The Key Role of Pathology in the Context of Precision Medicine Trials



The pathologist’s role in the context of precision medicine integrates samples preparation for nucleic acids extractions together with pathological analysis, a mandatory step before molecular analyses. The morphological and phenotypical diagnosis contributes to the appropriate interpretation of the identified molecular alterations providing the exact nature of the tumor, the tumoral cellularity of the analyzed sample useful to interpret molecular alterations such as alternative allele frequency. In some circumstances, genomic alterations require to be validated at the protein level using immunohistochemistry expression.


Molecular Alteration Genomic Alteration Nucleic Acid Extraction Precision Medicine PTEN Loss 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Le Tourneau C, Mitry E, Goncalves A et al (2014) Randomized phase II trial comparing therapy based on tumor molecular profiling versus conventional therapy in patients with refractory cancer: results of the feasibility part of the SHIVA trial. Br J Cancer 111:17–24PubMedCentralCrossRefPubMedGoogle Scholar

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© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Department of PathologyInstitut CurieParisFrance

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