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The Ontogeny of Cerebrovascular Pressure Autoregulation in Premature Infants

  • Christopher J. RheeEmail author
  • Charles D. Fraser
  • Kathleen Kibler
  • Ronald B. Easley
  • Dean B. Andropoulos
  • Marek Czosnyka
  • Georgios V. Varsos
  • Peter Smielewski
  • Craig G. Rusin
  • Ken M. Brady
  • Jeffrey R. Kaiser
Part of the Acta Neurochirurgica Supplement book series (NEUROCHIRURGICA, volume 122)

Abstract

Our objective was to quantify cerebrovascular autoregulation as a function of gestational age (GA) and across the phases of the cardiac cycle. One hundred eighty-six premature infants, with a GA range of 23–33 weeks, were monitored using umbilical artery catheters and transcranial Doppler insonation of middle cerebral artery flow velocity (FV) for 1-h sessions over the first week of life. Autoregulation was quantified as a moving correlation coefficient between systolic arterial blood pressure (ABP) and systolic FV (Sx); mean ABP and mean FV (Mx); diastolic ABP and diastolic FV (Dx). Autoregulation was compared across GAs for each aspect of the cardiac cycle. Systolic FV was pressure-passive in infants with the lowest GA, and Sx decreased with increased GA (r = −0.3; p < 0.001). By contrast, Dx was elevated in all subjects, and showed minimal change with increased GA (r = −0.06; p = 0.05). Multivariate analysis confirmed that GA (p < 0.001) and the “closing margin” (p < 0.01) were associated with Sx. Premature infants have low and almost always pressure-passive diastolic cerebral blood FV. Conversely, the regulation of systolic cerebral blood FV by autoregulation was manifested in this cohort at a GA of between 23 and 33 weeks.

Keywords

Cerebrovascular pressure autoregulation Arterial blood pressure Closing margin Prematurity 

Notes

Acknowledgments

Dr Kaiser was supported by the National Institutes of Health (1K23NS43185, RR20146, and 1R01NS060674) and the University of Arkansas for Medical Sciences (UAMS) Translational Research Institute (1UL1RR029884). The technical assistance of Natalie C. Sikes and Melanie J. Mason, and the support of the UAMS neonatologists, NICU nurses, respiratory therapists, and ultrasound technicians, are gratefully appreciated.

Conflict of Interest Statement

 There is no potential conflict of interest, real or perceived.

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Christopher J. Rhee
    • 1
    Email author
  • Charles D. Fraser
    • 2
  • Kathleen Kibler
    • 3
  • Ronald B. Easley
    • 3
  • Dean B. Andropoulos
    • 3
  • Marek Czosnyka
    • 5
  • Georgios V. Varsos
    • 4
  • Peter Smielewski
    • 5
  • Craig G. Rusin
    • 6
  • Ken M. Brady
    • 3
  • Jeffrey R. Kaiser
    • 7
  1. 1.Section of Neonatology, Department of PediatricsTexas Children’s Hospital, Baylor College of MedicineHoustonUSA
  2. 2.University of Texas at Houston School of MedicineHoustonUSA
  3. 3.Departments of Pediatrics and AnesthesiologyTexas Children’s Hospital, Baylor College of MedicineHoustonUSA
  4. 4.Division of NeurosurgeryAddenbrooke’s Hospital, Cambridge UniversityCambridgeUK
  5. 5.Division of NeurosurgeryDepartment of Clinical Neurosciences, University of CambridgeCambridgeUK
  6. 6.Department of CardiologyTexas Children’s Hospital, Baylor College of MedicineHoustonUSA
  7. 7.Section of Neonatology, Departments of Pediatrics and Obstetrics and GynecologyTexas Children’s Hospital, Baylor College of MedicineHoustonUSA

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