Nonneoplastic Hepatobiliary Disease

Chapter

Abstract

The liver is susceptible to infections, alcoholic and nonalcoholic fatty liver disease, metabolic diseases, and developmental abnormalities. Its central role in drug metabolism predisposes it to an array of drug-induced injuries which may mimic any known pattern of liver injury. However, notwithstanding the number of conditions discussed in this chapter, the majority of cases of liver disease are attributable to the big four: hepatitis C, hepatitis B, alcoholic fatty liver disease, and nonalcoholic fatty liver disease. This is followed by autoimmune and drug-induced liver injury in developed countries and by viral and parasitic infections in less developed and tropical parts of the globe.

Keywords

Viral hepatitis Autoimmune hepatitis Drugs Toxins Steatohepatitis Alcohol Total parenteral nutrition Primary biliary cirrhosis Primary sclerosing cholangitis Cholestasis 
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SUGGESTED READING

  1. Abbas Z, Afzal R. Life cycle and pathogenesis of hepatitis D virus: a review. World J Hepatol. 2013;5:666–75.PubMedCentralCrossRefPubMedGoogle Scholar
  2. Arends JE, Ghisetti V, Irving W, et al. Hepatitis E: an emerging infection in high income countries. J Clin Virol. 2014;59:81–8.CrossRefPubMedGoogle Scholar
  3. Batts KP, Ludwig J. Chronic hepatitis. An update on terminology and reporting. Am J Surg Pathol. 1995;19:1409–17.CrossRefPubMedGoogle Scholar
  4. Bhardwaj SS, Saxena R, Kwo PY. Granulomatous liver disease. Curr Gastroenterol Rep. 2009;11:42–9.CrossRefPubMedGoogle Scholar
  5. Carpenter HA, Czaja AJ. The role of histologic evaluation in the diagnosis and management of autoimmune hepatitis and its variants. Clin Liver Dis. 2002;6:685–705.CrossRefPubMedGoogle Scholar
  6. Ceni E, Mello T, Galli A. Pathogenesis of alcoholic liver disease: role of oxidative metabolism. World J Gastroenterol. 2014;20:17756–72.PubMedCentralPubMedGoogle Scholar
  7. Chanprasert S, Scaglia F. Adult liver disorders caused by inborn errors of metabolism: review and update. Mol Genet Metab. 2015;114:1–10.CrossRefPubMedGoogle Scholar
  8. Denk H, Scheuer PJ, Baptista A, et al. Guidelines for the diagnosis and interpretation of hepatic granulomas. Histopathology. 1994;25:209–18.CrossRefPubMedGoogle Scholar
  9. Devaney K, Goodman ZD, Epstein MS, Zimmerman HJ, Ishak KG. Hepatic sarcoidosis. Clinicopathologic features in 100 patients. Am J Surg Pathol. 1993;17:1272–80.CrossRefPubMedGoogle Scholar
  10. Erlinger S, Arias IM, Dhumeaux D. Inherited disorders of bilirubin transport and conjugation: new insights into molecular mechanisms and consequences. Gastroenterology. 2014;146:1625–38.CrossRefPubMedGoogle Scholar
  11. Fairbanks KD, Tavill AS. Liver disease in alpha 1-antitrypsin deficiency: a review. Am J Gastroenterol. 2008;103:2136–41.CrossRefPubMedGoogle Scholar
  12. Fattovich G. Natural history and prognosis of hepatitis B. Semin Liver Dis. 2003;23:47–58.CrossRefPubMedGoogle Scholar
  13. Fujiwara S, Yokokawa Y, Morino K, Hayasaka K, Kawabata M, Shimizu T. Chronic hepatitis E: a review of the literature. J Viral Hepat. 2014;21:78–89.CrossRefPubMedGoogle Scholar
  14. Gatselis NK, Zachou K, Koukoulis GK, Dalekos GN. Autoimmune hepatitis, one disease with many faces: etiopathogenetic, clinico-laboratory and histological characteristics. World J Gastroenterol. 2015;21:60–83.PubMedCentralCrossRefPubMedGoogle Scholar
  15. Gitlin JD. Wilson disease. Gastroenterology. 2003;125:1868–77.CrossRefPubMedGoogle Scholar
  16. Goodman ZD. Grading and staging systems for inflammation and fibrosis in chronic liver diseases. J Hepatol. 2007;47:598–607.CrossRefPubMedGoogle Scholar
  17. Hartleb M, Gutkowski K, Milkiewicz P. Nodular regenerative hyperplasia: evolving concepts on underdiagnosed cause of portal hypertension. World J Gastroenterol. 2011;17:1400–9.PubMedCentralCrossRefPubMedGoogle Scholar
  18. Ishak KG. Inherited metabolic diseases of the liver. Clin Liver Dis. 2002;6:455–79. viii.CrossRefPubMedGoogle Scholar
  19. Jungst C, Berg T, Cheng J, et al. Intrahepatic cholestasis in common chronic liver diseases. Eur J Clin Invest. 2013;43:1069–83.CrossRefPubMedGoogle Scholar
  20. Kahi CJ, Saxena R, Temkit M, et al. Hepatobiliary disease in sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2006;23:117–23.PubMedGoogle Scholar
  21. Kleiner DE, Brunt EM, Van Natta M, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 2005;41:1313–21.CrossRefPubMedGoogle Scholar
  22. Kleiner DE, Chalasani NP, Lee WM, et al. Hepatic histological findings in suspected drug-induced liver injury: systematic evaluation and clinical associations. Hepatology. 2014;59:661–70.PubMedCentralCrossRefPubMedGoogle Scholar
  23. Knodell RG, Ishak KG, Black WC, et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology. 1981;1:431–5.CrossRefPubMedGoogle Scholar
  24. Kohli A, Shaffer A, Sherman A, Kottilil S. Treatment of hepatitis C: a systematic review. JAMA. 2014;312:631–40.CrossRefPubMedGoogle Scholar
  25. Koskinas J, Gomatos IP, Tiniakos DG, et al. Liver histology in ICU patients dying from sepsis: a clinico-pathological study. World J Gastroenterol. 2008;14:1389–93.PubMedCentralCrossRefPubMedGoogle Scholar
  26. Kuo A, Gish R. Chronic hepatitis B infection. Clin Liver Dis. 2012;16:347–69.CrossRefPubMedGoogle Scholar
  27. LaRusso NF, Shneider BL, Black D, et al. Primary sclerosing cholangitis: summary of a workshop. Hepatology. 2006;44:746–64.CrossRefPubMedGoogle Scholar
  28. Lee MH, Yang HI, Yuan Y, L'Italien G, Chen CJ. Epidemiology and natural history of hepatitis C virus infection. World J Gastroenterol. 2014;20:9270–80.PubMedCentralPubMedGoogle Scholar
  29. Lefkowitch JH. Bile ductular cholestasis: an ominous histopathologic sign related to sepsis and “cholangitis lenta”. Hum Pathol. 1982;13:19–24.CrossRefPubMedGoogle Scholar
  30. Lefkowitch JH. Morphology of alcoholic liver disease. Clin Liver Dis. 2005;9:37–53.CrossRefPubMedGoogle Scholar
  31. Lok AS, McMahon BJ. Chronic hepatitis B: update 2009. Hepatology. 2009;50:661–2.CrossRefPubMedGoogle Scholar
  32. Mani H, Kleiner DE. Liver biopsy findings in chronic hepatitis B. Hepatology. 2009;49:S61–71.CrossRefPubMedGoogle Scholar
  33. McMahon BJ. The natural history of chronic hepatitis B virus infection. Hepatology. 2009;49:S45–55.CrossRefPubMedGoogle Scholar
  34. Nakamura K, Tanoue A. Etiology of biliary atresia as a developmental anomaly: recent advances. J Hepatobiliary Pancreat Sci. 2013;20:459–64.CrossRefPubMedGoogle Scholar
  35. Riveiro-Barciela M, Rodriguez-Frias F, Buti M. Hepatitis E virus: new faces of an old infection. Ann Hepatol. 2013;12:861–70.PubMedGoogle Scholar
  36. Rubbia-Brandt L. Sinusoidal obstruction syndrome. Clin Liver Dis. 2010;14:651–68.CrossRefPubMedGoogle Scholar
  37. Seeff LB. The history of the “natural history” of hepatitis C (1968–2009). Liver Int. 2009;29 Suppl 1:89–99.PubMedCentralCrossRefPubMedGoogle Scholar
  38. Seeff LB, Bonkovsky HL, Navarro VJ, Wang G. Herbal products and the liver: a review of adverse effects and mechanisms. Gastroenterology. 2015;148:517–32.e3.Google Scholar
  39. Shapiro MA, Lewis JH. Causality assessment of drug-induced hepatotoxicity: promises and pitfalls. Clin Liver Dis. 2007;11:477–505. v.CrossRefPubMedGoogle Scholar
  40. Sherman KE. HCV and HIV: a tale of two viruses. Rev Gastroenterol Disord. 2004;4 Suppl 1:S48–54.PubMedGoogle Scholar
  41. Smyth C, Kelleher D, Keeling PW. Hepatic manifestations of gastrointestinal diseases. Inflammatory bowel disease, celiac disease, and Whipple's disease. Clin Liver Dis. 2002;6:1013–32.CrossRefPubMedGoogle Scholar
  42. Theise ND. Liver biopsy assessment in chronic viral hepatitis: a personal, practical approach. Mod Pathol. 2007;20 Suppl 1:S3–14.Google Scholar
  43. Trepo C. A brief history of hepatitis milestones. Liver Int. 2014;34 Suppl 1:29–37.CrossRefPubMedGoogle Scholar
  44. Uibo R, Kisand K, Yang CY, Gershwin ME. Primary biliary cirrhosis: a multi-faced interactive disease involving genetics, environment and the immune response. APMIS. 2012;120:857–71.CrossRefPubMedGoogle Scholar
  45. van der Woerd WL, van Mil SW, Stapelbroek JM, Klomp LW, van de Graaf SF, Houwen RH. Familial cholestasis: progressive familial intrahepatic cholestasis, benign recurrent intrahepatic cholestasis and intrahepatic cholestasis of pregnancy. Best Pract Res Clin Gastroenterol. 2010;24:541–53.CrossRefPubMedGoogle Scholar
  46. Vernon G, Baranova A, Younossi ZM. Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment Pharmacol Ther. 2011;34:274–85.CrossRefPubMedGoogle Scholar
  47. Wieser V, Gerner R, Moschen AR, Tilg H. Liver complications in inflammatory bowel diseases. Dig Dis. 2013;31:233–8.CrossRefPubMedGoogle Scholar
  48. Yeh MM, Brunt EM. Pathological features of fatty liver disease. Gastroenterology. 2014;147:754–64.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Department of Pathology and Laboratory MedicineTulane UniversityNew OrleansUSA
  2. 2.Department of Pathology and Laboratory MedicineIndiana University School of MedicineIndianapolisUSA

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