Closed-Loop Deep Brain Stimulation for Parkinson’s Disease

  • R. Eitan
  • H. Bergman
  • Z. IsraelEmail author


  • Optimal outcomes of deep brain stimulation (DBS) surgery are often an elusive goal.

  • Constant “one-program” stimulation does not reflect the reality of changing clinical symptoms.

  • Closed-loop technology might provide a solution.

  • Closed-loop design will likely integrate multi-sourced sensing data, computed using information from a population database and individual hierarchical paradigms to continuously titrate parameters of stimulation.

  • Proof of principle already exists for the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) primate model and in human Parkinson’s disease (PD) patients.

  • Many elements of such a feedback system have already been developed.


Closed loop Deep brain stimulation 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Medical Neurobiology (Physiology)Institute of Medical Research Israel-Canada (IMRIC), Edmond and Lily Safra Center (ELSC) for Brain Research, The Hebrew UniversityJerusalemIsrael
  2. 2.Department of NeurosurgeryHadassah University HospitalJerusalemIsrael

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