Continuous Monitoring of the Complexity of Intracranial Pressure After Head Injury

  • Cheng-Wei LuEmail author
  • Marek Czosnyka
  • Jiann-Shing Shieh
  • John D. Pickard
  • Peter Smielewski
Part of the Acta Neurochirurgica Supplement book series (NEUROCHIRURGICA, volume 122)


Multiscale entropy (MSE) has been increasingly used to investigate the complexity of biological signals. Our previous study demonstrated that the complexity of mean intracranial pressure (ICP), assessed by MSE based on the whole recording periods, is associated with the outcome after traumatic brain injury (TBI). To improve the feasibility of MSE in a clinical setting, this study examined whether the complexity of ICP waveforms based on shorter periods could be a reliable predictor of the outcome in patients with TBI. Results showed that the complexity of ICP slow waves, calculated in 3-h moving windows, correlates with the outcome of patients with TBI. Thus, the complexity of ICP may be a promising index to be incorporated into multimodal monitoring in patients with TBI.


Complexity Intracranial pressure Multiscale entropy Outcome Traumatic brain injury 



This research was supported by the Center for Dynamical Biomarkers and Translational Medicine, which is sponsored by the National Science Council (grant number: NSC 101-2911-I-008-001).

Conflict of Interest Statement

We declare that we have no conflict of interest.


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Cheng-Wei Lu
    • 1
    • 2
    • 3
    Email author
  • Marek Czosnyka
    • 3
  • Jiann-Shing Shieh
    • 2
  • John D. Pickard
    • 4
  • Peter Smielewski
    • 3
  1. 1.Department of AnaesthesiologyFar-Eastern Memorial HospitalNew Taipei CityTaiwan
  2. 2.Department of Mechanical EngineeringYuan Ze UniversityTaoyuanTaiwan
  3. 3.Division of Neurosurgery, Department of Clinical NeurosciencesUniversity of CambridgeCambridgeUK
  4. 4.Department of NeurosurgeryAddenbrooke’s Hospital, University of CambridgeCambridgeUK

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