas, stops pain and relieves itching. The root and stem also expel gas, improve blood flow, and they are used to treat malaria, snake bites, traumatic injury and rheumatism (Lin et al. 2003).
Cypripedium franchetii Rolfe
Chinese name: Maozhuo Lan (hairy spoon orchid), Maoshao Lan
Chinese medicinal name: Wugongqi
Description: A pink to purplish-red Cypripedium endemic to China, plant is 20–35 cm tall with elliptical leaves 10–16 by 4–6.5 cm, lightly pubescent over the veins on both surfaces. The single flower on the inflorescence is 9–10 cm across, with prominent deep purplish veins on both surfaces of the sepals and petals but lighter markings on the pouch. It flowers in May to July (Chen et al. 1999).
Cypripedium franchetii occurs in humid, humus-rich soil on shrubby slopes and sparse woods at 1500–3700 m in Sichuan and southern Gansu eastwards to southern Shaanxi, southern Shanxi, western Henan and western Hubei (Chen and Cribb 2009).
Herbal Usage: Herb is collected from Shaanxi, Shanxi, Gansu, Henan, Hubei and Sichuan (Wu 1994). It is credited with the ability to regulate the flow of vital energy (qi) to eliminate obstruction to its flow, and improve blood circulation (Chen and Tang 1982). It is used to stop coughs, relief pain, “wind stagnation”, chest and epigastric pain (Wu 1994). Roots and stems are used in the same manner as Cypripedium fasciolatum (Zhonghua Bencao 2000).
Cypripedium guttatum Sw.
Chinese name: Zidianshao Lan
Chinese medicinal name: Banhuashaolan
Description: Plant is 15–25 cm tall, with slender creeping rhizome and an erect, pubescent, glandular stem bearing several sheaths at the base. Leaves, are 2–3, usually two, elliptic or ovate-lanceolate, 5–12 by 2.5–4.5 cm, green, turning black when dried. The small pink flowers are 2.5 cm tall, borne single on a pubescent inflorescence. They appear from May to July (Chen et al. 1999). Cypripedium guttatum enjoys the greatest distribution among Cypripediums being present in eastern Europe, northern Asia through Japan and North America. It is a small herb which is distributed throughout northern China (except Xinjiang) and southwest China except Guizhou, in forests, scrub and marshes at 1000–4100 m (Yang, Zhang, Feng, et al. 1993). It can be found in both open and shady habitats over a wide geographical range because of a greater efficiency in photochemical utilisation of absorbed light energy and a lower non-photochemical dissipation of excess light energy, but does best with 45 % sunlight (Zhang, Hu, Xu, et al. 2007).
Herbal Usage: The roots and leaves of this orchid have been used in eastern Russia and Siberia to treat epilepsy (Gmelin 1747, Dragendorff 1898, and Hawkes 1944, all quoted by Lawler 1984)
Cypripedium henryi Rolfe
Chinese names: Luhuazhuo Lan (green flower spoon orchid);
Chinese medicinal name: Longshejian (dragon tongue sword); Jinlongqi (gold dragon seven)
Description: Stem is erect, pubescent, 30–60 cm tall, carrying 4–5 broadly elliptical leaves near its tip, 10–18 cm by 6–8 cm. Inflorescence is terminal, 30–70 cm tall, with 2–4 yellowish-green flowers, 6–7 cm across, with narrow petals and sepals and a smooth surfaced, pouched lip. Flowers have the scent of spicy honey and attract a small black wasp, Lasioglossum sauterum (Perner and Luo 2007). Flowers appear in April and May.
Cypripedium henryi is an elegant, endemic, terrestrial herb found in open scrub in the Chinese highlands. It thrives in damp humus-rich soil in fairly open places at 800–2800 m from northwest Yunnan towards the northeast to Sichuan, southern Shaanxi, Guizhou and western Hubei.
Herbal Usage: Herb is collected from Shanxi, Gansu, Hubei and from China’s southwest (Wu 1994). Roots are used to improve qi and blood circulation, reduce swelling and pain, “cold in the stomach”, pain around the waist and thighs and pain resulting from injury. A decoction is prepared by boiling 6–9 g of the orchid roots. A standard dose contains 0.3–0.6 g of the roots (Zhongyao Da Cidian 1986)
Cypripedium himalaicum Rolfe
Chinese name: Xiaezhuo Lan (narrow calyx spoon orchid), Gaoshanshao Lan
Nepali name: Khujukpa
Herbal Usage: Cypripedium himalaicum is used in CHM to treat female infertility, hernia and pain at the waist in women (Wu 1994). In Nepal, juice extracted from fresh plants or a drink made with dried plants are used (Subedi et al. 2013). In Nepal, it is used to treat difficulty in passing urine, urinary stones, heart and lung disease and coughs (Baral and Kurmi 2006; Pant and Raskoti 2013).
Cypripedium japonicum Thunb.
Chinese name: Shanmaishao Lan
Chinese medicinal name: Shanziqi
Japanese name: Kumagiso
1. Indication: Tertian malaria
Pulverizse 1.5 g of roots for consumption with cold water 1 h before onset of symptoms.
Caution: Abstain from warm wine and rice for half a day.
2. Indication: pruritic rash
Boil whole plants to clean the skin
3. Indication: swellings of unknown etiology
Grind whole plants and mix with vinegar for application.
4. Indication: snake bite
(a) Fresh roots of Cypipedium japonicum 9–12 g
Goodyera sp. (Banye Lan) 6 g
Jinbuhuagen, fresh roots, 60–90 g
Boil the three ingredients and add to warm wine. Consume three times a day
(b) For application, 60–90 g of Cypripedium japonicum mixed with wine and rendered into a paste.
5. Indication: Low backache
Cypripedium japonicum 6 g decocted and added to wine
Cypripedium macranthos Sw.
Chinese names: Qilaixipuxie Lan (big flowered spoon orchid), Dahuashao Lan (big flowered spoon orchid), Dakoudaihua (large pocket orchid)
Chinese medicinal name: Dunshengcao, Wugongqi
Japanese name: Atsumoriso
A large, beautiful, northern Lady Slipper Orchid, C. macranthos, occurs in large populations in alpine meadows and scrub land across northern Asia from eastern Russia to the Kamchatka Peninsula, northeastern China (Heilongjiang, Jilin, Liaoning, Nei Mongolia, Hebei and Shandong), Korea and Japan, at 500–2400 m, overlapping with the same distribution as C. calceolus, but, unlike the latter species, it does not extend to North America.
A minature C. macranthos is present in Taiwan, C. macranthos var. taiwanianum (Masamune) F. Maekawa, (= C. segawai Masamune) or Ch-lai Cypripedium. This plant is 20 cm tall with leaves 6 by 3 cm, and flowers 6 cm across. It occurs in the Central Mountains at 3000 m, on ridges and rocky cliffs in the company of dwarf junipers (Perner 2007).
Herbal Usage: Chinese Herbals state that roots and stem promote diuresis, reduce swelling, clear ecchymosis, expel gas, stop pain and improve blood flow. The orchid is used to treat generalised oedema, swelling of the lower limbs, oliguria, leucorrhoea, gonorrhoea, rheumatism, traumatic injuries, dysentery and illness resulting from overwork (Zhongyao Da Cidian 1986; Wu 1994; Ou et al. 2003). Pulverised, dried flowers are used to stop bleeding from wounds. For oral consumption, the decoction is prepared with 6–9 g of the orchid plant and consumed with, or without, wine (Zhongyao Da Cidian 1986).
Cypripedium margaritaceum Franch.
Chinese names: Banyeshao Lan;
Chinese medicinal name: Lanhuashuangyecao
Description: This short, Chinese Cypripedium has a 10-cm, erect stem wrapped by two tubular sheaths and carrying two rounded ovate dark green leaves which are heavily spotted with blackish-purple on the superior surface. The leaves are held horizontally across the forest floor. A single flower, 3–4 cm across, appears terminally from May to July. Sepals are yellow with red spots and stripes; the petals and pouch white and similarly marked. The dorsal surfaces of the tepals are hairy while the anterior surface of the pouch is warty.
An endemic species, C. margaritaceum’s distribution is limited to grassy slopes at 2500–3600 m in southwest Sichuan and northwest Yunnan (Chen and Cribb 2009). It grows in deep shade (Puy and Cribb 1991).
Herbal Usage: C. margaritaceum is used when there is a need to nourish the liver and kidneys. It moderates qi (vital energy) and blood, promotes diuresis and relieves oedema, and improves blurred vision or night blindness. A commonly used folk herb in Yunnan, decoction is prepared by boiling 9–15 g of the herb (Zhongyao Da Cidian 1986).
Cypripedium tibeticum King ex Rolfe
Chinese name: Xizang Zhuolan (Tibetan scoop orchid); Zhoushao Lan (crepe spoon orchid)
Chinese medicinal name: Wugongqi; Zhoushao Lan (crepe spoon orchid)
C. tibeticum occurs in open forests and on grassy or rocky slopes and at 2300–4200 m from southern Gansu to western Sichuan, Tibet, Sikkim and Bhutan. It is numerous in open scrub, on humus pockets in the central and lower valley of Huanglong, the famous scenic spot in Sichuan (Perner 2002).
Herbal Usage: Herb is collected from Yunnan. Roots of C. tibeticum are thought to be anti-inflammatory and capable of preventing pain. They are used to increase urine output, relieve painful swellings, or to improve blood circulation and to treat menstrual disorders. Roots of C. tibeticum, 6–9 g in decoction, is consumed in Tibet to treat rheumatism, leg oedema, external injuries, gonorrhoea and leucorrhoea (Zhongyao Da Cidian 1986; Wu 1994). With the low boiling point of water at the high altitude of Tibet which can be as low as 56 °C, extraction of the ingredients of any plant would not be as efficient as in the lowlands. This could affect the potency of a decoction.
Phytochemistry: Cypritibetquinone A and B are two new phenanthraquinones isolated from C. tibetium. They are 7-hydroxy-2-methoxy-1,4-phenthraquinone and 7-hydroxy-2,10-dimethoxy-l1-4-phenanthraquinone, respectively (Liu et al. 2005).
Cypripediums are now attracting attraction from taxonomists, gardeners and biochemists. At the Institute of Medicinal Plant Development in Beijing and the Peking Union Medical College (PUMC), Liu et al. (2005) managed to isolate two new phenanthraquinones, cypritibetquinones A and B, from C. tibeticum. Cypripediquinone-A isolated from C. macranthum in 2000 (Ju et al. 2000) has been synthesised by oxidative coupling using MoC15 (Trosien and Waldvogel 2012), but its medicinal usage, if any, has not been described.
Cypripedium has been used medicinally in western medicine in Europe and in North America. Many Cypripedium species are distributed in North America, and American Indians used roots of C.s as sedatives and antispasmodics, as well as to treat hysteria and chorea (Griffith 1847). Cherokees prepared root tea with roots of C. acaule or C. calceolus to treat worms, stomach ache, flu and neuralgia (Hamel and Chiltoskey 1975). Fluidextractum Cypripedii, U.S.P. or extract of C. parvifolium and C. pubescens (sic) was official in the United States Pharmacopeia and included in the British Pharmaceutical Codex just a hundred years ago. The extract was used to treat nerve disorders and sometimes used as an aphrodisiac. It is interesting to note that, in India, there is a similar usage for C. elegans, the root of which is used to treat such disorders of the nervous system as hysteria, spasms, fits, madness and epilepsy (Duggal 1971).
Contact dermatitis occurred in a high percentage of subjects who came into contact with the glandular hairs of C. spectabile and C. pubescens (MacDougal 1894), but this has not been reported with the Asian species. Contact dermitis following contact with Cypripediums is caused by exposure to quinines and oxalate. Taken internally, overdose of Cypripedium induces hallucination (Wilson 2007).
The employment of C. japonicum by Chinese herbalists to treat bouts of malaria that recurs every other day (tertian malaria) is interesting and bears further investigation. There are three types of tertian malaria, each caused by a different parasite. Benign tertian malaria produces bouts of high fever with chills and rigours occurring every other day, and is caused by Plasmodium vivax. As its name denotes, it only weakens the patient and results in anaemia but is not fatal. Numerous antimalarial drugs like quinine, chloroquine and doxycycline work well for benign tertian malaria. Malignant tertian malaria is quite a different matter. The causative parasite, Plasmodium falciparum, does not provoke a high fever response but is capable of infecting the brain, and when it does the disease is often fatal (Hunter 1956). Common antimalarial drugs do not work on falciparum malaria but the parasite is killed by artemesinin, which is derived from an ancient Chinese herbal remedy for malaria, Artemesia annua. Thus, it would be important to know which type of malaria responds to C. japonicum, but that information is not available.
Genus: Cyrtosia Blume
Chinese name: Rou guo lan
Cyrtosia is a small genus of achlorophyllous, mycotrophic orchids constituted by five Asian species, three of which are found in China. Rhizomes are stout, simple or branched, with fleshy roots and scales at the nodes. Raceme is hairy and many-flowered. Flowers do not open fully and sepals are hairy on their dorsal surface (Chen and Cribb 2009).
C. septentrionalis has the largest seeds among orchids: they weigh 22 mcg each, which is ten times the weight of Goodyera repens seed that weigh only 2 mcg each (Rasmussen 1995). Seeds are winged.
Cyrtosia septentrionalis (Rchb. f.) Garay
Chinese name: Xue hong rou guo lan
Chinese medicinal name: Shanshanhu
Japanese name: Tsuchi-akebi, Dutuusoo
In the shaded and sparse understory of forests where C. septentrionalis occurs, insect pollinators are limited and the orchid has adapted by developing an effective self-pollinating system. Fruit set following autogamous and xenogamous pollinations were both recorded in central Japan (Suetsugu 2013).
4-(beta-d-glucopyranosyloxy)benzyl alcohol or gastrodin
Herbal Usage: Indications for use of this parasitic orchid mentioned in the Zhonghua Bencao are to use the root, 30 g in decoction, to treat stiffness or spasm of the muscles; a paste made with the whole plant and vegetable oil for sores and fungal infection of the skin with ulceration; and fruit with liquorice and prepared in decoction for treating gonorrhea. Another method of preparing the paste for external application to sores, used in Zhejiang, is to fry the plant to dryness and render it as powder before mixing with vegetable oil (Zhonghua Bencao 2000). Decoction of the root of Galeola septentrionalis was formerly used in Japan to treat gonorrhoea. Ash produced by burning the plant was used as a hair tonic for diseases of the scalp (Lawler 1984).
In its natural environment in Japan, C. septentrionalis was observed not to be capable of attracting pollinators despite its striking flowers, but the species manages to set fruit through autogamy (Suetsugu 2012). It is also not particular about its mycorrhizal association, albeit it is commonly associated with Armillaria mellea (Merckx 2012). Germination occurs in sawdust-based medium containing one of four fungal species, Armillaria gallica, Armillaria mellea, subsp. Nipponica, Armillaria tabescens and Xylobolus annosus; germination even occurred in the absence of direct seed–mycobiont contact (Umata et al. 2012). C. septentrionalis is therefore quite different from Gastrodia elata in its requirements for germination: Mycena osmundicola supports germination of Gastrodia elata whereas Armillaria mellea is required for its subsequent growth.
It is interesting to note that Cyrtosia (Galeola) septentrionalis has a permanent relationship with either Honey Mushroom (Armillaria mellea) or Armillaria tabescens, and that gastrodin is present in the tubers of C. septentrionalis. Armillaria mellea is responsible for many of the medicinal compounds derived from Gastrodia elata (Chinese herbal name: Tianma) which is so highly regarded by Chinese herbalists who use it to treat nerve disorders, in particular to promote recovery from stroke (see Gastrodia elata in this Chapter). It would not be surprising if either or both of these two achlorophyllous Cyrtosia species should share some similar pharmacological properties with Tianma. Nevertheless, presently, C. septentrionalis is not used in TCM to treat disorders of the nervous system nor hypertension.
Meanwhile, eight phenolic derivatives have been isolated from C. faberi Rolfe (reported as Galeola faberi) (Li et al. 1993a, b) (Fig. 9.58). Several compounds found in C. faberi were also present in Gastrodia elata, e.g. gastrodin, 4-hydroxybenzaldehye, 4-hydroxybenzylalcohol (Yang et al. 2007), which is not unexpected since both orchids parasitise on Armillaria mellea (Baumgartner et al. 2011). It would not be surprising if similar compounds are present in C. septentrionalis.
- Abraham A, Vatsala P (1981) Introduction to Orchids, with illustrations and descriptions of 150 South Indian Orchids. TPGRI, TrivandrumGoogle Scholar
- Balakrishna A, Srivastava A, Mishra R et al (2012) Astavarga plants – threatened medicinal herbs of the North-west Himalaya. Int J Med Arom Plants 2(4):661–676Google Scholar
- Balzarini J, Neyts J, Schols D, Hosoya M, Van Damme E, Peomans W, De Clerq E (1992) The mannose-specific plant lectins from Cymbidium hybrid and Epipactis helleborine and the (N-acetylglucosamine)n-specific plant lectin from Urtica dioica are potent and elective inhibitors of human immunodeficiency virus and cytomegalovirus replication in vitro. Antiviral Res 18(2):191–207PubMedCrossRefGoogle Scholar
- Baral SR, Kurmi PP (2006) A compendium of medicinal plants in Nepal. Mrs Rachana Sharma and IUCN, KathmanduGoogle Scholar
- Bensky D, Clavey S, Stoger E, Gambie A (2004) Herbal medicine materia medica, 3rd edn. Eastland Press, Seattle, WAGoogle Scholar
- Bhattacharjee SK (1998) Handbook of medicinal plants. Pointer Publishers, JaipurGoogle Scholar
- Boorsma WG (1902) Pharmakologische Mitteilungen I. Bull de l’Institut Botanique de Buitenzorg 14:1–39Google Scholar
- Bose TK, Bhattacharjee SK (1980) Orchids of India. Naya Prokash, CalcuttaGoogle Scholar
- Burkhill IH, Haniff M (1930) Malay village medicine. Gard Bull Straits Settl 6:165–321Google Scholar
- Burkill IH (1935) (1966 reprint, 2nd edn, with contributions by Birtwistle W, Foxworthy FW, Scrivenor JB, Watson IG). A dictionary of economic products of the Malay Peninsula, vol II. Crown Agents for the Colonies, London. Ministry of Agriculture & Co-operatives, Kuala LumpurGoogle Scholar
- Campbell F (2014) A summary of holomycotrophic orchids. MIOS J 15(4):6–17Google Scholar
- Caius JF (1936) The medicinal and poisonous plants of India. J Bombay Nat Hist Soc 38(4):791–799Google Scholar
- Chen XQ, Clayton D (2009) Coelogyne. In: Chen XQ, Zj L, Zhu GH et al (eds) Flora of China – Orchidaceae. Science Press, Beijing, pp 315–325Google Scholar
- Chen XQ, Cribb PJ (2009) Cyrtosia. In: Chen XQ, Zj L, Zhu GH et al (eds) Flora of China – Orchidaceae. Science Press, Beijing, pp 168–169Google Scholar
- Chen SC, Lang KY (1986) Cephalanthera calcarata, a new saprophytic orchid from China. Acta Bot Yunnanica 8:271–274Google Scholar
- Chen SC, Tang T (1982) A general review of the orchid flora of China. In: Arditti J (ed) Orchid biology. Reviews and perspectives II. Cornell University Press, ItcacaGoogle Scholar
- Chen SC, Tsi ZH (1998) The orchids of China. Native cymbidiums of China. Wanhai Books, BeijingGoogle Scholar
- Chen SC, Tsi ZH, Luo YB (1999) Native orchids of China in colour. Science Press, BeijingGoogle Scholar
- Chen XQ, Wood JJ (2009) Cleisostoma blume. In: Chen XQ, Zj L, Zhu GH et al (eds) Flora of China – Orchidaceae. Science, Beijing, pp 458–463Google Scholar
- Chen XQ, Cribb PJ, Gale SW (2009a) Calanthe R. Brown In: Chen XQ, Liu Zj, Zhu GH, et al (eds) Flora of China - Orchidaceae. Science Press, Beijing, pp 292–309Google Scholar
- Chen XQ, Gale SW, Cribb PJ, Ormerod P (2009b) Cephalanthera. In: Chen XQ, Liu ZJ, Zhu GH et al (eds) Flora of China – Orchidaceae. Science, Beijing, pp 174–175Google Scholar
- Chen XQ, Zj L, Zhu GH et al (eds) (2009) Flora of China – Orchidaceae. Science, BeijingGoogle Scholar
- Cho KH, Beyoung HK (1995) Significance of some environmental factors in the natural distribution of Cymbidium goeringii growing wild in Korea and the consideration for cultural practice. Proceedings of 5th Asia Pacific Orchid Conference and Show, Fukuoka, JapanGoogle Scholar
- Chuakul W (2002) Ethnomedical uses of thai orchidaceous plants. Mohidol Univ J Pharm Soc 29(3-4):41–45Google Scholar
- Comber JB (2001) Orchids of Sumatra. Natural History Publications (Borneo), Kota KinabaluGoogle Scholar
- Cragg GM, Boyd MR (1996) Drug development at the National Cancer Institute. In: Balick MJ, Elisabetsky E, Laird SA (eds) Medical resources of the tropical forest: biodiversity and its importance. Columbia University Press, New YorkGoogle Scholar
- Das SP (2004) Indian orchids in indigenous medicine system. In: Brirto SJ (ed) Orchids diversity and conservation. The Rapinat Herbarium, St John’s College, TiruchirappalliGoogle Scholar
- Dash PK, Sahoo S, Bal S (2008) Ethnobotanical studies on orchids of Niyamgiri Hill ranges, Orissa, India. Ethnobot Leaflets 12:70–78Google Scholar
- Dhayani A, Nautiyal BP, Nautiyal MC (2011) Importance of Astavarga plants in traditional systems of medicine in Garhwal, Indian Himalaya. Int J Biodiv Sci Ecosyst Serv Manage 6(1–2):13–19Google Scholar
- Du Puy D, Cribb PJ (2007) The Genus Cymbidium. Kew Publishing, Royal Botanic Gardens, KewGoogle Scholar
- Duggal SC (1971) Orchids in human affairs (a review). Pharm Biol 11(2):1727–1734Google Scholar
- Ernst R, Rodriguez E (1984) Carbohydrates of the Orchidaceae. In: Arditti J (ed) Orchid biology. Reviews and perspectives III. Cornell University Press, IthacaGoogle Scholar
- Fung TK (1999) Cymbidium ensifolium. Proceedings of the 16th World Orchid Conference, pp 314–319Google Scholar
- Ganesan S, Kesaavan L (2003) Ethnomedicinal plants used by the ethnic group Valaiyans of Vellimalai Hills (Reserve Forest), Tamil Nadu, India. In: Singh V, Jain AP (eds) Ethnobotany and medicinal Plants of India and Nepal. Scientific Publishers (India), Jodhpur, pp 754–760Google Scholar
- Ghosh BB, Ray S, Bhattacharyya P et al (1992) Cymbinodin B, a phenanthraquinone from Cymbidium aloifolium. Indian J Chem 31B:557–558Google Scholar
- Gimlette JD, Thomson HW (1939) A dictionary of Malayan medicine. Oxford University Press, LondonGoogle Scholar
- Gopal BB, Shankar DS, Kumar PS (2014) Study of antioxidant property of the pseudobulb Extract of Crepidium acuminatum (Jeevak) and its use in the green synthesis of gold nanoparticles. Int J Res Chem Environ 4(3):133–138Google Scholar
- Grant B (1895) The Orchids of Burma. Hanthawaddy Press, RangoonGoogle Scholar
- Gurong DB (2006) An illustrated guide to the orchids of Bhutan. DSB Publications, ThimphuGoogle Scholar
- Hamel PB, Chiltoskey MU (1975) Cherokee plants – their uses. A 400 year history. Self published.Google Scholar
- Handoyo F (2010) Orchids of Indonesia, vol 1. Indonesian Orchid Society, JakartaGoogle Scholar
- Hawkes AD (1965) Encyclopaedia of Cultivated Orchids. Faber & Faber, LondonGoogle Scholar
- Hedley C (1888) Uses of Queensland plants. Proc R Soc Queensland 5:10–13Google Scholar
- Henderson CP, Hancock IR (1988) A guide to the useful plants of Solomon Islands. Research Department, University of Agriculture and Lands, Honiara, Solomon IsGoogle Scholar
- Heyne K (1927) De nuttige planten van Nederlandsche Indie, vol 1, pp 508–513. Uitgave van het Departement van Landbouw, Nijverheid & Handel in Nederlandsche-IndieGoogle Scholar
- Hu SY (1971) Orchids in the life and culture of the Chinese people. Chung Chi J 10:1–26Google Scholar
- Hung T (2014) Lan Thanh Dam – Coelogyne: được tinh (Thanh Lan – Coelogyne: pharmacology). www.hoalanvietnam.org
- Hunter D (ed) (1956) Price’s textbook of the practice of medicine, 9th edn. Oxford University Press, LondonGoogle Scholar
- Hur S, Kim T (2009a) Homoisoflavanone, an extract from Cremastra appendiculata Makino, inhibits inflammatory and allergic response in mast cell. J Invest Dermatol 129(Suppl 1):S125Google Scholar
- Hur S, Kim T (2009b) Homoisoflavanone, an extract from Cremastra appendiculata Makino, inhibits UVB-induced skin inflammation. J Invest Dermatol 129(Suppl 1):S23Google Scholar
- Inoue S, Wakai A, Konishi T, Kiyosawa S, Sawada T (1984) Studies on Galeola septentrionalis Reichb. fil. I. Isolation and structure of the constituents of “Dotuusoo”. Yakugaka Zasshi 104(1):42–49Google Scholar
- Jain SP (2003) An inventory of threatened medicinal and aromatic plants of northwestern India. In: Singh V, Jain AP (eds) Ethnobotany and medicinal Plants of India and Nepal. Scientific Publishers (India), Jodhpur, pp 908–913Google Scholar
- Jaiswal S, Singh SV, Singh B, Singh HN (2004) Plant used for tissue healing of animals. Nat Prod Rad 3:284–292Google Scholar
- Jalal JS, Kumar P, Pangtey YPS (2008) Ethnomedicinal Orchids of Uttarakhand. Western Himalayas Ethnobot Leaflets 12:1227–1230Google Scholar
- Jalal JS, Kumar P, Tewari L, Pangtey YPS (2010) Orchids: uses in traditional medicine in India. In: National Seminars on Medicinal Plants of Himalayas. Regional Research Institute, Himalaya, India, TarikatGoogle Scholar
- Japan Calanthean Society (1987) Brochure, 12th World Orchid Conference, TokyoGoogle Scholar
- Jayaweera DMA (1981) A revised handbook of the flora of Ceylon, vol II. A.A. Balkema, RotterdamGoogle Scholar
- Jiangsu College of New Medicine (1986) Zhongyao Da Cidian (Encyclopaedia of Chinese medicine. First class award winner, Vol 1 and II). Shanghai Science and Technology PublishersGoogle Scholar
- Jin XH, Zhao XD, Shi XC (2009) Native orchids from Gaoligongshan mountains China. Science Press, BeijingGoogle Scholar
- Joseph J (1982) Orchids of Nilgiris. Records of the botanical survey of India, Vol XXII, 1982. Botanical Survey of India (Department of Environment), HowrahGoogle Scholar
- Ju JH, Yang JS, Li J, Xiao PG (2000) Cypripediquinone A, a new phenanthraquinone from Cypripedium macranthum (Orchidaceae). Chinese Chem Lett 11(1):37Google Scholar
- Kanda K (1977) The native orchids of Japan. Seibundo-Shinkosha, TokyoGoogle Scholar
- Karthikeyan S, Jain SK, Nayar MP, Sanjappa M (1989) Florae Indicae Enumeratio: Monocotyledonae. Botanical Survey of India, CalcuttaGoogle Scholar
- Kimura T, But PPH, Guo JX, Sung CK (eds) (2001) International collation of traditional and folk medicine, Northeast Asia Part 1. World Scientific, Singapore, New Jersey, London & Hong KongGoogle Scholar
- Kurzweil H, Lwin S (2014) A guide to orchids of Myanmar. Natural History Publications (Borneo), Kota KinabaluGoogle Scholar
- Lawler LJ (1984) Ethnobotany of the orchidaceae. In: Arditti J (ed) Orchid biology reviews and perspectives, vol 3. Cornell University Press, IthacaGoogle Scholar
- Lawler LJ (1986) Orchid ethnobotany in the ASEAN area. In: Rao AN (ed) Proceedings of the 5th ASEAN orchid congress. Parks & Recreation Department, Ministry of National Development, Singapore, pp 42–45Google Scholar
- Li L (1994) Chinese medicinal herbs of Hong Kong, vol 6, 198. Hong Kong Chinese Medical Research Institute, Hong KongGoogle Scholar
- Lin TP (1858) Calanthe Dominii (Hybrida): Gardeners’ ChronicleGoogle Scholar
- Lin TP (1975) Native orchids of Taiwan, vol 1. Southern Materials Center Inc., TaipeiGoogle Scholar
- Lin IH, Chang YS, Chen IS, Hsieh WC (2003) The catalogue of medicinal plant resources in Taiwan. China Press, Kuala Lumpur, p 153Google Scholar
- Liu YFP, Nakayama H (2007) Cymbidium goeringii in Japan. AOS Orchids 76:450–456Google Scholar
- Liu ZJ, Chen XQ, Cribb PJ (1969) Cymbidium Swartz. In: Chen XQ, Zj L, Zhu GH et al (eds) Flora of China - Orchidaceae. Science Press, Beijing, pp 260–280Google Scholar
- Liu TS, Su HJ (1978) Flora of Taiwan, vol 5. National University of Taiwan, TaipeiGoogle Scholar
- Liu ZJ, Chen SC, Ru ZZ, Chen LJ (2006) The genus cymbidium in China. www.sciencep.com
- Liu J, Yu ZB, Ye YH, Zhou YW (2008) Chemical constituents from the tuber of Cremastra appendiculata. Yaoxue Xuebao 43(2):181–184Google Scholar
- Luning B (1974b) Alkaloids of the Orchidaceae. In: Withner CL (ed) The orchid. Scientific studies. Wiley, New York, pp 347–382Google Scholar
- Luning B (1980) Alkaloids of the Orchidaceae. In: Sukshom Kashemsanta MR (ed) Proceedings of the 9th World Orchid Conference, BangkokGoogle Scholar
- MacDougal DT (1894) Poisonous influence of various species of cypripedium. Med Plants Nat Hist Bull 9:450–451Google Scholar
- Maikhuri RK, Phodani PC, Rao KS et al (2014) Ethnobiology and traditional knowledge of medicinal plants in health care system. In: Uniyal PL, Chamda BP, Semwal DP (eds) The plant wealth of Uttarakhand. Jagdamba Publishing Co., New DelhiGoogle Scholar
- Majumder PL, Datta N (1982) Structures of flavidinin and oxoflavidinin, two new modified 9,10-dihydrophenanthrenes of the orchid, Coelogyne flavida. Indian J Chem 21B:534–536Google Scholar
- Majumder PL, Laha S (1981) Occurrence of 2,7-dihydroxy-3,4,6-trimethoxy-9,10-dihydrophenenthrene in Coelogyne ovalis, a high altitude Himalayan orchid: application of C-13 NMR (nuclear magnetic resonance) spectroscopy in structure elucidation. J Indian Chem Soc 58:928–929Google Scholar
- Majumder PL, Pal S (nee Roy) (1985) A steroidal ester from Coelogyne uniflora. Phytochemistry 29(8):2717–2720Google Scholar
- Majumder PL, Sarkar AK (1982) Imbricatin, a new modified 9,10-dihydrophenanthrene derivative of the orchid Pholidota imbricata. Indian J Chem 21B:829–831Google Scholar
- Majumder PL, Bandyopadhyay D, Joardar S (1982a) Coelogin and Coeloginin: Two novel 9,10-dihydrophenanthrene derivatives from the orchid Coelogyne cristata. J Chem Soc I:1131–1136Google Scholar
- Manandhar NP, Manandhar S (2002) Plants and people of Nepal. Timber, PortlandGoogle Scholar
- Marasini R, Joshi S (2012) Antibacterial and antifungal activities of medicinal orchids growing in Nepal. J Nepal Chem Soc 29:104–109Google Scholar
- Matthew KM (1995) An excursion flora of Central Tamilnadu, India. A.A. Balkaema, RotterdamGoogle Scholar
- Merckx V (2012) Mycoheterotrophy: the biology of plants living on fungi. Springer (eBook)Google Scholar
- Min CC, Wang XJ, Liu WB (2012) Preliminary study on isolation of endophytic fungi from Cymbidium goeringii and its antimicrobial activity. Xibei Zhiwu Xuebao 32(3):596–599Google Scholar
- Misra S (2007) Orchids of India a glimpse. Bishen Singh Mahendra Pal Singh, DelhiGoogle Scholar
- Musharof Hossain M (2009) Traditional therapeutic uses of some indigenous orchids of Bangladesh. Med Arom Plant Sci Biotechnol 3:100–106Google Scholar
- Naing AH, Myint KT, Hwang YJ et al (2010) Micropropagation and conservation of the wild medicinal orchid, coelogyne cristata. Hort Environ Biotechnol 51(2):109–114Google Scholar
- Nakamura S, Tokado K, Onata A (1990) Japan prize fragrance competition. Am Orchid Soc Bull 59:1031–1036Google Scholar
- Nanakorn W, Watthana S (2008) Queen Sirikit Botanic Garden (Thai Native Orchids 1 and 2). Wanida Press, Chiang maiGoogle Scholar
- O’Byrne P (2001) A to Z of South East Asian Orchid Species. Orchid Society of South East Asia, SingaporeGoogle Scholar
- Ou JC, Hsieh WC, Lin IH, Chang YS, Chen IS (eds) (2003) The catalogue of medicinal plant resources in Taiwan. Department of Health, Executive Yuan, TaipeiGoogle Scholar
- Oudhia P (2013) Medicinal orchid Cymbidium macrorhizon Lindl. based herbal formulations used in Rheumatism in Indian traditional healing: Pankaj Oudhia’s Ethnobotanical Surveys 1990–2012Google Scholar
- Pandey NK, Joshi GC, Mudaiya RK et al (2003) Management and conservation of medicinal orchids of Kumaon and Garhwal Himalaya. In: Singh V, Jain AP (eds) Ethnobotany and medicinal plants of India and Nepal. Scientific Publishers (India), Jodhpur, pp 114–118Google Scholar
- Pant B, Raskoti BB (2013) Medicinal orchids of Nepal. Himalayan Map House (P) Ltd, KathmanduGoogle Scholar
- Pearce NR, Cribb PJ (2002) The orchids of Bhutan. Royal Botanic Gardens/Royal Government of Bhutan, Edinburgh/ThimpuGoogle Scholar
- Perner H (2002) Orchids and eco-tourism: the world natural heritage and biosphere reserve, Huanglong. Proceedings of the 17th World Orchid Conference, Shah Alam, Malaysia, pp 158–164Google Scholar
- Perner H (2007) Cypripediums in China Part IV. Orchids 76(4):291–292Google Scholar
- Perner H, Luo Y (2007) Orchids of Huanglong. Huanglong National Park, Sichuan Province, ChinaGoogle Scholar
- Perry LM, Metzger J (1980) Medicinal plants of east and southeast asia: attributed properties and uses. MIT Press, Cambridge, MAGoogle Scholar
- Pollicita M, Schols D, Aquaro S et al (2008) Carbohydrate-binding agents (CBAs) inhibit HIV-1 infection in human primary monocyte-derived macrophages (MDMs) and efficiently prevent MDM-directed viral capture and subsequent transmission to CD4+ T lymphocytes. Virology 370(2):3822–3891CrossRefGoogle Scholar
- Pradhan UC (1975) The Himalayan Cypripediums. In: Senghas K (ed) Proceedings of the 8th world orchid conference, Frankfurt, 10–17 Apr 1975, German Orchid Society, Frankfurt am Main, 199–204Google Scholar
- Puri HS (1970c) Salep – the drug from Orchids. Am Orchid Soc Bull 39(1):723Google Scholar
- Pushpa S, Nipunar M, Pankaj G et al (2001) Malaxis acuminata. A review. Int J Res Ayurveda Pharm 2(2):422–425Google Scholar
- Puy DD, Cribb PJ (1991) The genus Cymbidium. Batsford, DunfermlineGoogle Scholar
- Rao AN (2004) Medicinal orchid wealth of Arunachal Pradesh. Newslett ENVISNODE Indian Med Plants 1(2):1–7Google Scholar
- Rao TA (2007) Ethno botanical data on wild orchids of medicinal value as practised by tribals at Kudremukh National Park in Karnataka. Orchid Newslett 2(2):1–7Google Scholar
- Rao TA, Sridhar S (2007) Wild Orchids in Karnataka. A pictorial compendium. Institute of Natural Resources Conservation, Education, Research and Training (INCERT), BangaloreGoogle Scholar
- Raskoti BB (2009) The orchids of Nepal. Bhakta Bahadur Raskoti and Rita Ale, KathmanduGoogle Scholar
- Rathore SR (1983) Endemic and rare Species of Calanthe R. Br. (Orchidaceeae) in India. In: Jian SK, Rao RR (eds) An assessment of threatened plants of India. Botanical Survey of India, DelhiGoogle Scholar
- Reddy KN, Raju GV, Reddy CS, Raju VS (2005) Ethno-orchidology of orchids of Eastern Ghats of Andra Pradesh. EPRTI Newsl 11(3)Google Scholar
- Rhodehamel WA (2005) Calanthe ceciliae. Orchids 74(12):900–902Google Scholar
- Ridley HN (1906) Malay Drugs. Agricultural Bull. Straits Settlements and Fed Malay Staes 5, 245 and 277Google Scholar
- Rumphius GE (1741–1750, posthumus). Amboinsch Kruidboek (The Amboinese Herbal, Vol. 1–6). Translated and annotated into English, with an introduction by EM Beekman (2011). Yale University Press, New Haven and LondonGoogle Scholar
- Santapau H, Kapadia Z (1966) The Orchids of Bombay. Government of India Press, CalcuttaGoogle Scholar
- Sarin YK (1995) Ethnopharmacological perspectives of ayurvedic drugs having controversial botanical identity. In: Pushpangadan P, Nyman U, George V (eds) Glimpses of Indian ethnopharmacology. Tropical Botanic Garden and Research Institute, Thiruvananthapuram, pp 179–184Google Scholar
- Schuiteman A, de Vogel EF (2000) Cac Ci Ho Lan (Orchidaceae) Cua Thai Lan, Lao, Campuchia Va Viet Nam. Orchid Genera of Thailand Laos, Cambodia and Vietnam. (Vietnamese-English edition). Leiden: National Herbarium NederlandGoogle Scholar
- Seidenfaden G (1985) Contributions to the Orchid Flora of Thailand. XII. Dendrobium Sw. Opera Botanica 83, CopenhagenGoogle Scholar
- Seidenfaden G, Wood JJ (1992) The orchids of Peninsular Malaysia and Singapore. Olsen & Olsen, FredensborgGoogle Scholar
- Singh H (2010) Haat kali sacred grove, central himalaya, Utttarakhand. Curr Sci 98:290Google Scholar
- Singh A, Duggal S (2009) Medicinal orchids: an overview. Ethnobot Leaflets 13:351–363Google Scholar
- Slaytor MB (1977) The distribution and chemistry of alkaloids in the Orchidaceae. In: Arditti JA (ed) Orchids biology reviews and perspectives, vol 1. Cornell University Press, Ithaca and LondonGoogle Scholar
- Su, HJ (1985) Native orchids of Taiwan. Revised Third Ed. Harvest Farm Magazine, TaipeiGoogle Scholar
- Sun HQ, Liu YB, Song GE (2003) A preliminary on pollination of an endangered orchid, Changnienia amoena in Shennongjia. Acta Bot Sin 45(9):1019–1023Google Scholar
- Tang SL, Su HJ (1978) Flora of Taiwan, vol 5. Department of Botany, Taiwan National University, TaipeiGoogle Scholar
- Teoh ES (1982) A joy forever. Vanda Miss Joaquim. Singapore’s National Flower. Singapore: Times (reprinted 2008. Singapore: Marshall Cavendish)Google Scholar
- Trosien S, Waldvogel SR (2012) Synthesis of Highly funtionalized 9,10-phenenthrenequinones by oxidative coupling using MoC15. OrganLett 14(12):2976–2979Google Scholar
- University of Yangon Department of Botany (undated, possibly 2004). Myanmar Native OrchidsGoogle Scholar
- Usher G (1971) A dictionary of plants used by man. Constable, LondonGoogle Scholar
- Vaddhanaphuti N (2001) A field guide to the wild orchids of Thailand, 3rd edn. Silkworm Books, Chiang MaiGoogle Scholar
- Vaddhanaphuti N (2005). A field guide to the wild orchids of Thailand, Fourth and Expanded Edition. Silkworm Books, Chiang MaiGoogle Scholar
- van der Pijl L, Dodson CH (1966) Orchid flowers and their pollination. University of Miami Press, Coral GablesGoogle Scholar
- van Rheede HA (1703) Hortus Indicus Malabaricus, vol 12. Dutch East India Company, KeralaGoogle Scholar
- Veitch N, Grayer R (2007a) Calanthe. Phytochemistry. In: Pridgeon AM, Cribb PJ, Chase MW (eds) Genera Orchidacearum, vol 4, Epidendroideae (Part One). University Press, Oxford, pp 126–127Google Scholar
- Veitch N, Grayor R (2007b) Cephalanthera. Phytochemistry. In: Pridgeon AM, Cribb PJ, Chase MW (eds) Genera Orchidacearum, vol 4, Epidendroideae (Part Two). University Press, Oxford, pp 500–501Google Scholar
- Vidal J (1963) Les plantes utiles Du Laos. Cryptograms – Gymnospermes – Monocotyledones. Museum National d’Historie Naturelle, ParisGoogle Scholar
- Vij SP (1995) Orchid genetic diversity in india: conservation and commercialization. In: Proceedings of the 5th Asia Pacific orchid conference and Show, Fukuoka, pp 20–39Google Scholar
- Wang FQ, Tong QY, Ma HR (2015) Indole diketopiperazines from endophytic Chaeomium sp 88194 induce breast cancer cell apoptotic death. Sci Reports 5: Article 9294: 1–9Google Scholar
- Wilson MF (2007) Medicinal plant fact sheet. Cypripedium: Lady slipper orchids. A collaboration of the IUCN Medicinal Plant Specialist Group, PCA Medicinal Plant Working Group, and the North American Pollinator Protection Campaign. Arlington, Virginia. http://www.pollinator.org/Resources/Cypripedium.draft.pdf
- Wu XR (1994) A concise edition of medicinal plants in China. Guangdong Higher Education Publication House, Guangdong (in Chinese)Google Scholar
- Wu TL, Hu QM, Xia NH, Lai PCC, Yip KL (2001) Check list of Hong Kong plants 2001. Agriculture, Fisheries and Conservation Department, Hong KongGoogle Scholar
- Wu TL, Hu QM, Xia NH, Lai PCC, Yip KL (2002) Check List of Hong Kong Plants 2001. Agriculture, Fisheries and Conservation Department Bulletin 1 (Revised), HongkongGoogle Scholar
- Yan J, Li C, Chen S et al (2002) The effects of twenty one traditional Chinese medicines on tyrosinase. Zhang Yao Cai 25(10):724–726Google Scholar
- Yang ZH, Zhang QT, Feng ZZ, Lang KY, Li H (1998) English edition translated by ZR Xiong (ed.) Orchids. Beijing: China Esperanto PressGoogle Scholar
- Yong HS (1990) Orchid Portraits. Tropical Press Sdn Bhd, Kuala LumpurGoogle Scholar
- Yang ZH, Zhang QT, Feng ZZ, Lang KY, Li H (1993) English edition: Orchids (trans: Xiong ZR). China Esperanto, BeijingGoogle Scholar
- Yoshikawa M, Murakami T, Kishi A, Sakurama T, Matsuda H, Nomura M, Matsuda H, Kubo M (1998) Novel indole S, O-bisdesmoside, calanthoside, the precursor glycoside of tryptanthrin, indirubin and insatin, with increasing skin blood flow promoting effects, from two Calanthe species (Orchidaceae). Chem Pharm Bull (Tokyo) 46(5):886–888CrossRefGoogle Scholar
- Yuzammi and Hidayat S (eds) (2002) The unique, endemic and rare Flora of Sulawesi. Centre for Plant Conservation, Bogor Botanic Gardens, Institute of Indonesian Sciences, BogorGoogle Scholar
- Zhonghua Bencao (eds) (2000) Health Department and National Chinese Management Office. Shanghai Science and Technology, ShanghaiGoogle Scholar
- Zhongyao Da Cidian (1986) Jiangsu New Medical College (eds). Shanghai Science and Technology, ShanghaiGoogle Scholar