The Key Role of Pathology in the Context of Precision Medicine Trials
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The pathologist’s role in the context of precision medicine integrates samples preparation for nucleic acids extractions together with pathological analysis, a mandatory step before molecular analyses. The morphological and phenotypical diagnosis contributes to the appropriate interpretation of the identified molecular alterations providing the exact nature of the tumor, the tumoral cellularity of the analyzed sample useful to interpret molecular alterations such as alternative allele frequency. In some circumstances, genomic alterations require to be validated at the protein level using immunohistochemistry expression.
KeywordsMolecular Alteration Genomic Alteration Nucleic Acid Extraction Precision Medicine PTEN Loss
- Le Tourneau C, Mitry E, Goncalves A et al (2014) Randomized phase II trial comparing therapy based on tumor molecular profiling versus conventional therapy in patients with refractory cancer: results of the feasibility part of the SHIVA trial. Br J Cancer 111:17–24PubMedCentralCrossRefPubMedGoogle Scholar