Is There a Role for MRI-Guided Focused Ultrasound Lesioning for PD?
Ultrasound has been used diagnostically in medicine for decades, but the advent of multiple phased array ultrasound transducers and MRI thermography has allowed precise transcranial application of therapeutic ultrasound energy. Stereotactic ablations can now be made in the brain without making incisions or disrupting the skull in any way. These lesions can be made in awake patients while monitoring for clinical improvement and side effects with real-time thermal mapping of the evolving ablation. This technology has been validated and approved by the FDA in the treatment of Essential Tremor, and is now undergoing evaluation for the treatment of Parkinson’s disease and several other chronic neurologic disorders. This chapter reviews the history of therapeutic ultrasound technology, the medical evidence for its efficacy in treating central nervous system disorders including Parkinson’s disease, and its future therapeutic applications.
KeywordsFocused Ultrasound MRgFUS MRI-guided focused ultrasound Parkinson’s disease HIFU Sonication ExAblate 4000
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