Bionic Graphene Nanosensors

Part of the Springer Series in Biomaterials Science and Engineering book series (SSBSE, volume 5)


The synergistic integration of electronics with biological systems could enable the development of novel sensing devices that could provide new fundamental insights to biomolecular interactions, as well as facilitating the development of novel biointerfaced device architectures. Indeed, the creation of high-performance biomedical sensors with real-time, point-of-care detection could potentially revolutionize the field of early diagnosis and treatment of diseases, improving quality of life. Of particular interest is multitiered interfacing of sensing materials with biology; for example, by coupling the innate selectivity of naturally evolved biomolecules with highly sensitive nanosensors, and subsequently biointerfacing such devices onto the body for real-time detection. This is particularly useful for continual monitoring and diagnosis of complex diseases such as asthma, in which understandings of disease development and the role of environmental triggers are limited. Here, we provide an overview of our specific contributions in: (1) biotransfering graphene sensors onto biological systems to enable a unique bionic nanosensor platform, (2) the detection of bacteria using such platforms via the coupling of antimicrobial peptide bio-recognition molecules to the graphene transducer, (3) the integration of an inductive meander coil with such devices to enable wireless powering and remote readout, (4) the scaling of such devices to wafer-scale arrays using standard microfabrication processing techniques, and (5) the functionalization of these graphene device arrays with a variety of antibodies for ultrasensitive detection of cytokines that are relevant to the detection and diagnosis of asthma from exhaled breath condensate. These results suggest a next-generation “bionic nanosensing” platform that may ultimately promote effective, noninvasive diagnosis and advanced mediation of diseases via early onset detection and continuous tracking of disease progression. Ultimately, large-scale adoption of such systems may enable population pool clinical studies involving dynamic, noninvasive collection of biomarkers for health infrastructure statistical analyses. The graphene bionic nanosensor platform thus represents a powerful new biointerfaced sensing paradigm, with a diverse range of applications.


Chronic Obstructive Pulmonary Disease Silk Fibroin Exhale Breath Condensate Graphene Film Noninvasive Diagnosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We acknowledge support of this work by the Air Force Office of Scientific Research (#FA9550-09-1-0096 and #FA9550-12-1-0368), by the American Asthma Foundation (#09–0038), and by the Grand Challenges Program at Princeton University.


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Department of Mechanical and Aerospace EngineeringPrinceton UniversityPrincetonUSA

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