DBS Innovations in the Near Future?

  • Vignessh Kumar
  • Andre G. Machado
  • Adolfo Ramirez-Zamora
  • Julie G. Pilitsis


Advancement in deep brain stimulation (DBS) technology through the identification and development of new stimulation targets, stimulation hardware, and programming methods continues to drive innovation in stimulation treatment. In addition to the well-established DBS targets of the subthalamic nucleus (STN), the globus pallidus interna (GPi), and the ventralis intermedius (VIM) thalamus used in the treatment of Parkinson’s disease (PD), emerging targets that have recently gained attention include the zona incerta (ZI), subthalamic white matter fibers, pedunculopontine nucleus (PPN), and substantia nigra reticulata (SNr). Advances in electrode design and options in closed-loop DBS systems show promise in tailoring stimulation to individual patient preferences. Innovations in programming parameters, including interleaved stimulation and burst stimulation, can serve to optimize the balance between adequate energy delivery and reducing recharging burden. The vast future potential of these technologies is instrumental in optimizing patient outcomes and expanding potential DBS indications for years to come.


Deep brain stimulation Surgical innovation Technology Stimulation targets Programming parameters 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Vignessh Kumar
    • 1
  • Andre G. Machado
    • 2
    • 3
  • Adolfo Ramirez-Zamora
    • 4
  • Julie G. Pilitsis
    • 1
    • 5
  1. 1.Department of NeurosurgeryAlbany Medical CenterAlbanyUSA
  2. 2.Department of NeurosurgeryCleveland Clinic, Neurologic InstituteClevelandUSA
  3. 3.Cleveland Clinic, Neurologic Institute, Center for Neurological RestorationClevelandUSA
  4. 4.Department of NeurologyUniversity of FloridaGainesvilleUSA
  5. 5.Department of Neuroscience and Experimental TherapeuticsAlbany Medical CenterAlbanyUSA

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